Suguru Imaeda, MD

Assistant Professor of Dermatology; Director of Dermatology, Yale University Health Services; Director of Dermatology Service, Veteran Affairs Medical Center

Research Departments & Organizations

Dermatology: Medical Dermatology

Yale Cancer Center

Office of Cooperative Research

Research Interests

Chromatography, Reverse-Phase; Dermatology; Immunomodulation; Lymphoma, T-Cell; Major Histocompatibility Complex; T-Lymphocytes

Research Summary

Identification of major histocompatibility complex class I (MHC I) associated tumor-specific peptides and immunomodulation of T cell tumors. 2) MHC I antigen processing and presentation in cutaneous T cell lymphoma (CTCL) cells. The research involves isolation, purification and characterization of MHC I self-peptides from a murine and human % cell lymphoma cell lines. Immunoaffinity purification, reversed phase high performance liquid chromatography (RP-HPLC), automated chemical sequencing and peptide synthesis have been used to identify and characterize octamer and nonamer self-peptides from a murine B cell lymphoma cell line. Similar techniques are used to isolate distinctive peptide antigens of CTCL cells and murine T cell tumors. The biological significance of isolated antigens is determined by cytotoxicity assays.

Extensive Research Description

Identification of major histocompatibility complex class I (MHC I) associated tumor-specific peptides and immunomodulation of T cell tumors. 2) MHC I antigen processing and presentation in cutaneous T cell lymphoma (CTCL) cells. The research involves isolation, purification and characterization of MHC I self-peptides from a murine and human % cell lymphoma cell lines. Immunoaffinity purification, reversed phase high performance liquid chromatography (RP-HPLC), automated chemical sequencing and peptide synthesis have been used to identify and characterize octamer and nonamer self-peptides from a murine B cell lymphoma cell line. Similar techniques are used to isolate distinctive peptide antigens of CTCL cells and murine T cell tumors. The biological significance of isolated antigens is determined by cytotoxicity assays.

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Contact Info

Suguru Imaeda, MD
Mailing Address
DermatologyPO Box 208059
333 Cedar Street

New Haven, CT 06520-8059

Curriculum Vitae