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INFORMATION FOR

Xavier Llor, MD, PhD

Professor of Medicine; Associate CEHE Director for Cancer Screening, Smilow Cancer Hospital; Medical Director, Cancer Screening and Prevention Program, and Colorectal Cancer Prevention Program; Co-Director, Cancer Genetics and Prevention Program

Contact Information

Xavier Llor, MD, PhD

Mailing Address

  • Yale School of Medicine

    Department of Medicine (Digestive Diseases), PO Box 208019

    New Haven, CT 06520-8019

    United States

Research Summary

Dr. Llor’s research interests relate to colorectal cancer. He focuses his studies on forms of colorectal cancers that can be passed along through the genes and thus can affect multiple members in a family. He is trying to unveil specific genes that can be responsible for some of these cases and how cancers in these families develop. He is also interested in understanding why some racial groups are more prone to develop colorectal cancer than others and how environmental factors can play a key role in colorectal cancer development

Specialized Terms: Mismatch Repair Proficient Hereditary Non-Polyposis Colorectal Cancer; MSS-HNPCC: Lynch syndrome; Colorectal Cancer Disparities: Colorectal Cancer in African Americans

Extensive Research Description

Dr. Llor obtained his MD degree at the Autonomous University of Barcelona and his PhD in molecular biology at the University of Barcelona. He completed his Internal Medicine Residency at the University of Chicago-Lutheran General Hospital Program and his GI fellowship at the University of Illinois at Chicago. In 2014, Dr. Llor joined Yale University as co-Director of the Cancer Genetics and Prevention Program, Medical Director of the Colorectal Cancer Prevention Program, and more recently Associate Director of Cancer Screening at Yale's Cancer Center.

A clinically active gastroenterologist, Dr. Llor's research and clinical interests relate to GI cancer, mostly colorectal and stomach, with an emphasis on genetics and disparities. He spearheaded and carried out three large prospective cohorts of colorectal cancer patients and controls that produced a wealth of information. Some important contributions from Dr. Llor's lab include the description of the best diagnostic approaches to Lynch syndrome diagnosis; clinical and molecular characterization of mismatch repair proficient hereditary non-polyposis colorectal cancer (type X); identification of distinct clinical and molecular features of colorectal cancers in young African Americans, phenotypic features of hereditary gastric cancer.

Some of the themes of my research include:

1. Lynch syndrome (LS) is the most common inherited CRC syndrome and it is characterized by cancer development at a young age and very high risk of different extra-colonic malignancies. Affected family members require intensive cancer surveillance. LS is caused by mutations in the mismatch repair genes that result in tumor microsatellite instability (MSI) and loss of expression of the corresponding protein. A tremendous challenge is still diagnosing individuals with LS as patients do not have an obvious pre-morbid phenotype (development of multiple polyps) that could suggest the presence of this syndrome. Thus, establishing the best diagnostic approaches has been an important priority over the last few years. I have performed several studies that have become seminal in the diagnostic process of LS.

a. Pinol, Castells A, Andreu M, Castellví-Bel S, Alenda C, et al. Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer. JAMA. 2005 Apr 27;293(16):1986-94.

b. Xicola RM, Llor X*, Pons E, Castells A, Alenda C, et al. Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors. J Natl Cancer Inst. 2007 Feb 7;99(3):244-52. *Corresponding author.

c. Balaguer F, Balmaña J, Castellví-Bel S, Steyerberg EW, Andreu M, et al. Validation and extension of the PREMM1,2 model in a population-based cohort of colorectal cancer patients. Gastroenterology. 2008 Jan;134(1):39-46. PMCID: PMC2542581.

d. Bessa X, Ballesté B, Andreu M, Castells A, Bellosillo B, et al. A prospective, multicenter, population-based study of BRAF mutational analysis for Lynch syndrome screening. Clin Gastroenterol Hepatol. 2008 Feb;6(2):206-14.

2. African Americans have the highest incidence and mortality from colorectal cancer and several studies have suggested some clear biological differences. In order to better understand these differences while taking into account social and environmental factors, I established and lead the Chicago Colorectal Cancer Consortium (CCCC), a multiethnic cohort that recruited over 600 patients with CRC of which over 60% are African Americans. The CCCC established a strong team of collaborators working towards the identification of genetic-environmental interactions and socio-economic aspects. Some important findings have already been published and other manuscripts are under preparation. As these is a rich repository of clinical data and biological samples, we expect many more studies will be published in the future based on this cohort

a. RM Xicola, Z Manojlovic, GJ. Augustus, SS Kupfer, R Emmadi, et al. Lack of APC somatic mutation is associated with early-onset colorectal cancer in African Americans. Carcinogenesis. 2018 Dec 13;39(11):1331-1341. PMCID: PMC6292413

b. Pibiri F, Kittles RA, Sandler RS, Keku TO, Kupfer SS, et al. Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans. Cancer Causes Control. 2014 May;25(5):561-70. PMCID: PMC3978221.

c. Xicola RM, Gagnon M, Clark JR, Carroll T, Gao W, et al. Excess of proximal microsatellite-stable colorectal cancer in African Americans from a multiethnic study. Clin Cancer Res. 2014 Sep 15;20(18):4962-70. PMCID: PMC4167473.

d. Guindalini RS, Win AK, Gulden C, Lindor NM, Newcomb PA, et al. Mutation spectrum and risk of colorectal cancer in African American families with Lynch syndrome. Gastroenterology. 2015 Nov;149(6):1446-53. PMCID: PMC4648287.

3. Colorectal cancer is among all common malignancies one with the highest percentage of familial clustering. In fact, several hereditary colorectal cancer syndromes have already been well characterized, which has allowed the implementation of genetic screening and prophylactic and preventive measures. Nevertheless, about half of the families showing a pedigree strongly suggestive of an autosomal dominant inheritance pattern with no polyposis phenotype do not have known genetic predisposing mutations identified so far. I have carried out different studies to characterize these patients, investigating germline associations as well as distinctive carcinogenic processes in order to identify their potential biological cause. Several key features have been identified and these describe this group as a different colorectal cancer entity.

a. Llor X, Pons E, Xicola RM, Castells A, Alenda C, et al. Differential features of colorectal cancers fulfilling Amsterdam criteria without involvement of the mutator pathway. Clin Cancer Res. 2005 Oct 15;11(20):7304-10.

b. Goel A, Xicola RM, Nguyen TP, Doyle BJ, Sohn VR, et al. Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology. 2010 May;138(5):1854-62. PMCID: PMC2859993.

c. Rodríguez-Soler M, Pérez-Carbonell L, Guarinos C, Zapater P, Castillejo A, et al. Risk of cancer in cases of suspected lynch syndrome without germline mutation. Gastroenterology. 2013 May;144(5):926-932.e1; quiz e13-4.

b. Xicola RM, Bontu S, Doyle BJ, Rawson J, Garre P, et al. Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC). Carcinogenesis. 2016 Aug;37(8):751-8. PMCID: PMC4967215.

Coauthors

Research Interests

African Americans; Digestive System Neoplasms; Genetics, Medical; Genetics, Population; Colorectal Neoplasms; Lynch Syndrome II

Public Health Interests

Cancer; Nutrition; Health Equity, Disparities, Social Determinants and Justice

Selected Publications

  • Abstract 5897: Paired tumor/normal clinical sequencing enables identification of patients with pathogenic germline variantsDimopoulos C, Brierley K, Gibson J, Walther Z, Llor X. Abstract 5897: Paired tumor/normal clinical sequencing enables identification of patients with pathogenic germline variants Cancer Research 2022, 82: 5897-5897. DOI: 10.1158/1538-7445.am2022-5897.
  • Abstract 484: Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancersPadi M, Bellomo D, Grant A, Xicola R, Thorne C, Salhia B, Llor X, Ellis N. Abstract 484: Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers Cancer Research 2022, 82: 484-484. DOI: 10.1158/1538-7445.am2022-484.
  • Tu1100: HETEROZYGOUS MUTATIONS IN DNA REPAIR GENES CONFER GENETIC SUSCEPTIILITY TO COLORECTAL CANCER AMONG LYNCH-LIKE CASESGiner-Calabuig M, De Leon S, Vidal-Pedrola G, Fehlmann T, Ukaegbu C, Gibson J, Picó M, Alenda C, Reyes J, Ortega S, LLado C, de la Torre Rubio P, Obrador-Hevia A, Castillejo A, Soto J, Castellví-Bel S, Syngal S, Stoffel E, Ellis N, Jover R, Llor X, Xicola R. Tu1100: HETEROZYGOUS MUTATIONS IN DNA REPAIR GENES CONFER GENETIC SUSCEPTIILITY TO COLORECTAL CANCER AMONG LYNCH-LIKE CASES Gastroenterology 2022, 162: s-883. DOI: 10.1016/s0016-5085(22)62088-2.
  • Abstract PO-052: A multisystem approach doubles the number of patients referred for genetic testing and diagnosed with Lynch syndrome with equally success among ethnic/racial groupsSingh V, Ganzak A, Gershkovich P, Gibson J, Xicola R, Llor X. Abstract PO-052: A multisystem approach doubles the number of patients referred for genetic testing and diagnosed with Lynch syndrome with equally success among ethnic/racial groups Cancer Epidemiology Biomarkers & Prevention 2022, 31: po-052-po-052. DOI: 10.1158/1538-7755.disp21-po-052.
  • Abstract 898: Survival for patients with early-onset colorectal cancer - An overall survival analysis from the National Cancer Database, 2004-2015Cheng E, Cheng E, Blackburn H, Ng K, Ng K, Spiegelman D, Irwin M, Ma X, Gross C, Tabung F, Tabung F, Giovannucci E, Giovannucci E, Kunz P, Llor X, Billingsley K, Meyerhardt J, Meyerhardt J, Ahuja N, Fuchs C. Abstract 898: Survival for patients with early-onset colorectal cancer - An overall survival analysis from the National Cancer Database, 2004-2015 Cancer Research 2021, 81: 898-898. DOI: 10.1158/1538-7445.am2021-898.
  • Su076 COST-EFFECTIVENESS ANALYSIS OF SCREENING STRATEGIES FOR LYNCH SYNDROME UNDER DIFFERENT SYSTEMS APPROACHESZhu J, Singh V, Gershkovich P, Ganzak A, Gibson J, Yaesoubi R, Llor X. Su076 COST-EFFECTIVENESS ANALYSIS OF SCREENING STRATEGIES FOR LYNCH SYNDROME UNDER DIFFERENT SYSTEMS APPROACHES Gastroenterology 2021, 160: s-606-s-607. DOI: 10.1016/s0016-5085(21)02152-1.
  • Abstract CT236: A phase 1b, multicenter, randomized, blinded, placebo-controlled study to evaluate the efficacy of guselkumab in subjects with familial adenomatous polyposisVilar-Sanchez E, Burke C, Correa M, Dekker E, Grady W, Grandval P, Katona B, Llor X, Riegert-Johnson D, Saurin J, Stanich P, Sussman D, Weinberg D, Attiyeh E, Joseph D, Raybold K, Borzillo G, Prior T, Smith M, Xie H, Bachman K, Infante J, Samadder N. Abstract CT236: A phase 1b, multicenter, randomized, blinded, placebo-controlled study to evaluate the efficacy of guselkumab in subjects with familial adenomatous polyposis Cancer Research 2020, 80: ct236-ct236. DOI: 10.1158/1538-7445.am2020-ct236.
  • Abstract IA26: Mechanistic differences in early-onset colorectal cancerXicola R, Manojlovic Z, Augustus G, Kupfer S, Emmadi R, Alagiozian-Angelova V, Triche T, Bodour S, Carpten J, Llor X, Ellis N. Abstract IA26: Mechanistic differences in early-onset colorectal cancer Cancer Epidemiology Biomarkers & Prevention 2020, 29: ia26-ia26. DOI: 10.1158/1538-7755.disp18-ia26.
  • 1 IMPROVING LYNCH SYNDROME IDENTIFICATION THROUGH THE IMPLEMENTATION OF ENHANCED TUMOR TESTING AND A COMPREHENSIVE SYSTEMS APPROACHSingh V, Ganzak A, Gershkovich P, Gibson J, Llor X. 1 IMPROVING LYNCH SYNDROME IDENTIFICATION THROUGH THE IMPLEMENTATION OF ENHANCED TUMOR TESTING AND A COMPREHENSIVE SYSTEMS APPROACH Gastroenterology 2020, 158: s-1. DOI: 10.1016/s0016-5085(20)30682-x.
  • Tu1212 RELEVANT HETEROGENEITY IN MISMATCH REPAIR DEFICIENT TUMORSGiner-Calabuig M, Ukaegbu C, Syngal S, Stoffel E, Jover R, Llor X, Xicola R. Tu1212 RELEVANT HETEROGENEITY IN MISMATCH REPAIR DEFICIENT TUMORS Gastroenterology 2020, 158: s-1020. DOI: 10.1016/s0016-5085(20)33223-6.
  • 1066 - Phenotypic Expression of Cdh1 Germline Mutations Unselected for Hereditary Diffuse Gastric CancerRodriguez N, Reineke P, LaDuca H, Xicola R, Llor X. 1066 - Phenotypic Expression of Cdh1 Germline Mutations Unselected for Hereditary Diffuse Gastric Cancer Gastroenterology 2018, 154: s-204. DOI: 10.1016/s0016-5085(18)31081-3.
  • Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability, and CIMP status: Prognostic implications and response to chemotherapy.Murcia O, Juárez M, Hernández-Illán E, Rodriguez-Soler M, Giner-Calabuig M, Alustiza M, Egoavil C, Castillejo A, Alenda C, Mangas C, Barberá V, Yuste A, Bujanda L, Clofent J, Andreu M, Castells A, Llor X, Zapater P, Jover R. Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability, and CIMP status: Prognostic implications and response to chemotherapy. Journal Of Clinical Oncology 2018, 36: 668-668. DOI: 10.1200/jco.2018.36.4_suppl.668.
  • Abstract 1759: Description of molecular marker disparities and KRAS mutational spectrum of colorectal tumors from Puerto Rican HispanicsPerez-Mayoral J, Rivera-Lynch C, Soto-Salgado M, Llor X, Tous-Lopez L, Torres-Torres M, Reyes J, Torres C, Goel A, Rodriguez-Quillichini S, Cruz-Correa M. Abstract 1759: Description of molecular marker disparities and KRAS mutational spectrum of colorectal tumors from Puerto Rican Hispanics Cancer Research 2017, 77: 1759-1759. DOI: 10.1158/1538-7445.am2017-1759.
  • 235 Mutational and Epigenetic Spectrum of Colorectal Cancers in African AmericansXicola R, Manojlovic Z, Augustus G, Kupfer S, Carpten J, Ellis N, Llor X. 235 Mutational and Epigenetic Spectrum of Colorectal Cancers in African Americans Gastroenterology 2017, 152: s60. DOI: 10.1016/s0016-5085(17)30558-9.
  • 86 Outcomes and Cost Analysis of a Colonoscopy-Based Colorectal Cancer Screening Program in a Lower Income us Hispanic CohortAlvarenga J, Kwak Y, Vazquez-Gillamet L, Vargas-Torres M, Vega M, Lagarde S, McCloskey B, Xicola R, Llor X. 86 Outcomes and Cost Analysis of a Colonoscopy-Based Colorectal Cancer Screening Program in a Lower Income us Hispanic Cohort Gastroenterology 2017, 152: s23. DOI: 10.1016/s0016-5085(17)30447-x.
  • Su1014 Resource Utilization and Colorectal Cancer Screening Compliance with Patient Navigation in Under-Screened PopulationsKwak Y, Alvarenga J, Vazquez-Gillamet L, Vega M, Vargas-Torres M, Lagarde S, McCloskey B, Xicola R, Llor X. Su1014 Resource Utilization and Colorectal Cancer Screening Compliance with Patient Navigation in Under-Screened Populations Gastroenterology 2017, 152: s443. DOI: 10.1016/s0016-5085(17)31692-x.
  • Tu1974 Molecular Disparities and Kras Mutational Spectrum of Colorectal Tumors from Puerto Rican Hispanic SubjectsMarquez J, Pérez-Mayoral J, Gonzalez-Pons M, Rodriguez-Mañon N, Rivera-Lynch C, Soto M, Llor X, Xicola R, Lopez L, Torres-Torres M, Reyes J, Goel A, Torres-Cintrón C, Rodriguez-Quilichini S, Cruz-Correa M. Tu1974 Molecular Disparities and Kras Mutational Spectrum of Colorectal Tumors from Puerto Rican Hispanic Subjects Gastroenterology 2017, 152: s1022. DOI: 10.1016/s0016-5085(17)33461-3.
  • Abstract B31: Sulfidogenic bacteria are an important diet-driven exposure promoting colorectal cancer in African AmericansYazici C, Wolf P, Liu T, Vermillion K, Carroll T, Mutlu E, Tussing-Humphreys L, Braunschweig C, Xicola R, Jung B, Llor X, Ellis N, Gaskins H. Abstract B31: Sulfidogenic bacteria are an important diet-driven exposure promoting colorectal cancer in African Americans Cancer Epidemiology Biomarkers & Prevention 2017, 26: b31-b31. DOI: 10.1158/1538-7755.disp16-b31.
  • Abstract 5013: A meta-analysis of MSI frequency and race in colorectal cancerAshktorab H, Ahuja S, Kannan L, Llor X, Ellis N, Xicola R, Laiyemo A, Carethers J, Brim H, Nouraie M. Abstract 5013: A meta-analysis of MSI frequency and race in colorectal cancer Cancer Research 2016, 76: 5013-5013. DOI: 10.1158/1538-7445.am2016-5013.
  • 775 Unveiling New Colorectal Cancer Phenotypes With Mismatch Repair DeficiencyXicola R, Clark J, Carroll T, Alvikas J, Marwaha P, Regan M, Emmadi R, Alagiozian-Angelova V, Kupfer S, Ellis N, Llor X. 775 Unveiling New Colorectal Cancer Phenotypes With Mismatch Repair Deficiency Gastroenterology 2016, 150: s160. DOI: 10.1016/s0016-5085(16)30630-8.
  • Abstract B35: Molecular characterization of colorectal tumors from Puerto Rican Hispanic patientsDíaz-Algorri Y, Pérez-Mayoral J, González-Pons M, Rodríguez N, Suárez B, Colón G, Sevilla J, Jorge D, Llor X, Xicola R, Tous L, Reyes J, Torres M, Goel A, Rodriguez S, Cruz-Correa M. Abstract B35: Molecular characterization of colorectal tumors from Puerto Rican Hispanic patients Cancer Epidemiology Biomarkers & Prevention 2016, 25: b35-b35. DOI: 10.1158/1538-7755.disp15-b35.
  • Abstract PR02: Homologous recombination drives African American colorectal carcinogenesisAugustus G, Xicola R, Brothman A, Llor X, Ellis N. Abstract PR02: Homologous recombination drives African American colorectal carcinogenesis Cancer Epidemiology Biomarkers & Prevention 2016, 25: pr02-pr02. DOI: 10.1158/1538-7755.disp15-pr02.
  • Abstract A75: Excess of proximal microsatellite-stable colorectal cancer in African Americans from a multiethnic studyXicola R, Kupfer S, Braunschweig C, Ellis N, Llor X. Abstract A75: Excess of proximal microsatellite-stable colorectal cancer in African Americans from a multiethnic study Cancer Epidemiology Biomarkers & Prevention 2015, 24: a75-a75. DOI: 10.1158/1538-7755.disp14-a75.
  • Abstract 4582: Enrichment of colorectal cancer and inflammatory bowel disease risk variants in colon expression quantitative trait loci in African AmericansKupfer S, Hulur I, Gamazon E, Skol A, Llor X, Onel K, Ellis N. Abstract 4582: Enrichment of colorectal cancer and inflammatory bowel disease risk variants in colon expression quantitative trait loci in African Americans 2015, 4582-4582. DOI: 10.1158/1538-7445.am2015-4582.
  • Abstract LB-059: Opposing roles for protein tyrosine kinase 6 (PTK6) in colon cancerMathur P, Gierut J, Xicola R, Llor X, Tyner A. Abstract LB-059: Opposing roles for protein tyrosine kinase 6 (PTK6) in colon cancer 2015, lb-059-lb-059. DOI: 10.1158/1538-7445.am2015-lb-059.
  • Su1993 Somatic Mutations in the Mismatch Repair System Are Responsible for a Majority of Unexplained Lynch Syndrome Cases: Time to Revise Lynch Syndrome Screening?Xicola R, Carroll T, Emmadi R, Alagiozian-Angelova V, Alvikas J, Marwaha P, Regan M, Gibson J, Mitchell K, Kupfer S, Ellis N, Llor X. Su1993 Somatic Mutations in the Mismatch Repair System Are Responsible for a Majority of Unexplained Lynch Syndrome Cases: Time to Revise Lynch Syndrome Screening? Gastroenterology 2015, 148: s-570. DOI: 10.1016/s0016-5085(15)31922-3.
  • Su1997 Colorectal Cancer With Methylator Phenotype. Clinical Characterisitics, Prognosis and Response to Adjuvant ChemotherapyMurcia O, Rodriguez-Soler M, Juarez-Quesada M, Guarinos C, Hernandez-Illan E, Andreu M, Castells A, Llor X, Carracedo A, Jover R. Su1997 Colorectal Cancer With Methylator Phenotype. Clinical Characterisitics, Prognosis and Response to Adjuvant Chemotherapy Gastroenterology 2015, 148: s-570-s-571. DOI: 10.1016/s0016-5085(15)31926-0.
  • 511 Bilophila wadsworthia Is More Abundant in the Colonic Microbiome of Colorectal Cancer Cases Compared to Healthy ControlsYazici C, Wolf P, Carroll T, Mutlu E, Xicola R, Llor X, Jung B, Ellis N, Gaskins H. 511 Bilophila wadsworthia Is More Abundant in the Colonic Microbiome of Colorectal Cancer Cases Compared to Healthy Controls Gastroenterology 2015, 148: s-100. DOI: 10.1016/s0016-5085(15)30343-7.
  • Abstract 1279: Association between vitamin D levels and colorectal cancer in African AmericansSiddiqi S, Pibiri F, Xicola R, Kittles R, Llor X, Kupfer S, Ellis N. Abstract 1279: Association between vitamin D levels and colorectal cancer in African Americans 2014, 1279-1279. DOI: 10.1158/1538-7445.am2014-1279.
  • Abstract 2191: Identification of functional risk alleles in colorectal cancer-associated regions in African AmericansPibiri F, Rechenmacher R, Xicola R, Kittles R, Sandler R, Keku T, Llor X, Carpten J, Kupfer S, Ellis N. Abstract 2191: Identification of functional risk alleles in colorectal cancer-associated regions in African Americans 2014, 2191-2191. DOI: 10.1158/1538-7445.am2014-2191.
  • Mo1153 Association of a Variant in FADS2 the Gene Encoding the Polyunsaturated Fatty Acid Metabolizing Enzyme FADS2 With Colorectal Cancer in African AmericansRavella S, Xicola R, Pibiri F, Carroll T, Sandler R, Kupfer S, Ellis N, Llor X. Mo1153 Association of a Variant in FADS2 the Gene Encoding the Polyunsaturated Fatty Acid Metabolizing Enzyme FADS2 With Colorectal Cancer in African Americans Gastroenterology 2014, 146: s-571. DOI: 10.1016/s0016-5085(14)62069-2.
  • 50 PTK6 Antagonizes the EMT in Colon Cancer Cell LinesMathur P, Xicola R, Llor X, Tyner A. 50 PTK6 Antagonizes the EMT in Colon Cancer Cell Lines Gastroenterology 2014, 146: s-14. DOI: 10.1016/s0016-5085(14)60050-0.
  • Sa1897 Novel Evidence for Interleukin-8 (IL-8) As a Predictive Biomarker of Response to 5fluorouracil Based Chemotherapy in Colorectal CancerPérez-Carbonell L, Egoavil C, Rojas E, Alenda C, Rodriguez-Soler M, Guarinos C, Juarez-Quesada M, Andreu M, Llor X, Castells A, Jover R, Boland C, Goel A. Sa1897 Novel Evidence for Interleukin-8 (IL-8) As a Predictive Biomarker of Response to 5fluorouracil Based Chemotherapy in Colorectal Cancer Gastroenterology 2014, 146: s-323. DOI: 10.1016/s0016-5085(14)61166-5.
  • 675 Unveiling of DNA Repair Gene Alterations in Non-Lynch Hereditary Colorectal Cancer Through Exome SequencingMarwaha P, Xicola R, Kim Y, Snyder C, Carroll T, Syngal S, Buxbaum S, Zhang M, Want S, Lynch H, Bessa X, Andreu M, Jover R, Carracedo A, Castells A, Caldes T, Ellis N, Llor X. 675 Unveiling of DNA Repair Gene Alterations in Non-Lynch Hereditary Colorectal Cancer Through Exome Sequencing Gastroenterology 2014, 146: s-119. DOI: 10.1016/s0016-5085(14)60429-7.
  • 719 Expression Quantitative Trait Loci Mapping in the Human ColonHulur I, Skol A, Llor X, Onel K, Ellis N, Kupfer S. 719 Expression Quantitative Trait Loci Mapping in the Human Colon Gastroenterology 2014, 146: s-125-s-126. DOI: 10.1016/s0016-5085(14)60451-0.
  • Colorectal cancer: From the laboratory to the patient, a now indispensable stepLlor X. Colorectal cancer: From the laboratory to the patient, a now indispensable step Revista De Gastroenterología De México (English Edition) 2014, 79: 71-72. DOI: 10.1016/j.rgmxen.2014.05.012.
  • Racial Differences in Colorectal Cancer: A Large Single Institution ExperienceParepally M, Rajaram P, Xicola R, Ellis N, Llor X, Venepalli N. Racial Differences in Colorectal Cancer: A Large Single Institution Experience The American Journal Of Gastroenterology 2013, 108: s180. DOI: 10.14309/00000434-201310001-00613.
  • Sa2002 IGFBP3 Methylation As a Novel Diagnostic and Prognostic Marker in Colorectal CancerPérez-Carbonell L, Toiyama Y, Balaguer F, Guarinos C, Hur K, Andreu M, Llor X, Castells A, Jover R, Boland C, Goel A. Sa2002 IGFBP3 Methylation As a Novel Diagnostic and Prognostic Marker in Colorectal Cancer Gastroenterology 2013, 144: s-356. DOI: 10.1016/s0016-5085(13)61311-6.
  • 470 TFAP2E Methylation and Expression Status Do Not Serve As Predictors of Response to 5-FU Based Chemotherapy in Colorectal CancerPérez-Carbonell L, Egoavil C, Toiyama Y, Guarinos C, Rojas E, Alenda C, Balaguer F, Hur K, Andreu M, Llor X, Castells A, Jover R, Boland C, Goel A. 470 TFAP2E Methylation and Expression Status Do Not Serve As Predictors of Response to 5-FU Based Chemotherapy in Colorectal Cancer Gastroenterology 2013, 144: s-84-s-85. DOI: 10.1016/s0016-5085(13)60314-5.
  • 106 Implication of the 3′Utr Region of TGFβR1 With MSS HNPCC and Sporadic Colorectal CancerXicola R, Doyle B, Rawson J, Garre P, Abulí A, Murugappan S, Lee J, Bessa X, Clofent J, Bujanda L, Balaguer F, Castellvi-Bel S, Alenda C, Jover R, Ruiz-Ponte C, Syngal S, Andreu M, Carracedo A, Castells A, Ellis N, Caldes T, Llor X. 106 Implication of the 3′Utr Region of TGFβR1 With MSS HNPCC and Sporadic Colorectal Cancer Gastroenterology 2013, 144: s-25. DOI: 10.1016/s0016-5085(13)60086-4.
  • Su1087 Clinicopathological Characterization and Nutritional Assessment of Hispanics With Sporadic Microsatellite Unstable Colorectal CancersDiaz-Algorri Y, Xicola R, Llor X, Tucker K, Cruz-Correa M. Su1087 Clinicopathological Characterization and Nutritional Assessment of Hispanics With Sporadic Microsatellite Unstable Colorectal Cancers Gastroenterology 2013, 144: s-395. DOI: 10.1016/s0016-5085(13)61454-7.
  • 107 Somatic MLH1 Promoter Hypermethylation Is a Frequent Event in Lynch Syndrome Colorectal CancersMoreira L, Munoz J, Cuatrecasas M, Quintanilla I, Leoz M, Carballal S, Ocana T, Fernandez P, Arnold M, Pellise M, Jover R, Andreu M, Carracedo A, Llor X, Boland C, Goel A, Castells A, Balaguer F. 107 Somatic MLH1 Promoter Hypermethylation Is a Frequent Event in Lynch Syndrome Colorectal Cancers Gastroenterology 2013, 144: s-25. DOI: 10.1016/s0016-5085(13)60087-6.
  • Abstract 1330: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African Americans.Pibiri F, Ellis N, Kittles R, LLor X, Xicola R, Kupfer S, Sandler R, Keku T. Abstract 1330: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African Americans. Cancer Research 2013, 73: 1330-1330. DOI: 10.1158/1538-7445.am2013-1330.
  • Abstract 1334: Implication of the 3′UTR region of TGFβR1 with MSS HNPCC and sporadic colorectal cancer.Munoz Xicola R, Doyle B, Rawson J, Garre P, Abuli A, Lee E, Murugappan S, Bessa X, Bujanda L, Balaguer F, Castellvi-Bel S, Clofent J, Alenda C, Jover R, Ruiz-Ponte C, Singal S, Andreu M, Carracedo A, Castells A, Ellis N, Caldes T, LLor X. Abstract 1334: Implication of the 3′UTR region of TGFβR1 with MSS HNPCC and sporadic colorectal cancer. Cancer Research 2013, 73: 1334-1334. DOI: 10.1158/1538-7445.am2013-1334.
  • Abstract PR02: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African Americans.Pibiri F, Kittles R, Sandler R, Keku T, Kupfer S, Xicola R, Llor X, Ellis N. Abstract PR02: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African Americans. Cancer Epidemiology Biomarkers & Prevention 2012, 21: pr02-pr02. DOI: 10.1158/1055-9965.disp12-pr02.
  • Sa1774 Prevalence of MLH1 Constitutional Epimutations as a Cause of Lynch Syndrome in Unselected Consecutive Cases of Colorectal CancerRodriguez-Soler M, Pérez-Carbonell L, Guarinos C, Castillejo A, Egoavil C, Barberà V, Martinez-Dueńas E, Castillejo M, Martinez-Canto A, Sanchez-Heras A, Ruiz-Ponte C, Brea A, Alenda C, Paya A, Sanchez-Fortun C, Juarez-Quesada M, Bujanda L, Clofent J, Llor X, Andreu M, Castells A, Carracedo A, Soto J, Jover R. Sa1774 Prevalence of MLH1 Constitutional Epimutations as a Cause of Lynch Syndrome in Unselected Consecutive Cases of Colorectal Cancer Gastroenterology 2012, 142: s-322. DOI: 10.1016/s0016-5085(12)61211-6.
  • Su1813 Susceptibility Genetic Variants Associated With Early-Onset Colorectal CancerGiráldez M, López-Dóriga A, Bujanda L, Abulí A, Bessa X, Fernandez-Rozadilla C, Munoz J, Cuatrecasas M, Jover R, Xicola R, Llor X, Piqué J, Carracedo A, Ruiz-Ponte C, Cosme A, Enriquez-Navascués J, Moreno V, Andreu M, Castells A, Balaguer F, Castellvi-Bel S. Su1813 Susceptibility Genetic Variants Associated With Early-Onset Colorectal Cancer Gastroenterology 2012, 142: s-510. DOI: 10.1016/s0016-5085(12)61954-4.
  • Abstract 1653: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African AmericansPibiri F, Kittles R, Sandler R, Keku T, Kupfer S, LLor X, Ellis N. Abstract 1653: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African Americans Cancer Research 2012, 72: 1653-1653. DOI: 10.1158/1538-7445.am2012-1653.
  • Abstract 3597: The Chicago Colorectal Cancer Consortium (CCCC) experience: Understanding colorectal cancer disparitiesXicola R, Gagnon M, Shaw J, Rodriguez G, Pusatcioglu C, Clark J, James R, Ravella S, Guzman G, Janoski A, Morrissey M, Mraz K, Cerye K, Chaudhry V, Kupfer S, Melson J, Freeman V, Xie H, Braunchweig C, Ellis N, Llor X. Abstract 3597: The Chicago Colorectal Cancer Consortium (CCCC) experience: Understanding colorectal cancer disparities Cancer Research 2012, 72: 3597-3597. DOI: 10.1158/1538-7445.am2012-3597.
  • Comparison Between Universal Immunohistochemistry for Mismatch Repair Proteins Versus Revised Bethesda Guidelines in the Detection of Patients With Lynch SyndromePérez-Carbonell L, Guarinos C, Soler M, Sanchez-Fortun C, Sempere-Robles L, Ruiz-Ponte C, Castillejo A, Brea A, Carracedo A, Barberá V, Rojas E, Bujanda L, Clofent J, Andreu M, Llor X, Castells A, Soto J, Jover R. Comparison Between Universal Immunohistochemistry for Mismatch Repair Proteins Versus Revised Bethesda Guidelines in the Detection of Patients With Lynch Syndrome Gastroenterology 2011, 140: s-97. DOI: 10.1016/s0016-5085(11)60394-6.
  • Differential Features of Colorectal Cancer (CRC) in Patients With Probable Non-Sporadic Mismatch Repair Deficiency Without Germline MutationSoler M, Pérez-Carbonell L, Guarinos C, Ruiz-Ponte C, Brea A, Castillejo A, Barberá V, Sanchez-Fortun C, Sempere-Robles L, Bujanda L, Clofent J, Llor X, Andreu M, Castells A, Carracedo A, Soto J, Payá A, Alenda C, Jover R. Differential Features of Colorectal Cancer (CRC) in Patients With Probable Non-Sporadic Mismatch Repair Deficiency Without Germline Mutation Gastroenterology 2011, 140: s-190-s-191. DOI: 10.1016/s0016-5085(11)60767-1.
  • Identification of a Chromosome 10 Region Potentially Implicated in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair MutationsXicola R, Below J, Doyle B, Garre P, Zhang W, Caldes T, Cox N, Llor X. Identification of a Chromosome 10 Region Potentially Implicated in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair Mutations Gastroenterology 2011, 140: s-97. DOI: 10.1016/s0016-5085(11)60395-8.
  • Identification of Mirnas and Their Gene Targets Differentially Expressed in Microsatellite Stable and Unstable Colorectal Cancers Through an Integrated AnalysisXicola R, Mu W, Huang L, Sohn V, Doyle B, Jover R, Carracedo A, Andreu M, Bessa X, Castells A, Boland C, Goel A, Investigators E, Dai Y, Llor X. Identification of Mirnas and Their Gene Targets Differentially Expressed in Microsatellite Stable and Unstable Colorectal Cancers Through an Integrated Analysis Gastroenterology 2011, 140: s-819. DOI: 10.1016/s0016-5085(11)63391-x.
  • Increased Line-1 Hypomethylation is a Unique Feature of Early-Onset Colorectal Cancer (CRC)Balaguer F, Antelo M, Shen Y, Hur K, Giraldez M, Bujanda L, Takahashi M, Cabanne A, Barugel M, Arnold M, Roca E, Andreu M, Llor X, Jover R, Castells A, Boland C, Goel A. Increased Line-1 Hypomethylation is a Unique Feature of Early-Onset Colorectal Cancer (CRC) Gastroenterology 2011, 140: s-820-s-821. DOI: 10.1016/s0016-5085(11)63397-0.
  • S1993 Comparison Between Routine Immunohistochemistry for Mismatch Repair Proteins Versus Revised Bethesda Guidelines in the Diagnosis of Lynch Syndrome in a Non-Selected Population of Colorectal Cancer PatientsPérez-Carbonell L, Ruiz-Ponte C, Bessa X, Soto J, Castillejo A, Barberá V, Brea A, Sempere L, Sánchez-Fortún C, Castellvi-Bel S, Balaguer F, Xicola R, Llor X, Abulí A, Andreu M, Alenda C, Payá A, Carracedo A, Castells A, Jover R. S1993 Comparison Between Routine Immunohistochemistry for Mismatch Repair Proteins Versus Revised Bethesda Guidelines in the Diagnosis of Lynch Syndrome in a Non-Selected Population of Colorectal Cancer Patients Gastroenterology 2010, 138: s-297. DOI: 10.1016/s0016-5085(10)61364-9.
  • S1984 Case-Control Genetic Association Study of Candidates Genes for Genetic Susceptibility to Colorectal CancerAbulí A, Fernandez-Rozadilla C, Alonso-Espinaco V, Giráldez M, Muñoz J, Bessa X, Llor X, Jover R, Carvajal-Carmona L, Tomlinson I, Moreno V, Carracedo A, Castells A, Andreu M, Ruiz-Ponte C, Castellvi-Bel S. S1984 Case-Control Genetic Association Study of Candidates Genes for Genetic Susceptibility to Colorectal Cancer Gastroenterology 2010, 138: s-295. DOI: 10.1016/s0016-5085(10)61355-8.
  • 745 Colorectal Cancers (CRCs) With the CpG Island Methylator Phenotype (CIMP) Do Not Show Improved Survival With 5-Fluorouracil (5FU)-Based Adjuvant ChemotherapyJover R, Nguyen T, Pérez-Carbonell L, Payá A, Alenda C, Rojas E, Castells A, Andreu M, Llor X, Boland C, Goel A. 745 Colorectal Cancers (CRCs) With the CpG Island Methylator Phenotype (CIMP) Do Not Show Improved Survival With 5-Fluorouracil (5FU)-Based Adjuvant Chemotherapy Gastroenterology 2010, 138: s-102. DOI: 10.1016/s0016-5085(10)60466-0.
  • T1710 MicroRNA Expression Profiles Distinguish Various Molecular Subtypes of Colorectal Cancer (CRC)Balaguer F, Moreira L, Lozano J, Link A, Ramirez G, Cuatrecasas M, Arnold M, Stoffel E, Syngal S, Jover R, Llor X, Castells A, Boland C, Gironella M, Goel A. T1710 MicroRNA Expression Profiles Distinguish Various Molecular Subtypes of Colorectal Cancer (CRC) Gastroenterology 2010, 138: s-562-s-563. DOI: 10.1016/s0016-5085(10)62588-7.
  • S1994 Base Excision Repair Genes MYH, Ogg1 and Nudt1 and Mismatch Repair Gene Variants in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair Deficiency (MSS HNPCC)Xicola R, Garre P, Doyle B, Bandipalliam P, Sapoznik V, Syngal S, Castells A, Jover R, Andreu M, Boland C, Goel A, Caldes T, Llor X. S1994 Base Excision Repair Genes MYH, Ogg1 and Nudt1 and Mismatch Repair Gene Variants in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair Deficiency (MSS HNPCC) Gastroenterology 2010, 138: s-297. DOI: 10.1016/s0016-5085(10)61365-0.
  • M1930 Identification of Genomic Variants in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair Deficiency (MSS HNPCC)Xicola R, Caldes T, Garre P, Doyle B, Bandipalliam P, Syngal S, Grzybowski J, Sapoznik V, Grzybowski M, Martinez T, Murugappan S, Castells A, Jover R, Andreu M, Goel A, Llor X. M1930 Identification of Genomic Variants in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair Deficiency (MSS HNPCC) Gastroenterology 2009, 136: a-449. DOI: 10.1016/s0016-5085(09)62065-5.
  • 198 CpG-Island Methylator Phenotype (CIMP) and Alterations in RAS-Raf Signaling in Hereditary Non-Polyposis Colorectal Cancers Without Mismatch Repair Deficiency (MSS HNPCC)Xicola R, Nguyen T, Doyle B, Bandipalliam P, Syngal S, Reyes J, Cordero C, Grzybowski J, Sapoznik V, Grzybowski M, Castells A, Jover R, Andreu M, Boland C, Llor X, Goel A. 198 CpG-Island Methylator Phenotype (CIMP) and Alterations in RAS-Raf Signaling in Hereditary Non-Polyposis Colorectal Cancers Without Mismatch Repair Deficiency (MSS HNPCC) Gastroenterology 2009, 136: a-37. DOI: 10.1016/s0016-5085(09)60169-4.
  • 767 Genotype-Phenotype Correlation of Genetic Susceptibility Variants Identified Through Genome-Wide Association Studies for Colorectal CancerAbulí A, Bessa X, Ruiz-Ponte C, Fernandez-Rozadilla C, Carracedo A, Ilzarbe L, Llor X, Jover R, Muñoz J, Castells A, Castellvi-Bel S, Andreu M. 767 Genotype-Phenotype Correlation of Genetic Susceptibility Variants Identified Through Genome-Wide Association Studies for Colorectal Cancer Gastroenterology 2009, 136: a-120. DOI: 10.1016/s0016-5085(09)60537-0.
  • M1953 Frequency and Characteristics of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) and Other Non-Syndromic Colorectal Cancer (CRC) Familial Forms in Spain. Preliminary Data of a Prospective, Multicenter, Population-Based Study (Epicolon-II)Bessa X, Gonzalez D, Roman E, Bujanda L, Enriquez-Navascués J, Reñe J, Gonzalo V, Jover R, Llor X, Peña E, Latorre M, de Castro Parga M, Carracedo A, Castells A, Andreu M. M1953 Frequency and Characteristics of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) and Other Non-Syndromic Colorectal Cancer (CRC) Familial Forms in Spain. Preliminary Data of a Prospective, Multicenter, Population-Based Study (Epicolon-II) Gastroenterology 2009, 136: a-454. DOI: 10.1016/s0016-5085(09)62088-6.
  • W1975 African Americans Fail to Undergo Screening for Colorectal Cancer Independently of Insurance or Self-Reported IncomeKim J, Ewing R, Llor X, Carroll R, Benya R. W1975 African Americans Fail to Undergo Screening for Colorectal Cancer Independently of Insurance or Self-Reported Income Gastroenterology 2009, 136: a-765. DOI: 10.1016/s0016-5085(09)63533-2.
  • S1271 Plantago Ovata Husk Regulates Cell Cycle Progression and Wnt Signaling Pathway, Crucial Elements Implicated in Colorectal CarcinogenesisSapoznik V, Grzybowski M, Xicola R, Doyle B, Grzybowski J, Martinez T, Anguera A, Llor X. S1271 Plantago Ovata Husk Regulates Cell Cycle Progression and Wnt Signaling Pathway, Crucial Elements Implicated in Colorectal Carcinogenesis Gastroenterology 2009, 136: a-226. DOI: 10.1016/s0016-5085(09)61020-9.
  • W1891 Smoking Promotes the Formation of Hyperplastic, But Not Adenomatous, PolypsKim J, Ewing R, Llor X, Carroll R, Benya R. W1891 Smoking Promotes the Formation of Hyperplastic, But Not Adenomatous, Polyps Gastroenterology 2009, 136: a-748. DOI: 10.1016/s0016-5085(09)63450-8.
  • S1272 Differential Regulation of Apoptosis Induction By Plantago Ovata Husk in Colorectal Cancer Cells. Induction of the TNF-Alpha Apoptosis Cascade in Metastatic CellsGrzybowski M, Sapoznik V, Xicola R, Doyle B, Grzybowski J, Martinez T, Anguera A, Llor X. S1272 Differential Regulation of Apoptosis Induction By Plantago Ovata Husk in Colorectal Cancer Cells. Induction of the TNF-Alpha Apoptosis Cascade in Metastatic Cells Gastroenterology 2009, 136: a-226. DOI: 10.1016/s0016-5085(09)61021-0.
  • CORRELACIÓN GENOTIPO-FENOTIP EN EL CÁNCER COLORRECTAL EN RELACIÓN A VARIANTES GENÉTICAS DE SUSCEPTIBILIDADAbulí A, Bessa X, Ruiz-Ponte C, Fernández-Gómez C, Carracedo A, Ilzarbe L, Llor X, Jover R, Muñoz J, Castells A, Castellví-Bel S, Andreu M, Gastroenterología G. CORRELACIÓN GENOTIPO-FENOTIP EN EL CÁNCER COLORRECTAL EN RELACIÓN A VARIANTES GENÉTICAS DE SUSCEPTIBILIDAD Gastroenterología Y Hepatología 2009, 32: 181-182. DOI: 10.1016/j.gastrohep.2009.01.006.
  • EVOLUCIÓN DEL PRONÓSTICO DEL CÁNCER DE COLON EN LOS ÚLTIMOS 20 AÑOSBujanda L, Sarasqueta C, Beraza M, Hijona L, Cosme A, Elorza J, Jover R, Balaguer F, Llor X, Andreu M, Bessa X, Paya A, Castells A, Gastroenterología G. EVOLUCIÓN DEL PRONÓSTICO DEL CÁNCER DE COLON EN LOS ÚLTIMOS 20 AÑOS Gastroenterología Y Hepatología 2009, 32: 232. DOI: 10.1016/j.gastrohep.2009.01.116.
  • FRECUENCIA Y CARACTERÍSTICAS DEL CÁNCER COLORRECTAL HEREDITARIO NO POLIPOSIS (CCHNP) Y OTROS CÁNCERES COLORRECTALES NO SINDRÓMICOS EN ESPAÑA. DATOS PRELIMINARES DE UN ESTUDIO POBLACIONAL, PROSPECTIVO Y MULTICÉNTRICO (EPICOLON-II)Bessa X, Gonzalez D, Roman E, Bujanda L, Enriquez-Navascués J, Reñe J, Gonzalo V, Jover R, Xicolà R, Llor X, Peña E, Latorre M, De Castro L, Carracedo A, Castells A, Andreu M, del Grupo de Oncología E. FRECUENCIA Y CARACTERÍSTICAS DEL CÁNCER COLORRECTAL HEREDITARIO NO POLIPOSIS (CCHNP) Y OTROS CÁNCERES COLORRECTALES NO SINDRÓMICOS EN ESPAÑA. DATOS PRELIMINARES DE UN ESTUDIO POBLACIONAL, PROSPECTIVO Y MULTICÉNTRICO (EPICOLON-II) Gastroenterología Y Hepatología 2009, 32: 232-233. DOI: 10.1016/j.gastrohep.2009.01.118.
  • "What the Primary Care Provider Needs to Know About Hereditary Colorectal Cancer"J Clin Outcomes Manage,16(12):1-9
  • "Hereditary Colorectal Cancer"Colorectal Cancer: Early detection and prevention. Editor: Kim, K. Slack Inc. New Jersey. 2009: pp. 149-166
  • M2051 Genome-Wide Expression Profiling Reveals a Common Biomarker Gene Signature in ColitisMontero T, Llor X, Gil A, Gassull M, Suarez A. M2051 Genome-Wide Expression Profiling Reveals a Common Biomarker Gene Signature in Colitis Gastroenterology 2008, 134: a-458-a-459. DOI: 10.1016/s0016-5085(08)62144-7.
  • T2027 Comparison of Predictive Models and Clinical Criteria for the Identification of Patients with Lynch Syndrome in a Population-Based Cohort of Colorectal Cancer (CRC) PatientsBalmaña J, Balaguer F, Castellvi-Bel S, Steyerberg E, Andreu M, Llor X, Jover R, Castells A, Syngal S. T2027 Comparison of Predictive Models and Clinical Criteria for the Identification of Patients with Lynch Syndrome in a Population-Based Cohort of Colorectal Cancer (CRC) Patients Gastroenterology 2008, 134: a-603. DOI: 10.1016/s0016-5085(08)62817-6.
  • M1636 Gene-Expression Signature-Based Approach Identifies Pro-Apoptotic Compounds in CACO-2 Cell LineMontero T, Llor X, Suarez A. M1636 Gene-Expression Signature-Based Approach Identifies Pro-Apoptotic Compounds in CACO-2 Cell Line Gastroenterology 2008, 134: a-387. DOI: 10.1016/s0016-5085(08)61806-5.
  • 151 Docosahexaenoic and Eicosahexaenoic N-3 Fatty Acids Inhibit DNA Synthesis and Cell Proliferation in Colorectal Cancer Cells Independent of the Responsible Underlying Molecular PathwaysGiros A, Sapoznik V, Fernandez-Morales J, Xicola R, Llor X. 151 Docosahexaenoic and Eicosahexaenoic N-3 Fatty Acids Inhibit DNA Synthesis and Cell Proliferation in Colorectal Cancer Cells Independent of the Responsible Underlying Molecular Pathways Gastroenterology 2008, 134: a-27. DOI: 10.1016/s0016-5085(08)60133-x.
  • T1093 Aberrant Crypt Focus Size Predicts Distal Polyp HistopathologyKim J, Ewing R, Carroll R, Llor X, Benya R. T1093 Aberrant Crypt Focus Size Predicts Distal Polyp Histopathology Gastroenterology 2008, 134: a-482. DOI: 10.1016/s0016-5085(08)62254-4.
  • S2007 Bacterial Microbiota Fingerprints Are Altered in Colon CancerMutlu E, Glover S, Gillevet P, Llor X, Quander C, Sikaroodi M, Engen P, Bracamonte S, Keshavarzian A. S2007 Bacterial Microbiota Fingerprints Are Altered in Colon Cancer Gastroenterology 2008, 134: a-296. DOI: 10.1016/s0016-5085(08)61377-3.
  • P079 IMPLICATION OF BCL-2 FAMILY PROTEINS IN THE INDUCTION OF JURKAT T LYMPHOCYTE APOPTOSIS BY THE MAIN N-3 FATTY ACIDS PRESENT IN FISH OIL DOCOSAHEXAENOIC AND EICOSAPENTAENOIC ACIDHommes T, Giros A, Llor X, Pons E, Fernandez-Morales J, Xicola R, Gassull M. P079 IMPLICATION OF BCL-2 FAMILY PROTEINS IN THE INDUCTION OF JURKAT T LYMPHOCYTE APOPTOSIS BY THE MAIN N-3 FATTY ACIDS PRESENT IN FISH OIL DOCOSAHEXAENOIC AND EICOSAPENTAENOIC ACID Journal Of Crohn's And Colitis 2007, 1: 23. DOI: 10.1016/s1873-9954(07)70091-5.
  • "Cancer and Inflammatory Bowel DiseasesInflammatory bowel diseases. 3rd Edition. Editors: Gassull, Gomollon, Hinojosa, Obrador. Aran Publishing. Madrid. Spain. 2007: 475-480.
  • "Inner and outer environment"Intestinal Inflammation and Colorectal Cancer. Editors: Gasche, Gassull, Herrerias Gutierrez, Monterio. Springer Science. Lancaster, UK. 2007: pp. 185-192.
  • "The Effect of Olive Oil in Inflammatory Bowel Disease"Olive Oil and Health, pp. 309-16
  • The effect of olive oil on inflammatory bowel disease.Llor X, Cabré E, Gassull M. The effect of olive oil on inflammatory bowel disease. 2006, 309-316. DOI: 10.1079/9781845930684.0309.
  • "New Familial Colorectal Cancer Forms"Latest gastroenterology advances. Gastroenterol Hepatol. 2005; 3(1):54-58. Latest gastroenterology advances. Gastroenterol Hepatol. 2005; 3(1):54-58. Latest gastroenterology advances. Gastroenterol Hepatol. 2005; 3(1):54-58. Latest Gastroenterology Advances. Gastroenterol Hepatol. 2005; 3(1):54-58
  • Olive oil induces apoptosis and cell differentiation in Caco-2 cellsLlor X, Pons E, Alvarez M, Fernandez-Banares F, Gassull M. Olive oil induces apoptosis and cell differentiation in Caco-2 cells Gastroenterology 2000, 118: a536-a537. DOI: 10.1016/s0016-5085(00)84276-6.
  • "Characterization of the novel breast tumor kinase Brk"Book chapter. Breast Cancer Research Program. Department of Defense, USA. Era of Hope. Vol II. 1997; 2:121-127
  • "Expression of Tyrosine Kinases in the Mouse Small Intestine"Proceedings on Regulation of Cell Growth, Differentiation and Genetics in Cancer, pp. 308-318
  • Expression of Tyrosine Kinases in the Mouse Small IntestineTyner A, Vasioukhin V, Serfas M, Siyanova E, Llor X. Expression of Tyrosine Kinases in the Mouse Small Intestine 1996, 309-318. DOI: 10.1007/978-3-642-61180-3_28.

Clinical Trials

ConditionsStudy Title
Diseases of the Digestive System - Small Intestines, Large Intestines & RectumBlood and Stool Sample Collection in Subjects with a Diagnosis of Colorectal Cancer or Colorectal Lesion 2018-07 Act Fast
Diseases of the Digestive System - Small Intestines, Large Intestines & RectumClinical Validation of An Optimized Multi-Target Stool DNA (Mt-sDNA 2.0) Test, for Colorectal Cancer Screening "BLUE-C"
Diseases of the Digestive System - Small Intestines, Large Intestines & RectumEvaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode (ECLIPSE)