Xiaoyang Cheng
Research Scientist
Research & Publications
Biography
Coauthors
Selected Publications
- Genetic, electrophysiological, and pathological studies on patients with SCN9A‐related pain disordersYuan J, Cheng X, Matsuura E, Higuchi Y, Ando M, Hashiguchi A, Yoshimura A, Nakachi R, Mine J, Taketani T, Maeda K, Kawakami S, Kira R, Tanaka S, Kanai K, Dib‐Hajj F, Dib‐Hajj S, Waxman S, Takashima H. Genetic, electrophysiological, and pathological studies on patients with SCN9A‐related pain disorders. Journal Of The Peripheral Nervous System 2023, 28: 597-607. PMID: 37555797, DOI: 10.1111/jns.12590.
- Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 functionJami S, Deuis J, Klasfauseweh T, Cheng X, Kurdyukov S, Chung F, Okorokov A, Li S, Zhang J, Cristofori-Armstrong B, Israel M, Ju R, Robinson S, Zhao P, Ragnarsson L, Andersson Å, Tran P, Schendel V, McMahon K, Tran H, Chin Y, Zhu Y, Liu J, Crawford T, Purushothamvasan S, Habib A, Andersson D, Rash L, Wood J, Zhao J, Stehbens S, Mobli M, Leffler A, Jiang D, Cox J, Waxman S, Dib-Hajj S, Neely G, Durek T, Vetter I. Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications 2023, 14: 2442. PMID: 37117223, PMCID: PMC10147923, DOI: 10.1038/s41467-023-37963-2.
- Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitabilityEstacion M, Liu S, Cheng X, Dib-Hajj S, Waxman S. Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability. Frontiers In Pharmacology 2023, 14: 1138556. PMID: 36923357, PMCID: PMC10008904, DOI: 10.3389/fphar.2023.1138556.
- Altered allostery of the left flipper domain underlies the weak ATP response of rat P2X5 receptorsSun L, Liu Y, Wang J, Huang L, Yang Y, Cheng X, Fan Y, Zhu M, Liang H, Tian Y, Wang H, Guo C, Yu Y. Altered allostery of the left flipper domain underlies the weak ATP response of rat P2X5 receptors. Journal Of Biological Chemistry 2019, 294: 19589-19603. PMID: 31727741, PMCID: PMC6926468, DOI: 10.1074/jbc.ra119.009959.
- Molecular mechanism underlying the subtype-selectivity of competitive inhibitor NF110 and its distinct potencies in human and rat P2X3 receptorsLi B, Wang J, Cheng X, Liu Y, Yang Y, Yang X, Guo C, Niu Y, Cao P, Lu X, Zhu M, Tian Y, Yu Y. Molecular mechanism underlying the subtype-selectivity of competitive inhibitor NF110 and its distinct potencies in human and rat P2X3 receptors. Science Bulletin 2018, 63: 1616-1625. PMID: 36658853, DOI: 10.1016/j.scib.2018.11.016.
- Druggable negative allosteric site of P2X3 receptorsWang J, Wang Y, Cui W, Huang Y, Yang Y, Liu Y, Zhao W, Cheng X, Sun W, Cao P, Zhu M, Wang R, Hattori M, Yu Y. Druggable negative allosteric site of P2X3 receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 4939-4944. PMID: 29674445, PMCID: PMC5948998, DOI: 10.1073/pnas.1800907115.
- Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent mannerLi Y, Zhu T, Yang H, Dib-Hajj S, Waxman S, Yu Y, Xu TL, Cheng X. Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner. Molecular Pain 2018, 14: 1744806918782229. PMID: 29790812, PMCID: PMC6024516, DOI: 10.1177/1744806918782229.
- The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptideYang X, Niu Y, Liu Y, Yang Y, Wang J, Cheng X, Liang H, Wang H, Hu Y, Lu X, Zhu M, Xu T, Tian Y, Yu Y. The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide. Journal Of Biological Chemistry 2017, 292: 21662-21675. PMID: 29123030, PMCID: PMC5766947, DOI: 10.1074/jbc.m117.814707.
- N1366S mutation of human skeletal muscle sodium channel causes paramyotonia congenitaKe Q, Ye J, Tang S, Wang J, Luo B, Ji F, Zhang X, Yu Y, Cheng X, Li Y. N1366S mutation of human skeletal muscle sodium channel causes paramyotonia congenita. The Journal Of Physiology 2017, 595: 6837-6850. PMID: 28940424, PMCID: PMC5685822, DOI: 10.1113/jp274877.
- Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptorsWang J, Sun L, Cui W, Zhao W, Ma X, Li B, Liu Y, Yang Y, Hu Y, Huang L, Cheng X, Li L, Lu X, Tian Y, Yu Y. Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors. Journal Of Biological Chemistry 2017, 292: 7619-7635. PMID: 28302727, PMCID: PMC5418059, DOI: 10.1074/jbc.m116.771121.
- FGF13 Selectively Regulates Heat Nociception by Interacting with Nav1.7Yang L, Dong F, Yang Q, Yang P, Wu R, Wu Q, Wu D, Li C, Zhong Y, Lu Y, Cheng X, Xu F, Chen L, Bao L, Zhang X. FGF13 Selectively Regulates Heat Nociception by Interacting with Nav1.7. Neuron 2017, 93: 806-821.e9. PMID: 28162808, DOI: 10.1016/j.neuron.2017.01.009.
- Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activating GPC3Zhu X, Yuan J, Zhu T, Li Y, Cheng X. Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activating GPC3. The FEBS Journal 2016, 283: 3739-3754. PMID: 27573079, DOI: 10.1111/febs.13839.
- Exploration of the Peptide Recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel*Niu Y, Yang Y, Liu Y, Huang L, Yang X, Fan Y, Cheng X, Cao P, Hu Y, Li L, Lu X, Tian Y, Yu Y. Exploration of the Peptide Recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel*. Journal Of Biological Chemistry 2016, 291: 7571-7582. PMID: 26867576, PMCID: PMC4817185, DOI: 10.1074/jbc.m115.710251.
- A Highly Conserved Salt Bridge Stabilizes the Kinked Conformation of β2,3-Sheet Essential for Channel Function of P2X4 Receptors*Zhao W, Sun M, Sun L, Liu Y, Yang Y, Huang L, Fan Y, Cheng X, Cao P, Hu Y, Li L, Tian Y, Wang R, Yu Y. A Highly Conserved Salt Bridge Stabilizes the Kinked Conformation of β2,3-Sheet Essential for Channel Function of P2X4 Receptors*. Journal Of Biological Chemistry 2016, 291: 7990-8003. PMID: 26865631, PMCID: PMC4825005, DOI: 10.1074/jbc.m115.711127.
- ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton LigandPeng Z, Li W, Huang C, Jiang Y, Wang X, Zhu M, Cheng X, Xu T. ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand. Cell Reports 2015, 13: 387-398. PMID: 26440887, DOI: 10.1016/j.celrep.2015.09.002.
- Cytotoxic T cell responses are enhanced by antigen design involving the presentation of MUC1 peptide on cholera toxin B subunitLu W, Qiu L, Yan Z, Lin Z, Cao M, Hu C, Wang Z, Wang J, Yu Y, Cheng X, Cao P, Li R. Cytotoxic T cell responses are enhanced by antigen design involving the presentation of MUC1 peptide on cholera toxin B subunit. Oncotarget 2015, 6: 34537-34548. PMID: 26417929, PMCID: PMC4741471, DOI: 10.18632/oncotarget.5307.
- Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activationZhao W, Wang J, Ma X, Yang Y, Liu Y, Huang L, Fan Y, Cheng X, Chen H, Wang R, Yu Y. Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation. Nature Communications 2014, 5: 4189. PMID: 24943126, DOI: 10.1038/ncomms5189.
- Inherent Dynamics of Head Domain Correlates with ATP-Recognition of P2X4 Receptors: Insights Gained from Molecular SimulationsHuang L, Fan Y, Tian Y, Yang Y, Liu Y, Wang J, Zhao W, Zhou W, Cheng X, Cao P, Lu X, Yu Y. Inherent Dynamics of Head Domain Correlates with ATP-Recognition of P2X4 Receptors: Insights Gained from Molecular Simulations. PLOS ONE 2014, 9: e97528. PMID: 24878662, PMCID: PMC4039465, DOI: 10.1371/journal.pone.0097528.
- CaV1.2 Channel N-terminal Splice Variants Modulate Functional Surface Expression in Resistance Size Artery Smooth Muscle Cells*Bannister J, Thomas-Gatewood C, Neeb Z, Adebiyi A, Cheng X, Jaggar J. CaV1.2 Channel N-terminal Splice Variants Modulate Functional Surface Expression in Resistance Size Artery Smooth Muscle Cells*. Journal Of Biological Chemistry 2011, 286: 15058-15066. PMID: 21357696, PMCID: PMC3083159, DOI: 10.1074/jbc.m110.182816.
- CaV1.2 N‐terminal splice variants regulate cerebral artery diameterBannister J, Thomas C, Adebiyi A, Cheng X, Zhao G, Jaggar J. CaV1.2 N‐terminal splice variants regulate cerebral artery diameter. The FASEB Journal 2010, 24: 985.9-985.9. DOI: 10.1096/fasebj.24.1_supplement.985.9.
- Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological propertiesCheng X, Pachuau J, Blaskova E, Asuncion-Chin M, Liu J, Dopico A, Jaggar J. Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties. AJP Heart And Circulatory Physiology 2009, 297: h680-h688. PMID: 19502562, PMCID: PMC2724194, DOI: 10.1152/ajpheart.00109.2009.
- The CaV1.2 α1 subunit N‐terminus regulates cerebral artery contractilityBannister J, Adebiyi A, Cheng X, Zhao G, Jaggar J. The CaV1.2 α1 subunit N‐terminus regulates cerebral artery contractility. The FASEB Journal 2009, 23: 775.13-775.13. DOI: 10.1096/fasebj.23.1_supplement.775.13.
- A Novel CaV1.2 N Terminus Expressed in Smooth Muscle Cells of Resistance Size Arteries Modifies Channel Regulation by Auxiliary Subunits*Cheng X, Liu J, Asuncion-Chin M, Blaskova E, Bannister J, Dopico A, Jaggar J. A Novel CaV1.2 N Terminus Expressed in Smooth Muscle Cells of Resistance Size Arteries Modifies Channel Regulation by Auxiliary Subunits*. Journal Of Biological Chemistry 2007, 282: 29211-29221. PMID: 17699517, PMCID: PMC2276565, DOI: 10.1074/jbc.m610623200.
- Myocytes of resistance‐size arteries express CaV1.2 channels with a novel N‐terminusCheng X, Liu J, Blaskova E, Asuncion‐Chin M, Bondarenko A, Dopico A, Jaggar J. Myocytes of resistance‐size arteries express CaV1.2 channels with a novel N‐terminus. The FASEB Journal 2007, 21: a1240-a1240. DOI: 10.1096/fasebj.21.6.a1240-c.
- Genetic Ablation of Caveolin‐1 Modifies Ca2+ Spark Coupling in Murine Arterial Smooth Muscle CellsCheng X, Jaggar J. Genetic Ablation of Caveolin‐1 Modifies Ca2+ Spark Coupling in Murine Arterial Smooth Muscle Cells. The FASEB Journal 2006, 20: a1173-a1174. DOI: 10.1096/fasebj.20.5.a1173-d.
- Genetic ablation of caveolin-1 modifies Ca2+ spark coupling in murine arterial smooth muscle cellsCheng X, Jaggar J. Genetic ablation of caveolin-1 modifies Ca2+ spark coupling in murine arterial smooth muscle cells. AJP Heart And Circulatory Physiology 2006, 290: h2309-h2319. PMID: 16428350, PMCID: PMC1698957, DOI: 10.1152/ajpheart.01226.2005.
- Carbon Monoxide Dilates Cerebral Arterioles by Enhancing the Coupling of Ca2+ Sparks to Ca2+-Activated K+ ChannelsJaggar J, Leffler C, Cheranov S, Tcheranova D, E S, Cheng X. Carbon Monoxide Dilates Cerebral Arterioles by Enhancing the Coupling of Ca2+ Sparks to Ca2+-Activated K+ Channels. Circulation Research 2002, 91: 610-617. PMID: 12364389, DOI: 10.1161/01.res.0000036900.76780.95.
- Effect of Zinc Ions on Caffeine-Induced Contracture in Vascular Smooth Muscle and Skeletal Mu-scle of RatCheng X, Chen K, Zhang X, Zhu P. Effect of Zinc Ions on Caffeine-Induced Contracture in Vascular Smooth Muscle and Skeletal Mu-scle of Rat. Cellular Physiology And Biochemistry 2002, 12: 119-126. PMID: 12077557, DOI: 10.1159/000063788.
- Inhibition of Ryanodine Binding to Sarcoplasmic Reticulum Vesicles of Cardiac Muscle by Zn2+ IonsWang H, Wei Q, Cheng X, Chen K, Zhu P. Inhibition of Ryanodine Binding to Sarcoplasmic Reticulum Vesicles of Cardiac Muscle by Zn2+ Ions. Cellular Physiology And Biochemistry 2001, 11: 83-92. PMID: 11275686, DOI: 10.1159/000047795.
- Topography of skeletal muscle ryanodine receptors studied by atomic force microscopyWei Q, Chen S, Cheng X, Yu X, Hu J, Li M, Zhu P. Topography of skeletal muscle ryanodine receptors studied by atomic force microscopy. Journal Of Vacuum Science & Technology B Nanotechnology And Microelectronics Materials Processing Measurement And Phenomena 2000, 18: 636-638. DOI: 10.1116/1.591252.
- Biphasic modulation of ryanodine binding to sarcoplasmic reticulum vesicles of skeletal muscle by Zn2+ ionsXIA R, CHENG X, WANG H, CHEN K, WEI Q, ZHANG X, ZHU P. Biphasic modulation of ryanodine binding to sarcoplasmic reticulum vesicles of skeletal muscle by Zn2+ ions. Biochemical Journal 2000, 345: 279. DOI: 10.1042/0264-6021:3450279.
- Biphasic modulation of ryanodine binding to sarcoplasmic reticulum vesicles of skeletal muscle by Zn2+ ionsXIA R, CHENG X, Hui W, CHEN K, WEI Q, ZHANG X, ZHU P. Biphasic modulation of ryanodine binding to sarcoplasmic reticulum vesicles of skeletal muscle by Zn2+ ions. Biochemical Journal 2000, 345: 279-286. PMID: 10620505, PMCID: PMC1220757, DOI: 10.1042/bj3450279.