Sabrina Diano, PhD
Research & Publications
Biography
News
Research Summary
My research focuses on CNS (hypothalamic) mechanisms relating to the regulation of energy and glucose homeostasis. These studies on hypothalamic inter- and intra-cellular mechanisms that regulates metabolism add critical information to the current understanding of the central regulation of energy and glucose homeostasis and how alterations in stored energy are sensed in the hypothalamus. The results of my research have important implications for understanding the pathogenesis of metabolic syndrome, obesity and type 2 diabetes, disorders that are the leading cause of morbidity and mortality in the U.S., and the developed world in general, with the highest financial burden on the national economy.
Coauthors
Research Interests
Endocrine System; Nervous System; Diseases
Selected Publications
- Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1αLiu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett A, Diano S, Huang Y. Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α. Diabetologia 2024, 67: 724-737. PMID: 38216792, PMCID: PMC10904493, DOI: 10.1007/s00125-023-06073-5.
- Microglia in Central Control of MetabolismKim J, Copperi F, Diano S. Microglia in Central Control of Metabolism. Physiology 2023, 39: 5-17. PMID: 37962895, DOI: 10.1152/physiol.00021.2023.
- 146-OR: Causative Role of Hypothalamic Ventromedial Glucose-Inhibited Neurons in Impaired Counterregulatory Responses to HypoglycemiaCOPPERI F, SHEN X, DIANO S. 146-OR: Causative Role of Hypothalamic Ventromedial Glucose-Inhibited Neurons in Impaired Counterregulatory Responses to Hypoglycemia. Diabetes 2023, 72 DOI: 10.2337/db23-146-or.
- POMC Neurons: From Birth to DeathToda C, Santoro A, Kim JD, Diano S. POMC Neurons: From Birth to Death. Annual Review Of Physiology 2017, 79: 209-236. PMID: 28192062, PMCID: PMC5669621, DOI: 10.1146/annurev-physiol-022516-034110.
- DRP1 Suppresses Leptin and Glucose Sensing of POMC NeuronsSantoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metabolism 2017, 25: 647-660. PMID: 28190775, PMCID: PMC5366041, DOI: 10.1016/j.cmet.2017.01.003.
- UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose ResponsivenessToda C, Kim JD, Impellizzeri D, Cuzzocrea S, Liu ZW, Diano S. UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness. Cell 2016, 164: 872-883. PMID: 26919426, PMCID: PMC4770556, DOI: 10.1016/j.cell.2016.02.010.
- Hypothalamic POMC neurons promote cannabinoid-induced feedingKoch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 2015, 519: 45-50. PMID: 25707796, PMCID: PMC4496586, DOI: 10.1038/nature14260.
- Minireview: Ghrelin and the Regulation of Energy Balance—A Hypothalamic PerspectiveHorvath T, Diano S, Sotonyi P, Heiman M, Tschöp M. Minireview: Ghrelin and the Regulation of Energy Balance—A Hypothalamic Perspective. Endocrinology 2001, 142: 4163-4169. DOI: 10.1210/en.142.10.4163.
- Mitochondrial Uncoupling Protein 2 (UCP2) in the Nonhuman Primate Brain and Pituitary**This work was supported by NSF Grant IBN-9728581, NIH Grants NS-36111, MH-59847, RR-00163, HD-29186, and HD-37186.Diano S, Urbanski H, Horvath B, Bechmann I, Kagiya A, Nemeth G, Naftolin F, Warden C, Horvath T. Mitochondrial Uncoupling Protein 2 (UCP2) in the Nonhuman Primate Brain and Pituitary**This work was supported by NSF Grant IBN-9728581, NIH Grants NS-36111, MH-59847, RR-00163, HD-29186, and HD-37186. Endocrinology 2000, 141: 4226-4238. DOI: 10.1210/en.141.11.4226.
- 3,5-Diiodo-l-Thyronine Regulates Glucose-6-Phosphate Dehydrogenase Activity in the Rat*Lombardi A, Beneduce L, Moreno M, Diano S, Colantuoni V, Ursini M, Lanni A, Goglia F. 3,5-Diiodo-l-Thyronine Regulates Glucose-6-Phosphate Dehydrogenase Activity in the Rat*. Endocrinology 2000, 141: 1729-1734. DOI: 10.1210/en.141.5.1729.
- Interactions between Neuropeptide Y and γ -Aminobutyric Acid in Stimulation of Feeding: A Morphological and Pharmacological Analysis*Pu S, Jain M, Horvath T, Diano S, Kalra P, Kalra S. Interactions between Neuropeptide Y and γ -Aminobutyric Acid in Stimulation of Feeding: A Morphological and Pharmacological Analysis*. Endocrinology 1999, 140: 933-940. DOI: 10.1210/en.140.2.933.
- Fasting-Induced Increase in Type II Iodothyronine Deiodinase Activity and Messenger Ribonucleic Acid Levels Is Not Reversed by Thyroxine in the Rat Hypothalamus*Diano S, Naftolin F, Goglia F, Horvath T. Fasting-Induced Increase in Type II Iodothyronine Deiodinase Activity and Messenger Ribonucleic Acid Levels Is Not Reversed by Thyroxine in the Rat Hypothalamus*. Endocrinology 1998, 139: 2879-2884. DOI: 10.1210/en.139.6.2879.
- Evidence Showing That β-Endorphin Regulates Cyclic Guanosine 3′,5′-Monophosphate (cGMP) Efflux: Anatomical and Functional Support for an Interaction between Opiates and Nitric Oxide*Pu S, Horvath T, Diano S, Naftolin F, Kalra P, Kalra S. Evidence Showing That β-Endorphin Regulates Cyclic Guanosine 3′,5′-Monophosphate (cGMP) Efflux: Anatomical and Functional Support for an Interaction between Opiates and Nitric Oxide*. Endocrinology 1997, 138: 1537-1543. DOI: 10.1210/en.138.4.1537.
- Gonadal Steroids Target AMPA Glutamate Receptor-Containing Neurons in the Rat Hypothalamus, Septum and Amygdala: A Morphological and Biochemical Study*Diano S, Naftolin F, Horvath T. Gonadal Steroids Target AMPA Glutamate Receptor-Containing Neurons in the Rat Hypothalamus, Septum and Amygdala: A Morphological and Biochemical Study*. Endocrinology 1997, 138: 778-789. DOI: 10.1210/en.138.2.778.