Stephanie Perniciaro, PhD, MPH
Research & Publications
Biography
Research Summary
There are numerous vaccines designed to prevent acute respiratory disease, including those targeted to influenza, COVID-19, RSV, Streptococcus pneumoniae, Bordatella pertussis, Corynebacterim diphtheriae, and Haemophilus influenzae. I study vaccine effectiveness and vaccine impact, describing when, where, and how well the vaccines are preventing disease and death in various populations. I'm interested in respiratory disease surveillance, pneumococcal serotype replacement and serotype distribution, vaccine scheduling policy and recommendations, and optimizing vaccine use to protect the full population.
Extensive Research Description
I worked in a sewage treatment facility, analyzing wastewater, sludge, and solids in the laboratory and catching fish and aqueous invertebrates on the bioinventory team. I worked in a VA hospital laboratory, performing endocrine experiments on obese rats. I assisted on a study of thermoregulatory behavior of lizards in the Sonoran Desert. I worked in a nutritional epidemiology laboratory, processing blood and urine samples. I worked in intraoperative research, testing medical devices and collecting various secretions. I worked in the German National Reference Center for Streptococci, registering and analyzing high volumes of bacterial isolates, then designing and carrying out various epidemiological studies related to the surveillance and sample collection.
The overarching goal of my research now is to optimize vaccine impact for respiratory disease, which requires unity between surveillance, policy, and advocacy. I want to determine how we should select vaccines for particular populations and how we should design future vaccine candidates. I want to establish the best way to structure vaccine schedules, which segments of the population should receive vaccines, and how to improve vaccine uptake. I investigate the current and potential effects of using vaccines. In order to unravel these questions, high-quality, long-term, stable disease surveillance systems are essential.
Coauthors
Research Interests
Child; Data Collection; Disease Outbreaks; Immunization; Infant; Influenza, Human; Pneumonia; Population Surveillance; Public Health; Refugees; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; Streptococcus pyogenes; Epidemiologic Studies; Bacteremia; Gram-Positive Bacterial Infections; Community-Acquired Infections; Molecular Epidemiology; Pneumonia, Bacterial; Disease Transmission, Infectious; Disease Notification; Sentinel Surveillance; Endemic Diseases; Communicable Diseases, Emerging; Vulnerable Populations; Emigrants and Immigrants; Genome-Wide Association Study; Coinfection; Public Health Systems Research; Vaccine-Preventable Diseases
Public Health Interests
Antimicrobial Resistance; Emerging Infectious Diseases; Global Health; Health Care Quality, Efficiency; Health Policy; Modeling; Respiratory Disease/Infections; Vaccines; Health Systems Reform
Selected Publications
- 150. Evaluation of a novel mHealth tool to promote adolescent vaccination: The Vaccine Information for Teens App (VITA)Grant W, Hansen C, Perniciaro S, Niccolai L. 150. Evaluation of a novel mHealth tool to promote adolescent vaccination: The Vaccine Information for Teens App (VITA) Journal Of Adolescent Health 2022, 70: s79. DOI: 10.1016/j.jadohealth.2022.01.067.
- Reemergence of Invasive Pneumococcal Disease in Germany During the Spring and Summer of 2021Perniciaro S, van der Linden M, Weinberger DM. Reemergence of Invasive Pneumococcal Disease in Germany During the Spring and Summer of 2021 Clinical Infectious Diseases 2022, 75: 1149-1153. PMID: 35136983, PMCID: PMC9383454, DOI: 10.1093/cid/ciac100.
- Pneumococcal vaccine uptake and vaccine effectiveness in older adults with invasive pneumococcal disease in Germany: A retrospective cohort studyPerniciaro S, van der Linden M. Pneumococcal vaccine uptake and vaccine effectiveness in older adults with invasive pneumococcal disease in Germany: A retrospective cohort study The Lancet Regional Health - Europe 2021, 7: 100126. PMID: 34557837, PMCID: PMC8454757, DOI: 10.1016/j.lanepe.2021.100126.
- Bacterial Spectrum of Spontaneously Ruptured Otitis Media in a 7-Year, Longitudinal, Multicenter, Epidemiological Cross-Sectional Study in GermanyImöhl M, Perniciaro S, Busse A, van der Linden M. Bacterial Spectrum of Spontaneously Ruptured Otitis Media in a 7-Year, Longitudinal, Multicenter, Epidemiological Cross-Sectional Study in Germany Frontiers In Medicine 2021, 8: 675225. PMID: 34095179, PMCID: PMC8172772, DOI: 10.3389/fmed.2021.675225.
- The Impact of Changes in Diagnostic Testing Practices on Estimates of COVID-19 Transmission in the United StatesPitzer VE, Chitwood M, Havumaki J, Menzies NA, Perniciaro S, Warren JL, Weinberger DM, Cohen T. The Impact of Changes in Diagnostic Testing Practices on Estimates of COVID-19 Transmission in the United States American Journal Of Epidemiology 2021, 190: kwab089. PMID: 33831148, PMCID: PMC8083380, DOI: 10.1093/aje/kwab089.
- The impact of changes in diagnostic testing practices on estimates of COVID-19 transmission in the United States.Pitzer VE, Chitwood M, Havumaki J, Menzies NA, Perniciaro S, Warren JL, Weinberger DM, Cohen T. The impact of changes in diagnostic testing practices on estimates of COVID-19 transmission in the United States. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32511624, PMCID: PMC7276051, DOI: 10.1101/2020.04.20.20073338.
- Limited indirect effects of an infant pneumococcal vaccination program in an aging populationvan der Linden M, Imöhl M, Perniciaro S. Limited indirect effects of an infant pneumococcal vaccination program in an aging population PLOS ONE 2019, 14: e0220453. PMID: 31369597, PMCID: PMC6675109, DOI: 10.1371/journal.pone.0220453.
- Regional variations in serotype distribution and vaccination status in children under six years of age with invasive pneumococcal disease in GermanyPerniciaro S, Imöhl M, Fitzner C, van der Linden M. Regional variations in serotype distribution and vaccination status in children under six years of age with invasive pneumococcal disease in Germany PLOS ONE 2019, 14: e0210278. PMID: 30625215, PMCID: PMC6326516, DOI: 10.1371/journal.pone.0210278.
- Invasive Pneumococcal Disease in Refugee Children, GermanyPerniciaro S, Imöhl M, van der Linden M. Invasive Pneumococcal Disease in Refugee Children, Germany Emerging Infectious Diseases 2018, 24: 1934-1936. PMID: 30226179, PMCID: PMC6154141, DOI: 10.3201/eid2410.180253.
- Reassessing the 1 + 1 pneumococcal conjugate vaccine schedulePerniciaro S, van der Linden M. Reassessing the 1 + 1 pneumococcal conjugate vaccine schedule The Lancet Infectious Diseases 2018, 18: 381-382. PMID: 29582765, DOI: 10.1016/s1473-3099(18)30129-4.
- Reduzierte Effekte der pädiatrischen Pneumokokken-Konjugatimpfung auf invasive Pneumokokkenerkrankungen bei Erwachsenen in DeutschlandPerniciaro S, Imöhl M, van der Linden M. Reduzierte Effekte der pädiatrischen Pneumokokken-Konjugatimpfung auf invasive Pneumokokkenerkrankungen bei Erwachsenen in Deutschland Pneumologie 2018, 72: s97-s98. DOI: 10.1055/s-0037-1619380.
- Epidemiology and distribution of 10 superantigens among invasive Streptococcus pyogenes disease in Germany from 2009 to 2014Imöhl M, Fitzner C, Perniciaro S, van der Linden M. Epidemiology and distribution of 10 superantigens among invasive Streptococcus pyogenes disease in Germany from 2009 to 2014 PLOS ONE 2017, 12: e0180757. PMID: 28719668, PMCID: PMC5515411, DOI: 10.1371/journal.pone.0180757.
- Effectiveness of Pneumococcal Conjugate Vaccines (PCV7 and PCV13) against Invasive Pneumococcal Disease among Children under Two Years of Age in Germanyvan der Linden M, Falkenhorst G, Perniciaro S, Fitzner C, Imöhl M. Effectiveness of Pneumococcal Conjugate Vaccines (PCV7 and PCV13) against Invasive Pneumococcal Disease among Children under Two Years of Age in Germany PLOS ONE 2016, 11: e0161257. PMID: 27526117, PMCID: PMC4985133, DOI: 10.1371/journal.pone.0161257.
- Effects of Infant Pneumococcal Conjugate Vaccination on Serotype Distribution in Invasive Pneumococcal Disease among Children and Adults in Germanyvan der Linden M, Falkenhorst G, Perniciaro S, Imöhl M. Effects of Infant Pneumococcal Conjugate Vaccination on Serotype Distribution in Invasive Pneumococcal Disease among Children and Adults in Germany PLOS ONE 2015, 10: e0131494. PMID: 26132078, PMCID: PMC4488910, DOI: 10.1371/journal.pone.0131494.
- Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination eravan der Linden M, Perniciaro S, Imöhl M. Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era BMC Infectious Diseases 2015, 15: 207. PMID: 25940580, PMCID: PMC4424534, DOI: 10.1186/s12879-015-0941-9.
- Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in GermanyImöhl M, Möller J, Reinert R, Perniciaro S, van der Linden M, Aktas O. Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany BMC Infectious Diseases 2015, 15: 61. PMID: 25885764, PMCID: PMC4335684, DOI: 10.1186/s12879-015-0787-1.
- Epidemiology of Streptococcus pneumoniae Serogroup 6 Isolates from IPD in Children and Adults in Germanyvan der Linden M, Winkel N, Küntzel S, Farkas A, Perniciaro S, Reinert R, Imöhl M. Epidemiology of Streptococcus pneumoniae Serogroup 6 Isolates from IPD in Children and Adults in Germany PLOS ONE 2013, 8: e60848. PMID: 23593324, PMCID: PMC3621884, DOI: 10.1371/journal.pone.0060848.