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Raphael Sherak, MD, MPH

Hospital Resident

Contact Information

Raphael Sherak, MD, MPH

Research Summary

As an emergency physician and decision scientist, both my clinical work and research centers on making decisions with incomplete and imperfect information. My primary research focus is on antibiotic selection for suspected infections (primarily UTIs and STIs) in emergency department patients. The emergency clinician must consider competing factors including the likelihood of infection, local antibiotic resistance rates, potential harms of overtreatment, loss to follow up and other social determinants of health.

While antibiotic decisions are made under uncertainty, a (near) ground truth becomes available several days later when cultures result. These unique features and challenges are well suited to decision-analytic modeling. I use a variety of modeling techniques including deterministic, compartmental, and machine learning models to develop heuristics for antibiotic selection.

Extensive Research Description

Current projects:

  • Decision Analytic Model Comparing Azithromycin with Doxycycline for the Treatment of Chlamydia Infections in Emergency Department Patients
  • Epidemiology of Emergency Department Patients with Sexually Transmitted Infections
  • Improving and Standardizing Care for Survivors of Sexual Assault in the Emergency Medical System
  • Cost-Effectiveness Analysis of Empiric Treatment Strategies for Urinary Tract Infections in the Emergency Department Setting
  • Modeling ED patient flow and hospital crowding

Prior projects:

  • Assessment of SOFA Score for Mortality Prediction in Patients with COVID-19
  • Treatment of sodium disorders in ICU patients


Research Interests

Economics; Emergency Medicine; Emergency Treatment; Epidemiology; Urinary Tract Infections; Economics, Pharmaceutical; Informatics; Disaster Medicine; Evidence-Based Emergency Medicine; Policy; Inappropriate Prescribing; Clinical Decision-Making; Data Science; Cost-Effectiveness Analysis

Public Health Interests

Antimicrobial Resistance; Clinical Guidelines; Epidemiology Methods; Health Economics; Health Policy; Infectious Diseases; Modeling; Sexually-Transmitted Infections; Health Equity, Disparities, Social Determinants and Justice

Selected Publications