Patrick Cudahy, MD, MSc
Assistant Professor of Medicine (Infectious Diseases); Affiliated Faculty, Yale Institute for Global Health
Research & Publications
Biography
News
Research Summary
Tuberculosis mortality remains high globally. In South Africa, fueled by a high prevalence of HIV, tuberculosis is the leading cause of death. I have been involved in research and clinical care for people co-infected with HIV and tuberculosis, especially drug-resistant tuberculosis, in South Africa for over a decade. My research focuses on improving outcomes in HIV and tuberculosis co-infection as well as better understanding of its epidemiology. To accomplish this I have established a research site at Doris Goodwin Hospital, a large multidrug-resistant tuberculosis (MDR-TB) referral center in KwaZulu-Natal, South Africa as well as set up collaborations with scientists locally and internationally. These efforts have resulted in a K01 career development award from the NIH/Fogarty International Center.
Coauthors
Research Interests
Epidemiology; HIV; Mycobacterium Infections; Mycobacterium tuberculosis; Tuberculosis; Global Health; Biomarkers; Tuberculosis, Multidrug-Resistant; Mycobacterium kansasii
Public Health Interests
Global Health; HIV/AIDS; Tuberculosis
Selected Publications
- Urine and sputum tuberculosis tests: defining the trade-offs in endemic HIV and tuberculosis settingsWilson D, Cudahy P, Drain P. Urine and sputum tuberculosis tests: defining the trade-offs in endemic HIV and tuberculosis settings. The Lancet Global Health 2023, 11: e809-e810. PMID: 37202010, DOI: 10.1016/s2214-109x(23)00215-2.
- A doctor at a PHC clinic: A ‘must-have’ or ‘nice-to-have’?Kerry T, Cudahy P, Holst H, Ramsunder A, McGrath N. A doctor at a PHC clinic: A ‘must-have’ or ‘nice-to-have’? South African Medical Journal 2022, 113: 24-30. PMID: 36537544, DOI: 10.7196/samj.2023.v113i1.16700.
- Whole-Genome Sequencing Has the Potential To Improve Treatment for Rifampicin-Resistant Tuberculosis in High-Burden Settings: a Retrospective Cohort StudyCox H, Goig GA, Salaam-Dreyer Z, Dippenaar A, Reuter A, Mohr-Holland E, Daniels J, Cudahy PGT, Nicol MP, Borrell S, Reinhard M, Doetsch A, Beisel C, Gagneux S, Warren RM, Furin J. Whole-Genome Sequencing Has the Potential To Improve Treatment for Rifampicin-Resistant Tuberculosis in High-Burden Settings: a Retrospective Cohort Study. Journal Of Clinical Microbiology 2022, 60: e02362-21. PMID: 35170980, PMCID: PMC8925891, DOI: 10.1128/jcm.02362-21.
- Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysisYang C, Sobkowiak B, Naidu V, Codreanu A, Ciobanu N, Gunasekera KS, Chitwood MH, Alexandru S, Bivol S, Russi M, Havumaki J, Cudahy P, Fosburgh H, Allender CJ, Centner H, Engelthaler DM, Menzies NA, Warren JL, Crudu V, Colijn C, Cohen T. Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis. PLOS Medicine 2022, 19: e1003933. PMID: 35192619, PMCID: PMC8903246, DOI: 10.1371/journal.pmed.1003933.
- Potential contribution of HIV during first-line tuberculosis treatment to subsequent rifampicin-monoresistant tuberculosis and acquired tuberculosis drug resistance in South Africa: a retrospective molecular epidemiology studyCox H, Salaam-Dreyer Z, Goig GA, Nicol MP, Menardo F, Dippenaar A, Mohr-Holland E, Daniels J, Cudahy PGT, Borrell S, Reinhard M, Doetsch A, Beisel C, Reuter A, Furin J, Gagneux S, Warren RM. Potential contribution of HIV during first-line tuberculosis treatment to subsequent rifampicin-monoresistant tuberculosis and acquired tuberculosis drug resistance in South Africa: a retrospective molecular epidemiology study. The Lancet Microbe 2021, 2: e584-e593. PMID: 34766068, PMCID: PMC8563432, DOI: 10.1016/s2666-5247(21)00144-0.
- Rifampicin-Monoresistant Tuberculosis Is Not the Same as Multidrug-Resistant Tuberculosis: a Descriptive Study from Khayelitsha, South AfricaSalaam-Dreyer Z, Streicher EM, Sirgel FA, Menardo F, Borrell S, Reinhard M, Doetsch A, Cudahy PGT, Mohr-Holland E, Daniels J, Dippenaar A, Nicol MP, Gagneux S, Warren RM, Cox H. Rifampicin-Monoresistant Tuberculosis Is Not the Same as Multidrug-Resistant Tuberculosis: a Descriptive Study from Khayelitsha, South Africa. Antimicrobial Agents And Chemotherapy 2021, 65: e00364-21. PMID: 34460307, PMCID: PMC8522772, DOI: 10.1128/aac.00364-21.
- Use of the antenatal antiretroviral (ARV) tracking form in maternity case records to improve ARV managementKerry T, Cudahy P. Use of the antenatal antiretroviral (ARV) tracking form in maternity case records to improve ARV management. South African Medical Journal 2020, 110: 1206-1212. PMID: 33403967, DOI: 10.7196/samj.2020.v110i12.14505.
- Risk factors for recurrent tuberculosis after successful treatment in a high burden setting: a cohort studyCudahy PGT, Wilson D, Cohen T. Risk factors for recurrent tuberculosis after successful treatment in a high burden setting: a cohort study. BMC Infectious Diseases 2020, 20: 789. PMID: 33097000, PMCID: PMC7585300, DOI: 10.1186/s12879-020-05515-4.
- Spatially targeted screening to reduce tuberculosis transmission in high-incidence settingsCudahy PGT, Andrews JR, Bilinski A, Dowdy DW, Mathema B, Menzies NA, Salomon JA, Shrestha S, Cohen T. Spatially targeted screening to reduce tuberculosis transmission in high-incidence settings. The Lancet Infectious Diseases 2018, 19: e89-e95. PMID: 30554997, PMCID: PMC6401264, DOI: 10.1016/s1473-3099(18)30443-2.
- Trends in C-Reactive Protein, D-Dimer, and Fibrinogen during Therapy for HIV-Associated Multidrug-Resistant Tuberculosis.Cudahy PGT, Warren JL, Cohen T, Wilson D. Trends in C-Reactive Protein, D-Dimer, and Fibrinogen during Therapy for HIV-Associated Multidrug-Resistant Tuberculosis. American Journal Of Tropical Medicine And Hygiene 2018, 99: 1336-1341. PMID: 30226135, PMCID: PMC6221241, DOI: 10.4269/ajtmh.18-0322.
- Evaluation of Tuberculosis Treatment Response With Serial C-Reactive Protein MeasurementsWilson D, Moosa MS, Cohen T, Cudahy P, Aldous C, Maartens G. Evaluation of Tuberculosis Treatment Response With Serial C-Reactive Protein Measurements. Open Forum Infectious Diseases 2018, 5: ofy253. PMID: 30474046, PMCID: PMC6240901, DOI: 10.1093/ofid/ofy253.
- Diagnostic outcomes after chest radiograph interpretation in patients with suspected tuberculosis and negative sputum smears in a high burden HIV and tuberculosis settingCudahy PGT, Dawson R, Allwood BW, Maartens G, Wilson D. Diagnostic outcomes after chest radiograph interpretation in patients with suspected tuberculosis and negative sputum smears in a high burden HIV and tuberculosis setting. Open Forum Infectious Diseases 2017, 4: ofx123. PMID: 28721354, PMCID: PMC5508775, DOI: 10.1093/ofid/ofx123.
- Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysisNathavitharana RR, Cudahy PG, Schumacher SG, Steingart KR, Pai M, Denkinger CM. Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysis. European Respiratory Journal 2017, 49: 1601075. PMID: 28100546, PMCID: PMC5898952, DOI: 10.1183/13993003.01075-2016.
- Diagnostics for pulmonary tuberculosisCudahy P, Shenoi SV. Diagnostics for pulmonary tuberculosis. Postgraduate Medical Journal 2016, 92: 187-193. PMID: 27005271, PMCID: PMC4854647, DOI: 10.1136/postgradmedj-2015-133278.