Matthew Z Madden, MD, PhD
he/him/his
Hospital Resident
Research & Publications
Biography
Coauthors
Selected Publications
- Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells.Madden M, Ye X, Chi C, Fisher E, Wolf M, Needle G, Bader J, Patterson A, Reinfeld B, Landis M, Hathaway E, Muka J, O'Neil R, Karijolich J, Philip M, Rathmell J. Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells. The Journal Of Immunology 2023, 211: 563-575. PMID: 37341499, PMCID: PMC10526752, DOI: 10.4049/jimmunol.2200715.
- The Complex Integration of T-cell Metabolism and ImmunotherapyMadden M, Rathmell J. The Complex Integration of T-cell Metabolism and Immunotherapy. Cancer Discovery 2021, 11: 1636-1643. PMID: 33795235, PMCID: PMC8295173, DOI: 10.1158/2159-8290.cd-20-0569.
- Cell-programmed nutrient partitioning in the tumour microenvironmentReinfeld B, Madden M, Wolf M, Chytil A, Bader J, Patterson A, Sugiura A, Cohen A, Ali A, Do B, Muir A, Lewis C, Hongo R, Young K, Brown R, Todd V, Huffstater T, Abraham A, O’Neil R, Wilson M, Xin F, Tantawy M, Merryman W, Johnson R, Williams C, Mason E, Mason F, Beckermann K, Vander Heiden M, Manning H, Rathmell J, Rathmell W. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature 2021, 593: 282-288. PMID: 33828302, PMCID: PMC8122068, DOI: 10.1038/s41586-021-03442-1.
- STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapyWang-Bishop L, Kimmel B, Ngwa V, Madden M, Baljon J, Florian D, Hanna A, Pastora L, Sheehy T, Kwiatkowski A, Wehbe M, Wen X, Becker K, Garland K, Schulman J, Shae D, Edwards D, Wolf M, Delapp R, Christov P, Beckermann K, Balko J, Rathmell W, Rathmell J, Chen J, Wilson J. STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy. Science Immunology 2023, 8: eadd1153. PMID: 37146128, PMCID: PMC10226150, DOI: 10.1126/sciimmunol.add1153.
- Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic–Epigenetic Cross-TalkGreenwood D, Ramsey H, Nguyen P, Patterson A, Voss K, Bader J, Sugiura A, Bacigalupa Z, Schaefer S, Ye X, Dahunsi D, Madden M, Wellen K, Savona M, Ferrell P, Rathmell J. Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic–Epigenetic Cross-Talk. ImmunoHorizons 2022, 6: 837-850. PMID: 36547387, PMCID: PMC9935084, DOI: 10.4049/immunohorizons.2200086.
- Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancerGlass E, Hoover A, Bullock K, Madden M, Reinfeld B, Harris W, Parker D, Hufnagel D, Crispens M, Khabele D, Rathmell W, Rathmell J, Wilson A, Giorgio T, Yull F. Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer. BMC Cancer 2022, 22: 497. PMID: 35513776, PMCID: PMC9074180, DOI: 10.1186/s12885-022-09612-2.
- Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages.Dudzinski S, Bader J, Beckermann K, Young K, Hongo R, Madden M, Abraham A, Reinfeld B, Ye X, MacIver N, Giorgio T, Rathmell J. Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages. The Journal Of Immunology 2021, 207: 3122-3130. PMID: 34772698, PMCID: PMC9095767, DOI: 10.4049/jimmunol.2001152.
- MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and functionSugiura A, Andrejeva G, Voss K, Heintzman D, Xu X, Madden M, Ye X, Beier K, Chowdhury N, Wolf M, Young A, Greenwood D, Sewell A, Shahi S, Freedman S, Cameron A, Foerch P, Bourne T, Garcia-Canaveras J, Karijolich J, Newcomb D, Mangalam A, Rabinowitz J, Rathmell J. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity 2021, 55: 65-81.e9. PMID: 34767747, PMCID: PMC8755618, DOI: 10.1016/j.immuni.2021.10.011.
- Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway InflammationHealey D, Cephus J, Barone S, Chowdhury N, Dahunsi D, Madden M, Ye X, Yu X, Olszewski K, Young K, Gerriets V, Siska P, Dworski R, Hemler J, Locasale J, Poyurovsky M, Peebles R, Irish J, Newcomb D, Rathmell J. Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation. The Journal Of Immunology 2021, 206: 1127-1139. PMID: 33558372, PMCID: PMC7946768, DOI: 10.4049/jimmunol.2001029.
- Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune responseLevine L, Hiam-Galvez K, Marquez D, Tenvooren I, Madden M, Contreras D, Dahunsi D, Irish J, Oluwole O, Rathmell J, Spitzer M. Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response. Immunity 2021, 54: 829-844.e5. PMID: 33705706, PMCID: PMC8046726, DOI: 10.1016/j.immuni.2021.02.018.
- EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repairKoyen A, Madden M, Park D, Minten E, Kapoor-Vazirani P, Werner E, Pfister N, Haji-Seyed-Javadi R, Zhang H, Xu J, Deng N, Duong D, Pecen T, Frazier Z, Nagel Z, Lazaro J, Mouw K, Seyfried N, Moreno C, Owonikoko T, Deng X, Yu D. EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair. Oncogene 2020, 39: 4798-4813. PMID: 32457468, PMCID: PMC7305988, DOI: 10.1038/s41388-020-1332-2.
- Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 SplicingRaddatz M, Huffstater T, Bersi M, Reinfeld B, Madden M, Booton S, Rathmell W, Rathmell J, Lindman B, Madhur M, Merryman W. Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing. Arteriosclerosis Thrombosis And Vascular Biology 2020, 40: e153-e165. PMID: 32295422, PMCID: PMC7285853, DOI: 10.1161/atvbaha.120.314360.
- Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent MetabolismJohnson M, Wolf M, Madden M, Andrejeva G, Sugiura A, Contreras D, Maseda D, Liberti M, Paz K, Kishton R, Johnson M, de Cubas A, Wu P, Li G, Zhang Y, Newcomb D, Wells A, Restifo N, Rathmell W, Locasale J, Davila M, Blazar B, Rathmell J. Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism. Cell 2018, 175: 1780-1795.e19. PMID: 30392958, PMCID: PMC6361668, DOI: 10.1016/j.cell.2018.10.001.
- SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous RecombinationDaddacha W, Koyen AE, Bastien AJ, Head PE, Dhere VR, Nabeta GN, Connolly EC, Werner E, Madden MZ, Daly MB, Minten EV, Whelan DR, Schlafstein AJ, Zhang H, Anand R, Doronio C, Withers AE, Shepard C, Sundaram RK, Deng X, Dynan WS, Wang Y, Bindra RS, Cejka P, Rothenberg E, Doetsch PW, Kim B, Yu DS. SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. Cell Reports 2017, 20: 1921-1935. PMID: 28834754, PMCID: PMC5576576, DOI: 10.1016/j.celrep.2017.08.008.
- ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNAZhang H, Head P, Daddacha W, Park S, Li X, Pan Y, Madden M, Duong D, Xie M, Yu B, Warren M, Liu E, Dhere V, Li C, Pradilla I, Torres M, Wang Y, Dynan W, Doetsch P, Deng X, Seyfried N, Gius D, Yu D. ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. Cell Reports 2016, 14: 1435-1447. PMID: 26854234, PMCID: PMC4758896, DOI: 10.1016/j.celrep.2016.01.018.
- A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress responseSmith S, Petrova A, Madden M, Wang H, Pan Y, Warren M, Hardy C, Liang D, Liu E, Robinson M, Rudra S, Wang J, Ehdaivand S, Torres M, Wang Y, Yu D. A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response. Nucleic Acids Research 2014, 42: 11517-11527. PMID: 25217585, PMCID: PMC4191414, DOI: 10.1093/nar/gku840.
- CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic CancerColbert L, Petrova A, Fisher S, Pantazides B, Madden M, Hardy C, Warren M, Pan Y, Nagaraju G, Liu E, Saka B, Hall W, Shelton J, Gandhi K, Pauly R, Kowalski J, Kooby D, El-Rayes B, Staley C, Adsay N, Curran W, Landry J, Maithel S, Yu D. CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer. Cancer Research 2014, 74: 2677-2687. PMID: 24626090, PMCID: PMC4025946, DOI: 10.1158/0008-5472.can-13-1996.