Jonathan Ellman, PhD
Eugene Higgins Professor of Chemistry and Professor of Pharmacology
Research & Publications
Biography
News
Research Summary
The ability to rapidly and efficiently synthesize new chemical matter provides unlimited opportunities to discover and develop compounds with incredibly diverse properties and applications ranging from precise tools for the study biological phenomena to pharmaceutical agents that treat unmet medical conditions. The Ellman group designs and develops synthetic compounds to potently and selectively interact with specific biomolecular targets to define their biological role, establish relevance for the treatment of disease, and provide key starting points for drug development.
Extensive Research Description
For a detailed research description please look at my group website: https://ellman.chem.yale.edu/
Research Interests
Chemicals and Drugs
Selected Publications
- Copper-Catalyzed Three-Component Synthesis of Highly Substituted MorpholinesChu D, Zoll A, Ellman J. Copper-Catalyzed Three-Component Synthesis of Highly Substituted Morpholines. Organic Letters 2024, 26: 4803-4807. PMID: 38810982, PMCID: PMC11195447, DOI: 10.1021/acs.orglett.4c01634.
- Correction to “Catalytic Enantioselective Sulfur Alkylation of Sulfenamides for the Asymmetric Synthesis of Sulfoximines”Greenwood N, Champlin A, Ellman J. Correction to “Catalytic Enantioselective Sulfur Alkylation of Sulfenamides for the Asymmetric Synthesis of Sulfoximines”. Journal Of The American Chemical Society 2024, 146: 5712-5712. PMID: 38364827, DOI: 10.1021/jacs.4c00239.
- Visible-Light-Mediated, Diastereoselective Epimerization of Exocyclic AminesVargas-Rivera M, Liu A, Ellman J. Visible-Light-Mediated, Diastereoselective Epimerization of Exocyclic Amines. Organic Letters 2023, 25: 9197-9201. PMID: 38114418, PMCID: PMC10771010, DOI: 10.1021/acs.orglett.3c03801.
- Synthesis of N‐Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One‐Pot Sulfur‐Arylation and DealkylationGreenwood N, Cerny N, Deziel A, Ellman J. Synthesis of N‐Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One‐Pot Sulfur‐Arylation and Dealkylation. Angewandte Chemie International Edition 2023, 63: e202315701. PMID: 38015869, PMCID: PMC10813656, DOI: 10.1002/anie.202315701.
- Synthesis of N‐Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One‐Pot Sulfur‐Arylation and DealkylationGreenwood N, Cerny N, Deziel A, Ellman J. Synthesis of N‐Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One‐Pot Sulfur‐Arylation and Dealkylation. Angewandte Chemie 2023, 136 DOI: 10.1002/ange.202315701.