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Jong Woo Lee, PhD

Research Scientist, Internal Medicine (Medical Oncology)

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Selected Publications

E2F8 Induces Cell Proliferation and Invasion through the Epithelial–Mesenchymal Transition and Notch Signaling Pathways in Ovarian CancerEoh KJ, Kim HJ, Lee JW, Kim LK, Park SA, Kim HS, Kim YT, Koo PJ. E2F8 Induces Cell Proliferation and Invasion through the Epithelial–Mesenchymal Transition and Notch Signaling Pathways in Ovarian Cancer. International Journal Of Molecular Sciences 2020, 21: 5813. PMID: 32823614, PMCID: PMC7460858, DOI: 10.3390/ijms21165813.
Correlation of tumor mutational burden (TMB) with CDKN2A and TP53 mutation in HPV-negative head and neck squamous cell carcinoma (HNSCC).Burtness B, Deneka A, Baca Y, Serebriiskii I, Parker M, Nicolas E, Lee J, Wise-Draper T, Sukari A, Somer B, Golemis E. Correlation of tumor mutational burden (TMB) with CDKN2A and TP53 mutation in HPV-negative head and neck squamous cell carcinoma (HNSCC). Journal Of Clinical Oncology 2020, 38: 6552-6552. DOI: 10.1200/jco.2020.38.15_suppl.6552.
Synthetic Lethal Targeting of Mitotic Checkpoints in HPV-Negative Head and Neck CancerDeneka AY, Einarson MB, Bennett J, Nikonova AS, Elmekawy M, Zhou Y, Lee JW, Burtness BA, Golemis EA. Synthetic Lethal Targeting of Mitotic Checkpoints in HPV-Negative Head and Neck Cancer. Cancers 2020, 12: 306. PMID: 32012873, PMCID: PMC7072436, DOI: 10.3390/cancers12020306.
Abstract 346: E2F8 induces proliferation and invasion through the epithelial-mesenchymal transition and notch signaling pathways in ovarian cancerEoh K, Lee J, Kim Y, Koo P. Abstract 346: E2F8 induces proliferation and invasion through the epithelial-mesenchymal transition and notch signaling pathways in ovarian cancer. 2019, 346-346. DOI: 10.1158/1538-7445.sabcs18-346.
Abstract 346: E2F8 induces proliferation and invasion through the epithelial-mesenchymal transition and notch signaling pathways in ovarian cancerEoh K, Lee J, Kim Y, Koo P. Abstract 346: E2F8 induces proliferation and invasion through the epithelial-mesenchymal transition and notch signaling pathways in ovarian cancer. Cancer Research 2019, 79: 346-346. DOI: 10.1158/1538-7445.am2019-346.
Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and NeckLee JW, Parameswaran J, Sandoval-Schaefer T, Eoh KJ, Yang DH, Zhu F, Mehra R, Sharma R, Gaffney SG, Perry EB, Townsend JP, Serebriiskii IG, Golemis EA, Issaeva N, Yarbrough WG, Koo JS, Burtness B. Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck. Clinical Cancer Research 2019, 25: 3430-3442. PMID: 30755439, PMCID: PMC6548643, DOI: 10.1158/1078-0432.ccr-18-0440.
The Combination of MEK Inhibitor With Immunomodulatory Antibodies Targeting Programmed Death 1 and Programmed Death Ligand 1 Results in Prolonged Survival in Kras/p53-Driven Lung CancerLee JW, Zhang Y, Eoh KJ, Sharma R, Sanmamed MF, Wu J, Choi J, Park HS, Iwasaki A, Kaftan E, Chen L, Papadimitrakopoulou V, Herbst RS, Koo JS. The Combination of MEK Inhibitor With Immunomodulatory Antibodies Targeting Programmed Death 1 and Programmed Death Ligand 1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer. Journal Of Thoracic Oncology 2019, 14: 1046-1060. PMID: 30771521, PMCID: PMC6542636, DOI: 10.1016/j.jtho.2019.02.004.
Abstract 5814: Synthetic lethal therapy to overcome resistance to AURKA inhibition in HPV-negative head and neck cancerDeneka A, Einarson M, Lee J, Nikonova A, Burtness B, Golemis E. Abstract 5814: Synthetic lethal therapy to overcome resistance to AURKA inhibition in HPV-negative head and neck cancer. Cancer Research 2018, 78: 5814-5814. DOI: 10.1158/1538-7445.am2018-5814.
Abstract 3334: CREB is required for KRAS -driven lung tumorigenesisLee J, Slack F, Nestler E, Herbst R, Koo J. Abstract 3334: CREB is required for KRAS -driven lung tumorigenesis. Cancer Research 2018, 78: 3334-3334. DOI: 10.1158/1538-7445.am2018-3334.
Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation InhibitorLangdon CG, Platt JT, Means RE, Iyidogan P, Mamillapalli R, Klein M, Held MA, Lee JW, Koo JS, Hatzis C, Hochster HS, Stern DF. Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation Inhibitor. Molecular Cancer Therapeutics 2017, 16: 1041-1053. PMID: 28292938, PMCID: PMC5457712, DOI: 10.1158/1535-7163.mct-16-0794.
Combination of WEE1 and AURKA inhibition in HPV negative head and neck squamous cell carcinoma.Parameswaran J, Lee J, Sandoval-Schaefer T, Koo J, Burtness B. Combination of WEE1 and AURKA inhibition in HPV negative head and neck squamous cell carcinoma. Journal Of Clinical Oncology 2017, 35: e14105-e14105. DOI: 10.1200/jco.2017.35.15_suppl.e14105.
P3.02c-070 Combination Immunotherapy with MEK Inhibitor for Treatment of Kras-Mutant Lung Cancer in Animal Model Topic: IT BiomarkersLee J, Zhang Y, Choi J, Sharma R, Park H, Kaftan E, Papadimitrakopoulou V, Herbst R, Koo J. P3.02c-070 Combination Immunotherapy with MEK Inhibitor for Treatment of Kras-Mutant Lung Cancer in Animal Model Topic: IT Biomarkers. Journal Of Thoracic Oncology 2017, 12: s1319. DOI: 10.1016/j.jtho.2016.11.1865.
Abstract 2334: Anti-cancer efficacy of the combination with immunomodulatory antibodies and MEK inhibitor for Kras mutation and p53 knockout driven lung cancerLee J, Zhang Y, Park H, Park S, Koo J, Herbst R. Abstract 2334: Anti-cancer efficacy of the combination with immunomodulatory antibodies and MEK inhibitor for Kras mutation and p53 knockout driven lung cancer. Cancer Research 2016, 76: 2334-2334. DOI: 10.1158/1538-7445.am2016-2334.
GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung CancerPark SA, Lee JW, Herbst RS, Koo JS. GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung Cancer. PLOS ONE 2016, 11: e0153075. PMID: 27049759, PMCID: PMC4822949, DOI: 10.1371/journal.pone.0153075.
E2F8 and its target genes as novel therapeutic targets for lung cancerPark S, Lee J, Platt J, Sweasy J, Glazer P, Herbst R, Koo J. E2F8 and its target genes as novel therapeutic targets for lung cancer. Journal Of Thoracic Oncology 2016, 11: s29. DOI: 10.1016/j.jtho.2015.12.048.
Abstract C172: Concomitant disruption of WEE1 and AurKA synergistically enhances anti-cancer effects in p53 mutated head and neck squamous cell carcinomaLee J, Parameswaran J, Koo J, Burtness B. Abstract C172: Concomitant disruption of WEE1 and AurKA synergistically enhances anti-cancer effects in p53 mutated head and neck squamous cell carcinoma. Molecular Cancer Therapeutics 2015, 14: c172-c172. DOI: 10.1158/1535-7163.targ-15-c172.
Abstract 2094: GSK-3 is a novel target of CREB and GSK-3-CREB signaling participates in cell survival in lung cancerPark S, Lee J, Herbst R, Koo J. Abstract 2094: GSK-3 is a novel target of CREB and GSK-3-CREB signaling participates in cell survival in lung cancer. 2015, 2094-2094. DOI: 10.1158/1538-7445.am2015-2094.
E2F8 as a Novel Therapeutic Target for Lung CancerPark SA, Platt J, Lee JW, López-Giráldez F, Herbst RS, Koo JS. E2F8 as a Novel Therapeutic Target for Lung Cancer. Journal Of The National Cancer Institute 2015, 107 PMID: 26089541, PMCID: PMC4651101, DOI: 10.1093/jnci/djv151.
A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum StressLee JW, Park HS, Park SA, Ryu SH, Meng W, Jürgensmeier JM, Kurie JM, Hong WK, Boyer JL, Herbst RS, Koo JS. A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress. PLOS ONE 2015, 10: e0122628. PMID: 25897662, PMCID: PMC4405579, DOI: 10.1371/journal.pone.0122628.
Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.Li Y, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology 2014, 146: 539-49.e7. PMID: 24184811, PMCID: PMC4228483, DOI: 10.1053/j.gastro.2013.10.059.
Abstract B04: Targeting CREB-CBP transcription factor complex using small molecule inhibitors with multifunctional anticancer mechanisms.Lee J, Park H, Park S, Herbst R, Koo J. Abstract B04: Targeting CREB-CBP transcription factor complex using small molecule inhibitors with multifunctional anticancer mechanisms. Clinical Cancer Research 2014, 20: b04-b04. DOI: 10.1158/1078-0432.14aacriaslc-b04.
Abstract PR03: Targeting CREB-CBP transcription factor complex using small molecule inhibitors with multifunctional anticancer mechanisms.Lee J, Park H, Park S, Herbst R, Koo J. Abstract PR03: Targeting CREB-CBP transcription factor complex using small molecule inhibitors with multifunctional anticancer mechanisms. Clinical Cancer Research 2014, 20: pr03-pr03. DOI: 10.1158/1078-0432.14aacriaslc-pr03.
Abstract 4382: Genome-Wide Gene Expression analysis and molecular portraits regulated by NASEp, an inhibitor of CREB and CBP interaction, in non-small cell lung cancer.Park S, Platt J, Park H, Lee J, Stern D, Herbst R, Koo J. Abstract 4382: Genome-Wide Gene Expression analysis and molecular portraits regulated by NASEp, an inhibitor of CREB and CBP interaction, in non-small cell lung cancer. Cancer Research 2013, 73: 4382-4382. DOI: 10.1158/1538-7445.am2013-4382.
Abstract 2878: Targeting the CXCL5-CXCR2-CREB signaling axis suppresses growth, survival, and invasion of lung adenocarcinoma.Park H, Lee J, Saintigny P, Kurie J, Herbst R, Koo J. Abstract 2878: Targeting the CXCL5-CXCR2-CREB signaling axis suppresses growth, survival, and invasion of lung adenocarcinoma. Cancer Research 2013, 73: 2878-2878. DOI: 10.1158/1538-7445.am2013-2878.
Abstract 3414: Disruption of CREB-CREBBP association by 2-Naphthol AS-E phosphate induces cell cycle arrest and apoptosis in non-small cell lung cancer cells .Lee J, Park H, Ryu S, Koch P, Boyer J, Morgensztern D, Herbst R, Koo J. Abstract 3414: Disruption of CREB-CREBBP association by 2-Naphthol AS-E phosphate induces cell cycle arrest and apoptosis in non-small cell lung cancer cells . Cancer Research 2013, 73: 3414-3414. DOI: 10.1158/1538-7445.am2013-3414.
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver.Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2011, 25: 1664-79. PMID: 21321189, PMCID: PMC3079300, DOI: 10.1096/fj.10-173492.
The association of AMPK with ULK1 regulates autophagy.Lee JW, Park S, Takahashi Y, Wang HG. The association of AMPK with ULK1 regulates autophagy. PloS One 2010, 5: e15394. PMID: 21072212, PMCID: PMC2972217, DOI: 10.1371/journal.pone.0015394.
Expressional and mutational analysis of pro-apoptotic Bcl-2 member PUMA in hepatocellular carcinomas.Ahn CH, Jeong EG, Kim SS, Lee JW, Lee SH, Kim SH, Kim MS, Yoo NJ, Lee SH. Expressional and mutational analysis of pro-apoptotic Bcl-2 member PUMA in hepatocellular carcinomas. Digestive Diseases And Sciences 2008, 53: 1395-9. PMID: 17934815, DOI: 10.1007/s10620-007-9987-x.
hCDC4 gene mutation is rare in colorectal carcinomas in Korean patients.Lee JW, Jeong EG, Lee SH, Yoo NJ, Lee SH. hCDC4 gene mutation is rare in colorectal carcinomas in Korean patients. Pathology 2008, 40: 305. PMID: 18428053, DOI: 10.1080/00313020701813693.
Absence of GNAS and EGFL6 mutations in common human cancers.Lee SH, Jeong EG, Soung YH, Lee JW, Yoo NJ, Lee SH. Absence of GNAS and EGFL6 mutations in common human cancers. Pathology 2008, 40: 95-7. PMID: 18038328, DOI: 10.1080/00313020701716375.
Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers.Ahn CH, Jeong EG, Lee JW, Kim MS, Kim SH, Kim SS, Yoo NJ, Lee SH. Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2007, 115: 1344-9. PMID: 18184403, DOI: 10.1111/j.1600-0463.2007.00858.x.
Pro-apoptotic PUMA and anti-apoptotic phospho-BAD are highly expressed in colorectal carcinomas.Kim MR, Jeong EG, Chae B, Lee JW, Soung YH, Nam SW, Lee JY, Yoo NJ, Lee SH. Pro-apoptotic PUMA and anti-apoptotic phospho-BAD are highly expressed in colorectal carcinomas. Digestive Diseases And Sciences 2007, 52: 2751-6. PMID: 17393317, DOI: 10.1007/s10620-007-9799-z.
Absence of MLL3 mutations in colorectal carcinomas of Korean patients.Ahn CH, Yoo NJ, Lee JW, Lee SH, Lee SH. Absence of MLL3 mutations in colorectal carcinomas of Korean patients. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2007, 115: 859-60. PMID: 17614854, DOI: 10.1111/j.1600-0463.2007.apm_696.x.
Somatic mutations of BECN1, an autophagy-related gene, in human cancers.Lee JW, Jeong EG, Lee SH, Yoo NJ, Lee SH. Somatic mutations of BECN1, an autophagy-related gene, in human cancers. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2007, 115: 750-6. PMID: 17550384, DOI: 10.1111/j.1600-0463.2007.apm_640.x.
Absence of fusion of TMPRSS2 and ETS transcription factor genes in gastric and colorectal carcinomas.Yoo NJ, Lee JW, Lee SH. Absence of fusion of TMPRSS2 and ETS transcription factor genes in gastric and colorectal carcinomas. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2007, 115: 252-3. PMID: 17367471, DOI: 10.1111/j.1600-0463.2007.apm_652.x.
Immunohistochemical analysis of pro-apoptotic PUMA protein and mutational analysis of PUMA gene in gastric carcinomas.Yoo NJ, Lee JW, Jeong EG, Lee SH. Immunohistochemical analysis of pro-apoptotic PUMA protein and mutational analysis of PUMA gene in gastric carcinomas. Digestive And Liver Disease : Official Journal Of The Italian Society Of Gastroenterology And The Italian Association For The Study Of The Liver 2007, 39: 222-7. PMID: 17267315, DOI: 10.1016/j.dld.2006.11.006.
Mutational analysis of PTPRT phosphatase domains in common human cancers.Lee JW, Jeong EG, Lee SH, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. Mutational analysis of PTPRT phosphatase domains in common human cancers. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2007, 115: 47-51. PMID: 17223850, DOI: 10.1111/j.1600-0463.2007.apm_554.x.
Expression of nuclear and cytoplasmic phosphorylated FADD in gastric cancers.Yoo NJ, Lee SH, Jeong EG, Lee JW, Soung YH, Nam SW, Kim SH, Lee JY, Lee SH. Expression of nuclear and cytoplasmic phosphorylated FADD in gastric cancers. Pathology, Research And Practice 2007, 203: 73-8. PMID: 17207586, DOI: 10.1016/j.prp.2006.11.002.
ERBB3 kinase domain mutations are rare in lung, breast and colon carcinomas.Jeong EG, Soung YH, Lee JW, Lee SH, Nam SW, Lee JY, Yoo NJ, Lee SH. ERBB3 kinase domain mutations are rare in lung, breast and colon carcinomas. International Journal Of Cancer. Journal International Du Cancer 2006, 119: 2986-7. PMID: 16998794, DOI: 10.1002/ijc.22257.
Immunohistochemical and mutational analysis of apoptosis-inducing factor (AIF) in colorectal carcinomas.Jeong EG, Lee JW, Soung YH, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. Immunohistochemical and mutational analysis of apoptosis-inducing factor (AIF) in colorectal carcinomas. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2006, 114: 867-73. PMID: 17207087, DOI: 10.1111/j.1600-0463.2006.apm_502.x.
Mitochondrial microsatellite instability of colorectal cancer stroma.Kim HS, Lim HS, Lee SH, Lee JW, Nam SW, Park WS, Lee YS, Lee JY, Yoo NJ. Mitochondrial microsatellite instability of colorectal cancer stroma. International Journal Of Cancer. Journal International Du Cancer 2006, 119: 2607-11. PMID: 16991127, DOI: 10.1002/ijc.22244.
Expressional analysis of anti-apoptotic phospho-BAD protein and mutational analysis of pro-apoptotic BAD gene in hepatocellular carcinomas.Yoo NJ, Lee JW, Jeong EG, Soung YH, Nam SW, Lee JY, Lee SH. Expressional analysis of anti-apoptotic phospho-BAD protein and mutational analysis of pro-apoptotic BAD gene in hepatocellular carcinomas. Digestive And Liver Disease : Official Journal Of The Italian Society Of Gastroenterology And The Italian Association For The Study Of The Liver 2006, 38: 683-7. PMID: 16807152, DOI: 10.1016/j.dld.2006.05.018.
Mutational analysis of the hCDC4 gene in gastric carcinomas.Lee JW, Soung YH, Kim HJ, Park WS, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. Mutational analysis of the hCDC4 gene in gastric carcinomas. European Journal Of Cancer (Oxford, England : 1990) 2006, 42: 2369-73. PMID: 16824748, DOI: 10.1016/j.ejca.2005.10.034.
Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.Lee JW, Kim MR, Soung YH, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2006, 114: 646-50. PMID: 16948818, DOI: 10.1111/j.1600-0463.2006.apm_417.x.
Absence of the mutation of serine/threonine kinase genes AKT2 and MYLK2 in acute leukemias.Soung YH, Lee JW, Kim SY, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. Absence of the mutation of serine/threonine kinase genes AKT2 and MYLK2 in acute leukemias. European Journal Of Haematology 2006, 77: 175-6. PMID: 16856912, DOI: 10.1111/j.1600-0609.2006.00676.x.
Somatic mutation of pro-apoptosis caspase-6 gene is rare in breast and lung carcinomas.Lee JW, Soung YH, Kim SY, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH. Somatic mutation of pro-apoptosis caspase-6 gene is rare in breast and lung carcinomas. Pathology 2006, 38: 358-9. PMID: 16916729, DOI: 10.1080/00313020600820799.
Absence of the BH3 domain mutation of proapoptotic Bcl-2 family gene BAD in serous and mucinous tumors of ovary.Kim MR, Jeong EG, Lee JW, Lee SH. Absence of the BH3 domain mutation of proapoptotic Bcl-2 family gene BAD in serous and mucinous tumors of ovary. Gynecologic Oncology 2006, 102: 412-3. PMID: 16712907, DOI: 10.1016/j.ygyno.2006.03.041.
Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas.Lee JW, Jeong EG, Soung YH, Nam SW, Lee JY, Yoo NJ, Lee SH. Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas. Pathology 2006, 38: 312-5. PMID: 16916719, DOI: 10.1080/00313020600820880.
ERBB2 kinase domain mutation in the lung squamous cell carcinoma.Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Wang YP, Jo KH, Moon SW, Song SY, Lee JY, Yoo NJ, Lee SH. ERBB2 kinase domain mutation in the lung squamous cell carcinoma. Cancer Letters 2006, 237: 89-94. PMID: 16029927, DOI: 10.1016/j.canlet.2005.05.026.
Kinase domain mutation of MAP2K4 is rare in gastric, colorectal and lung carcinomas.Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Kinase domain mutation of MAP2K4 is rare in gastric, colorectal and lung carcinomas. Pathology 2006, 38: 263-4. PMID: 16753753, DOI: 10.1080/00313020600699219.
Mutational analysis of MYC in common epithelial cancers and acute leukemias.Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Mutational analysis of MYC in common epithelial cancers and acute leukemias. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2006, 114: 436-9. PMID: 16856965, DOI: 10.1111/j.1600-0463.2006.apm_383.x.
Kinase domain mutation of MLK4 gene is uncommon in gastric and hepatocellular carcinomas.Soung YH, Lee JW, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Kinase domain mutation of MLK4 gene is uncommon in gastric and hepatocellular carcinomas. Digestive And Liver Disease : Official Journal Of The Italian Society Of Gastroenterology And The Italian Association For The Study Of The Liver 2006, 38: 283. PMID: 16309983, DOI: 10.1016/j.dld.2005.10.012.
Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas.Soung YH, Lee JW, Kim SY, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH. Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2006, 114: 292-7. PMID: 16689829, DOI: 10.1111/j.1600-0463.2006.apm_364.x.
Somatic mutations of the ERBB4 kinase domain in human cancers.Soung YH, Lee JW, Kim SY, Wang YP, Jo KH, Moon SW, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH. Somatic mutations of the ERBB4 kinase domain in human cancers. International Journal Of Cancer. Journal International Du Cancer 2006, 118: 1426-9. PMID: 16187281, DOI: 10.1002/ijc.21507.
The JAK2 V617F mutation in de novo acute myelogenous leukemias.Lee JW, Kim YG, Soung YH, Han KJ, Kim SY, Rhim HS, Min WS, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. The JAK2 V617F mutation in de novo acute myelogenous leukemias. Oncogene 2006, 25: 1434-6. PMID: 16247455, DOI: 10.1038/sj.onc.1209163.
Kinase domain mutation of ERBB family genes is uncommon in acute leukemias.Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Kinase domain mutation of ERBB family genes is uncommon in acute leukemias. Leukemia Research 2006, 30: 241-2. PMID: 16054688, DOI: 10.1016/j.leukres.2005.06.016.
BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder.Soung YH, Lee JW, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH. BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder. Pathology 2006, 38: 33-4. PMID: 16484005, DOI: 10.1080/00313020500455811.
JAK2 V617F mutation is uncommon in non-Hodgkin lymphomas.Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. JAK2 V617F mutation is uncommon in non-Hodgkin lymphomas. Leukemia & Lymphoma 2006, 47: 313-4. PMID: 16321863, DOI: 10.1080/10428190500271723.
Absence of JAK2 V617F mutation in gastric cancers.Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Absence of JAK2 V617F mutation in gastric cancers. Acta Oncologica (Stockholm, Sweden) 2006, 45: 222-3. PMID: 16546874, DOI: 10.1080/02841860500341223.
Mutational analysis of PDPK1 kinase domain in gastric, colorectal and lung carcinomas.Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Mutational analysis of PDPK1 kinase domain in gastric, colorectal and lung carcinomas. Acta Oncologica (Stockholm, Sweden) 2006, 45: 340-1. PMID: 16644580, DOI: 10.1080/02841860500468968.
Absence of DKC1 exon 3 mutation in common human cancers.Soung YH, Lee JW, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Absence of DKC1 exon 3 mutation in common human cancers. Acta Oncologica (Stockholm, Sweden) 2006, 45: 342-3. PMID: 16644581, DOI: 10.1080/02841860500437336.
Mutational analysis of P-loop domains of proapoptotic Nod1 and ARTS genes in colon carcinomas.Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Mutational analysis of P-loop domains of proapoptotic Nod1 and ARTS genes in colon carcinomas. Acta Oncologica (Stockholm, Sweden) 2006, 45: 101-2. PMID: 16464805, DOI: 10.1080/02841860500374497.
Mutational analysis of the kinase domain of MYLK2 gene in common human cancers.Soung YH, Lee JW, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Mutational analysis of the kinase domain of MYLK2 gene in common human cancers. Pathology, Research And Practice 2006, 202: 137-40. PMID: 16448786, DOI: 10.1016/j.prp.2005.12.003.
Absence of BH3 domain mutations in the proapoptotic Bcl-2 gene family in non-Hodgkin lymphomas.Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Absence of BH3 domain mutations in the proapoptotic Bcl-2 gene family in non-Hodgkin lymphomas. Acta Haematologica 2006, 116: 213-5. PMID: 17016043, DOI: 10.1159/000094685.
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.Lee JW, Soung YH, Seo SH, Kim SY, Park CH, Wang YP, Park K, Nam SW, Park WS, Kim SH, Lee JY, Yoo NJ, Lee SH. Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2006, 12: 57-61. PMID: 16397024, DOI: 10.1158/1078-0432.CCR-05-0976.
Immunohistochemical analysis of apoptosis-inducing factor (AIF) expression in gastric carcinomas.Lee JW, Jeong EG, Soung YH, Kim SY, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. Immunohistochemical analysis of apoptosis-inducing factor (AIF) expression in gastric carcinomas. Pathology, Research And Practice 2006, 202: 497-501. PMID: 16723191, DOI: 10.1016/j.prp.2006.03.004.
Mutational analysis of proapoptotic ARTS P-loop domain in common human cancers.Lee JW, Soung YH, Young Kim S, Woo Nam S, Sang Park W, Young Lee J, Jin Yoo N, Lee SH. Mutational analysis of proapoptotic ARTS P-loop domain in common human cancers. Pathology, Research And Practice 2006, 202: 67-70. PMID: 16376484, DOI: 10.1016/j.prp.2005.11.001.
Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas.Soung YH, Lee JW, Nam SW, Lee JY, Yoo NJ, Lee SH. Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas. Oncology 2006, 70: 285-9. PMID: 17047397, DOI: 10.1159/000096289.
ERBB2 kinase domain mutation in a gastric cancer metastasis.Lee JW, Soung YH, Kim SY, Park WS, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. ERBB2 kinase domain mutation in a gastric cancer metastasis. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2005, 113: 683-7. PMID: 16309427, DOI: 10.1111/j.1600-0463.2005.apm_284.x.
Absence of the ERBB2 kinase domain mutation in lung adenocarcinomas in Korean patients.Lee JW, Soung YH, Kim SY, Park WS, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. Absence of the ERBB2 kinase domain mutation in lung adenocarcinomas in Korean patients. International Journal Of Cancer. Journal International Du Cancer 2005, 116: 652-3. PMID: 15825173, DOI: 10.1002/ijc.21113.
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas.Soung YH, Lee JW, Kim SY, Seo SH, Park WS, Nam SW, Song SY, Han JH, Park CK, Lee JY, Yoo NJ, Lee SH. Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas. Virchows Archiv : An International Journal Of Pathology 2005, 446: 483-8. PMID: 15815931, DOI: 10.1007/s00428-005-1254-y.
Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck.Lee JW, Soung YH, Kim SY, Nam HK, Park WS, Nam SW, Kim MS, Sun DI, Lee YS, Jang JJ, Lee JY, Yoo NJ, Lee SH. Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2005, 11: 2879-82. PMID: 15837736, DOI: 10.1158/1078-0432.CCR-04-2029.
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.Lee JW, Soung YH, Kim SY, Lee HW, Park WS, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. Oncogene 2005, 24: 1477-80. PMID: 15608678, DOI: 10.1038/sj.onc.1208304.
CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas.Soung YH, Lee JW, Kim SY, Jang J, Park YG, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH. CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas. Cancer Research 2005, 65: 815-21. PMID: 15705878.
Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer.Lee JW, Soung YH, Kim SY, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH. Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer. International Journal Of Cancer. Journal International Du Cancer 2005, 113: 510-1. PMID: 15455340, DOI: 10.1002/ijc.20591.
Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas.Soung YH, Lee JW, Kim SY, Sung YJ, Park WS, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas. Oncogene 2005, 24: 141-7. PMID: 15531912, DOI: 10.1038/sj.onc.1208244.
Kinase domain mutation of NTRK3 gene is uncommon in gastric carcinomas.Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Kinase domain mutation of NTRK3 gene is uncommon in gastric carcinomas. Acta Oncologica (Stockholm, Sweden) 2005, 44: 924-5. PMID: 16332604, DOI: 10.1080/02841860500374489.
Mutational analysis of the ARAF gene in human cancers.Lee JW, Soung YH, Kim SY, Park WS, Nam SW, Min WS, Kim SH, Lee JY, Yoo NJ, Lee SH. Mutational analysis of the ARAF gene in human cancers. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2005, 113: 54-7. PMID: 15676015, DOI: 10.1111/j.1600-0463.2005.apm1130108.x.
Mutation of FADD gene is rare in human colon and stomach cancers.Soung YH, Lee JW, Kim SY, Nam SW, Park WS, Kim SH, Lee JY, Yoo NJ, Lee SH. Mutation of FADD gene is rare in human colon and stomach cancers. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2004, 112: 595-7. PMID: 15601308, DOI: 10.1111/j.1600-0463.2004.apm1120906.x.
Inactivating mutations of proapoptotic Bad gene in human colon cancers.Lee JW, Soung YH, Kim SY, Nam SW, Kim CJ, Cho YG, Lee JH, Kim HS, Park WS, Kim SH, Lee JY, Yoo NJ, Lee SH. Inactivating mutations of proapoptotic Bad gene in human colon cancers. Carcinogenesis 2004, 25: 1371-6. PMID: 15033904, DOI: 10.1093/carcin/bgh145.
Somatic mutations of CASP3 gene in human cancers.Soung YH, Lee JW, Kim SY, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH. Somatic mutations of CASP3 gene in human cancers. Human Genetics 2004, 115: 112-5. PMID: 15127291, DOI: 10.1007/s00439-004-1129-3.
Loss of caspase-2, -6 and -7 expression in gastric cancers.Yoo NJ, Lee JW, Kim YJ, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Lee SH. Loss of caspase-2, -6 and -7 expression in gastric cancers. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2004, 112: 330-5. PMID: 15511269, DOI: 10.1111/j.1600-0463.2004.apm1120602.x.
Inactivating mutation of the pro-apoptotic gene BID in gastric cancer.Lee JH, Soung YH, Lee JW, Park WS, Kim SY, Cho YG, Kim CJ, Seo SH, Kim HS, Nam SW, Yoo NJ, Lee SH, Lee JY. Inactivating mutation of the pro-apoptotic gene BID in gastric cancer. The Journal Of Pathology 2004, 202: 439-45. PMID: 15095271, DOI: 10.1002/path.1532.
Colorectal tumors frequently express phosphorylated mitogen-activated protein kinase.Lee SH, Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Kim SH, Yoo NJ, Lee JY. Colorectal tumors frequently express phosphorylated mitogen-activated protein kinase. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2004, 112: 233-8. PMID: 15233637, DOI: 10.1111/j.1600-0463.2004.apm11204-0502.x.
BRAF mutations in acute leukemias.Lee JW, Soung YH, Park WS, Kim SY, Nam SW, Min WS, Lee JY, Yoo NJ, Lee SH. BRAF mutations in acute leukemias. Leukemia 2004, 18: 170-2. PMID: 14603338, DOI: 10.1038/sj.leu.2403201.
Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas.Kim CJ, Cho YG, Park JY, Kim TY, Lee JH, Kim HS, Lee JW, Song YH, Nam SW, Lee SH, Yoo NJ, Lee JY, Park WS. Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas. European Journal Of Cancer (Oxford, England : 1990) 2004, 40: 136-41. PMID: 14687797, DOI: 10.1016/s0959-8049(03)00659-2.
BRAF mutations in non-Hodgkin's lymphoma.Lee JW, Yoo NJ, Soung YH, Kim HS, Park WS, Kim SY, Lee JH, Park JY, Cho YG, Kim CJ, Ko YH, Kim SH, Nam SW, Lee JY, Lee SH. BRAF mutations in non-Hodgkin's lymphoma. British Journal Of Cancer 2003, 89: 1958-60. PMID: 14612909, PMCID: PMC2394455, DOI: 10.1038/sj.bjc.6601371.
BRAF and KRAS mutations in stomach cancer.Lee SH, Lee JW, Soung YH, Kim HS, Park WS, Kim SY, Lee JH, Park JY, Cho YG, Kim CJ, Nam SW, Kim SH, Lee JY, Yoo NJ. BRAF and KRAS mutations in stomach cancer. Oncogene 2003, 22: 6942-5. PMID: 14534542, DOI: 10.1038/sj.onc.1206749.
Inactivating mutations of CASPASE-7 gene in human cancers.Soung YH, Lee JW, Kim HS, Park WS, Kim SY, Lee JH, Park JY, Cho YG, Kim CJ, Park YG, Nam SW, Jeong SW, Kim SH, Lee JY, Yoo NJ, Lee SH. Inactivating mutations of CASPASE-7 gene in human cancers. Oncogene 2003, 22: 8048-52. PMID: 12970753, DOI: 10.1038/sj.onc.1206727.
Inactivating mutations of caspase-8 gene in colorectal carcinomas.Kim HS, Lee JW, Soung YH, Park WS, Kim SY, Lee JH, Park JY, Cho YG, Kim CJ, Jeong SW, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. Inactivating mutations of caspase-8 gene in colorectal carcinomas. Gastroenterology 2003, 125: 708-15. PMID: 12949717, DOI: 10.1016/s0016-5085(03)01059-x.
A single nucleotide polymorphism in the E-cadherin gene promoter-160 is not associated with risk of Korean gastric cancer.Park WS, Cho YG, Park JY, Kim CJ, Lee JH, Kim HS, Lee JW, Song YH, Park CH, Park YK, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY. A single nucleotide polymorphism in the E-cadherin gene promoter-160 is not associated with risk of Korean gastric cancer. Journal Of Korean Medical Science 2003, 18: 501-4. PMID: 12923325, PMCID: PMC3055075, DOI: 10.3346/jkms.2003.18.4.501.
Mutational analysis of Noxa gene in human cancers.Lee SH, Soung YH, Lee JW, Kim HS, Lee JH, Kim HS, Lee JH, Park JY, Cho YG, Kim CJ, Kim SY, Park WS, Kim SH, Lee JY, Yoo NJ. Mutational analysis of Noxa gene in human cancers. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2003, 111: 599-604. PMID: 12969015, DOI: 10.1034/j.1600-0463.2003.1110602.x.
Mutational analysis of salvador gene in human carcinomas.Yoo NJ, Soung YH, Lee JW, Park WS, Kim SY, Nam SW, Han JH, Kim SH, Lee JY, Lee SH. Mutational analysis of salvador gene in human carcinomas. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2003, 111: 595-8. PMID: 12969014, DOI: 10.1034/j.1600-0463.2003.1110601.x.
Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer.Cho YG, Nam SW, Kim TY, Kim YS, Kim CJ, Park JY, Lee JH, Kim HS, Lee JW, Park CH, Song YH, Lee SH, Yoo NJ, Lee JY, Park WS. Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2003, 111: 539-45. PMID: 12887505, DOI: 10.1034/j.1600-0463.2003.1110502.x.
Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer.Lee SH, Lee JW, Kim HS, Kim SY, Park WS, Kim SH, Lee JY, Yoo NJ. Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2003, 111: 586-90. PMID: 12887511, DOI: 10.1034/j.1600-0463.2003.1110508.x.
Mutational analysis of Fas ligand gene in human non-Hodgkin lymphoma.Kim HS, Lee SH, Lee JW, Soung YH, Lee JH, Park JY, Cho YG, Kim CJ, Kim SY, Lee YS, Park WS, Kim SH, Lee JY, Yoo NJ. Mutational analysis of Fas ligand gene in human non-Hodgkin lymphoma. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica 2003, 111: 490-6. PMID: 12780524, DOI: 10.1034/j.1600-0463.2003.1110407.x.
Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer.Shin MS, Kim HS, Lee SH, Lee JW, Song YH, Kim YS, Park WS, Kim SY, Lee SN, Park JY, Lee JH, Xiao W, Jo KH, Wang YP, Lee KY, Park YG, Kim SH, Lee JY, Yoo NJ. Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer. Oncogene 2002, 21: 4129-36. PMID: 12037669, DOI: 10.1038/sj.onc.1205527.

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Jong Woo Lee, PhD

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