Jose G Grajales, MD/PhD
Hospital Resident
Research & Publications
Biography
Coauthors
Selected Publications
- Cell type-specific dissection of sensory pathways involved in descending modulation.Nguyen E, Grajales-Reyes JG, Gereau RW 4th, Ross SE. Cell type-specific dissection of sensory pathways involved in descending modulation. Trends Neurosci 2023, 46: 539-550. PMID: 37164868, DOI: 10.1016/j.tins.2023.04.002.
- Wireless multilateral devices for optogenetic studies of individual and social behaviors.Yang Y, Wu M, Vázquez-Guardado A, Wegener AJ, Grajales-Reyes JG, Deng Y, Wang T, Avila R, Moreno JA, Minkowicz S, Dumrongprechachan V, Lee J, Zhang S, Legaria AA, Ma Y, Mehta S, Franklin D, Hartman L, Bai W, Han M, Zhao H, Lu W, Yu Y, Sheng X, Banks A, Yu X, Donaldson ZR, Gereau RW, Good CH, Xie Z, Huang Y, Kozorovitskiy Y, Rogers JA. Wireless multilateral devices for optogenetic studies of individual and social behaviors. Nature Neuroscience 2021, 24: 1035-1045. PMID: 33972800, PMCID: PMC8694284, DOI: 10.1038/s41593-021-00849-x.
- Surgical implantation of wireless, battery-free optoelectronic epidural implants for optogenetic manipulation of spinal cord circuits in mice.Grajales-Reyes JG, Copits BA, Lie F, Yu Y, Avila R, Vogt SK, Huang Y, Banks AR, Rogers JA, Gereau RW, Golden JP. Surgical implantation of wireless, battery-free optoelectronic epidural implants for optogenetic manipulation of spinal cord circuits in mice. Nature Protocols 2021, 16: 3072-3088. PMID: 34031611, PMCID: PMC9273129, DOI: 10.1038/s41596-021-00532-2.
- Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala.Samineni VK, Grajales-Reyes JG, Grajales-Reyes GE, Tycksen E, Copits BA, Pedersen C, Ankudey ES, Sackey JN, Sewell SB, Bruchas MR, Gereau RW. Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala. ELife 2021, 10 PMID: 34032210, PMCID: PMC8172243, DOI: 10.7554/eLife.68130.
- A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea.Rengarajan S, Knoop KA, Rengarajan A, Chai JN, Grajales-Reyes JG, Samineni VK, Russler-Germain EV, Ranganathan P, Fasano A, Sayuk GS, Gereau RW, Kau AL, Knights D, Kashyap PC, Ciorba MA, Newberry RD, Hsieh CS. A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea. Cell Reports Medicine 2020, 1 PMID: 33196055, PMCID: PMC7659537, DOI: 10.1016/j.xcrm.2020.100124.
- Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray.Samineni VK, Grajales-Reyes JG, Sundaram SS, Yoo JJ, Gereau RW. Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray. Nature Communications 2019, 10: 4356. PMID: 31554789, PMCID: PMC6761157, DOI: 10.1038/s41467-019-12316-0.
- Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves.Zhang Y, Mickle AD, Gutruf P, McIlvried LA, Guo H, Wu Y, Golden JP, Xue Y, Grajales-Reyes JG, Wang X, Krishnan S, Xie Y, Peng D, Su CJ, Zhang F, Reeder JT, Vogt SK, Huang Y, Rogers JA, Gereau RW. Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves. Science Advances 2019, 5: eaaw5296. PMID: 31281895, PMCID: PMC6611690, DOI: 10.1126/sciadv.aaw5296.
- Untangling a canopy of spinal itch circuits.Grajales-Reyes JG, Samineni VK. Untangling a canopy of spinal itch circuits. Pain 2019, 160: 987-988. PMID: 30817439, PMCID: PMC7386460, DOI: 10.1097/j.pain.0000000000001537.
- The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders.Capó-Vélez CM, Morales-Vargas B, García-González A, Grajales-Reyes JG, Delgado-Vélez M, Madera B, Báez-Pagán CA, Quesada O, Lasalde-Dominicci JA. The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders. Scientific Reports 2018, 8: 1829. PMID: 29379089, PMCID: PMC5788855, DOI: 10.1038/s41598-018-20271-x.
- Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics.Noh KN, Park SI, Qazi R, Zou Z, Mickle AD, Grajales-Reyes JG, Jang KI, Gereau RW, Xiao J, Rogers JA, Jeong JW. Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics. Small (Weinheim An Der Bergstrasse, Germany) 2018, 14 PMID: 29215787, PMCID: PMC5912318, DOI: 10.1002/smll.201702479.
- Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain.Samineni VK, Mickle AD, Yoon J, Grajales-Reyes JG, Pullen MY, Crawford KE, Noh KN, Gereau GB, Vogt SK, Lai HH, Rogers JA, Gereau RW. Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain. Scientific Reports 2017, 7: 15865. PMID: 29158567, PMCID: PMC5696510, DOI: 10.1038/s41598-017-16129-3.
- Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray.Samineni VK, Grajales-Reyes JG, Copits BA, O'Brien DE, Trigg SL, Gomez AM, Bruchas MR, Gereau RW. Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray. ENeuro 2017, 4 PMID: 28374016, PMCID: PMC5370278, DOI: 10.1523/ENEURO.0129-16.2017.
- A Panel of Slow-Channel Syndrome Mice Reveals a Unique Locomotor Behavioral Signature.Grajales-Reyes JG, García-González A, María-Ríos JC, Grajales-Reyes GE, Delgado-Vélez M, Báez-Pagán CA, Quesada O, Gómez CM, Lasalde-Dominicci JA. A Panel of Slow-Channel Syndrome Mice Reveals a Unique Locomotor Behavioral Signature. Journal Of Neuromuscular Diseases 2017, 4: 341-347. PMID: 29036836, DOI: 10.3233/JND-170226.
- Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics.Park SI, Brenner DS, Shin G, Morgan CD, Copits BA, Chung HU, Pullen MY, Noh KN, Davidson S, Oh SJ, Yoon J, Jang KI, Samineni VK, Norman M, Grajales-Reyes JG, Vogt SK, Sundaram SS, Wilson KM, Ha JS, Xu R, Pan T, Kim TI, Huang Y, Montana MC, Golden JP, Bruchas MR, Gereau RW, Rogers JA. Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics. Nature Biotechnology 2015, 33: 1280-1286. PMID: 26551059, PMCID: PMC4880021.
- Fluoxetine is neuroprotective in slow-channel congenital myasthenic syndrome.Zhu H, Grajales-Reyes GE, Alicea-Vázquez V, Grajales-Reyes JG, Robinson K, Pytel P, Báez-Pagán CA, Lasalde-Dominicci JA, Gomez CM. Fluoxetine is neuroprotective in slow-channel congenital myasthenic syndrome. Experimental Neurology 2015, 270: 88-94. PMID: 25448156, PMCID: PMC4430442, DOI: 10.1016/j.expneurol.2014.10.008.
- Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility.Cruz-Orengo L, Daniels BP, Dorsey D, Basak SA, Grajales-Reyes JG, McCandless EE, Piccio L, Schmidt RE, Cross AH, Crosby SD, Klein RS. Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility. The Journal Of Clinical Investigation 2014, 124: 2571-84. PMID: 24812668, PMCID: PMC4089451, DOI: 10.1172/JCI73408.
- Transgenic mouse model reveals an unsuspected role of the acetylcholine receptor in statin-induced neuromuscular adverse drug reactions.Grajales-Reyes GE, Báez-Pagán CA, Zhu H, Grajales-Reyes JG, Delgado-Vélez M, García-Beltrán WF, Luciano CA, Quesada O, Ramírez R, Gómez CM, Lasalde-Dominicci JA. Transgenic mouse model reveals an unsuspected role of the acetylcholine receptor in statin-induced neuromuscular adverse drug reactions. The Pharmacogenomics Journal 2013, 13: 362-8. PMID: 22688219, PMCID: PMC3972001, DOI: 10.1038/tpj.2012.21.