Paul Gravel
Associate Research Scientist
Research & Publications
Biography
Coauthors
Selected Publications
- Dopamine D2/3 receptor availability in cocaine use disorder individuals with obesity as measured by [11C]PHNO PETMatuskey D, Angarita GA, Worhunsky P, Koohsari S, Gravel P, Pittman B, Gaiser EC, Gallezot JD, Nabulsi N, Huang Y, Carson RE, Potenza MN, Malison RT. Dopamine D2/3 receptor availability in cocaine use disorder individuals with obesity as measured by [11C]PHNO PET. Drug And Alcohol Dependence 2021, 220: 108514. PMID: 33454626, PMCID: PMC7889720, DOI: 10.1016/j.drugalcdep.2021.108514.
- Neuroimaging of Obsessive-Compulsive Disorder: Insights into Serotonergic MechanismsLissemore J, Booij L, Leyton M, Gravel P, Sookman D, Nordahl T, Benkelfat C. Neuroimaging of Obsessive-Compulsive Disorder: Insights into Serotonergic Mechanisms. 2020, 457-478. DOI: 10.1007/978-3-030-57231-0_13.
- Dopaminergic Plasticity in the Bilateral Hippocampus Following Threat Reversal in HumansLissemore J, Nagano-Saito A, Smart K, Gravel P, Leyton M, Benkelfat C. Dopaminergic Plasticity in the Bilateral Hippocampus Following Threat Reversal in Humans. Scientific Reports 2020, 10: 7627. PMID: 32376865, PMCID: PMC7203150, DOI: 10.1038/s41598-020-63977-7.
- Effects of TOF Resolution Models on Edge Artifacts in PET Reconstruction From Limited-Angle DataGravel P, Li Y, Matej S. Effects of TOF Resolution Models on Edge Artifacts in PET Reconstruction From Limited-Angle Data. IEEE Transactions On Radiation And Plasma Medical Sciences 2020, 4: 603-612. PMID: 33163754, PMCID: PMC7643853, DOI: 10.1109/trpms.2020.2989209.
- Effects of TOF Resolution Models on Edge Artifacts in PET Reconstruction from Limited Angle DataGravel P, Li Y, Matej S. Effects of TOF Resolution Models on Edge Artifacts in PET Reconstruction from Limited Angle Data. 2019, 00: 1-3. DOI: 10.1109/nss/mic42101.2019.9059970.
- Spatially-variant image-based modeling of PSF deformations with application to a limited angle geometry from a dual-panel breast-PET imagerGravel P, Surti S, Krishnamoorthy S, Karp J, Matej S. Spatially-variant image-based modeling of PSF deformations with application to a limited angle geometry from a dual-panel breast-PET imager. Physics In Medicine And Biology 2019, 64: 225015. PMID: 31569078, PMCID: PMC7236960, DOI: 10.1088/1361-6560/ab4914.
- Spatially-Variant Image-Based Modeling of PSF Deformations with Application to Limited Angle Dual-Panel Breast-PET DataGravel P, Surti S, Krishnamoorthy S, Karp J, Matej S. Spatially-Variant Image-Based Modeling of PSF Deformations with Application to Limited Angle Dual-Panel Breast-PET Data. 2018, 00: 1-3. DOI: 10.1109/nssmic.2018.8824650.
- Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertralineLissemore J, Sookman D, Gravel P, Berney A, Barsoum A, Diksic M, Nordahl T, Pinard G, Sibon I, Cottraux J, Leyton M, Benkelfat C. Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline. Translational Psychiatry 2018, 8: 82. PMID: 29666372, PMCID: PMC5904107, DOI: 10.1038/s41398-018-0128-4.
- Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBVAghourian M, Legault-Denis C, Soucy J, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard M. Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBV. Molecular Psychiatry 2017, 22: 1531-1538. PMID: 28894304, DOI: 10.1038/mp.2017.183.
- Altered Regional Cerebral Blood Flow in Idiopathic HypersomniaBoucetta S, Montplaisir J, Zadra A, Lachapelle F, Soucy J, Gravel P, Dang-Vu T. Altered Regional Cerebral Blood Flow in Idiopathic Hypersomnia. Sleep 2017, 40: zsx140. PMID: 28958044, DOI: 10.1093/sleep/zsx140.
- Posterior dopamine D2/3 receptors and brain network functional connectivityNagano‐Saito A, Lissemore J, Gravel P, Leyton M, Carbonell F, Benkelfat C. Posterior dopamine D2/3 receptors and brain network functional connectivity. Synapse 2017, 71 PMID: 28700819, DOI: 10.1002/syn.21993.
- Direct PET Reconstruction of Regional Binding PotentialsGravel P, Soucy J, Reader A. Direct PET Reconstruction of Regional Binding Potentials. 2016, 1-3. DOI: 10.1109/nssmic.2016.8069457.
- Cocaine cue–induced dopamine release in the human prefrontal cortexMilella M, Fotros A, Gravel P, Casey K, Larcher K, Verhaeghe J, Cox S, Reader A, Dagher A, Benkelfat C, Leyton M. Cocaine cue–induced dopamine release in the human prefrontal cortex. Journal Of Psychiatry And Neuroscience 2016, 41: 322-330. PMID: 26900792, PMCID: PMC5008921, DOI: 10.1503/jpn.150207.
- Direct 4D PET MLEM reconstruction of parametric images using the simplified reference tissue model with the basis function method for [11C]racloprideGravel P, Reader A. Direct 4D PET MLEM reconstruction of parametric images using the simplified reference tissue model with the basis function method for [11C]raclopride. Physics In Medicine And Biology 2015, 60: 4533-4549. PMID: 25992999, DOI: 10.1088/0031-9155/60/11/4533.
- Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha‐[11C]methyl‐l‐tryptophan studyBooij L, Soucy J, Young S, Regoli M, Gravel P, Diksic M, Leyton M, Pihl R, Benkelfat C. Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha‐[11C]methyl‐l‐tryptophan study. Journal Of Neurochemistry 2014, 131: 634-644. PMID: 25041501, DOI: 10.1111/jnc.12826.
- OCD: Serotonergic MechanismsLissemore J, Leyton M, Gravel P, Sookman D, Nordahl T, Benkelfat C. OCD: Serotonergic Mechanisms. 2014, 433-450. DOI: 10.1007/978-3-642-40384-2_17.
- Cue-Induced Dopamine Release in Striatal and Extra-striatal Regions in Cocaine Dependent Users A High Resolution PET [18F]Fallypride StudyFotros A, Casey K, Larcher K, Verhaeghe J, Cox S, Gravel P, Reader A, Dagher A, Benkelfat C, Leyton M. Cue-Induced Dopamine Release in Striatal and Extra-striatal Regions in Cocaine Dependent Users A High Resolution PET [18F]Fallypride Study. 2014, 183. DOI: 10.1016/b978-0-12-800044-1.00166-5.
- Applying a [11C]Raclopride Template to Automated Binding Potential Estimation in HRRT Brain PETNovosad P, Bieth M, Gravel P, Lombaert H, Siddiqi K, Reader A. Applying a [11C]Raclopride Template to Automated Binding Potential Estimation in HRRT Brain PET. 2013, 1-8. DOI: 10.1109/nssmic.2013.6829396.
- Direct 4D PET MLEM Reconstruction of Parametric Images Using the Simplified Reference Tissue Model with the Basis Function MethodGravel P, Reader A. Direct 4D PET MLEM Reconstruction of Parametric Images Using the Simplified Reference Tissue Model with the Basis Function Method. 2013, 1-7. DOI: 10.1109/nssmic.2013.6829041.
- Stress‐induced dopamine release in human medial prefrontal cortex—18F‐Fallypride/PET study in healthy volunteersNagano‐Saito A, Dagher A, Booij L, Gravel P, Welfeld K, Casey K, Leyton M, Benkelfat C. Stress‐induced dopamine release in human medial prefrontal cortex—18F‐Fallypride/PET study in healthy volunteers. Synapse 2013, 67: 821-830. PMID: 23939822, DOI: 10.1002/syn.21700.
- Towards fully automated MR-independent binding potential estimation for PETBieth M, Gravel P, Siddiqi K, Reader A. Towards fully automated MR-independent binding potential estimation for PET. 2011 IEEE Nuclear Science Symposium Conference Record 2013, 4011-4016. DOI: 10.1109/nssmic.2012.6551919.
- Direct 4D PET reconstruction of parametric images into a stereotaxic brain atlas for [11C]racloprideGravel P, Verhaeghe J, Reader A. Direct 4D PET reconstruction of parametric images into a stereotaxic brain atlas for [11C]raclopride. 2011 IEEE Nuclear Science Symposium Conference Record 2013, 3994-3998. DOI: 10.1109/nssmic.2012.6551915.
- Cocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent ParticipantsFotros A, Casey K, Larcher K, Verhaeghe J, Cox S, Gravel P, Reader A, Dagher A, Benkelfat C, Leyton M. Cocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent Participants. Neuropsychopharmacology 2013, 38: 1780-1788. PMID: 23546387, PMCID: PMC3717549, DOI: 10.1038/npp.2013.77.
- Grey matter density and GABAA binding potential show a positive linear relationship across cortical regionsDuncan N, Gravel P, Wiebking C, Reader A, Northoff G. Grey matter density and GABAA binding potential show a positive linear relationship across cortical regions. Neuroscience 2013, 235: 226-231. PMID: 23380503, DOI: 10.1016/j.neuroscience.2012.12.075.
- 3D PET image reconstruction including both motion correction and registration directly into an MR or stereotaxic spatial atlasGravel P, Verhaeghe J, Reader A. 3D PET image reconstruction including both motion correction and registration directly into an MR or stereotaxic spatial atlas. Physics In Medicine And Biology 2012, 58: 105-126. PMID: 23221063, DOI: 10.1088/0031-9155/58/1/105.
- External awareness and GABA—A multimodal imaging study combining fMRI and [18F]flumazenil‐PETWiebking C, Duncan N, Qin P, Hayes D, Lyttelton O, Gravel P, Verhaeghe J, Kostikov A, Schirrmacher R, Reader A, Bajbouj M, Northoff G. External awareness and GABA—A multimodal imaging study combining fMRI and [18F]flumazenil‐PET. Human Brain Mapping 2012, 35: 173-184. PMID: 22996793, PMCID: PMC6869063, DOI: 10.1002/hbm.22166.
- Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: A 27-year longitudinal studyBooij L, Benkelfat C, Leyton M, Vitaro F, Gravel P, Lévesque M, Arseneault L, Diksic M, Tremblay R. Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: A 27-year longitudinal study. European Neuropsychopharmacology 2012, 22: 419-423. PMID: 22257439, DOI: 10.1016/j.euroneuro.2011.11.002.
- GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulationQin P, Duncan N, Wiebking C, Gravel P, Lyttelton O, Hayes D, Verhaeghe J, Kostikov A, Schirrmacher R, Reader A, Northoff G. GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation. Frontiers In Human Neuroscience 2012, 6: 337. PMID: 23293594, PMCID: PMC3533380, DOI: 10.3389/fnhum.2012.00337.
- Direct 3D PET Image Reconstruction into MR Image SpaceGravel P, Verhaeghe J, Reader A. Direct 3D PET Image Reconstruction into MR Image Space. 2011, 3955-3962. DOI: 10.1109/nssmic.2011.6153752.
- Tryptophan hydroxylase2 gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humansBooij L, Turecki G, Leyton M, Gravel P, Lopez De Lara C, Diksic M, Benkelfat C. Tryptophan hydroxylase2 gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans. Molecular Psychiatry 2011, 17: 809-817. PMID: 21747395, DOI: 10.1038/mp.2011.79.
- Brain Regionalα-[11C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive-Compulsive DisorderBerney A, Leyton M, Gravel P, Sibon I, Sookman D, Neto P, Diksic M, Nakai A, Pinard G, Todorov C, Okazawa H, Blier P, Nordahl T, Benkelfat C. Brain Regionalα-[11C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive-Compulsive Disorder. JAMA Psychiatry 2011, 68: 732-741. PMID: 21383250, PMCID: PMC3677917, DOI: 10.1001/archgenpsychiatry.2011.16.
- Task-oriented quantitative image reconstruction in emission tomography for single- and multi-subject studiesVerhaeghe J, Gravel P, Reader A. Task-oriented quantitative image reconstruction in emission tomography for single- and multi-subject studies. Physics In Medicine And Biology 2010, 55: 7263-7285. PMID: 21081825, DOI: 10.1088/0031-9155/55/23/006.
- Where in-vivo imaging meets cytoarchitectonics: The relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PETla Fougère C, Grant S, Kostikov A, Schirrmacher R, Gravel P, Schipper H, Reader A, Evans A, Thiel A. Where in-vivo imaging meets cytoarchitectonics: The relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PET. NeuroImage 2010, 56: 951-960. PMID: 21073964, DOI: 10.1016/j.neuroimage.2010.11.015.
- Quantification task-optimized estimates from OSEM and FBP reconstructions in single-and multi-subject studiesVerhaeghe J, Gravel P, Reader A. Quantification task-optimized estimates from OSEM and FBP reconstructions in single-and multi-subject studies. 2010, 2977-2981. DOI: 10.1109/nssmic.2010.5874342.
- Task-Oriented and Study-Dependent Optimization of 3D and Fully 4D Reconstruction Parameters for [18F]FDG ImagingGravel P, Verhaeghe J, Reader A. Task-Oriented and Study-Dependent Optimization of 3D and Fully 4D Reconstruction Parameters for [18F]FDG Imaging. 2010, 2088-2091. DOI: 10.1109/nssmic.2010.5874145.
- Motion compensation for fully 4D PET reconstruction using PET superset dataVerhaeghe J, Gravel P, Mio R, Fukasawa R, Rosa-Neto P, Soucy J, Thompson C, Reader A. Motion compensation for fully 4D PET reconstruction using PET superset data. Physics In Medicine And Biology 2010, 55: 4063-4082. PMID: 20601774, DOI: 10.1088/0031-9155/55/14/008.
- P1‐388: Imaging of cholinergic terminals in the non‐human primate brain using 18F‐FEOBV PET: Development of a tool to assess cholinergic losses in Alzheimer's diseaseSoucy J, Rosa P, Massarweh G, Aliaga A, Schirrmacher E, Bédard M, Sanchez-Legaspi M, Gravel P, Reader A. P1‐388: Imaging of cholinergic terminals in the non‐human primate brain using 18F‐FEOBV PET: Development of a tool to assess cholinergic losses in Alzheimer's disease. Alzheimer's & Dementia 2010, 6: s286-s286. DOI: 10.1016/j.jalz.2010.05.942.
- Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood: A 21-Year Longitudinal StudyBooij L, Tremblay R, Leyton M, Séguin J, Vitaro F, Gravel P, Perreau-Linck E, Lévesque M, Durand F, Diksic M, Turecki G, Benkelfat C. Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood: A 21-Year Longitudinal Study. PLOS ONE 2010, 5: e11255. PMID: 20582306, PMCID: PMC2889822, DOI: 10.1371/journal.pone.0011255.
- Impact of Fully 4D Reconstruction on Kinetic Parameter EstimatesGravel P, Verhaeghe J, Reader A. Impact of Fully 4D Reconstruction on Kinetic Parameter Estimates. 2009, 3546-3549. DOI: 10.1109/nssmic.2009.5401812.
- Motion-Compensated Fully 4D PET Reconstruction using PET Data SupersetsVerhaeghe J, Gravel P, Mio R, Fukasawa R, Rosa-Neto P, Soucy J, Thompson C, Reader A. Motion-Compensated Fully 4D PET Reconstruction using PET Data Supersets. 2009, 3000-3004. DOI: 10.1109/nssmic.2009.5401590.
- Improved work-up procedure for the production of [18F]flumazenil and first results of its use with a high-resolution research tomograph in human strokeMassaweh G, Schirrmacher E, la Fougere C, Kovacevic M, Wängler C, Jolly D, Gravel P, Reader A, Thiel A, Schirrmacher R. Improved work-up procedure for the production of [18F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke. Nuclear Medicine And Biology 2009, 36: 721-727. PMID: 19720284, DOI: 10.1016/j.nucmedbio.2009.05.008.
- MicroPET imaging of 5-HT1A receptors in rat brain: a test–retest [18F]MPPF studyAznavour N, Benkelfat C, Gravel P, Aliaga A, Rosa-Neto P, Bedell B, Zimmer L, Descarries L. MicroPET imaging of 5-HT1A receptors in rat brain: a test–retest [18F]MPPF study. European Journal Of Nuclear Medicine And Molecular Imaging 2008, 36: 53. PMID: 18704404, DOI: 10.1007/s00259-008-0891-1.
- Decreased [18F]MPPF Binding Potential in the Dorsal Raphe Nucleus After a Single Oral Dose of Fluoxetine: A Positron-Emission Tomography Study in Healthy VolunteersSibon I, Benkelfat C, Gravel P, Aznavour N, Costes N, Mzengeza S, Booij L, Baker G, Soucy J, Zimmer L, Descarries L. Decreased [18F]MPPF Binding Potential in the Dorsal Raphe Nucleus After a Single Oral Dose of Fluoxetine: A Positron-Emission Tomography Study in Healthy Volunteers. Biological Psychiatry 2008, 63: 1135-1140. PMID: 18191817, DOI: 10.1016/j.biopsych.2007.11.016.
- In vivo measurements of brain trapping of C-labelled alpha-methyl-L-tryptophan during acute changes in mood states.Perreau-Linck E, Beauregard M, Gravel P, Paquette V, Soucy J, Diksic M, Benkelfat C. In vivo measurements of brain trapping of C-labelled alpha-methyl-L-tryptophan during acute changes in mood states. Journal Of Psychiatry And Neuroscience 2007, 32: 430-4. PMID: 18043767, PMCID: PMC2077345.
- Acute prefrontal cortex TMS in healthy volunteers: Effects on brain 11C-αMtrp trappingSibon I, Strafella A, Gravel P, Ko J, Booij L, Soucy J, Leyton M, Diksic M, Benkelfat C. Acute prefrontal cortex TMS in healthy volunteers: Effects on brain 11C-αMtrp trapping. NeuroImage 2006, 34: 1658-1664. PMID: 17188517, DOI: 10.1016/j.neuroimage.2006.08.059.
- Assessing whole brain perfusion changes in patients with REM sleep behavior disorderMazza S, Soucy J, Gravel P, Michaud M, Postuma R, Massicotte-Marquez J, Decary A, Montplaisir J. Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. Neurology 2006, 67: 1618-1622. PMID: 17101893, DOI: 10.1212/01.wnl.0000242879.39415.49.
- 124 Sleep apnea syndrome and cerebral perfusionMazza S, Mathieu A, Soucy J, Gravel P, Petit D, Gosselin N, Decary A, Montplaisir J. 124 Sleep apnea syndrome and cerebral perfusion. Sleep Medicine 2006, 7: s10. DOI: 10.1016/j.sleep.2006.07.028.
- α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attemptersLeyton M, Paquette V, Gravel P, Rosa-Neto P, Weston F, Diksic M, Benkelfat C. α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. European Neuropsychopharmacology 2005, 16: 220-223. PMID: 16269239, DOI: 10.1016/j.euroneuro.2005.09.006.