Jason Sico, MD, MHS, FAHA, FAAN(Neurology), FANA, FACP

Associate Professor of Neurology; Associate Professor Internal Medicine (Section of General Medicine), Internal Medicine; Director, Stroke Care VA Connecticut Healthcare System; Director of Research and Clinical Care, Headache Center of Excellence, Neurology

Research Departments & Organizations


Center for Neuroepidemiology and Clinical Neurological Research

Office of Cooperative Research

Research Interests

Acquired Immunodeficiency Syndrome; Burnout, Professional; Global Health; Headache; Health Services Research; Hematologic Diseases; HIV; Mortality; Neurology; Organizational Innovation; Patient Readmission; Qualitative Research; Sleep Apnea, Obstructive; Stroke; Veterans

Research Summary

As a health services research and implementation scientist, my research falls under two domains: improving post-ischemic stroke vascular risk factor management and investigating how medical comorbidities among ischemic stroke patients may be both novel stroke risk factors and adversely affect outcomes (e.g., mortality and readmission rates). Several areas that I am actively examining include: the use implementation science strategies and Lean Six Sigma approaches to improve the delivery of guideline-concordant post-stroke vascular risk factor management, understanding the culture of communication and collaboration between neurologists and primary care providers in post-stroke care, identifying barriers and facilitators to the delivery of high-quality stroke care, the role of HIV and stroke risk in the era of combined anti-retroviral therapy, hematologic abnormalities associated with higher mortality rates among stroke patients, and addressing cardiac screening in this high risk vascular population.

Specialized Terms: Ischemic stroke; Implementation Science; Lean Six Sigma/Systems Redesign; Health services research; Outcomes based research; Vascular Risk Factor Management; Obstructive sleep apnea; HIV/AIDS; Neuropathy

Extensive Research Description

  • Health Services Research
  • Implementation Science
  • Improving Post-Stroke Vascular Risk Factor Control
  • Hypertension Control and Management
  • Screening for and Testing Obstructive Sleep Apnea among Stroke Survivors
  • Medical comorbidities and their influence on stroke outcome
  • Use of Systems Redesign/Health Systems Engineering in Stroke Care
  • Pragmatic Trials
  • Organizational and Provider-level Interventions
  • HIV and Ischemic Stroke in the era of combined antiretroviral therapy
  • HIV Neuropathy
  • Neurological Disease among Veterans and Active Military Personnel
  • Headache Care
  • Pain
  • Demonstrating the Value of Neurologists among Patients with Neurological Conditions
  • Care Collaboration between Specialists and Generalists
  • Burnout among Neurologists


  • Morbidity and Mortality Related to Neurological Disease Kampala, Uganda (2007 - 2011)

Selected Publications

  • Barriers and facilitators to provide quality TIA care in the Veterans Healthcare Administration

    Damush TM, Miech EJ, Sico JJ, Phipps MS, Arling G, Ferguson J, Austin C, Myers L, Baye F, Luckhurst C, Keating AB, Moran E, Bravata DM. Neurology. 2017 Dec 12;89(24):2422-2430. 2017

  • Taking care of volunteers in a stroke trial: a new assisted-management strategy.

    Stuart AC, Sico JJ, Viscoli CM, Tayal AH, Inzucchi SE, Ford GA, Furie KL, Cote R, Spence JD, Tanne D, Kernan WN. Stroke Vasc Neurol. 2016 Oct 25;1(3):108-114. 2016

  • Crossing the Communication Chasm: Challenges and Opportunities in Transitions of Care from the Hospital to the Primary Care Clinic.

    Rattray NA, Sico JJ, Cox LM, Russ AL, Matthias MS, Frankel RM. Jt Comm J Qual Patient Saf. 2017

  • Thrombocytopenia and in-hospital mortality risk among ischemic stroke patients.

    Sico JJ, Phipps MS, Concato J, Wells CK, Lo AC, Nadeau SE, Williams LS, Peixoto AJ, Gorman M, Boice JL, Bravata DM. Thrombocytopenia and in-hospital mortality risk among ischemic stroke patients. Journal Of Stroke And Cerebrovascular Diseases : The Official Journal Of National Stroke Association 2013, 22:e99-e102. 2013

  • Development and Validation of Electronic Quality Measures to Assess Care for Patients With Transient Ischemic Attack and Minor Ischemic Stroke.

    Bravata DM, Myers LJ, Cheng E, Reeves M, Baye F, Yu Z, Damush T, Miech EJ, Sico J, Phipps M, Zillich A, Johanning J, Chaturvedi S, Austin C, Ferguson J, Maryfield B, Snow K, Ofner S, Graham G, Rhude R, Williams LS, Arling G. Circ Cardiovasc Qual Outcomes. 2017 Sep;10(9) 2017

  • Have clinicians adopted the use of brain MRI for patients with TIA and minor stroke?

    Chaturvedi S, Ofner S, Baye F, Myers LJ, Phipps M, Sico JJ, Damush T, Miech E, Reeves M, Johanning J, Williams LS, Arling G, Cheng E, Yu Z, Bravata D. Have clinicians adopted the use of brain MRI for patients with TIA and minor stroke? Neurology 2017, 88:237-244. 2017

See list of PubMed publications

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