Laxminarayana Korutla
Research Scientist
Research & Publications
Biography
Coauthors
Selected Publications
- Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trialKaushal S, Hare J, Hoffman J, Boyd R, Ramdas K, Pietris N, Kutty S, Tweddell J, Husain S, Menon S, Lambert L, Danford D, Kligerman S, Hibino N, Korutla L, Vallabhajosyula P, Campbell M, Khan A, Naioti E, Yousefi K, Mehranfard D, McClain-Moss L, Oliva A, Davis M. Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial. European Heart Journal Open 2023, 3: oead002. PMID: 36950450, PMCID: PMC10026620, DOI: 10.1093/ehjopen/oead002.
- Donor extracellular vesicle trafficking via the pleural space represents a novel pathway for allorecognition after lung transplantationHabertheuer A, Chatterjee S, Sada Japp A, Ram C, Korutla L, Ochiya T, Li W, Terada Y, Takahashi T, Nava RG, Puri V, Kreisel D, Vallabhajosyula P. Donor extracellular vesicle trafficking via the pleural space represents a novel pathway for allorecognition after lung transplantation. American Journal Of Transplantation 2022, 22: 1909-1918. PMID: 35285127, DOI: 10.1111/ajt.17023.
- Unlocking the Potential of Induced Pluripotent Stem Cells for Wound Healing: The Next Frontier of Regenerative MedicineDash BC, Korutla L, Vallabhajosyula P, Hsia HC. Unlocking the Potential of Induced Pluripotent Stem Cells for Wound Healing: The Next Frontier of Regenerative Medicine. Advances In Wound Care 2021, 11: 622-638. PMID: 34155919, DOI: 10.1089/wound.2021.0049.
- Circulating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation ModelHabertheuer A, Ram C, Schmierer M, Chatterjee S, Hu R, Freas A, Zielinski P, Rogers W, Silvestro EM, McGrane M, Moore JS, Korutla L, Siddiqui S, Xin Y, Rizi R, Tao J, Kreisel D, Naji A, Ochiya T, Vallabhajosyula P. Circulating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model. Transplantation 2021, 106: 754-766. PMID: 33993180, DOI: 10.1097/tp.0000000000003820.
- Circulating Donor Heart Exosome Profiling Enables Noninvasive Detection of Antibody-mediated RejectionHu RW, Korutla L, Reddy S, Harmon J, Zielinski PD, Bueker A, Molina M, Romano C, Margulies K, McLean R, Lal P, Vallabhajosyula P. Circulating Donor Heart Exosome Profiling Enables Noninvasive Detection of Antibody-mediated Rejection. Transplantation Direct 2020, 6: e615. PMID: 33134491, PMCID: PMC7575166, DOI: 10.1097/txd.0000000000001057.
- Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetesYu M, Agarwal D, Korutla L, May CL, Wang W, Griffith NN, Hering BJ, Kaestner KH, Velazquez OC, Markmann JF, Vallabhajosyula P, Liu C, Naji A. Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes. Nature Metabolism 2020, 2: 1013-1020. PMID: 32895576, PMCID: PMC7572844, DOI: 10.1038/s42255-020-0269-7.
- Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsiaLevine L, Habertheuer A, Ram C, Korutla L, Schwartz N, Hu RW, Reddy S, Freas A, Zielinski PD, Harmon J, Molugu SK, Parry S, Vallabhajosyula P. Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia. Scientific Reports 2020, 10: 6398. PMID: 32286341, PMCID: PMC7156695, DOI: 10.1038/s41598-020-62193-7.
- 905: Release of placental exosomes is reduced in spontaneous preterm birthsParry S, Leite R, Korutla L, Vallabhajosyula P. 905: Release of placental exosomes is reduced in spontaneous preterm births. American Journal Of Obstetrics And Gynecology 2020, 222: s561-s562. DOI: 10.1016/j.ajog.2019.11.916.
- Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardiumSaha P, Sharma S, Korutla L, Datla SR, Shoja-Taheri F, Mishra R, Bigham GE, Sarkar M, Morales D, Bittle G, Gunasekaran M, Ambastha C, Arfat MY, Li D, Habertheuer A, Hu R, Platt MO, Yang P, Davis ME, Vallabhajosyula P, Kaushal S. Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium. Science Translational Medicine 2019, 11 PMID: 31118291, PMCID: PMC6857931, DOI: 10.1126/scitranslmed.aau1168.
- Noninvasive diagnosis of recurrent autoimmune type 1 diabetes after islet cell transplantationKorutla L, Rickels MR, Hu RW, Freas A, Reddy S, Habertheuer A, Harmon J, Korutla V, Ram C, Naji A, Vallabhajosyula P. Noninvasive diagnosis of recurrent autoimmune type 1 diabetes after islet cell transplantation. American Journal Of Transplantation 2019, 19: 1852-1858. PMID: 30801971, PMCID: PMC7043773, DOI: 10.1111/ajt.15322.
- (492) Donor Lung Specific Exosome Profiles for Noninvasive Monitoring of Acute Rejection in a Rat Orthotopic Left Lung Transplant ModelHabertheuer A, Korutla L, Rostami S, Siddiqui S, Xin Y, Rizi R, Naji A, Zielinski P, Hu R, Ochiya T, Vallabhajosyula P. (492) Donor Lung Specific Exosome Profiles for Noninvasive Monitoring of Acute Rejection in a Rat Orthotopic Left Lung Transplant Model. The Journal Of Heart And Lung Transplantation 2018, 37: s203-s204. DOI: 10.1016/j.healun.2018.01.495.
- (842) Characterization of Circulating Donor Heart Specific Exosomes in Clinical Heart TransplantationKorutla L, Habertheuer A, Hu R, Zielinski P, Reddy S, Naji A, Vallabhajosyula P. (842) Characterization of Circulating Donor Heart Specific Exosomes in Clinical Heart Transplantation. The Journal Of Heart And Lung Transplantation 2018, 37: s331. DOI: 10.1016/j.healun.2018.01.845.
- Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantationHabertheuer A, Korutla L, Rostami S, Reddy S, Lal P, Naji A, Vallabhajosyula P. Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation. Journal Of Thoracic And Cardiovascular Surgery 2018, 155: 2479-2489. PMID: 29499866, DOI: 10.1016/j.jtcvs.2017.12.125.
- Abstract 197: Heat Shock Factor 1 Enhances Therapeutic Potential of c-kit+ Cardiac Progenitor Cells Derived ExosomesSharma S, Bigham G, Mishra R, Korutla L, Vallabhajosyula P, Karanthasis S, Kaushal S. Abstract 197: Heat Shock Factor 1 Enhances Therapeutic Potential of c-kit+ Cardiac Progenitor Cells Derived Exosomes. Circulation Research 2017, 121 DOI: 10.1161/res.121.suppl_1.197.
- Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissueVallabhajosyula P, Korutla L, Habertheuer A, Yu M, Rostami S, Yuan CX, Reddy S, Liu C, Korutla V, Koeberlein B, Trofe-Clark J, Rickels MR, Naji A. Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue. Journal Of Clinical Investigation 2017, 127: 1375-1391. PMID: 28319051, PMCID: PMC5373894, DOI: 10.1172/jci87993.
- Ex Vivo Lung Perfusion Model to Study Pulmonary Tissue Extracellular Microvesicle ProfilesVallabhajosyula P, Korutla L, Habertheuer A, Reddy S, Schaufler C, Lasky J, Diamond J, Cantu E. Ex Vivo Lung Perfusion Model to Study Pulmonary Tissue Extracellular Microvesicle Profiles. The Annals Of Thoracic Surgery 2017, 103: 1758-1766. PMID: 28242077, DOI: 10.1016/j.athoracsur.2016.11.074.
- NAC1, A POZ/BTB protein interacts with Parkin and may contribute to Parkinson’s diseaseKorutla L, Furlong H, Mackler S. NAC1, A POZ/BTB protein interacts with Parkin and may contribute to Parkinson’s disease. Neuroscience 2013, 257: 86-95. PMID: 24231739, DOI: 10.1016/j.neuroscience.2013.11.001.
- Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral SclerosisScofield M, Korutla L, Jackson T, Kalivas P, Mackler S. Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis. Neuroscience 2012, 227: 44-54. PMID: 23022214, PMCID: PMC3505276, DOI: 10.1016/j.neuroscience.2012.09.043.
- NAC1, a POZ/BTB protein that functions as a corepressorKorutla L, Wang P, Jackson T, Mackler S. NAC1, a POZ/BTB protein that functions as a corepressor. Neurochemistry International 2008, 54: 245-252. PMID: 19121354, DOI: 10.1016/j.neuint.2008.12.008.
- NAC1 Regulates the Recruitment of the Proteasome Complex into Dendritic SpinesShen H, Korutla L, Champtiaux N, Toda S, LaLumiere R, Vallone J, Klugmann M, Blendy J, Mackler S, Kalivas P. NAC1 Regulates the Recruitment of the Proteasome Complex into Dendritic Spines. Journal Of Neuroscience 2007, 27: 8903-8913. PMID: 17699672, PMCID: PMC6672176, DOI: 10.1523/jneurosci.1571-07.2007.
- NAC1, a cocaine‐regulated POZ/BTB protein interacts with CoRESTKorutla L, Degnan R, Wang P, Mackler S. NAC1, a cocaine‐regulated POZ/BTB protein interacts with CoREST. Journal Of Neurochemistry 2007, 101: 611-618. PMID: 17254023, DOI: 10.1111/j.1471-4159.2006.04387.x.
- The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal‐like culturesKorutla L, Wang P, Mackler S. The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal‐like cultures. Journal Of Neurochemistry 2005, 94: 786-793. PMID: 16033423, DOI: 10.1111/j.1471-4159.2005.03206.x.
- The mouse nac1 gene, encoding a cocaine-regulated bric-a-brac tramtrac broad complex/pox virus and zinc finger protein, is regulated by ap1Mackler S, Homan Y, Korutla L, Conti A, Blendy J. The mouse nac1 gene, encoding a cocaine-regulated bric-a-brac tramtrac broad complex/pox virus and zinc finger protein, is regulated by ap1. Neuroscience 2003, 121: 355-361. PMID: 14521994, DOI: 10.1016/s0306-4522(03)00376-2.
- NAC1, a POZ/BTB protein present in the adult mammalian brain, triggers apoptosis after adenovirus-mediated overexpression in PC-12 cellsKorutla L, Neustadter J, Fournier K, Mackler S. NAC1, a POZ/BTB protein present in the adult mammalian brain, triggers apoptosis after adenovirus-mediated overexpression in PC-12 cells. Neuroscience Research 2003, 46: 33-39. PMID: 12725910, DOI: 10.1016/s0168-0102(03)00024-5.
- Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1Korutla L, Wang P, Lewis D, Neustadter J, Stromberg M, Mackler S. Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1. Neuroscience 2002, 110: 421-429. PMID: 11906783, DOI: 10.1016/s0306-4522(01)00518-8.
- NAC-1 Is a Brain POZ/BTB Protein That Can Prevent Cocaine-Induced Sensitization in the RatMackler S, Korutla L, Cha X, Koebbe M, Fournier K, Bowers M, Kalivas P. NAC-1 Is a Brain POZ/BTB Protein That Can Prevent Cocaine-Induced Sensitization in the Rat. Journal Of Neuroscience 2000, 20: 6210-6217. PMID: 10934270, PMCID: PMC6772573, DOI: 10.1523/jneurosci.20-16-06210.2000.
- Activation of surfactant protein‐B transcription: Signaling through the SP‐A receptor utilizing the PI3 kinase pathwayStrayer D, Korutla L. Activation of surfactant protein‐B transcription: Signaling through the SP‐A receptor utilizing the PI3 kinase pathway. Journal Of Cellular Physiology 2000, 184: 229-238. PMID: 10867648, DOI: 10.1002/1097-4652(200008)184:2<229::aid-jcp11>3.0.co;2-x.
- SP‐A as a cytokine: Surfactant protein‐A–regulated transcription of surfactant proteins and other genesKorutla L, Strayer D. SP‐A as a cytokine: Surfactant protein‐A–regulated transcription of surfactant proteins and other genes. Journal Of Cellular Physiology 1999, 178: 379-386. PMID: 9989784, DOI: 10.1002/(sici)1097-4652(199903)178:3<379::aid-jcp12>3.0.co;2-c.
- Surfactant protein-A receptor-mediated inhibition of calcium signaling in alveolar type II cells.Strayer D, Korutla L, Thomas A. Surfactant protein-A receptor-mediated inhibition of calcium signaling in alveolar type II cells. Receptors & Signal Transduction 1997, 7: 111-20. PMID: 9392439.
- Inhibition of Vesicular Stomatitis Virus Replication by Epidermal Growth Factor in Human Epidermoid A-431 CellsKorutla L, Kumar R. Inhibition of Vesicular Stomatitis Virus Replication by Epidermal Growth Factor in Human Epidermoid A-431 Cells. Biochemical And Biophysical Research Communications 1996, 220: 670-674. PMID: 8607823, DOI: 10.1006/bbrc.1996.0462.
- Mechanism of interferon action: in vivo activation of 91 kDa transcription factor.Korutla L, Kumar R. Mechanism of interferon action: in vivo activation of 91 kDa transcription factor. Anticancer Research 1996, 16: 2789-95. PMID: 8917387.
- Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcuminKorutla L, Cheung J, Medelsohn J, Kumar R. Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin. Carcinogenesis 1995, 16: 1741-1745. PMID: 7634398, DOI: 10.1093/carcin/16.8.1741.
- Induction of Expression of Interferon-Stimulated Gene Factor-3 (ISGF-3) Proteins by InterferonsKumar R, Korutla L. Induction of Expression of Interferon-Stimulated Gene Factor-3 (ISGF-3) Proteins by Interferons. Experimental Cell Research 1995, 216: 143-148. PMID: 7529187, DOI: 10.1006/excr.1995.1018.
- Growth inhibition of human acute promyelocytic leukemia NB-4 cells by interferons and all-trans retinoic acid: trans-modulation of inducible gene expression pathways.Kumar R, Korutla L. Growth inhibition of human acute promyelocytic leukemia NB-4 cells by interferons and all-trans retinoic acid: trans-modulation of inducible gene expression pathways. Anticancer Research 1995, 15: 353-60. PMID: 7763006.
- Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cellsKorutla L, Kumar R. Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochimica Et Biophysica Acta 1994, 1224: 597-600. PMID: 7803521, DOI: 10.1016/0167-4889(94)90299-2.
- Cell cycle-dependent modulation of alpha-interferon-inducible gene expression and activation of signaling components in Daudi cells.Kumar R, Korutla L, Zhang K. Cell cycle-dependent modulation of alpha-interferon-inducible gene expression and activation of signaling components in Daudi cells. Journal Of Biological Chemistry 1994, 269: 25437-25441. PMID: 7929242, DOI: 10.1016/s0021-9258(18)47269-9.
- Evaluation of Recombinant Platelet Factor 4 and Protamine Sulfate for Heparin Neutralization: Clotting and Clearance Studies in RatKorutla L, Stewart G, Lasz E, Maione T, Niewiarowski S. Evaluation of Recombinant Platelet Factor 4 and Protamine Sulfate for Heparin Neutralization: Clotting and Clearance Studies in Rat. Thrombosis And Haemostasis 1994, 71: 609-614. PMID: 8091389, DOI: 10.1055/s-0038-1642491.