Research Departments & Organizations
Electrophysiology; Epilepsy; Immunohistochemistry; Magnetic Resonance Spectroscopy; Microdialysis; Microscopy, Confocal; Microscopy, Electron; Molecular Biology; Neurobiology; Neurosurgery; Pituitary Neoplasms
Dr. Spencer's research has brought together basic scientists and clinicians around a program concerning energetics, glutamate metabolism and the neurobiological study of human epileptogenic tissue. Study techniques include 4T MRS, C13 intraoperative glucose turnover studies, and in vivo and in vitro electrophysiology and microdialysis, immunohistochemistry, confocal and EM microscopy, and molecular biology. In particular, laboratory discoveries are correlated with the epileptogenic substrate in order to help define human epilepsy pathogenesis and potential therapies.
Specialized Terms: Cerebral metabolic abnormalities that sustain epileptogenesis using MR spectroscopy, Microdialysis, and human tissue studies
|Diseases of the Nervous System||Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN)|
|Diseases of the Nervous System, Mental Health & Behavioral Research||SV2A PET Imaging in Healthy Subjects and Epilepsy Patients|
Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy.
Eid T, Hammer J, Rundén-Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC. Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy. Acta Neuropathologica 2007, 113:137-52. 2007
Nonrigid 3D brain registration using intensity/feature information.
DeLorenzo C, Papademetris X, Wu K, Vives KP, Spencer D, Duncan JS. Nonrigid 3D brain registration using intensity/feature information. Medical Image Computing And Computer-assisted Intervention : MICCAI ... International Conference On Medical Image Computing And Computer-Assisted Intervention 2006, 9:932-9. 2006
Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy.
Malthankar-Phatak GH, de Lanerolle N, Eid T, Spencer DD, Behar KL, Spencer SS, Kim JH, Lai JC. Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy. Epilepsia 2006, 47:1292-9. 2006