YSM Faculty Developing “Game Changer” for Global Health
Dengue. Zika. Lyme. Yellow fever. Chikungunya virus. Malaria. These worldwide diseases, and others, are spread by the bite from an infected arthropod, a tick or mosquito. Five faculty from Yale School of Medicine (YSM) are collaborating on a project focusing on creating vaccines against infectious diseases by targeting the vector, which could be a “game changer” for global health.
‘Prime and Spike’ Nasal Vaccine Strategy Helps Combat COVID
The new “prime” and “spike” approach may help prevent breakthrough infections of vaccinated individuals by bolstering immune response within the mucosal lining of the respiratory tract, which are the first cells attacked by COVID-19.Source: YaleNews
Marie Robert, MD, Jordan Pober, MD, PhD, Awarded POINTS Grant to Study Pathogenesis of Celiac Disease
Marie Robert, MD, Professor of Pathology and of Medicine (Digestive Diseases), and Jordan Pober, MD, PhD, the Bayer Professor of Translational Medicine and Professor of Immunobiology, Pathology, and Dermatology, have been awarded a grant from the Program for the Promotion of Interdisciplinary Team Science (POINTS) at Yale School of Medicine to study the Pathogenesis of Celiac Disease.
Calorie Reduction Lowers Protein Linked to the Aging Process
In a new study, Yale researchers show that moderate calorie restriction in people reduces the production of a protein called SPARC, which then reins in harmful inflammation and improves health in the aged. It could be a target for extending human health span, they report.
Irina Krykbaeva, PhD, Awarded 2022 Milton C. Winternitz Prize in Pathology
Irina Krykbaeva, a recent PhD graduate in the Department of Pathology at Yale School of Medicine, is the winner of the 2022 Milton C. Winternitz Prize in Pathology. The prize is awarded annually to the student who, in the opinion of the department faculty and staff, has done outstanding work in the course.
Ask tough questions: PhD student Sebastian Diaz
Sebastian Diaz, a PhD student in immunobiology at Yale School of Medicine (YSM), said it’s hard to be among the pioneers, but because medical students from underrepresented backgrounds have pushed for greater emphasis on diversity, equity, and inclusion (DEI) supported by resources “We have a very robust system that is now becoming bigger and bigger every year.”
Common Cold Could Protect Against COVID In Early Stages Of Infection
t’s hard to envision the common cold, caused by rhinoviruses, as something of a superhero, but recent research from Yale University has found this bug to have an intriguing effect on the early success of the pathogen that causes COVID-19 in the body.Source: IFLScience
How T Cells Make Sure They Have Quiet Time
All cells, like all people, need “quiet” time to function properly, and this is particularly true of T cells, one of the immune system’s main weapons. They must be ready for activation at all times, and primed to divide more rapidly than almost any cell in the body.
The harmful effects of stress during pregnancy can last a lifetime
Mice exposed to stress in the womb and soon after birth can expect a lifetime of immune system deficiencies that hinder the ability to ward off infections and cancer, Yale University researchers report March 5 in the journal Cell.
From Paradox to Breakthrough
Aaron Ring, MD, PhD, was hooked by a paradox. He had been studying cytokines to understand their potential to stimulate anti-tumor immunity. Though cytokines, such as interleukin-2, have been in clinical use for decades, they have historically shown only limited effectiveness. Dr. Ring was hunting for interleukins that could deliver a specific signal to activate TILs.
Richard Flavell Is Named a Distinguished Fellow by the American Association of Immunologists
Richard A. Flavell, PhD, is one of 20 scientists who have been named Distinguished Fellows by the American Association of Immunologists, which recognizes members for distinguished careers and outstanding scientific contributions, as well as their service to AAI and the immunology community. It is one of the highest honors that AAI bestows.
Yale Scientists Breach Brain Barriers to Attack Tumors
The brain is a sort of fortress, equipped with barriers designed to keep out dangerous pathogens. But protection comes at a cost: These barriers interfere with the immune system when faced with dire threats such glioblastoma, a deadly brain tumor for which there are few effective treatments.
Yale Receives Funding to Study Myasthenia Gravis
The National Institutes of Health through the Rare Diseases Clinical Research Consortia has awarded a research team from Yale University, George Washington University, and Duke University $7.8 million to establish a rare disease network for myasthenia gravis.