Search Results < Yale School of Medicine

30 results

News
New Immunotherapy Treatment Brings Hope to Patients With Advanced Non-Small Cell Lung Cancer
The study's findings suggest that NC318, both alone and in combination with pembrolizumab, improved response rates and clinical outcomes for some patients with NSCLC.
8 Sep 2023
News
AI More Accurately Identifies Patients With Advanced Lung Cancer Who Respond to Immunotherapy
Researchers compared AI-powered digital scoring with traditional manual scoring of the PD-L1 immune biomarker to determine if a new immunotherapy treatment, atezolizumab, could benefit patients with advanced non-small cell lung cancer.
8 Sep 2023
News
Study Shows Promise of Immunotherapy Treatment for Penile Cancer
An international study led by Yale Cancer Center researchers at Yale School of Medicine found that the use of immune checkpoint inhibitors offers promising clinical benefits for some patients with advanced penile squamous cell carcinoma.
11 Aug 2023
News
Screening Mammograms Carry Risks for Older Women, Study Finds
Although some guidelines recommend continuing screening for older women, this new study emphasizes the importance of assessing potential harms associated with testing, such as overdiagnosis, which, researchers say, can negatively affect quality of life.
7 Aug 2023
News
Method Allows New Insights Into Interplay Between Immune System and Tumors
A new technique will enable researchers to study individual differences in cancer progression and treatment response.
Source: YaleNews
3 Aug 2023
News
Researchers Develop a New Way to Classify HPV-Associated Head and Neck Cancers
Researchers have identified a novel subclass of HPV+ head and neck squamous cell carcinoma and demonstrated that treatment could be tailored by tumor type.
31 Jul 2023
News
Yale Scientists Identify Immune Cells Critical for Immunologic Memory for Melanoma
A new study led by Yale Cancer Center researchers at Yale School of Medicine reveals that a specific population of CD8+ T-cells marked by IL-7R play an important role in better understanding anti-tumor memory.
27 Jul 2023
News
Taming the Self-Destructive Tendencies of Killer T Cells Used to Treat Cancer
Many engineered T cells become tainted with the remnants of cancer antigens, which causes them to turn against other T cells. This eventually depletes the body of cancer-fighting cells and opens the door for a recurrence of cancer. A new Yale study, however, has identified a way to tame the self-destructive tendencies of these killer T cells.
Source: YaleNews
27 Jul 2023
News
Combination Therapies Benefit Patients With Advanced Non-Small Cell Lung Cancer
An ongoing phase II study led by a Yale Cancer Center researcher reveals that combining pembrolizumab with other treatments reduced the size of target tumors, resulting in a higher response rate for patients with advanced NSCLC.
12 Jul 2023
News
Eliminating Extra Chromosomes in Cancer Cells Prevents Tumor Growth
Many cancer cells have too many chromosomes. A new study reveals their role in promoting cancer—and their potential as a new target for treatment.
Source: YaleNews
6 Jul 2023
News
Pancreatic Cancer Risk Lower if Cysts Remain Stable for Five Years
Low-risk branch duct intraductal papillary mucinous neoplasms (IPMN) are the most common precancerous form of mucinous pancreatic cysts and once identified require regular surveillance imaging. But consensus is still forming around how long that watchful period should last. In a new study, Yale Cancer Center researchers question the health benefit of extended surveillance for patients whose cyst has not changed size for at least five years and has no worrisome features.
30 Jun 2023
News
Study Hints at How Cancer Immunotherapy Can Be Safer
Cancer immunotherapy has revolutionized treatment of many forms of cancer by unleashing the immune system response against tumors. But in some cases, side effects can be severe.
21 Jun 2023
News
Impact of Changing Landscape for Patients With Cancer Who Are Prescribed Opioids
In response to the opioid epidemic in the United States, interventions to prevent over-prescribing and misuse of opioids were enacted at institutional, state, and federal levels. To assess how changes in the prescribing landscape affected patients, a research team from the Yale COPPER Center examined the rates of both new and persistent opioid prescribing in patients with cancer as well as in patients without cancer, utilizing data from SEER-Medicare.
31 May 2023
News
Study Identifies Bereaved Parents’ Medical Priorities for Children With Advanced Cancer
For families facing the end-of-life of a loved one with pediatric cancer, robust quality measures to benchmark what parents value most in their child’s medical care do not currently exist. A new study from Yale Cancer Center helps identify what parents prioritize for their children with advanced cancer, including alleviating the child’s symptoms and honoring the family’s goals and wishes. Researchers say the findings may help establish a patient-centered agenda for quality measurement and improvement in children with advanced, incurable cancer. The study titled, "Parent Priorities in End-of-Life Care for Children with Cancer,” was published in JAMA Network Open on May 15.
15 May 2023
News
Bosenberg Named Brady Professor of Dermatology, Pathology, and Immunobiology
Dr. Marcus Bosenberg, an accomplished clinician, teacher, and researcher who studies the factors that regulate anti-cancer immune responses, was recently appointed the Anthony N. Brady Professor of Dermatology, Pathology, and Immunobiology, effective immediately.
Source: YaleNews
7 Mar 2023
News
Trial Shows Significant Disease-free Survival for Patients Diagnosed With Non-small Cell Lung Cancer
The new data show there are ongoing benefits for patients taking osimertinib, including prolonged disease-free survival (DFS) over placebo, reduced risk of local and distant metastases (spread of tumor), and improved central nervous system DFS.
31 Jan 2023
News
Study Finds Large Gap in Breast Cancer Treatment Recommendations for Patients Aged 70 vs 69
Age-based heuristics can lead to large differences in breast cancer treatment based on small differences in chronologic age, according to a new analysis of more than 500,000 patient records.
31 Jan 2023
News
Older Patients Left Behind in Progress Against Lung Cancer, Yale Study Shows
Although widespread use of immune checkpoint inhibitors (ICIs) in patients with advanced lung cancer has led to meaningful improvements in survival in younger patients, older patients have not experienced similar survival benefits, new research from Yale Cancer Center shows. The study was published in JAMA Oncology.
25 Jan 2023
News
Yale Scientists Enable Massively Parallel DNA Insertions Into Human Cells
Yale Cancer Center scientists have developed a novel technology that for the first time enables massively parallel DNA substitutions (known as “knock-ins”) into human cells by taking advantage of messenger RNA (mRNA), a platform now well-known from its use as the COVID vaccine vehicle.
25 Jan 2023
News
With Discovery, Oxygen's Role in Growth of Tumors Reconsidered
Yale researchers have made a discovery that changes conventional thinking about the role that oxygen plays in the growth of tumors—an area of cancer research that has been intensely studied in recent years.
Source: Yale SEAS
15 Dec 2022