Research Departments & Organizations
Barrett Esophagus; Digestive System Diseases; Esophageal Neoplasms; Fatty Liver; Gastritis, Atrophic; Gastrointestinal Diseases; Gastrointestinal Motility; Gastrointestinal Neoplasms; Hepatitis C; Inflammatory Bowel Diseases; Liver; Liver Cirrhosis; Liver Cirrhosis, Biliary; Liver Diseases; Liver Neoplasms; Pancreas; Pathology
Liver cancer; Gastrointestinal stromal tumors; Motility disorders of the bowel; Cirrhosis; liver fibrosis; Hepatitis C; NASH; Pancreatic cancer; Gastric cancer; Esophageal cancer; Gastrointestinal stromal tumors;
Specialized Terms: Inflammatory Bowel Disease (IBD); Liver tumors; Motility disorders of GI tract; Esophageal and gastric carcinoma; Hepatocellular carcinoma; cholangiocarcinoma; Intraductal papillary mutinous neoplasm; Barrett's esophagus; esophageal carcinoma;
Extensive Research Description
Liver tumors: One of the major areas of my research interest liver tumors. Some of the studies have been collaborative efforts with other academic Institutions in the country, while some have been my own. We have evaluated various markers that can be applied in the diagnostic work-up of hepatocytic masses, including hepatocellular carcinoma (HCC), hepatic adenoma (HA) and focal nodular hyperplasia (FNH) over the years. Our ongoing research in this area is looking at new markers and their diagnostic utility in the work-up of hepatic masses. We are also studying the HCCs that arise in patients with cirrhosis and chronic liver disorders and compare them with those without cirrhosis and known liver disease.
One of my major areas of research interest in liver tumors is Cholangiocarcinoma (CC). It is the second most common primary malignant neoplasm of the liver. The precursor lesions of cholangiocarcinoma are not well understood. Based on observations from clinical cases, we suspect that many of these tumors arise from biliary microhamartomas or so called von-Meyenburg complexes (VMC). Our ongoing studies are focused on generating more molecular evidence to support progression of VMC to cholangiocarcinoma and build a cancer progression model for cholangiocarcinoma.
Motility disorders of the GI tract: Based on a case of visceral myopathy that I encountered in my clinical practice I realized that the interstitial cells of Cajal that play a major role in bowel motility, have not been studied in detail in such disorders. This led to a study of these cells in a variety of motility disorders. Subsequently, I have been interested in motility disorders of the GI tract and get cases in consultation from all over the world.
|Diseases of the Digestive System - Liver||AURORA: Phase 3 Study for the Efficacy and Safety of CVC for the Treatment of Liver Fibrosis in Adults With NASH|
|Diseases of the Digestive System - Liver, Diseases of the Eye, Diseases of the Nervous System||Wilson Disease Registry|
|Diseases Of The Digestive System, Diseases of the Digestive System - Liver||Randomized Global Phase 3 Study to Evaluate the Impact on NASH With Fibrosis of Obeticholic Acid Treatment (REGENERATE)|
Intraductal papillary cholangiocarcinoma associated with von Meyenberg complexes: a case report.
Neto AG, Dainiak C, Qin L, Salem RR, Jain D. Intraductal papillary cholangiocarcinoma associated with von Meyenberg complexes: a case report. Digestive Diseases And Sciences 2007, 52:2643-5. 2007
Gastric siderosis: patterns and significance.
Marginean EC, Bennick M, Cyczk J, Robert ME, Jain D. Gastric siderosis: patterns and significance. The American Journal Of Surgical Pathology 2006, 30:514-20. 2006
Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis.
Nagula S, Jain D, Groszmann RJ, Garcia-Tsao G. Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis. Journal Of Hepatology 2006, 44:111-7. 2006
Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis.
Kakar S, Burgart LJ, Batts KP, Garcia J, Jain D, Ferrell LD. Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2005, 18:1417-23. 2005
Total fibrous obliteration of main portal vein and portal foam cell venopathy in chronic hepatic allograft rejection.
Jain D, Robert ME, Navarro V, Friedman AL, Crawford JM. Total fibrous obliteration of main portal vein and portal foam cell venopathy in chronic hepatic allograft rejection. Archives Of Pathology & Laboratory Medicine 2004, 128:64-7. 2004
Benign fibroblastic polyps of the colon: a histologic, immunohistochemical, and ultrastructural study.
Eslami-Varzaneh F, Washington K, Robert ME, Kashgarian M, Goldblum JR, Jain D. Benign fibroblastic polyps of the colon: a histologic, immunohistochemical, and ultrastructural study. The American Journal Of Surgical Pathology 2004, 28:374-8. 2004
Role of interstitial cells of Cajal in motility disorders of the bowel.
Jain D, Moussa K, Tandon M, Culpepper-Morgan J, Proctor DD. Role of interstitial cells of Cajal in motility disorders of the bowel. The American Journal Of Gastroenterology 2003, 98:618-24. 2003
Heterotopic nephrogenic rests in the colon and multiple congenital anomalies: possibly related association.
Jain D, Martel M, Reyes-Múgica M, Parkash V. Heterotopic nephrogenic rests in the colon and multiple congenital anomalies: possibly related association. Pediatric And Developmental Pathology : The Official Journal Of The Society For Pediatric Pathology And The Paediatric Pathology Society 2002, 5:587-91. 2002