Thanh Thanh L. Nguyen, PhD
Postdoctoral Fellow
Research & Publications
Biography
Selected Publications
- Glucocorticoids unmask silent non-coding genetic risk variants for common diseases.Nguyen TTL, Gao H, Liu D, Philips TJ, Ye Z, Lee JH, Shi GX, Copenhaver K, Zhang L, Wei L, Yu J, Zhang H, Barath A, Luong M, Zhang C, Gaspar-Maia A, Li H, Wang L, Ordog T, Weinshilboum RM. Glucocorticoids unmask silent non-coding genetic risk variants for common diseases. Nucleic Acids Res 2022 PMID: 36399508, DOI: 10.1093/nar/gkac1045.
- Glucocorticoids mediate transcriptome-wide alternative polyadenylation: Potential mechanistic and clinical implications.Nguyen TTL, Liu D, Gao H, Ye Z, Lee JH, Wei L, Yu J, Zhang L, Wang L, Ordog T, Weinshilboum RM. Glucocorticoids mediate transcriptome-wide alternative polyadenylation: Potential mechanistic and clinical implications. Clin Transl Sci 2022, 15: 2758-2771. PMID: 36128656, DOI: 10.1111/cts.13402.
- TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling.Liu D, Nguyen TTL, Gao H, Huang H, Kim DC, Sharp B, Ye Z, Lee JH, Coombes BJ, Ordog T, Wang L, Biernacka JM, Frye MA, Weinshilboum RM. TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling. Mol Psychiatry 2021, 26: 7454-7464. PMID: 34535768, DOI: 10.1038/s41380-021-01274-z.
- APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, Younkin SG, Graff-Radford NR, Wszolek ZK, Brafman DA, Asmann YW, Ertekin-Taner N, Kanekiyo T, Bu G. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nat Commun 2020, 11: 5540. PMID: 33139712, DOI: 10.1038/s41467-020-19264-0.
- Proteomic Biomarkers of Sacubitril/Valsartan Treatment Response in Heart Failure With Preserved Ejection Fraction: Molecular Insights Into Sex Differences.Nguyen TTL, Wang M, Liu D, Iyer S, Gonzalez Bonilla HM, Acker N, Murthy V, Shrivastava S, Desai V, Burnett JC Jr, Redfield M, Bailey KR, Weinshilboum RM, Pereira NL. Proteomic Biomarkers of Sacubitril/Valsartan Treatment Response in Heart Failure With Preserved Ejection Fraction: Molecular Insights Into Sex Differences. Circ Heart Fail 2022, 15: e009629. PMID: 35656806, DOI: 10.1161/CIRCHEARTFAILURE.122.009629.
- Mood Regulatory Actions of Active and Sham Nucleus Accumbens Deep Brain Stimulation in Antidepressant Resistant Rats.Kale RP, Nguyen TTL, Price JB, Yates NJ, Walder K, Berk M, Sillitoe RV, Kouzani AZ, Tye SJ. Mood Regulatory Actions of Active and Sham Nucleus Accumbens Deep Brain Stimulation in Antidepressant Resistant Rats. Front Hum Neurosci 2021, 15: 644921. PMID: 34349629, DOI: 10.3389/fnhum.2021.644921.
- ERICH3: vesicular association and antidepressant treatment response.Liu D, Zhuang Y, Zhang L, Gao H, Neavin D, Carrillo-Roa T, Wang Y, Yu J, Qin S, Kim DC, Liu E, Nguyen TTL, Biernacka JM, Kaddurah-Daouk R, Dunlop BW, Craighead WE, Mayberg HS, Binder EB, Frye MA, Wang L, Weinshilboum RM. ERICH3: vesicular association and antidepressant treatment response. Mol Psychiatry 2021, 26: 2415-2428. PMID: 33230203, DOI: 10.1038/s41380-020-00940-y.
- Selective Serotonin Reuptake Inhibitor Pharmaco-Omics: Mechanisms and Prediction.Nguyen TTL, Liu D, Ho MF, Athreya AP, Weinshilboum R. Selective Serotonin Reuptake Inhibitor Pharmaco-Omics: Mechanisms and Prediction. Front Pharmacol 2021, 11: 614048. PMID: 33510640, DOI: 10.3389/fphar.2020.614048.
- Mood-Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome-Wide Association Study.Ho AM, Coombes BJ, Nguyen TTL, Liu D, McElroy SL, Singh B, Nassan M, Colby CL, Larrabee BR, Weinshilboum RM, Frye MA, Biernacka JM. Mood-Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome-Wide Association Study. Clin Pharmacol Ther 2020, 108: 1233-1242. PMID: 32627186, DOI: 10.1002/cpt.1982.
- A review of brain insulin signaling in mood disorders: From biomarker to clinical target.Nguyen TTL, Chan LC, Borreginne K, Kale RP, Hu C, Tye SJ. A review of brain insulin signaling in mood disorders: From biomarker to clinical target. Neurosci Biobehav Rev 2018, 92: 7-15. PMID: 29758232, DOI: 10.1016/j.neubiorev.2018.05.014.