Dennis Spencer, MD

Harvey and Kate Cushing Professor of Neurosurgery; Chief, Epilepsy Surgery; Director, Epilepsy Fellowship; Director, Pituitary Surgery

Research Departments & Organizations


Research Interests

Electrophysiology; Epilepsy; Immunohistochemistry; Magnetic Resonance Spectroscopy; Microdialysis; Microscopy, Confocal; Microscopy, Electron; Molecular Biology; Neurobiology; Neurosurgery; Pituitary Neoplasms

Research Summary

Dr. Spencer's research has brought together basic scientists and clinicians around a program concerning energetics, glutamate metabolism and the neurobiological study of human epileptogenic tissue. Study techniques include 4T MRS, C13 intraoperative glucose turnover studies, and in vivo and in vitro electrophysiology and microdialysis, immunohistochemistry, confocal and EM microscopy, and molecular biology. In particular, laboratory discoveries are correlated with the epileptogenic substrate in order to help define human epilepsy pathogenesis and potential therapies.

Specialized Terms: Cerebral metabolic abnormalities that sustain epileptogenesis using MR spectroscopy, Microdialysis, and human tissue studies

Clinical Trials

Conditions Study Title
Diseases of the Nervous System Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN)
Diseases of the Nervous System, Mental Health & Behavioral Research SV2A PET Imaging in Healthy Subjects and Epilepsy Patients

Selected Publications

See list of PubMed publications

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