Thanh Thanh L. Nguyen, PhD
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About
Titles
Postdoctoral Fellow
Education & Training
- PhD
- Mayo Clinic, Molecular Pharmacology (2022)
- BA
- Green Mountain College, Self-design in Biology, Math & Philosophy (2017)
Research
Overview
Medical Subject Headings (MeSH)
Nervous System Diseases; Psychiatry and Psychology
ORCID
0000-0002-2281-6540
Research at a Glance
Publications Timeline
A big-picture view of Thanh Thanh L. Nguyen's research output by year.
10Publications
Publications
Featured Publications
Glucocorticoids unmask silent non-coding genetic risk variants for common diseases.
Nguyen TTL, Gao H, Liu D, Philips TJ, Ye Z, Lee JH, Shi GX, Copenhaver K, Zhang L, Wei L, Yu J, Zhang H, Barath A, Luong M, Zhang C, Gaspar-Maia A, Li H, Wang L, Ordog T, Weinshilboum RM. Glucocorticoids unmask silent non-coding genetic risk variants for common diseases. Nucleic Acids Res 2022 PMID: 36399508, DOI: 10.1093/nar/gkac1045.Peer-Reviewed Original ResearchGlucocorticoids mediate transcriptome-wide alternative polyadenylation: Potential mechanistic and clinical implications.
Nguyen TTL, Liu D, Gao H, Ye Z, Lee JH, Wei L, Yu J, Zhang L, Wang L, Ordog T, Weinshilboum RM. Glucocorticoids mediate transcriptome-wide alternative polyadenylation: Potential mechanistic and clinical implications. Clin Transl Sci 2022, 15: 2758-2771. PMID: 36128656, DOI: 10.1111/cts.13402.Peer-Reviewed Original ResearchTCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling.
Liu D, Nguyen TTL, Gao H, Huang H, Kim DC, Sharp B, Ye Z, Lee JH, Coombes BJ, Ordog T, Wang L, Biernacka JM, Frye MA, Weinshilboum RM. TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling. Mol Psychiatry 2021, 26: 7454-7464. PMID: 34535768, DOI: 10.1038/s41380-021-01274-z.Peer-Reviewed Original ResearchAPOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, Younkin SG, Graff-Radford NR, Wszolek ZK, Brafman DA, Asmann YW, Ertekin-Taner N, Kanekiyo T, Bu G. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nat Commun 2020, 11: 5540. PMID: 33139712, DOI: 10.1038/s41467-020-19264-0.Peer-Reviewed Original Research
2022
Proteomic Biomarkers of Sacubitril/Valsartan Treatment Response in Heart Failure With Preserved Ejection Fraction: Molecular Insights Into Sex Differences.
Nguyen TTL, Wang M, Liu D, Iyer S, Gonzalez Bonilla HM, Acker N, Murthy V, Shrivastava S, Desai V, Burnett JC Jr, Redfield M, Bailey KR, Weinshilboum RM, Pereira NL. Proteomic Biomarkers of Sacubitril/Valsartan Treatment Response in Heart Failure With Preserved Ejection Fraction: Molecular Insights Into Sex Differences. Circ Heart Fail 2022, 15: e009629. PMID: 35656806, DOI: 10.1161/CIRCHEARTFAILURE.122.009629.Peer-Reviewed Original Research
2021
Mood Regulatory Actions of Active and Sham Nucleus Accumbens Deep Brain Stimulation in Antidepressant Resistant Rats.
Kale RP, Nguyen TTL, Price JB, Yates NJ, Walder K, Berk M, Sillitoe RV, Kouzani AZ, Tye SJ. Mood Regulatory Actions of Active and Sham Nucleus Accumbens Deep Brain Stimulation in Antidepressant Resistant Rats. Front Hum Neurosci 2021, 15: 644921. PMID: 34349629, DOI: 10.3389/fnhum.2021.644921.Peer-Reviewed Original ResearchERICH3: vesicular association and antidepressant treatment response.
Liu D, Zhuang Y, Zhang L, Gao H, Neavin D, Carrillo-Roa T, Wang Y, Yu J, Qin S, Kim DC, Liu E, Nguyen TTL, Biernacka JM, Kaddurah-Daouk R, Dunlop BW, Craighead WE, Mayberg HS, Binder EB, Frye MA, Wang L, Weinshilboum RM. ERICH3: vesicular association and antidepressant treatment response. Mol Psychiatry 2021, 26: 2415-2428. PMID: 33230203, DOI: 10.1038/s41380-020-00940-y.Peer-Reviewed Original ResearchSelective Serotonin Reuptake Inhibitor Pharmaco-Omics: Mechanisms and Prediction.
Nguyen TTL, Liu D, Ho MF, Athreya AP, Weinshilboum R. Selective Serotonin Reuptake Inhibitor Pharmaco-Omics: Mechanisms and Prediction. Front Pharmacol 2021, 11: 614048. PMID: 33510640, DOI: 10.3389/fphar.2020.614048.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
Mood-Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome-Wide Association Study.
Ho AM, Coombes BJ, Nguyen TTL, Liu D, McElroy SL, Singh B, Nassan M, Colby CL, Larrabee BR, Weinshilboum RM, Frye MA, Biernacka JM. Mood-Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome-Wide Association Study. Clin Pharmacol Ther 2020, 108: 1233-1242. PMID: 32627186, DOI: 10.1002/cpt.1982.Peer-Reviewed Original Research
2018
A review of brain insulin signaling in mood disorders: From biomarker to clinical target.
Nguyen TTL, Chan LC, Borreginne K, Kale RP, Hu C, Tye SJ. A review of brain insulin signaling in mood disorders: From biomarker to clinical target. Neurosci Biobehav Rev 2018, 92: 7-15. PMID: 29758232, DOI: 10.1016/j.neubiorev.2018.05.014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements