Michelle Kudron, PhD, AB
she/her/hers
Associate Research Scientist in Genetics
Research & Publications
Biography
Research Summary
Extensive Research Description
I am interested in the role that transcription factors (TFs) play at both the tissue-specific level as well as more globally in C. elegans. I pioneered the first in depth examination of tissue-specific binding of the Rb/E2F pathway in vivo. More recently, I have been a lead member of modERN (Model Organism Encyclopendia of Regulatory Networks) which is a multi-lab effort to capture the genome-wide binding sites of all the TFs in both worm and fly.
Coauthors
Selected Publications
- To mock or not: a comprehensive comparison of mock IP and DNA input for ChIP-seqXu J, Kudron MM, Victorsen A, Gao J, Ammouri HN, Navarro FCP, Gevirtzman L, Waterston RH, White KP, Reinke V, Gerstein M. To mock or not: a comprehensive comparison of mock IP and DNA input for ChIP-seq. Nucleic Acids Research 2020, 49: e17-e17. PMID: 33347581, PMCID: PMC7897498, DOI: 10.1093/nar/gkaa1155.
- The ModERN Resource: Genome-Wide Binding Profiles for Hundreds of Drosophila and Caenorhabditis elegans Transcription FactorsKudron MM, Victorsen A, Gevirtzman L, Hillier LW, Fisher WW, Vafeados D, Kirkey M, Hammonds AS, Gersch J, Ammouri H, Wall ML, Moran J, Steffen D, Szynkarek M, Seabrook-Sturgis S, Jameel N, Kadaba M, Patton J, Terrell R, Corson M, Durham TJ, Park S, Samanta S, Han M, Xu J, Yan KK, Celniker SE, White KP, Ma L, Gerstein M, Reinke V, Waterston R. The ModERN Resource: Genome-Wide Binding Profiles for Hundreds of Drosophila and Caenorhabditis elegans Transcription Factors. Genetics 2018, 208: 937-949. PMID: 29284660, PMCID: PMC5844342, DOI: 10.1534/genetics.117.300657.
- Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein AggregationSin O, de Jong T, Mata-Cabana A, Kudron M, Zaini MA, Aprile FA, Seinstra RI, Stroo E, Prins RW, Martineau CN, Wang HH, Hogewerf W, Steinhof A, Wanker EE, Vendruscolo M, Calkhoven CF, Reinke V, Guryev V, Nollen EA. Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular Cell 2017, 65: 1096-1108.e6. PMID: 28306505, PMCID: PMC5364375, DOI: 10.1016/j.molcel.2017.02.022.
- A novel small molecule that disrupts a key event during the oocyte-to-embryo transition in C. elegansWeicksel SE, Mahadav A, Moyle M, Cipriani PG, Kudron M, Pincus Z, Bahmanyar S, Abriola L, Merkel J, Gutwein M, Fernandez AG, Piano F, Gunsalus KC, Reinke V. A novel small molecule that disrupts a key event during the oocyte-to-embryo transition in C. elegans. Development 2016, 143: 3540-3548. PMID: 27510972, PMCID: PMC5087616, DOI: 10.1242/dev.140046.
- Tissue-specific direct targets of Caenorhabditis elegans Rb/E2F dictate distinct somatic and germline programsKudron M, Niu W, Lu Z, Wang G, Gerstein M, Snyder M, Reinke V. Tissue-specific direct targets of Caenorhabditis elegans Rb/E2F dictate distinct somatic and germline programs. Genome Biology 2013, 14: r5. PMID: 23347407, PMCID: PMC4053757, DOI: 10.1186/gb-2013-14-1-r5.
- C. elegans Nucleostemin Is Required for Larval Growth and Germline Stem Cell DivisionKudron MM, Reinke V. C. elegans Nucleostemin Is Required for Larval Growth and Germline Stem Cell Division. PLOS Genetics 2008, 4: e1000181. PMID: 18725931, PMCID: PMC2515194, DOI: 10.1371/journal.pgen.1000181.
- RecA Dimers Serve as a Functional Unit for Assembly of Active Nucleoprotein Filaments †Forget A, Kudron M, McGrew D, Calmann M, Schiffer C, Knight K. RecA Dimers Serve as a Functional Unit for Assembly of Active Nucleoprotein Filaments †. Biochemistry 2006, 45: 13537-13542. PMID: 17087507, PMCID: PMC2522307, DOI: 10.1021/bi060938q.