Dhanpat Jain, MD

Professor of Pathology and of Medicine (Digestive Diseases); Director, Program in Gastrointestinal and Liver Pathology; Director, Fellowship in Gastrointestinal and Liver Pathology

Research Departments & Organizations


Internal Medicine: Digestive Diseases: Liver Cancer Program | Liver Center

Yale Cancer Center: Genomics, Genetics, and Epigenetics | Liver Cancer Program

Office of Cooperative Research

Research Interests

Barrett Esophagus; Digestive System Diseases; Esophageal Neoplasms; Fatty Liver; Gastritis, Atrophic; Gastrointestinal Diseases; Gastrointestinal Motility; Gastrointestinal Neoplasms; Hepatitis C; Inflammatory Bowel Diseases; Liver; Liver Cirrhosis; Liver Cirrhosis, Biliary; Liver Diseases; Liver Neoplasms; Pancreas; Pathology

Research Summary

Liver cancer; Gastrointestinal stromal tumors; Motility disorders of the bowel; Cirrhosis; liver fibrosis; Hepatitis C; NASH; Pancreatic cancer; Gastric cancer; Esophageal cancer; Gastrointestinal stromal tumors;

Specialized Terms: Inflammatory Bowel Disease (IBD); Liver tumors; Motility disorders of GI tract; Esophageal and gastric carcinoma; Hepatocellular carcinoma; cholangiocarcinoma; Intraductal papillary mutinous neoplasm; Barrett's esophagus; esophageal carcinoma;

Extensive Research Description

Liver tumors: One of the major areas of my research interest liver tumors. Some of the studies have been collaborative efforts with other academic Institutions in the country, while some have been my own. We have evaluated various markers that can be applied in the diagnostic work-up of hepatocytic masses, including hepatocellular carcinoma (HCC), hepatic adenoma (HA) and focal nodular hyperplasia (FNH) over the years.  Our ongoing research in this area is looking at new markers and their diagnostic utility in the work-up of hepatic masses. We are also studying the HCCs that arise in patients with cirrhosis and chronic liver disorders and compare them with those without cirrhosis and known liver disease.

One of my major areas of research interest in liver tumors is Cholangiocarcinoma (CC). It is the second most common primary malignant neoplasm of the liver. The precursor lesions of cholangiocarcinoma are not well understood.  Based on observations from clinical cases, we suspect that many of these tumors arise from biliary microhamartomas or so called von-Meyenburg complexes (VMC). Our ongoing studies are focused on generating more molecular evidence to support progression of VMC to cholangiocarcinoma and build a cancer progression model for cholangiocarcinoma.

Motility disorders of the GI tract: Based on a case of visceral myopathy that I encountered in my clinical practice I realized that the interstitial cells of Cajal that play a major role in bowel motility, have not been studied in detail in such disorders. This led to a study of these cells in a variety of motility disorders. Subsequently, I have been interested in motility disorders of the GI tract and get cases in consultation from all over the world. 

Clinical Trials

Conditions Study Title
Diseases of the Digestive System - Liver AURORA: Phase 3 Study for the Efficacy and Safety of CVC for the Treatment of Liver Fibrosis in Adults With NASH
Diseases of the Digestive System - Liver, Diseases of the Eye, Diseases of the Nervous System Wilson Disease Registry

Selected Publications

See list of PubMed publications

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Contact Info

Dhanpat Jain, MD
Office Location
Department of PathologyYale New Haven Hospital
20 York Street, Ste EP2-609

New Haven, CT 06510
Mailing Address
Pathology310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Curriculum Vitae

Lysosomal acid lipase deficiency (LAL-D)

Liver showing micro-vesicular steatosis and ceroid laden macrophages in the portal area in a patient with LAL-D.

Von-Meyenburg comples

These are benign bile ductular proliferations that I suspect are colonic adenoma equivalent in the liver, and give rise to sporadic Cholangiocarcinoma.