My primary research interests have been in identifying and assessing predictive and prognostic biomarkers in a variety of human cancers including: breast, colon, melanoma, and renal.
In addition to developing methods for the quantitative analysis of biomarkers of tissue sessions, I have developed a number of algorithms and programs for quantifying and statistically analyzing biomarker expression. These include the AQUA (Automated Quantitative Analysis) System (US Patents 7219016, 7873480, 8036833, 8121794), as well X-Tile a graphical method for the identification of tumor subpopulations.
Data Interpretation, Statistical; Biomarkers; Automation, Laboratory