Research Departments & Organizations
Yale University: Yale School of Medicine
Alcoholism; Anxiety Disorders; Binge Drinking; Cocaine-Related Disorders; Depression, Postpartum; Depressive Disorder, Major; Marijuana Abuse; Opioid-Related Disorders; Personality; Stress Disorders, Traumatic; Tobacco Use Disorder
My primary research interest is identifying novel genetic risks and exploring the biological etiology for psychiatric diseases and comorbidities.
Extensive Research Description
I lead and participated in several innovative projects and got interesting findings: demonstrated the shared genetic susceptibility contributes to alcohol dependence (AD) and major depression (MD); detected the first gene for the AD-MD comorbidity by genome-wide association study (GWAS); accomplished the largest to date GWAS for alcohol consumption and alcohol use disorder in the Million Veteran Program (MVP); detected a glutamate ionotropic receptor gene as risk for comorbid nicotine dependence and MD. My ongoing projects are focus on: 1). understanding the genetic etiology of opioid use disorder by analyzing MVP data; 2). large scale whole exome sequencing to identify genetic risks for comorbid MD and substance use; 3). shared and causal mechanism between alcohol consumption and MD; 4). causal relationship between alcohol consumption and cancers.
Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.
Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. JAMA Psychiatry 2017, 74:1153-1160. 2017
Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.
Zhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression. JAMA Psychiatry 2017, 74:1234-1241. 2017
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
Kranzler HR, Zhou H, Kember RL, Vickers Smith R, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications 2019, 10:1499. 2019