Shan Xin
Postdoctoral Associate
Research & Publications
Biography
Coauthors
Selected Publications
- Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy.Liu C, Xie J, Lin B, Tian W, Wu Y, Xin S, Hong L, Li X, Liu L, Jin Y, Tang H, Deng X, Zou Y, Zheng S, Fang W, Cheng J, Dai X, Bao X, Zhao P. Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy. Adv Sci (Weinh) 2024, 11: e2401061. PMID: 38569519, DOI: 10.1002/advs.202401061.
- Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxiaPeng H, Xin S, Pfeiffer S, Müller C, Merl-Pham J, Hauck S, Harter P, Spitzer D, Devraj K, Varynskyi B, Arzberger T, Momma S, Schick J. Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia. Cell Death & Disease 2024, 15: 286. PMID: 38653992, PMCID: PMC11039673, DOI: 10.1038/s41419-024-06681-y.
- A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer.Bao X, Li Q, Chen D, Dai X, Liu C, Tian W, Zhang H, Jin Y, Wang Y, Cheng J, Lai C, Ye C, Xin S, Li X, Su G, Ding Y, Xiong Y, Xie J, Tano V, Wang Y, Fu W, Deng S, Fang W, Sheng J, Ruan J, Zhao P. A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer. Cell Rep Med 2024, 5: 101399. PMID: 38307032, DOI: 10.1016/j.xcrm.2024.101399.
- Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy.Verma N, Renauer PA, Dong C, Xin S, Lin Q, Zhang F, Glazer PM, Chen S. Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy. BioRxiv 2024 PMID: 38293095, DOI: 10.1101/2024.01.14.575614.
- An immunometabolism subtyping system identifies S100A9(+) macrophage as an immune therapeutic target in colorectal cancer based on multiomics analysis.Bao X, Wang D, Dai X, Liu C, Zhang H, Jin Y, Tong Z, Li B, Tong C, Xin S, Li X, Wang Y, Liu L, Zhu X, Fu Q, Zheng Y, Deng J, Tian W, Guo T, Zhao P, Chen W, Fang W. An immunometabolism subtyping system identifies S100A9(+) macrophage as an immune therapeutic target in colorectal cancer based on multiomics analysis. Cell Rep Med 2023, 4: 100987. PMID: 36990096, DOI: 10.1016/j.xcrm.2023.100987.
- PUFAs dictate the balance of power in ferroptosisXin S, Schick J. PUFAs dictate the balance of power in ferroptosis. Cell Calcium 2023, 110: 102703. PMID: 36773492, DOI: 10.1016/j.ceca.2023.102703.
- Massively parallel knock-in engineering of human T cellsDai X, Park J, Du Y, Na Z, Lam S, Chow R, Renauer P, Gu J, Xin S, Chu Z, Liao C, Clark P, Zhao H, Slavoff S, Chen S. Massively parallel knock-in engineering of human T cells. Nature Biotechnology 2023, 41: 1239-1255. PMID: 36702900, DOI: 10.1038/s41587-022-01639-x.
- MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodelingXin S, Mueller C, Pfeiffer S, Kraft V, Merl-Pham J, Bao X, Feederle R, Jin X, Hauck S, Schmitt-Kopplin P, Schick J. MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling. Cell Death & Differentiation 2021, 29: 670-686. PMID: 34663908, PMCID: PMC8901757, DOI: 10.1038/s41418-021-00883-z.
- Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cellsSong W, Xin S, He M, Pfeiffer S, Cao A, Li H, Schick J, Jin X. Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells. The FASEB Journal 2021, 35: e21550. PMID: 33960023, DOI: 10.1096/fj.202000856r.
- Immune Landscape of Invasive Ductal Carcinoma Tumor Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature.Bao X, Shi R, Zhang K, Xin S, Li X, Zhao Y, Wang Y. Immune Landscape of Invasive Ductal Carcinoma Tumor Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature. Front Oncol 2019, 9: 903. PMID: 31620363, DOI: 10.3389/fonc.2019.00903.
- Prognostic and Predictive Value of Three DNA Methylation Signatures in Lung Adenocarcinoma.Wang Y, Deng H, Xin S, Zhang K, Shi R, Bao X. Prognostic and Predictive Value of Three DNA Methylation Signatures in Lung Adenocarcinoma. Front Genet 2019, 10: 349. PMID: 31105737, DOI: 10.3389/fgene.2019.00349.
- A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis.Wang Y, Zhang Q, Gao Z, Xin S, Zhao Y, Zhang K, Shi R, Bao X. A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis. Cancer Cell Int 2019, 19: 100. PMID: 31015800, DOI: 10.1186/s12935-019-0822-1.
- Low GAS5 Levels as a Predictor of Poor Survival in Patients with Lower-Grade Gliomas.Wang Y, Xin S, Zhang K, Shi R, Bao X. Low GAS5 Levels as a Predictor of Poor Survival in Patients with Lower-Grade Gliomas. J Oncol 2019, 2019: 1785042. PMID: 30853980, DOI: 10.1155/2019/1785042.
- Cotton Ascorbate Oxidase Promotes Cell Growth in Cultured Tobacco Bright Yellow-2 Cells through Generation of Apoplast OxidationLi R, Xin S, Tao C, Jin X, Li H. Cotton Ascorbate Oxidase Promotes Cell Growth in Cultured Tobacco Bright Yellow-2 Cells through Generation of Apoplast Oxidation. International Journal Of Molecular Sciences 2017, 18: 1346. PMID: 28644407, PMCID: PMC5535839, DOI: 10.3390/ijms18071346.
- Cloning and Functional Analysis of the Promoter of an Ascorbate Oxidase Gene from Gossypium hirsutumXin S, Tao C, Li H. Cloning and Functional Analysis of the Promoter of an Ascorbate Oxidase Gene from Gossypium hirsutum. PLOS ONE 2016, 11: e0161695. PMID: 27597995, PMCID: PMC5012575, DOI: 10.1371/journal.pone.0161695.
- Establishing a special education management system--SEMS.Hayden D, Vance B, Irvin MS. Establishing a special education management system--SEMS. J Learn Disabil 1982, 15: 428-9. PMID: 6759595, DOI: 10.1177/002221948201500712.