Winifred Mak, MBBS, PhD
Research & Publications
Biography
Locations
Research Summary
Dr Mak, is currently one of a few physician-scientists appointed by the NIH as a WRHR (Women's Reproductive Health Research) scholar. She is presently carrying out her postdoctoral research under the supervision of Dr Haifan Lin, the director of the Yale Stem Cell Center. Her current projects include investigating the role of an RNA binding protein, Pumilio in the ovary and during embryonic development using a transgenic knockout model; the epigenetic regulation of trophoblast stem cells and their future potential use in placental therapy.
Specialized Terms: Embryogenesis; Epigenetic regulation of placental development; Role of Pumilio; RNA binding protein in oogenesis and embryogenesis; Trophoblast stem cells
Research Interests
Gynecology; Obstetrics; Oogenesis; Placenta; Trophoblasts; Women's Health; Embryonic Development
Selected Publications
- In Vitro Culture Increases the Frequency of Stochastic Epigenetic Errors at Imprinted Genes in Placental Tissues from Mouse Concepti Produced Through Assisted Reproductive Technologies1de Waal E, Mak W, Calhoun S, Stein P, Ord T, Krapp C, Coutifaris C, Schultz RM, Bartolomei MS. In Vitro Culture Increases the Frequency of Stochastic Epigenetic Errors at Imprinted Genes in Placental Tissues from Mouse Concepti Produced Through Assisted Reproductive Technologies1. Biology Of Reproduction 2014, 90: 22, 1-12. PMID: 24337315, PMCID: PMC4076403, DOI: 10.1095/biolreprod.113.114785.
- Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in FemalesMcGraw S, Oakes CC, Martel J, Cirio MC, de Zeeuw P, Mak W, Plass C, Bartolomei MS, Chaillet JR, Trasler JM. Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females. PLOS Genetics 2013, 9: e1003873. PMID: 24278026, PMCID: PMC3836718, DOI: 10.1371/journal.pgen.1003873.
- National study of factors influencing assisted reproductive technology outcomes with male factor infertilityNangia AK, Luke B, Smith JF, Mak W, Stern JE, Group T. National study of factors influencing assisted reproductive technology outcomes with male factor infertility. Fertility And Sterility 2011, 96: 609-614. PMID: 21733503, DOI: 10.1016/j.fertnstert.2011.06.026.
- Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation.Senner CE, Nesterova TB, Norton S, Dewchand H, Godwin J, Mak W, Brockdorff N. Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation. Development (Cambridge, England) 2011, 138: 1541-50. PMID: 21389056, PMCID: PMC3062423, DOI: 10.1242/dev.056812.
- Polycystic ovarian syndrome and the risk of cardiovascular disease and thrombosis.Mak W, Dokras A. Polycystic ovarian syndrome and the risk of cardiovascular disease and thrombosis. Seminars In Thrombosis And Hemostasis 2009, 35: 613-20. PMID: 20013528, DOI: 10.1055/s-0029-1242715.
- Reactivation of the paternal X chromosome in early mouse embryos.Mak W, Nesterova TB, de Napoles M, Appanah R, Yamanaka S, Otte AP, Brockdorff N. Reactivation of the paternal X chromosome in early mouse embryos. Science (New York, N.Y.) 2004, 303: 666-9. PMID: 14752160, DOI: 10.1126/science.1092674.
- Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells.Mak W, Baxter J, Silva J, Newall AE, Otte AP, Brockdorff N. Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells. Current Biology : CB 2002, 12: 1016-20. PMID: 12123576.