Yoshitaka Kimura
Associate Research Scientist
Research & Publications
Biography
Coauthors
Selected Publications
- Mechanosensing regulates tissue repair program in macrophagesMeizlish M, Kimura Y, Pope S, Matta R, Kim C, Philip N, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Science Advances 2024, 10: eadk6906. PMID: 38478620, PMCID: PMC10936955, DOI: 10.1126/sciadv.adk6906.
- Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells.Hangai S, Kawamura T, Kimura Y, Chang CY, Hibino S, Yamamoto D, Nakai Y, Tateishi R, Oshima M, Oshima H, Kodama T, Moriya K, Koike K, Yanai H, Taniguchi T. Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells. Nat Immunol 2021, 22: 947-957. PMID: 34239121, DOI: 10.1038/s41590-021-00967-5.
- Signal-transducing innate receptors in tumor immunity.Hangai S, Kimura Y, Taniguchi T, Yanai H. Signal-transducing innate receptors in tumor immunity. Cancer Sci 2021, 112: 2578-2591. PMID: 33570784, DOI: 10.1111/cas.14848.
- Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways.Kimura Y, Negishi H, Matsuda A, Endo N, Hangai S, Inoue A, Nishio J, Taniguchi T, Yanai H. Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways. Cancer Sci 2018, 109: 2687-2696. PMID: 29981256, DOI: 10.1111/cas.13726.
- Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice.Yanai H, Chiba S, Hangai S, Kometani K, Inoue A, Kimura Y, Abe T, Kiyonari H, Nishio J, Taguchi-Atarashi N, Mizushima Y, Negishi H, Grosschedl R, Taniguchi T. Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice. Proc Natl Acad Sci U S A 2018, 115: 5253-5258. PMID: 29712834, DOI: 10.1073/pnas.1803936115.
- Innate immune receptors in the regulation of tumor immunityHangai S, Kimura Y, Taniguchi T, Yanai H. Innate immune receptors in the regulation of tumor immunity. Oncoimmunology: A Practical Guide for Cancer Immunotherapy 2017; 407-427.
- The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T. The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis. Proc Natl Acad Sci U S A 2016, 113: 14097-14102. PMID: 27872290, DOI: 10.1073/pnas.1617903113.
- IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression.Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y. IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression. Cancer Sci 2016, 107: 1206-14. PMID: 27384869, DOI: 10.1111/cas.13005.
- PGE2 induced in and released by dying cells functions as an inhibitory DAMP.Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, Yanai H. PGE2 induced in and released by dying cells functions as an inhibitory DAMP. Proc Natl Acad Sci U S A 2016, 113: 3844-9. PMID: 27001836, DOI: 10.1073/pnas.1602023113.
- Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T. Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses. Elife 2014, 3: e04177. PMID: 25149452, DOI: 10.7554/eLife.04177.