Clark Fisher, MD, PhD
Clinical FellowAbout
Research
Publications
Featured Publications
Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience
Raredon MSB, Fisher C, Heerdt PM, Schonberger RB, Nargi A, Nivison S, Fajardo E, Deshpande R, Akhtar S, Greaney AM, Belter J, Raredon T, Zinter J, McKee A, Michalski M, Baevova P, Niklason LE. Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience. Anesthesia & Analgesia 2021, 134: 1094-1105. PMID: 34928890, DOI: 10.1213/ane.0000000000005825.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureClinical experienceIndividualized positive end-expiratory pressureIntensive care unitEnd-expiratory pressureCoronavirus disease 2019 (COVID-19) pandemicHealth care teamDisease 2019 pandemicVentilatory supportIll patientsCare unitCare teamVentilator sharingFuture clinical applicationsPatientsIndependent careVentilator capacityClinical applicationCOVID-19 pandemicVentilatorClinical environmentOutline recommendationsMass traumaPandemicHospital
2024
Variation in Intraoperative Opioid Administration by Patient, Clinician, and Hospital Contribution
Burns M, Hilliard P, Vandervest J, Mentz G, Josifoski A, Varghese J, Fisher C, Kheterpal S, Shah N, Bicket M. Variation in Intraoperative Opioid Administration by Patient, Clinician, and Hospital Contribution. JAMA Network Open 2024, 7: e2351689. PMID: 38227311, PMCID: PMC10792468, DOI: 10.1001/jamanetworkopen.2023.51689.Peer-Reviewed Original ResearchConceptsIntraoperative opioid administrationOral morphine equivalentsOpioid administrationSurgical proceduresHospital levelElectronic health record dataIntraclass correlationCohort studyAnalgesic categoriesSurgical categoriesHealth record dataQuality-improvement programHospital-level factorsPatient-level factorsNeuraxial analgesic techniquesCardiac surgical proceduresKnee surgical proceduresOpioid-reducing strategiesElective surgical proceduresMain OutcomesHospital contributionMorphine equivalentsOpioid exposureSurgical characteristicsOpioid prescriptions
2023
Association of adherence to individual components of Society of Thoracic Surgeons cardiac surgery antibiotic guidelines and postoperative infections
Bardia A, Michel G, Farela A, Fisher C, Mori M, Huttler J, Lang A, Geirsson A, Schonberger R. Association of adherence to individual components of Society of Thoracic Surgeons cardiac surgery antibiotic guidelines and postoperative infections. Journal Of Thoracic And Cardiovascular Surgery 2023, 167: 2170-2176.e5. PMID: 37075942, PMCID: PMC10579454, DOI: 10.1016/j.jtcvs.2023.03.031.Peer-Reviewed Original ResearchWeight-adjusted dosingPostoperative infectionAntibiotic guidelinesIncidence of nonadherenceCoronary artery bypassTertiary care hospitalAssociation of adherenceCohort of patientsRetrospective observational studyPost-operative infectionIntraoperative redosingValvular surgeryAntibiotic timingArtery bypassCoronary revascularizationPostoperative complicationsPostoperative sepsisAdult patientsFirst doseAntibiotic choiceCardiac surgeryCardiopulmonary bypassCare hospitalDose adjustmentPrimary outcome
2018
Brain Iron Distribution after Multiple Doses of Ultra-small Superparamagnetic Iron Oxide Particles in Rats.
Gorman A, Deh K, Schwiedrzik C, White J, Groman E, Fisher C, Gillen K, Spincemaille P, Rasmussen S, Prince M, Voss H, Freiwald W, Wang Y. Brain Iron Distribution after Multiple Doses of Ultra-small Superparamagnetic Iron Oxide Particles in Rats. Comparative Medicine 2018, 68: 139-147. PMID: 29663939, PMCID: PMC5897970.Peer-Reviewed Original ResearchConceptsSerum iron levelsHigh cumulative dosesWashout periodCumulative dosesIron levelsBrain ventriclesIron depositionMale Sprague-Dawley ratsUltra-small superparamagnetic iron oxide particlesQuantitative susceptibility mapsEnd of dosingSerum iron concentrationSprague-Dawley ratsBrain iron distributionGradient-echo MRIMultiple dosesBrain parenchymaSuperparamagnetic iron oxide particlesIron biodistributionFrequent administrationHistologic analysisParamagnetic iron oxideIron accumulationTime pointsDoses
2015
Whole-agent selectivity within the macaque face-processing system
Fisher C, Freiwald W. Whole-agent selectivity within the macaque face-processing system. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 14717-14722. PMID: 26464511, PMCID: PMC4664356, DOI: 10.1073/pnas.1512378112.Peer-Reviewed Original ResearchContrasting Specializations for Facial Motion within the Macaque Face-Processing System
Fisher C, Freiwald W. Contrasting Specializations for Facial Motion within the Macaque Face-Processing System. Current Biology 2015, 25: 261-266. PMID: 25578903, PMCID: PMC4302012, DOI: 10.1016/j.cub.2014.11.038.Peer-Reviewed Original ResearchConceptsMacaque face-processing systemFace processing systemFace patchesFacial motionFace patch systemHigh-level motionNeural machineryForm stimuliBrain activityFace motionNew organizational principlesMotion areaObject motionFunctional divideMacaque brainMacaque monkeysOrganizational principlesFacial formFaceFMRIStimuliBrain
2013
Alert Response to Motion Onset in the Retina
Chen EY, Marre O, Fisher C, Schwartz G, Levy J, da Silveira RA, Berry MJ. Alert Response to Motion Onset in the Retina. Journal Of Neuroscience 2013, 33: 120-132. PMID: 23283327, PMCID: PMC3711149, DOI: 10.1523/jneurosci.3749-12.2013.Peer-Reviewed Original Research
2011
Topographic enhancement mapping of the cancer-associated breast stroma using breast MRI
Nabavizadeh N, Klifa C, Newitt D, Lu Y, Chen Y, Hsu H, Fisher C, Tokayasu T, Olshen A, Spellman P, Gray J, Hylton N, Park C. Topographic enhancement mapping of the cancer-associated breast stroma using breast MRI. Integrative Biology 2011, 3: 490-496. PMID: 21416100, PMCID: PMC3698966, DOI: 10.1039/c0ib00089b.Peer-Reviewed Original ResearchConceptsCancer-associated stromaMagnetic resonance imagingBreast magnetic resonance imagingBreast cancer patientsCancer patientsPrimary tumorBreast cancerBreast tissueInvasive breast cancerNormal-appearing breast tissueHuman breast cancerNormal breast tissueNon-invasive imaging techniqueLocal therapyBreast stromaMicrovessel densityIntact stromaBreast fibroglandular tissueCorrelative histologyTumor edgeResonance imagingLocal tissueArray comparative genomic hybridizationStromaCancer
2009
MRI and Histologic Quantification of Neoangiogenesis in Normal Appearing Breast Beyond the Tumor Margin: Implications for Local Treatment
Nabavizadeh N, Klifa C, Chen Y, Newitt D, Lu Y, Hattangadi J, Fisher C, Hylton N, Park C. MRI and Histologic Quantification of Neoangiogenesis in Normal Appearing Breast Beyond the Tumor Margin: Implications for Local Treatment. International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s190. DOI: 10.1016/j.ijrobp.2009.07.441.Peer-Reviewed Original ResearchMR quantification of abnormal stromal enhancement in the periphery of invasive breast tumors
Nabavizadeh N, Klifa C, Newitt D, Lu Y, Hattangadi J, Fisher C, Hylton N, Park C. MR quantification of abnormal stromal enhancement in the periphery of invasive breast tumors. Journal Of Clinical Oncology 2009, 27: 636-636. DOI: 10.1200/jco.2009.27.15_suppl.636.Peer-Reviewed Original ResearchSignal enhancement ratioNormal breast tissueDynamic contrast-enhanced MRIBreast stromaBreast tissueInvasive breast cancer patientsDisease-free survivalBreast cancer patientsHigh tumor vascularityInvasive breast tumorsNormal breast stromaNon-cancerous stromaContrast-enhanced MRIPost-contrast imagesSignal intensity changesTumor-related angiogenesisTumor regionFree survivalCancer patientsPrimary tumorOverall vascularityTumor vascularityAdjusted p-values
Clinical Care
Overview
Clinical Specialties
Anesthesiology; Cardiac Anesthesiology
Board Certifications
Advanced Perioperative Transesophageal Echocardiography
- Certification Organization
- National Board of Echocardiography
- Original Certification Date
- 2023
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 2022
Links & Media
News
- September 29, 2020
Yale Department of Anesthesiology 5th Annual Celebration of Research 2020
- April 16, 2020
Sharing a Ventilator, Sparing a Life: Two Yale Groups Create Different Ways To Maximize Ventilator Capacity in a Crisis
- April 09, 2020Source: Yale School of Engineering and Applied Sciences
With an Urgent Need, Researchers Develop Multi-Patient Ventilators