Yiduo I Hu, PhD, MD
he/him/his
Clinical Fellow
Research & Publications
Biography
Coauthors
Selected Publications
- RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair fociVohhodina J, Toomire KJ, Petit SA, Micevic G, Kumari G, Botchkarev VV, Li Z, Livingston DM, Hu Y. RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 2084-2091. PMID: 31932421, PMCID: PMC6995001, DOI: 10.1073/pnas.1908003117.
- PARP1-Driven Poly-ADP-Ribosylation Regulates BRCA1 Function in Homologous Recombination–Mediated DNA RepairHu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM. PARP1-Driven Poly-ADP-Ribosylation Regulates BRCA1 Function in Homologous Recombination–Mediated DNA Repair. Cancer Discovery 2014, 4: 1430-1447. PMID: 25252691, PMCID: PMC4258125, DOI: 10.1158/2159-8290.cd-13-0891.
- Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycleDimitrov SD, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, Livingston DM. Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle. Genes & Development 2013, 27: 2274-2291. PMID: 24142877, PMCID: PMC3814647, DOI: 10.1101/gad.225045.113.
- Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repair.Xu Y, Ayrapetov MK, Xu C, Gursoy-Yuzugullu O, Hu Y, Price BD. Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repair. Molecular Cell 2012, 48: 723-33. PMID: 23122415, PMCID: PMC3525728, DOI: 10.1016/j.molcel.2012.09.026.
- Proteomic Identification of a Direct Role for Cyclin D1 in DNA Damage RepairJirawatnotai S, Hu Y, Livingston DM, Sicinski P. Proteomic Identification of a Direct Role for Cyclin D1 in DNA Damage Repair. Cancer Research 2012, 72: 4289-4293. PMID: 22915759, PMCID: PMC3432743, DOI: 10.1158/0008-5472.can-11-3549.
- Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication StressCiccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ. Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress. Molecular Cell 2012, 47: 396-409. PMID: 22704558, PMCID: PMC3613862, DOI: 10.1016/j.molcel.2012.05.024.
- A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancersJirawatnotai S, Hu Y, Michowski W, Elias JE, Becks L, Bienvenu F, Zagozdzon A, Goswami T, Wang YE, Clark AB, Kunkel TA, van Harn T, Xia B, Correll M, Quackenbush J, Livingston DM, Gygi SP, Sicinski P. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 2011, 474: 230-234. PMID: 21654808, PMCID: PMC3134411, DOI: 10.1038/nature10155.
- RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear fociHu Y, Scully R, Sobhian B, Xie A, Shestakova E, Livingston DM. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes & Development 2011, 25: 685-700. PMID: 21406551, PMCID: PMC3070932, DOI: 10.1101/gad.2011011.
- Alpha-fetoprotein-thymidine kinase–luciferase knockin mice: A novel model for dual modality longitudinal imaging of tumorigenesis in liverLu X, Guo H, Molter J, Miao H, Gerber L, Hu Y, Barnes EL, Vogel H, Lee Z, Luo G, Wang B. Alpha-fetoprotein-thymidine kinase–luciferase knockin mice: A novel model for dual modality longitudinal imaging of tumorigenesis in liver. Journal Of Hepatology 2010, 55: 96-102. PMID: 21354236, PMCID: PMC3465678, DOI: 10.1016/j.jhep.2010.10.020.
- Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apcmin miceHu Y, Lu X, Luo G. Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apcmin mice. World Journal Of Gastroenterology 2010, 16: 1482-1486. PMID: 20333788, PMCID: PMC2846253, DOI: 10.3748/wjg.v16.i12.1482.
- Targeting DNA repair pathways: A novel approach to reduce cancer therapeutic resistanceZhu Y, Hu J, Hu Y, Liu W. Targeting DNA repair pathways: A novel approach to reduce cancer therapeutic resistance. Cancer Treatment Reviews 2009, 35: 590-596. PMID: 19635647, DOI: 10.1016/j.ctrv.2009.06.005.
- Recql5 Plays an Important Role in DNA Replication and Cell Survival after Camptothecin TreatmentHu Y, Lu X, Zhou G, Barnes EL, Luo G. Recql5 Plays an Important Role in DNA Replication and Cell Survival after Camptothecin Treatment. Molecular Biology Of The Cell 2008, 20: 114-123. PMID: 18987339, PMCID: PMC2613109, DOI: 10.1091/mbc.e08-06-0565.
- RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filamentsHu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes & Development 2007, 21: 3073-3084. PMID: 18003859, PMCID: PMC2081974, DOI: 10.1101/gad.1609107.
- Recql5 and Blm RecQ DNA Helicases Have Nonredundant Roles in Suppressing CrossoversHu Y, Lu X, Barnes E, Yan M, Lou H, Luo G. Recql5 and Blm RecQ DNA Helicases Have Nonredundant Roles in Suppressing Crossovers. Molecular And Cellular Biology 2005, 25: 3431-3442. PMID: 15831450, PMCID: PMC1084310, DOI: 10.1128/mcb.25.9.3431-3442.2005.