Junichi Saito, PhD, MD
Postdoctoral Fellow
Research & Publications
Biography
News
Coauthors
Selected Publications
- Endothelial HIFα-PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension.Saddouk FZ, Kuzemczak AP, Saito J, Greif DM. Endothelial HIFα-PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension. JCI Insight 2024 PMID: 38652543, DOI: 10.1172/jci.insight.162449.
- Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathySaito J, Dave J, Lau F, Greif D. Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy. IScience 2023, 27: 108636. PMID: 38226162, PMCID: PMC10788461, DOI: 10.1016/j.isci.2023.108636.
- Hydrostatic pressure under hypoxia facilitates fabrication of tissue-engineered vascular grafts derived from human vascular smooth muscle cells in vitro.Kojima T, Nakamura T, Saito J, Hidaka Y, Akimoto T, Inoue H, Chick CN, Usuki T, Kaneko M, Miyagi E, Ishikawa Y, Yokoyama U. Hydrostatic pressure under hypoxia facilitates fabrication of tissue-engineered vascular grafts derived from human vascular smooth muscle cells in vitro. Acta Biomater 2023, 171: 209-222. PMID: 37793599, DOI: 10.1016/j.actbio.2023.09.041.
- Molecular mechanisms regulating extracellular matrix-mediated remodeling in the ductus arteriosus.Yokoyama U, Oka S, Saito J. Molecular mechanisms regulating extracellular matrix-mediated remodeling in the ductus arteriosus. Semin Perinatol 2023, 47: 151716. PMID: 36906477, DOI: 10.1016/j.semperi.2023.151716.
- JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiencyDave JM, Chakraborty R, Ntokou A, Saito J, Saddouk FZ, Feng Z, Misra A, Tellides G, Riemer RK, Urban Z, Kinnear C, Ellis J, Mital S, Mecham R, Martin KA, Greif DM. JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. Journal Of Clinical Investigation 2022, 132: e142338. PMID: 34990407, PMCID: PMC8884911, DOI: 10.1172/jci142338.
- Scaffold-free tissue-engineered arterial grafts derived from human skeletal myoblasts.Saito J, Yokoyama U, Nakamura T, Kanaya T, Ueno T, Naito Y, Takayama T, Kaneko M, Miyagawa S, Sawa Y, Ishikawa Y. Scaffold-free tissue-engineered arterial grafts derived from human skeletal myoblasts. Artif Organs 2021, 45: 919-932. PMID: 33539557, DOI: 10.1111/aor.13930.
- Transcriptome Analysis Reveals Differential Gene Expression between the Closing Ductus Arteriosus and the Patent Ductus Arteriosus in Humans.Saito J, Kojima T, Tanifuji S, Kato Y, Oka S, Ichikawa Y, Miyagi E, Tachibana T, Asou T, Yokoyama U. Transcriptome Analysis Reveals Differential Gene Expression between the Closing Ductus Arteriosus and the Patent Ductus Arteriosus in Humans. J Cardiovasc Dev Dis 2021, 8 PMID: 33923468, DOI: 10.3390/jcdd8040045.
- Challenges and Possibilities of Cell-Based Tissue-Engineered Vascular Grafts.Saito J, Kaneko M, Ishikawa Y, Yokoyama U. Challenges and Possibilities of Cell-Based Tissue-Engineered Vascular Grafts. Cyborg Bionic Syst 2021, 2021: 1532103. PMID: 36285145, DOI: 10.34133/2021/1532103.
- Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus.Ito S, Yokoyama U, Nakakoji T, Cooley MA, Sasaki T, Hatano S, Kato Y, Saito J, Nicho N, Iwasaki S, Umemura M, Fujita T, Masuda M, Asou T, Ishikawa Y. Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus. Arterioscler Thromb Vasc Biol 2020, 40: 2212-2226. PMID: 32640908, DOI: 10.1161/ATVBAHA.120.314729.
- Role of Tissue-Type Plasminogen Activator in Remodeling of the Ductus Arteriosus.Saito J, Ishikawa Y, Yokoyama U. Role of Tissue-Type Plasminogen Activator in Remodeling of the Ductus Arteriosus. Circ Rep 2020, 2: 211-217. PMID: 33693232, DOI: 10.1253/circrep.CR-20-0015.
- Antenatal Administration of Betamethasone Contributes to Intimal Thickening of the Rat Ductus Arteriosus.Kemmotsu T, Yokoyama U, Saito J, Ito S, Uozumi A, Nishimaki S, Iwasaki S, Seki K, Ito S, Ishikawa Y. Antenatal Administration of Betamethasone Contributes to Intimal Thickening of the Rat Ductus Arteriosus. Circ J 2019, 83: 654-661. PMID: 30726804, DOI: 10.1253/circj.CJ-18-1033.
- A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm.Mamun A, Yokoyama U, Saito J, Ito S, Hiromi T, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Masuda M, Ishikawa Y. A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm. Physiol Rep 2018, 6: e13878. PMID: 30230255, DOI: 10.14814/phy2.13878.
- Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus.Saito J, Yokoyama U, Nicho N, Zheng YW, Ichikawa Y, Ito S, Umemura M, Fujita T, Ito S, Taniguchi H, Asou T, Masuda M, Ishikawa Y. Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus. PLoS One 2018, 13: e0190871. PMID: 29304073, DOI: 10.1371/journal.pone.0190871.
- Attenuation of ductus arteriosus intimal thickening in preterm sheep twins compared with singletons.Ito S, Yokoyama U, Saito J, Sato S, Usuda H, Watanabe S, Kitanishi R, Miura Y, Saito M, Hanita T, Matsuda T, Ishikawa Y. Attenuation of ductus arteriosus intimal thickening in preterm sheep twins compared with singletons. J Physiol Sci 2017, 67: 723-729. PMID: 28836167, DOI: 10.1007/s12576-017-0565-5.
- Arterial graft with elastic layer structure grown from cells.Yokoyama U, Tonooka Y, Koretake R, Akimoto T, Gonda Y, Saito J, Umemura M, Fujita T, Sakuma S, Arai F, Kaneko M, Ishikawa Y. Arterial graft with elastic layer structure grown from cells. Sci Rep 2017, 7: 140. PMID: 28273941, DOI: 10.1038/s41598-017-00237-1.
- Temporal Relationship between Serum Levels of Interleukin-6 and C-Reactive Protein in Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy.Saito J, Shibasaki J, Shimokaze T, Kishigami M, Ohyama M, Hoshino R, Toyoshima K, Itani Y. Temporal Relationship between Serum Levels of Interleukin-6 and C-Reactive Protein in Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy. Am J Perinatol 2016, 33: 1401-1406. PMID: 27167641, DOI: 10.1055/s-0036-1583192.