Gary Cline, PhD

Professor; Director, Analytical Core, Mouse Metabolic Phenotyping Center at Yale Univ. School of Medicine; Co-Director, Clinical Metabolism Core, Yale Diabetes Research Center

Research Departments & Organizations

Internal Medicine: Diabetes Research Center | Endocrinology: Fellowship Training

Mouse Metabolic Phenotyping Center

Office of Cooperative Research

Research Interests

Diabetes Mellitus; Endocrinology; Lipid Metabolism; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular

Research Summary

Diabetes mellitus has a profound impact on hepatic and peripheral glucose metabolic fluxes. My studies on the biochemical mechanisms responsible for the pathophysiology of diabetes mellitus primarily employ nuclear magnetic resonance spectroscopy, mass spectroscopy, and stable isotopic techniques. Using these techniques, the flux and fate of key intermediates of carbohydrate and lipid metabolism can be determined in vitro and in vivo. These techniques are developed in cell systems and small animal models and when appropriate applied to studies of human physiology. New areas of research are the application and adaptation of these techniques to the study of pancreatic beta-cell metabolism and glucose-stimulated insulin release. In addition, we are developing PET imaging to evaluate whether loss of pancreatic beta-cell mass contributes to insufficient insulin secretion with T2DM.

Clinical Trials

Conditions Study Title
Diseases of the Nervous System Imaging pancreatic beta-cells with PET neuroimaging agent 11C-PHNO
Children's Health, Diseases of the Digestive System - Liver The Role of Hepatic De Novo Lipogenesis (DNL) in the Pathogenesis of Hepatic Steatosis

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Contact Info

Gary Cline, PhD
Mailing Address
Internal MedicinePO Box 208056
333 Cedar Street

New Haven, CT 06520-8056