Discovering the 'Cytokine Language' That Activates Immune Responses
Using a new computational method based on a causal inference framework, CINEMA-OT, the Yale team studied how individual immune cells react to combinations of cytokines, or small proteins released by cells that regulate inflammation. They discovered that certain cytokines have a synergistic effect, inducing unique gene activation programs compared to their individual effects. This cryptography of cytokine signals acts as a language, instructing immune cells.
Unveiling the Link Between Insomnia and Early-Onset Atrial Fibrillation
A new research article published in the Journal of American Heart Association sheds light on the potential link between insomnia and early-onset atrial fibrillation. This study, led by Allison E. Gaffey, PhD, clinical psychologist (cardiovascular medicine), examined electronic health records from over one million young veterans followed across more than 15 years. The authors found that patients with insomnia, a common type of chronic sleep disturbance, were more likely to develop atrial fibrillation compared to patients without insomnia.
Health Care Systems Should Integrate Mental Health Care Into Treatment of Peripheral Artery Disease
People with peripheral artery disease (PAD) have higher rates of mental health problems than the general population. Integrating mental health care into PAD treatment is essential to caring for people with PAD and may also improve their cardiovascular outcomes, argues an American Heart Association scientific statement, which Yale faculty co-authored.
Africa on the Global Stage: Analyzing 30 Years of African-Led Clinical Trials in Cardiovascular Medicine
In order to understand the limitations faced by African investigators in modern cardiology research, a group of researchers, led by Internal Medicine Resident Abdelrahman Abushouk, MD, analyzed 30 years of African-led clinical trials in cardiovascular medicine.
Electronic Health Record Strategies Can Improve Care of Patients with Heart Failure
Doctors frequently rely on the electronic health record (EHR) when caring for patients. Oftentimes, EHR systems will include clinical decision support tools that offer recommendations and reminders for physicians determining how to manage diagnosis or treatment plans.
Charting New Horizons in Medicine: An Inspiring Conversation with Dr. Stephania Libreros
Stephania Libreros, PhD, brings her expertise to Yale School of Medicine as a recently appointed assistant professor of pathology and a valued member of the Vascular Biology Therapeutics Program. In this engaging conversation with Kanika Jain, associate research scientist at the Yale Cardiovascular Research Center, Libreros discusses her remarkable journey and unwavering passion for science.
Introducing the Internal Medicine 2021-2022 Annual Report
In the new report, there are updates from our clinical programs, research endeavors, our work on diversity, equity, and inclusion, and educational programs. Our faculty members were honored for their educational excellence. Research initiatives at Yale received applause on the national and international stages. This book highlights all that we have accomplished together this past year…