Min Hee Oh
Associate Research Scientist
Research & Publications
Biography
Coauthors
Selected Publications
- Serendipitous Discovery of T Cell–Produced KLK1b22 as a Regulator of Systemic MetabolismArwood M, Sun I, Patel C, Sun I, Oh M, Bettencourt I, Claiborne M, Chan-Li Y, Zhao L, Waickman A, Mavrothalassitis O, Wen J, Aja S, Powell J. Serendipitous Discovery of T Cell–Produced KLK1b22 as a Regulator of Systemic Metabolism. ImmunoHorizons 2023, 7: 493-507. PMID: 37358498, PMCID: PMC10580127, DOI: 10.4049/immunohorizons.2300016.
- GOT1 constrains TH17 cell differentiation, while promoting iTreg cell differentiationXu W, Patel C, Alt J, Zhao L, Sun I, Oh M, Sun I, Wen J, Blosser R, Tam A, Powell J. GOT1 constrains TH17 cell differentiation, while promoting iTreg cell differentiation. Nature 2023, 614: e1-e11. PMID: 36726001, DOI: 10.1038/s41586-022-05602-3.
- GOT1 regulates CD8+ effector and memory T cell generationXu W, Patel C, Zhao L, Sun I, Oh M, Sun I, Helms R, Wen J, Powell J. GOT1 regulates CD8+ effector and memory T cell generation. Cell Reports 2023, 42: 111987. PMID: 36640309, PMCID: PMC9943022, DOI: 10.1016/j.celrep.2022.111987.
- Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1.Patel C, Heikamp E, Xu W, Sun I, Oh M, Sun I, Wen J, Tam A, Blosser R, Powell J. Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1. The Journal Of Immunology 2022, 209: 2287-2291. PMID: 36469844, PMCID: PMC10065985, DOI: 10.4049/jimmunol.2100669.
- RNA methylation in immune cellsChen Y, Oh M, Flavell R, Li H. RNA methylation in immune cells. 2022, 155: 39-94. PMID: 36357012, DOI: 10.1016/bs.ai.2022.08.002.
- mTORC1 Signaling Regulates Proinflammatory Macrophage Function and Metabolism.Collins S, Oh M, Sun I, Chan-Li Y, Zhao L, Powell J, Horton M. mTORC1 Signaling Regulates Proinflammatory Macrophage Function and Metabolism. The Journal Of Immunology 2021, 207: 913-922. PMID: 34290107, DOI: 10.4049/jimmunol.2100230.
- Abstract IA10: Targeting glutamine metabolism as a means of enhancing immunotherapy for cancerPowell J, Leone R, Oh M, Rais R, Majer P, Slusher B. Abstract IA10: Targeting glutamine metabolism as a means of enhancing immunotherapy for cancer. Clinical Cancer Research 2020, 26: ia10-ia10. DOI: 10.1158/1557-3265.aacrahns19-ia10.
- Targeting glutamine metabolism enhances tumor specific immunity by modulating suppressive myeloid cellsOh M, Sun I, Zhao L, Leone R, Sun I, Xu W, Collins S, Tam A, Blosser R, Patel C, Englert J, Arwood M, Wen J, Chan-Li Y, Tenora L, Majer P, Rais R, Slusher B, Horton M, Powell J. Targeting glutamine metabolism enhances tumor specific immunity by modulating suppressive myeloid cells. Journal Of Clinical Investigation 2020, 130: 3865-3884. PMID: 32324593, PMCID: PMC7324212, DOI: 10.1172/jci131859.
- Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasionLeone R, Zhao L, Englert J, Sun I, Oh M, Sun I, Arwood M, Bettencourt I, Patel C, Wen J, Tam A, Blosser R, Prchalova E, Alt J, Rais R, Slusher B, Powell J. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science 2019, 366: 1013-1021. PMID: 31699883, PMCID: PMC7023461, DOI: 10.1126/science.aav2588.
- Abstract LB-022: Targeting glutamine metabolism as a mean of treating a murine model of ovarian cancer and ascites developmentOh M, Travers M, Brown S, Zhao L, Sun I, Sun I, Arwood M, Xu W, Collins S, Leone R, Prchalova E, Rais R, Slusher B, Horton M, Zahnow C, Powell J. Abstract LB-022: Targeting glutamine metabolism as a mean of treating a murine model of ovarian cancer and ascites development. Cancer Research 2019, 79: lb-022-lb-022. DOI: 10.1158/1538-7445.am2019-lb-022.
- Abstract 4376: Targeting glutamine metabolism disables Warburg physiology by inhibiting proximal glycolysis and Krebs cycle rewiringZhao L, Arwood M, Oh M, Xu W, Sun I, Sun I, Patel C, Leone R, Alt J, Rais R, Slusher B, Powell J. Abstract 4376: Targeting glutamine metabolism disables Warburg physiology by inhibiting proximal glycolysis and Krebs cycle rewiring. Cancer Research 2019, 79: 4376-4376. DOI: 10.1158/1538-7445.am2019-4376.
- Abstract LB-022: Targeting glutamine metabolism as a mean of treating a murine model of ovarian cancer and ascites developmentOh M, Travers M, Brown S, Zhao L, Sun I, Sun I, Arwood M, Xu W, Collins S, Leone R, Prchalova E, Rais R, Slusher B, Horton M, Zahnow C, Powell J. Abstract LB-022: Targeting glutamine metabolism as a mean of treating a murine model of ovarian cancer and ascites development. 2019, lb-022-lb-022. DOI: 10.1158/1538-7445.sabcs18-lb-022.
- Abstract 4376: Targeting glutamine metabolism disables Warburg physiology by inhibiting proximal glycolysis and Krebs cycle rewiringZhao L, Arwood M, Oh M, Xu W, Sun I, Sun I, Patel C, Leone R, Alt J, Rais R, Slusher B, Powell J. Abstract 4376: Targeting glutamine metabolism disables Warburg physiology by inhibiting proximal glycolysis and Krebs cycle rewiring. 2019, 4376-4376. DOI: 10.1158/1538-7445.sabcs18-4376.
- mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T CellsSun I, Oh M, Zhao L, Patel C, Arwood M, Xu W, Tam A, Blosser R, Wen J, Powell J. mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells. The Journal Of Immunology 2018, 201: 481-492. PMID: 29884702, PMCID: PMC6089237, DOI: 10.4049/jimmunol.1701477.
- Abstract 4963: Targeting glutamine metabolism as a means of enhancing antitumor T-cell responsesLeone R, Englert J, Sun I, Oh M, Alt J, Sun I, Tam A, Majer P, Rais R, Slusher B, Powell J. Abstract 4963: Targeting glutamine metabolism as a means of enhancing antitumor T-cell responses. Cancer Research 2018, 78: 4963-4963. DOI: 10.1158/1538-7445.am2018-4963.
- Abstract 4730: Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation and function of suppressive myeloid cellsOh M, Sun I, Zhao L, Sun I, Xu W, Patel C, Leone R, Tam A, Englert J, Majer P, Rais R, Slusher B, Horton M, Powell J. Abstract 4730: Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation and function of suppressive myeloid cells. Cancer Research 2018, 78: 4730-4730. DOI: 10.1158/1538-7445.am2018-4730.
- Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer modelsLeone R, Sun I, Oh M, Sun I, Wen J, Englert J, Powell J. Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models. Cancer Immunology, Immunotherapy 2018, 67: 1271-1284. PMID: 29923026, DOI: 10.1007/s00262-018-2186-0.
- mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal MacrophagesOh M, Collins S, Sun I, Tam A, Patel C, Arwood M, Chan-Li Y, Powell J, Horton M. mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages. Cell Reports 2017, 20: 2439-2454. PMID: 28877476, PMCID: PMC5659290, DOI: 10.1016/j.celrep.2017.08.046.
- Abstract 573: Metabolism as checkpoint: Induction of anti-tumor immune response with the novel glutamine antagonist JHU-083Leone R, Englert J, Oh M, Cheng C, Rais R, Slusher B, Powell J. Abstract 573: Metabolism as checkpoint: Induction of anti-tumor immune response with the novel glutamine antagonist JHU-083. Cancer Research 2017, 77: 573-573. DOI: 10.1158/1538-7445.am2017-573.
- Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction, and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP PathwayLou H, Lu J, Choi EB, Oh MH, Jeong M, Barmettler S, Zhu Z, Zheng T. Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction, and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP Pathway. The Journal Of Immunology 2017, 198: 2543-2555. PMID: 28228560, PMCID: PMC5360537, DOI: 10.4049/jimmunol.1600126.
- Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T CellsVigeland C, Collins S, Chan-Li Y, Hughes A, Oh M, Powell J, Horton M. Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells. PLOS ONE 2016, 11: e0163288. PMID: 27649073, PMCID: PMC5029914, DOI: 10.1371/journal.pone.0163288.
- Abstract 4364: Adenosine A2a receptor blockade as a means of enhancing immune checkpoint inhibition and adoptive T-cell therapyLeone R, Englert J, Cheng C, Wen J, Oh M, Sun I, Patel C, Bettencourt I, Powell J. Abstract 4364: Adenosine A2a receptor blockade as a means of enhancing immune checkpoint inhibition and adoptive T-cell therapy. Cancer Research 2016, 76: 4364-4364. DOI: 10.1158/1538-7445.am2016-4364.
- Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiationPollizzi K, Sun I, Patel C, Lo Y, Oh M, Waickman A, Tam A, Blosser R, Wen J, Delgoffe G, Powell J. Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation. Nature Immunology 2016, 17: 704-711. PMID: 27064374, PMCID: PMC4873361, DOI: 10.1038/ni.3438.
- mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiationPollizzi K, Patel C, Sun I, Oh M, Waickman A, Wen J, Delgoffe G, Powell J. mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation. Journal Of Clinical Investigation 2015, 125: 2090-2108. PMID: 25893604, PMCID: PMC4463194, DOI: 10.1172/jci77746.
- Regulation of Nasal Airway Homeostasis and Inflammation in Mice by SHP-1 and Th2/Th1 Signaling PathwaysCho SH, Oh SY, Lane AP, Lee J, Oh MH, Lee S, Zheng T, Zhu Z. Regulation of Nasal Airway Homeostasis and Inflammation in Mice by SHP-1 and Th2/Th1 Signaling Pathways. PLOS ONE 2014, 9: e103685. PMID: 25090641, PMCID: PMC4121172, DOI: 10.1371/journal.pone.0103685.
- The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complexHeikamp E, Patel C, Collins S, Waickman A, Oh M, Sun I, Illei P, Sharma A, Naray-Fejes-Toth A, Fejes-Toth G, Misra-Sen J, Horton M, Powell J. The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex. Nature Immunology 2014, 15: 457-464. PMID: 24705297, PMCID: PMC4267697, DOI: 10.1038/ni.2867.
- TRPA1-Dependent Pruritus in IL-13–Induced Chronic Atopic DermatitisOh MH, Oh SY, Lu J, Lou H, Myers AC, Zhu Z, Zheng T. TRPA1-Dependent Pruritus in IL-13–Induced Chronic Atopic Dermatitis. The Journal Of Immunology 2013, 191: 5371-5382. PMID: 24140646, PMCID: PMC4175413, DOI: 10.4049/jimmunol.1300300.
- SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and AnaphylaxisZhou L, Oh SY, Zhou Y, Yuan B, Wu F, Oh MH, Wang Y, Takemoto C, Van Rooijen N, Zheng T, Zhu Z. SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis. PLOS ONE 2013, 8: e55763. PMID: 23390550, PMCID: PMC3563592, DOI: 10.1371/journal.pone.0055763.
- Selective Transgenic Expression of IL-22 in the Skin Induces Atopic Dermatitis (AD) Like DermatitisLou H, Oh M, Zhou L, Wu F, Zhu Z, Zheng T. Selective Transgenic Expression of IL-22 in the Skin Induces Atopic Dermatitis (AD) Like Dermatitis. Journal Of Allergy And Clinical Immunology 2013, 131: ab235. DOI: 10.1016/j.jaci.2012.12.1503.
- Epicutaneous Exposure to Staphylococcal Superantigen Enterotoxin B Enhances Allergic Lung Inflammation via an IL-17A Dependent MechanismYu J, Oh MH, Park JU, Myers AC, Dong C, Zhu Z, Zheng T. Epicutaneous Exposure to Staphylococcal Superantigen Enterotoxin B Enhances Allergic Lung Inflammation via an IL-17A Dependent Mechanism. PLOS ONE 2012, 7: e39032. PMID: 22848348, PMCID: PMC3407176, DOI: 10.1371/journal.pone.0039032.
- Role of Mast Cells in the Development of Atopic Dermatitis Induced by IL-13Oh M, Zhu Z, Yu J, Zheng T. Role of Mast Cells in the Development of Atopic Dermatitis Induced by IL-13. Journal Of Allergy And Clinical Immunology 2012, 129: ab36. DOI: 10.1016/j.jaci.2011.12.796.
- The Role of TSLP in IL-13-Induced Atopic MarchZhu Z, Oh MH, Yu J, Liu YJ, Zheng T. The Role of TSLP in IL-13-Induced Atopic March. Scientific Reports 2011, 1: 23. PMID: 22355542, PMCID: PMC3251897, DOI: 10.1038/srep00023.
- IL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal LymphopoietinOh MH, Oh SY, Yu J, Myers AC, Leonard WJ, Liu YJ, Zhu Z, Zheng T. IL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal Lymphopoietin. The Journal Of Immunology 2011, 186: 7232-7242. PMID: 21576506, PMCID: PMC3399513, DOI: 10.4049/jimmunol.1100504.
- The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and AsthmaZheng T, Yu J, Oh MH, Zhu Z. The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma. Allergy Asthma And Immunology Research 2011, 3: 67-73. PMID: 21461244, PMCID: PMC3062798, DOI: 10.4168/aair.2011.3.2.67.
- Thymic Stromal Lymphopoietin (TSLP) Signaling is Required for IL-13-Induced ”Atopic March”: Progression from Atopic Dermatitis (AD) to AsthmaYu J, Oh M, Oh S, Zhu Z, Zheng T. Thymic Stromal Lymphopoietin (TSLP) Signaling is Required for IL-13-Induced ”Atopic March”: Progression from Atopic Dermatitis (AD) to Asthma. Journal Of Allergy And Clinical Immunology 2010, 125: ab113. DOI: 10.1016/j.jaci.2009.12.446.
- SHP-1 Deficient Mast Cells Are Hyperresponsive to Stimulation and Critical in Initiating Allergic Inflammation in the LungZhang L, Oh SY, Wu X, Oh MH, Wu F, Schroeder JT, Takemoto CM, Zheng T, Zhu Z. SHP-1 Deficient Mast Cells Are Hyperresponsive to Stimulation and Critical in Initiating Allergic Inflammation in the Lung. The Journal Of Immunology 2009, 184: 1180-1190. PMID: 20042576, PMCID: PMC4755278, DOI: 10.4049/jimmunol.0901972.
- Increased Susceptibility to Bleomycin-Induced Pulmonary Injury and Fibrosis in Mice Deficient in Protein Tyrosine Phosphatase SHP-1Park J, Jeong J, Kim Y, Oh S, Oh M, Wu F, Zheng T, Zhu Z. Increased Susceptibility to Bleomycin-Induced Pulmonary Injury and Fibrosis in Mice Deficient in Protein Tyrosine Phosphatase SHP-1. Journal Of Allergy And Clinical Immunology 2009, 123: 729. DOI: 10.1016/j.jaci.2009.01.026.
- Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin RemodelingZheng T, Oh MH, Oh SY, Schroeder JT, Glick AB, Zhu Z. Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin Remodeling. Journal Of Investigative Dermatology 2008, 129: 742-751. PMID: 18830273, PMCID: PMC4356214, DOI: 10.1038/jid.2008.295.
- TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNAJeon SG, Oh SY, Park HK, Kim YS, Shim EJ, Lee HS, Oh MH, Bang B, Chun EY, Kim SH, Gho YS, Zhu Z, Kim YY, Kim YK. TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA. Journal Of Allergy And Clinical Immunology 2007, 120: 803-812. PMID: 17610940, DOI: 10.1016/j.jaci.2007.05.030.
- Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental AsthmaKim YK, Oh SY, Jeon SG, Park HW, Lee SY, Chun EY, Bang B, Lee HS, Oh MH, Kim YS, Kim JH, Gho YS, Cho SH, Min KU, Kim YY, Zhu Z. Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma. The Journal Of Immunology 2007, 178: 5375-5382. PMID: 17404323, DOI: 10.4049/jimmunol.178.8.5375.
- Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challengeJeon SG, Lee CG, Oh MH, Chun EY, Gho YS, Cho SH, Kim JH, Min KU, Kim YY, Kim YK, Elias JA. Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge. Journal Of Allergy And Clinical Immunology 2007, 119: 831-837. PMID: 17289133, DOI: 10.1016/j.jaci.2006.12.653.