Jonathan Dranoff, MD

• Dhanpat Jain
• James Lorenzen Boyer
• Michael H Nathanson

Acetaminophen; Fibrosis; Liver Cirrhosis; Chemical and Drug Induced Liver Injury; Non-alcoholic Fatty Liver Disease

• Coffee as chemoprotectant in fatty liver disease: caffeine-dependent and caffeine-independent effectsDranoff J. Coffee as chemoprotectant in fatty liver disease: caffeine-dependent and caffeine-independent effects AJP Gastrointestinal And Liver Physiology 2023, 324: g419-g421. PMID: 36976807, DOI: 10.1152/ajpgi.00026.2023.
• Obesity, but not glycemic control, predicts liver steatosis in children with type 1 diabetesTas E, Bai S, Mak D, Diaz E, Dranoff J. Obesity, but not glycemic control, predicts liver steatosis in children with type 1 diabetes Journal Of Diabetes And Its Complications 2022, 36: 108341. PMID: 36345110, DOI: 10.1016/j.jdiacomp.2022.108341.
• Review of existing evidence demonstrates that methotrexate does not cause liver fibrosisCheema HI, Haselow D, Dranoff JA. Review of existing evidence demonstrates that methotrexate does not cause liver fibrosis Journal Of Investigative Medicine 2022, 70: 1452-1460. PMID: 36002175, DOI: 10.1136/jim-2021-002206.
• COVID-19 and the liver: a narrative review of the present state of knowledgeThandassery RB, Dranoff JA, Perisetti A, Taddei T. COVID-19 and the liver: a narrative review of the present state of knowledge Translational Gastroenterology And Hepatology 2022, 0: 0-0. PMID: 36300154, PMCID: PMC9468988, DOI: 10.21037/tgh-20-243.
• Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways.Vazquez JH, Kennon-McGill S, Byrum SD, Mackintosh SG, Jaeschke H, Williams DK, Lee WM, Dranoff JA, McGill MR. Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways. Toxicological Sciences 2022, 187: 25-34. PMID: 35172013, PMCID: PMC9216044, DOI: 10.1093/toxsci/kfac015.
• Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated CirrhosisMcGill MR, James LP, McCullough SS, Moran JH, Mathews SE, Peterson EC, Fleming DP, Tripod ME, Vazquez JH, Kennon‐McGill S, Spencer HJ, Dranoff JA. Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis Hepatology Communications 2021, 6: 361-373. PMID: 34558847, PMCID: PMC8793989, DOI: 10.1002/hep4.1810.
• Su316 INCREASED DIAGNOSIS OF HEPATOCELLULAR CARCINOMA IN HOSPITALIZED PATIENTS WITH ALCOHOL RELATED HEPATITIS AFTER THE COVID-19 OUTBREAK: A GLOBAL MULTI-CENTER PROPENSITY MATCHED ANALYSIS.Perisetti A, Kaur R, Rude M, Dranoff J, Thandassery R. Su316 INCREASED DIAGNOSIS OF HEPATOCELLULAR CARCINOMA IN HOSPITALIZED PATIENTS WITH ALCOHOL RELATED HEPATITIS AFTER THE COVID-19 OUTBREAK: A GLOBAL MULTI-CENTER PROPENSITY MATCHED ANALYSIS. Gastroenterology 2021, 160: s-846-s-847. PMCID: PMC8108155, DOI: 10.1016/s0016-5085(21)02752-9.
• S1046 Non-Invasive Fibrosis Tests (APRI, FIB-4 and NFS) to Identify Advanced Fibrosis and Facilitate Referral to Liver ClinicsLavender C, Perisetti A, Salah H, Sharma T, Askew E, Dranoff J, Thandassery R. S1046 Non-Invasive Fibrosis Tests (APRI, FIB-4 and NFS) to Identify Advanced Fibrosis and Facilitate Referral to Liver Clinics The American Journal Of Gastroenterology 2020, 115: s531-s531. DOI: 10.14309/01.ajg.0000706232.06437.78.
• Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With ObesityTas E, Bai S, Ou X, Mercer K, Lin H, Mansfield K, Buchmann R, Diaz EC, Oden J, Børsheim E, Adams SH, Dranoff J. Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity Frontiers In Endocrinology 2020, 11: 654. PMID: 33071964, PMCID: PMC7533567, DOI: 10.3389/fendo.2020.00654.
• The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver InjuryLoBianco FV, Krager KJ, Carter GS, Alam S, Yuan Y, Lavoie EG, Dranoff JA, Aykin-Burns N. The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury Antioxidants 2020, 9: 409. PMID: 32403251, PMCID: PMC7278565, DOI: 10.3390/antiox9050409.
• Mo1447 NON-INVASIVE FIBROSIS TESTS (APRI, FIB-4 AND NFS) TO IDENTIFY ADVANCED LIVER DISEASE AND FACILITATE REFERRAL TO SPECIALTY CLINICS - A US VETERAN COHORT ANALYSISLavender C, Askew E, Sharma T, Salah H, Perisetti A, Dranoff J, Thandassery R. Mo1447 NON-INVASIVE FIBROSIS TESTS (APRI, FIB-4 AND NFS) TO IDENTIFY ADVANCED LIVER DISEASE AND FACILITATE REFERRAL TO SPECIALTY CLINICS - A US VETERAN COHORT ANALYSIS Gastroenterology 2020, 158: s-1406. DOI: 10.1016/s0016-5085(20)34183-4.
• Mo1402 IMPACT OF SARCOPENIA AND SARCOPENIC OBESITY ON TRANSPLANT-FREE SURVIVAL IN PATIENTS WITH HEPATOCELLULAR CARCINOMA UNDERGOING LOCOREGIONAL THERAPYLavender C, Perisetti A, Dranoff J, Beheshti M, Thandassery R. Mo1402 IMPACT OF SARCOPENIA AND SARCOPENIC OBESITY ON TRANSPLANT-FREE SURVIVAL IN PATIENTS WITH HEPATOCELLULAR CARCINOMA UNDERGOING LOCOREGIONAL THERAPY Gastroenterology 2020, 158: s-1395. DOI: 10.1016/s0016-5085(20)34156-1.
• Purinergic Regulation of Bile Ductular SecretionDranoff J. Purinergic Regulation of Bile Ductular Secretion 2020, 96-104. DOI: 10.1201/9780367813888-9.
• Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells.Eubanks HB, Lavoie EG, Goree J, Kamykowski JA, Gokden N, Fausther M, Dranoff JA. Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells. Gene Expression 2019, 20: 25-37. PMID: 31757226, PMCID: PMC7284106, DOI: 10.3727/105221619x15742818049365.
• Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in miceHintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA, Gershwin ME, Manns MP, Imhof BA, Christen U. Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice Journal Of Autoimmunity 2018, 91: 83-96. PMID: 29753567, DOI: 10.1016/j.jaut.2018.05.001.
• FRI-208 Leukemia inhibitory factor induces cholangiocyte proliferation and corrects the impaired bile duct proliferation in sortilin-deficient mice following cholestatic injuryZvibel I, Hubel E, Avraham R, Lavoie E, Fishman S, Dranoff J, Shibolet O. FRI-208 Leukemia inhibitory factor induces cholangiocyte proliferation and corrects the impaired bile duct proliferation in sortilin-deficient mice following cholestatic injury Journal Of Hepatology 2018, 68: s453-s454. DOI: 10.1016/s0168-8278(18)31150-4.
• Liver myofibroblasts of murine origins express mesothelin: Identification of novel rat mesothelin splice variants*Fausther M, Lavoie E, Dranoff JA. Liver myofibroblasts of murine origins express mesothelin: Identification of novel rat mesothelin splice variants* PLOS ONE 2017, 12: e0184499. PMID: 28898276, PMCID: PMC5595315, DOI: 10.1371/journal.pone.0184499.
• The Cholangiocyte Adenosine‐IL-6 Axis Regulates Survival During Biliary CirrhosisLavoie EG, Fausther M, Goree JR, Dranoff JA. The Cholangiocyte Adenosine‐IL-6 Axis Regulates Survival During Biliary Cirrhosis Gene Expression 2017, 17: 327-340. PMID: 28893353, PMCID: PMC5885153, DOI: 10.3727/105221617x15042723767876.
• Coffee Consumption and Prevention of Cirrhosis: In Support of the Caffeine HypothesisDranoff JA. Coffee Consumption and Prevention of Cirrhosis: In Support of the Caffeine Hypothesis Gene Expression 2017, 18: 1-3. PMID: 28893365, PMCID: PMC5885142, DOI: 10.3727/105221617x15046391179559.
• An Elf2-like transcription factor acts as repressor of the mouse ecto-5′-nucleotidase gene expression in hepatic myofibroblastsFausther M, Lavoie EG, Goree JR, Dranoff JA. An Elf2-like transcription factor acts as repressor of the mouse ecto-5′-nucleotidase gene expression in hepatic myofibroblasts Purinergic Signalling 2017, 13: 417-428. PMID: 28667437, PMCID: PMC5714833, DOI: 10.1007/s11302-017-9570-7.
• Transforming Growth Factors α and β Are Essential for Modeling Cholangiocarcinoma Desmoplasia and Progression in a Three-Dimensional Organotypic Culture ModelManzanares MÁ, Usui A, Campbell DJ, Dumur CI, Maldonado GT, Fausther M, Dranoff JA, Sirica AE. Transforming Growth Factors α and β Are Essential for Modeling Cholangiocarcinoma Desmoplasia and Progression in a Three-Dimensional Organotypic Culture Model American Journal Of Pathology 2017, 187: 1068-1092. PMID: 28315313, PMCID: PMC5417049, DOI: 10.1016/j.ajpath.2017.01.013.
• Sortilin Deficiency Reduces Ductular Reaction, Hepatocyte Apoptosis, and Liver Fibrosis in Cholestatic-Induced Liver InjuryHubel E, Saroha A, Park WJ, Pewzner-Jung Y, Lavoie EG, Futerman AH, Bruck R, Fishman S, Dranoff JA, Shibolet O, Zvibel I. Sortilin Deficiency Reduces Ductular Reaction, Hepatocyte Apoptosis, and Liver Fibrosis in Cholestatic-Induced Liver Injury American Journal Of Pathology 2016, 187: 122-133. PMID: 27842214, DOI: 10.1016/j.ajpath.2016.09.005.
• Extracellular vesicles carry microRNA‐195 to intrahepatic cholangiocarcinoma and improve survival in a rat modelLi L, Piontek K, Ishida M, Fausther M, Dranoff JA, Fu R, Mezey E, Gould SJ, Fordjour FK, Meltzer SJ, Sirica AE, Selaru FM. Extracellular vesicles carry microRNA‐195 to intrahepatic cholangiocarcinoma and improve survival in a rat model Hepatology 2016, 65: 501-514. PMID: 27474881, PMCID: PMC5258762, DOI: 10.1002/hep.28735.
• I drink for my liver, Doc: emerging evidence that coffee prevents cirrhosisFeld JJ, Lavoie ÉG, Fausther M, Dranoff JA. I drink for my liver, Doc: emerging evidence that coffee prevents cirrhosis F1000Research 2015, 4: 95. PMID: 25977756, PMCID: PMC4416533, DOI: 10.12688/f1000research.6368.2.
• Protein Shakes: An Unusual Cause of Gastric PhytobezoarKlair JS, Girotra M, Dranoff JA, Aduli F. Protein Shakes: An Unusual Cause of Gastric Phytobezoar ACG Case Reports Journal 2015, 2: 196-197. PMID: 26203434, PMCID: PMC4508936, DOI: 10.14309/crj.2015.54.
• I drink for my liver, Doc: emerging evidence that coffee prevents cirrhosisFeld J, Lavoie É, Fausther M, Dranoff J. I drink for my liver, Doc: emerging evidence that coffee prevents cirrhosis F1000Research 2015, 4: 95. DOI: 10.12688/f1000research.6368.1.
• Establishment and Characterization of Rat Portal Myofibroblast Cell LinesFausther M, Goree JR, Lavoie ÉG, Graham AL, Sévigny J, Dranoff JA. Establishment and Characterization of Rat Portal Myofibroblast Cell Lines PLOS ONE 2015, 10: e0121161. PMID: 25822334, PMCID: PMC4378927, DOI: 10.1371/journal.pone.0121161.
• Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014Torok NJ, Dranoff JA, Schuppan D, Friedman SL. Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014 Hepatology 2015, 62: 627-634. PMID: 25626988, PMCID: PMC4515973, DOI: 10.1002/hep.27720.
• Beyond scar formation: Portal myofibroblast‐mediated angiogenesis in the fibrotic liverFausther M, Dranoff JA. Beyond scar formation: Portal myofibroblast‐mediated angiogenesis in the fibrotic liver Hepatology 2015, 61: 766-768. PMID: 25502320, PMCID: PMC5115210, DOI: 10.1002/hep.27653.
• Macrophage Heterogeneity in Liver Injury: You Are Now Leaving KupffertownDranoff JA. Macrophage Heterogeneity in Liver Injury: You Are Now Leaving Kupffertown Gastroenterology 2014, 147: 1430-1431. PMID: 25457848, DOI: 10.1053/j.gastro.2014.10.020.
• MCP‐1 downregulates MMP‐9 export via vesicular redistribution to lysosomes in rat portal fibroblastsHickman DA, Syal G, Fausther M, Lavoie EG, Goree JR, Storrie B, Dranoff JA. MCP‐1 downregulates MMP‐9 export via vesicular redistribution to lysosomes in rat portal fibroblasts Physiological Reports 2014, 2: e12153. PMID: 25413315, PMCID: PMC4255798, DOI: 10.14814/phy2.12153.
• Proten Shakes: An Unusual Cause of Gastric Phytobezoar in a Health Obsessed PersonKlair J, Girotra M, Dranoff J, Aduli F. Proten Shakes: An Unusual Cause of Gastric Phytobezoar in a Health Obsessed Person The American Journal Of Gastroenterology 2014, 109: s250-s251. DOI: 10.14309/00000434-201410002-00855.
• Expression of mediators of purinergic signaling in human liver cell linesGoree JR, Lavoie EG, Fausther M, Dranoff JA. Expression of mediators of purinergic signaling in human liver cell lines Purinergic Signalling 2014, 10: 631-638. PMID: 25194703, PMCID: PMC4272373, DOI: 10.1007/s11302-014-9425-4.
• NT5E Mutations That Cause Human Disease Are Associated with Intracellular Mistrafficking of NT5E ProteinFausther M, Lavoie EG, Goree JR, Baldini G, Dranoff JA. NT5E Mutations That Cause Human Disease Are Associated with Intracellular Mistrafficking of NT5E Protein PLOS ONE 2014, 9: e98568. PMID: 24887587, PMCID: PMC4041762, DOI: 10.1371/journal.pone.0098568.
• How does coffee prevent liver fibrosis? biological plausibility for recent epidemiological observationsDranoff JA, Feld JJ, Lavoie É, Fausther M. How does coffee prevent liver fibrosis? biological plausibility for recent epidemiological observations Hepatology 2014, 60: 464-467. PMID: 24464631, PMCID: PMC4110162, DOI: 10.1002/hep.27032.
• Integrins, myofibroblasts, and organ fibrosisFausther M, Dranoff JA. Integrins, myofibroblasts, and organ fibrosis Hepatology 2014, 60: 756-758. PMID: 24700390, PMCID: PMC4110176, DOI: 10.1002/hep.27155.
• Pathological Changes in Pulmonary Circulation in Carbon Tetrachloride (ccl4)-Induced Cirrhotic MiceDas M, Boerma M, Goree JR, Lavoie EG, Fausther M, Gubrij IB, Pangle AK, Johnson LG, Dranoff JA. Pathological Changes in Pulmonary Circulation in Carbon Tetrachloride (ccl4)-Induced Cirrhotic Mice PLOS ONE 2014, 9: e96043. PMID: 24763616, PMCID: PMC3999097, DOI: 10.1371/journal.pone.0096043.
• P375 SORTILIN DEFICIENCY ABOLISHES DUCTULAR REACTION AND REDUCES HEPATOCYTE APOPTOSIS AND LIVER FIBROSIS IN BILE DUCT LIGATION-INDUCED CHOLESTASISZvibel I, Hubel E, Dranoff J, Park W, Lavoie E, Erez N, Fishman S, Bruck R. P375 SORTILIN DEFICIENCY ABOLISHES DUCTULAR REACTION AND REDUCES HEPATOCYTE APOPTOSIS AND LIVER FIBROSIS IN BILE DUCT LIGATION-INDUCED CHOLESTASIS Journal Of Hepatology 2014, 60: s193. DOI: 10.1016/s0168-8278(14)60537-7.
• [Successful eradication of genotype 4 HCV with telaprevir-based triple antiviral therapy].Deneke MG, Dranoff JA, Duarte-Rojo A. [Successful eradication of genotype 4 HCV with telaprevir-based triple antiviral therapy]. Revista De Gastroenterologia De Mexico 2014, 79: 64-6. PMID: 24679642, DOI: 10.1016/j.rgmx.2013.09.003.
• Posttranslational regulation of tissue inhibitor of metalloproteinase‐1 by calcium‐dependent vesicular exocytosisDranoff JA, Bhatia N, Fausther M, Lavoie EG, Granell S, Baldini G, Hickman DA, Sheung N. Posttranslational regulation of tissue inhibitor of metalloproteinase‐1 by calcium‐dependent vesicular exocytosis Physiological Reports 2013, 1: e00125. PMID: 24400134, PMCID: PMC3871447, DOI: 10.1002/phy2.125.
• Contribution of Myofibroblasts of Different Origins to Liver FibrosisFausther M, Lavoie EG, Dranoff JA. Contribution of Myofibroblasts of Different Origins to Liver Fibrosis Current Pathobiology Reports 2013, 1: 225-230. PMID: 23997993, PMCID: PMC3755779, DOI: 10.1007/s40139-013-0020-0.
• CXCL12 induces hepatic stellate cell contraction through a calcium-independent pathwaySaiman Y, Agarwal R, Hickman DA, Fausther M, El-Shamy A, Dranoff JA, Friedman SL, Bansal MB. CXCL12 induces hepatic stellate cell contraction through a calcium-independent pathway AJP Gastrointestinal And Liver Physiology 2013, 305: g375-g382. PMID: 23812037, PMCID: PMC3761245, DOI: 10.1152/ajpgi.00185.2012.
• Su1684 Adenosine Regulates Cholangiocyte IL-6 Secretion via the A2B ReceptorLavoie E, Yu J, Syal G, Fausther M, Dranoff J. Su1684 Adenosine Regulates Cholangiocyte IL-6 Secretion via the A2B Receptor Gastroenterology 2013, 144: s-996-s-997. DOI: 10.1016/s0016-5085(13)63701-4.
• Advances in cholangiocyte immunobiologySyal G, Fausther M, Dranoff JA. Advances in cholangiocyte immunobiology AJP Gastrointestinal And Liver Physiology 2012, 303: g1077-g1086. PMID: 22961800, PMCID: PMC3517647, DOI: 10.1152/ajpgi.00227.2012.
• Activated hepatic stellate cells upregulate transcription of ecto-5′-nucleotidase/CD73 via specific SP1 and SMAD promoter elementsFausther M, Sheung N, Saiman Y, Bansal MB, Dranoff JA. Activated hepatic stellate cells upregulate transcription of ecto-5′-nucleotidase/CD73 via specific SP1 and SMAD promoter elements AJP Gastrointestinal And Liver Physiology 2012, 303: g904-g914. PMID: 22899823, PMCID: PMC3469697, DOI: 10.1152/ajpgi.00015.2012.
• Erratum: Role of purinergic P2X receptors in the control of liver homeostasisFausther M, Gonzales E, Dranoff J. Erratum: Role of purinergic P2X receptors in the control of liver homeostasis Wiley Interdisciplinary Reviews Membrane Transport And Signalling 2012, 1: 829-829. DOI: 10.1002/wmts.60.
• Changes in LTCC protein expression and channel function in A7r5 cells by a truncated β subunitTelemaque S, Fausther M, Flynn S, Liu M, Singleton T, Dranoff J, Marsh J. Changes in LTCC protein expression and channel function in A7r5 cells by a truncated β subunit The FASEB Journal 2012, 26: lb638-lb638. DOI: 10.1096/fasebj.26.1_supplement.lb638.
• Role of purinergic P2X receptors in the control of liver homeostasisFausther M, Gonzales E, Dranoff JA. Role of purinergic P2X receptors in the control of liver homeostasis Wiley Interdisciplinary Reviews Membrane Transport And Signalling 2012, 1: 341-348. PMID: 22662313, PMCID: PMC3364537, DOI: 10.1002/wmts.32.
• Coexpression of ecto-5′-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liverFausther M, Lecka J, Soliman E, Kauffenstein G, Pelletier J, Sheung N, Dranoff JA, Sévigny J. Coexpression of ecto-5′-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver AJP Gastrointestinal And Liver Physiology 2011, 302: g447-g459. PMID: 22135310, PMCID: PMC3287391, DOI: 10.1152/ajpgi.00165.2011.
• New insights on the pathogenesis of biliary cirrhosis provided by studies in FXR knockout miceFausther M, Dranoff JA. New insights on the pathogenesis of biliary cirrhosis provided by studies in FXR knockout mice Journal Of Hepatology 2011, 55: 939-940. PMID: 21672564, PMCID: PMC3756144, DOI: 10.1016/j.jhep.2011.04.013.
• Activated Hepatic Stellate Cells Transcriptionally Upregulate Ecto-5'-Nucleotidase/CD73 via Specific Promoter ElementsFausther M, Dranoff J. Activated Hepatic Stellate Cells Transcriptionally Upregulate Ecto-5'-Nucleotidase/CD73 via Specific Promoter Elements Gastroenterology 2011, 140: s-915-s-916. DOI: 10.1016/s0016-5085(11)63798-0.
• Monocyte Chemoattractant Protein-1 Blocks Release of Matrix Metalloproteinase-9 From Portal Fibroblasts via Alterations in Vesicular TraffickingHickman D, Yu J, Sheung N, Dranoff J. Monocyte Chemoattractant Protein-1 Blocks Release of Matrix Metalloproteinase-9 From Portal Fibroblasts via Alterations in Vesicular Trafficking Gastroenterology 2011, 140: s-981. DOI: 10.1016/s0016-5085(11)64067-5.
• Biliary CirrhosisDranoff J. Biliary Cirrhosis 2010, 5: 467-473. DOI: 10.1007/978-1-4419-7107-4_31.
• Portal fibroblasts: Underappreciated mediators of biliary fibrosisDranoff JA, Wells RG. Portal fibroblasts: Underappreciated mediators of biliary fibrosis Hepatology 2009, 51: 1438-1444. PMID: 20209607, PMCID: PMC2850946, DOI: 10.1002/hep.23405.
• Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATPYu J, Sheung N, Soliman EM, Spirli C, Dranoff JA. Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP AJP Gastrointestinal And Liver Physiology 2009, 296: g563-g571. PMID: 19136380, PMCID: PMC2660176, DOI: 10.1152/ajpgi.90502.2008.
• Intracellular calcium signals regulate growth of hepatic stellate cells via specific effects on cell cycle progressionSoliman EM, Rodrigues MA, Gomes DA, Sheung N, Yu J, Amaya MJ, Nathanson MH, Dranoff JA. Intracellular calcium signals regulate growth of hepatic stellate cells via specific effects on cell cycle progression Cell Calcium 2009, 45: 284-292. PMID: 19131107, PMCID: PMC3018528, DOI: 10.1016/j.ceca.2008.11.006.
• Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibitionSohail MA, Hashmi AZ, Hakim W, Watanabe A, Zipprich A, Groszmann RJ, Dranoff JA, Torok NJ, Mehal WZ. Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition Hepatology 2008, 49: 185-194. PMID: 18844235, PMCID: PMC3129263, DOI: 10.1002/hep.22589.
• IL-6 downregulates transcription of NTPDase2 via specific promoter elementsYu J, Lavoie E, Sheung N, Tremblay JJ, Sévigny J, Dranoff JA. IL-6 downregulates transcription of NTPDase2 via specific promoter elements AJP Gastrointestinal And Liver Physiology 2008, 294: g748-g756. PMID: 18202114, PMCID: PMC5239663, DOI: 10.1152/ajpgi.00208.2007.
• Transforming growth factor‐β and substrate stiffness regulate portal fibroblast activation in cultureLi Z, Dranoff JA, Chan EP, Uemura M, Sévigny J, Wells RG. Transforming growth factor‐β and substrate stiffness regulate portal fibroblast activation in culture Hepatology 2007, 46: 1246-1256. PMID: 17625791, DOI: 10.1002/hep.21792.
• Succinate is a paracrine signal for liver damageCorrea PR, Kruglov EA, Thompson M, Leite MF, Dranoff JA, Nathanson MH. Succinate is a paracrine signal for liver damage Journal Of Hepatology 2007, 47: 262-269. PMID: 17451837, PMCID: PMC1986575, DOI: 10.1016/j.jhep.2007.03.016.
• The Spatial Distribution of Inositol 1,4,5-Trisphosphate Receptor Isoforms Shapes Ca2+ Waves*Hernandez E, Leite MF, Guerra MT, Kruglov EA, Bruna-Romero O, Rodrigues MA, Gomes DA, Giordano FJ, Dranoff JA, Nathanson MH. The Spatial Distribution of Inositol 1,4,5-Trisphosphate Receptor Isoforms Shapes Ca2+ Waves* Journal Of Biological Chemistry 2007, 282: 10057-10067. PMID: 17284437, PMCID: PMC2825872, DOI: 10.1074/jbc.m700746200.
• Molecular basis for calcium signaling in hepatic stellate cellsKruglov EA, Correa PR, Arora G, Yu J, Nathanson MH, Dranoff JA. Molecular basis for calcium signaling in hepatic stellate cells AJP Gastrointestinal And Liver Physiology 2007, 292: g975-g982. PMID: 17204544, DOI: 10.1152/ajpgi.00401.2006.
• Prevention of liver fibrosis by the purinoceptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS).Dranoff JA, Kruglov EA, Abreu-Lanfranco O, Nguyen T, Arora G, Jain D. Prevention of liver fibrosis by the purinoceptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS). In Vivo 2007, 21: 957-65. PMID: 18210741.
• Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8Fausther M, Lecka J, Kukulski F, Lévesque S, Pelletier J, Zimmermann H, Dranoff JA, Sévigny J. Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8 AJP Gastrointestinal And Liver Physiology 2006, 292: g785-g795. PMID: 17095758, PMCID: PMC3952495, DOI: 10.1152/ajpgi.00293.2006.
• Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cellsHashmi AZ, Hakim W, Kruglov EA, Watanabe A, Watkins W, Dranoff JA, Mehal WZ. Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cells AJP Gastrointestinal And Liver Physiology 2006, 292: g395-g401. PMID: 17053161, PMCID: PMC3224076, DOI: 10.1152/ajpgi.00208.2006.
• Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblastsKruglov EA, Nathanson RA, Nguyen T, Dranoff JA. Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts AJP Gastrointestinal And Liver Physiology 2005, 290: g765-g771. PMID: 16282363, DOI: 10.1152/ajpgi.00308.2005.
• The Anti-apoptotic Protein Mcl-1 Inhibits Mitochondrial Ca2+ Signals*Minagawa N, Kruglov EA, Dranoff JA, Robert ME, Gores GJ, Nathanson MH. The Anti-apoptotic Protein Mcl-1 Inhibits Mitochondrial Ca2+ Signals* Journal Of Biological Chemistry 2005, 280: 33637-33644. PMID: 16027162, DOI: 10.1074/jbc.m503210200.
• Portal Fibroblasts Regulate the Proliferation of Bile Duct Epithelia via Expression of NTPDase2*Jhandier MN, Kruglov EA, Lavoie É, Sévigny J, Dranoff JA. Portal Fibroblasts Regulate the Proliferation of Bile Duct Epithelia via Expression of NTPDase2* Journal Of Biological Chemistry 2005, 280: 22986-22992. PMID: 15799977, DOI: 10.1074/jbc.m412371200.
• Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary CirrhosisDranoff JA, Kruglov EA, Toure J, Braun N, Zimmermann H, Jain D, Knowles AF, Sévigny J. Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis Journal Of Investigative Medicine 2004, 52: 475. PMID: 15651265, DOI: 10.1136/jim-52-07-42.
• Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis.Dranoff J, Kruglov E, Toure J, Braun N, Zimmermann H, Jain D, Knowles A, Sévigny J. Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis. Journal Of Investigative Medicine 2004, 52: 475. DOI: 10.1097/00042871-200411000-00042.
• Ectonucleotidase NTPDase2 is Selectively Down-Regulated in Biliary CirrhosisDranoff J, Kruglov E, Toure J, Braun N, Zimmermann H, Jain D, Knowles A, Sévigny J. Ectonucleotidase NTPDase2 is Selectively Down-Regulated in Biliary Cirrhosis Journal Of Investigative Medicine 2004, 52: 475-482. DOI: 10.1177/108155890405200741.
• Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cellsDranoff JA, Ogawa M, Kruglov EA, Gaça M, Sévigny J, Robson SC, Wells RG. Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells AJP Gastrointestinal And Liver Physiology 2004, 287: g417-g424. PMID: 14764443, PMCID: PMC5241161, DOI: 10.1152/ajpgi.00294.2003.
• Autocrine release of TGF‐β by portal fibroblasts regulates cell growthWells RG, Kruglov E, Dranoff JA. Autocrine release of TGF‐β by portal fibroblasts regulates cell growth FEBS Letters 2004, 559: 107-110. PMID: 14960316, DOI: 10.1016/s0014-5793(04)00037-7.
• Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary CirrhosisDranoff J, Kruglov E, Toure J, Braun N, Zimmermann H, Jain D, Knowles A, Sévigny J. Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis Journal Of Investigative Medicine 2004, 52: 475. DOI: 10.2310/6650.2004.00710.
• Molecular Biology and Immunology in HepatologyDranoff J. Molecular Biology and Immunology in Hepatology Journal Of Clinical Gastroenterology 2003, 37: 352. DOI: 10.1097/00004836-200310000-00020.
• 377 The ecto-nucleotidase NTPDase2 selectively down-regulated in biliary fibrosisKruglov E, Toure J, Jhandier M, Jain D, Sévigny J, Robson S, Dranoff J. 377 The ecto-nucleotidase NTPDase2 selectively down-regulated in biliary fibrosis Hepatology 2003, 38: 341. DOI: 10.1016/s0270-9139(03)80420-2.
• 1101 Portal fibroblasts attenuate proliferation of bile duct epithelia through blockade of purinergic stimulation of MAP kinasesJhandier M, Kruglov E, Dranoff J. 1101 Portal fibroblasts attenuate proliferation of bile duct epithelia through blockade of purinergic stimulation of MAP kinases Hepatology 2003, 38: 686. DOI: 10.1016/s0270-9139(03)81139-4.
• The ecto‐nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liverDranoff JA, Kruglov EA, Robson SC, Braun N, Zimmermann H, Sévigny J. The ecto‐nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver Hepatology 2002, 36: 1135-1144. PMID: 12395323, DOI: 10.1053/jhep.2002.36823.
• Isolation of Primary Rat Liver FibroblastsKruglov EA, Jain D, Dranoff JA. Isolation of Primary Rat Liver Fibroblasts Journal Of Investigative Medicine 2002, 50: 179. PMID: 12033282, DOI: 10.2310/6650.2002.33431.
• The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytesHirata K, Pusl T, O'Neill AF, Dranoff JA, Nathanson MH. The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes Gastroenterology 2002, 122: 1088-1100. PMID: 11910359, DOI: 10.1053/gast.2002.32363.
• Polarized expression and function of P2Y ATP receptors in rat bile duct epitheliaDranoff J, Masyuk A, Kruglov E, LaRusso N, Nathanson M. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia AJP Gastrointestinal And Liver Physiology 2001, 281: g1059-g1067. PMID: 11557527, DOI: 10.1152/ajpgi.2001.281.4.g1059.
• The nucleotide triphosphate dihydrolases CD39 and CD39L1 are expressed in distinct compartments within the rat liverDranoff J, Kruglov E, Robson S. The nucleotide triphosphate dihydrolases CD39 and CD39L1 are expressed in distinct compartments within the rat liver Gastroenterology 2001, 120: a91. DOI: 10.1016/s0016-5085(08)80449-0.
• The nucleotide triphosphate dihydrolases CD39 and CD39L1 are expressed in distinct compartments within the rat liverDRANOFF J, KRUGLOV E, ROBSON S. The nucleotide triphosphate dihydrolases CD39 and CD39L1 are expressed in distinct compartments within the rat liver Gastroenterology 2001, 120: a91-a91. DOI: 10.1016/s0016-5085(01)80449-2.
• A Primitive ATP Receptor from the Little Skate Raja erinacea *Dranoff J, O'Neill A, Franco A, Cai S, Connolly G, Ballatori N, Boyer J, Nathanson M. A Primitive ATP Receptor from the Little Skate Raja erinacea * Journal Of Biological Chemistry 2000, 275: 30701-30706. PMID: 10900200, DOI: 10.1074/jbc.m003366200.
• It's swell to have ATP in the liverDranoff J, Nathanson M. It's swell to have ATP in the liver Journal Of Hepatology 2000, 33: 323-325. PMID: 10952251, DOI: 10.1016/s0168-8278(00)80374-8.
• Molecular identification of a primitive P2Y ATP receptor in liver from the little skate Raja erinaceaDranoff J, O’Neill A, Cai S, Franco A, Connelly G, Ballatori N, Boyer J, Nathanson M. Molecular identification of a primitive P2Y ATP receptor in liver from the little skate Raja erinacea Gastroenterology 2000, 118: a911. DOI: 10.1016/s0016-5085(00)85777-7.
• Transnasal endoscopy for enteral feeding tube placement in critically ill patientsDranoff J, Angood P, Topazian M. Transnasal endoscopy for enteral feeding tube placement in critically ill patients The American Journal Of Gastroenterology 1999, 94: ajg1999650. PMID: 10520841, DOI: 10.1111/j.1572-0241.1999.01434.x.
• Short‐term regulation of bile acid uptake by microfilament‐dependent translocation of rat ntcp to the plasma membraneDranoff J, McClure M, Burgstahler A, Denson L, Crawford A, Crawford J, Karpen S, Nathanson M. Short‐term regulation of bile acid uptake by microfilament‐dependent translocation of rat ntcp to the plasma membrane Hepatology 1999, 30: 223-229. PMID: 10385660, DOI: 10.1002/hep.510300136.
• Regulation of bile acid transport: Beyond molecular cloningDranoff J, Nathanson M. Regulation of bile acid transport: Beyond molecular cloning Hepatology 1999, 29: 1912-1913. PMID: 10347140, DOI: 10.1002/hep.510290643.
• Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells.Leite MF, Dranoff JA, Gao L, Nathanson MH. Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells. Biochemical Journal 1999, 337 ( Pt 2): 305-9. PMID: 9882629, PMCID: PMC1219966, DOI: 10.1042/0264-6021:3370305.
• Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cellsLEITE M, DRANOFF J, Ling G, NATHANSON M. Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells Biochemical Journal 1999, 337: 305-309. DOI: 10.1042/bj3370305.
• Stimulation of bile duct epithelial secretion by glybenclamide in normal and cholestatic rat liver.Nathanson MH, Burgstahler AD, Mennone A, Dranoff JA, Rios-Velez L. Stimulation of bile duct epithelial secretion by glybenclamide in normal and cholestatic rat liver. Journal Of Clinical Investigation 1998, 101: 2665-2676. PMID: 9637700, PMCID: PMC508857, DOI: 10.1172/jci2835.
• Kruglov EA, Nathanson RA, Nguyen T, Dranoff JA. Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts. Am. J. Physiol. 290:G765-71 (2006). Kruglov EA, Nathanson RA, Nguyen T, Dranoff JA. Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts. Am. J. Physiol. 290:G765-71 (2006).
• Minagawa N, Kruglov EA, Dranoff JA, Robert ME, Gores GF, and Nathanson MH. The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals. J. Biol. Chem. 280:33637-44 (2005). Minagawa N, Kruglov EA, Dranoff JA, Robert ME, Gores GF, and Nathanson MH. The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals. J. Biol. Chem. 280:33637-44 (2005).
• Jhandier MN, Kruglov EA, Lavoie EG, Sevigny J, and Dranoff JA. Portal Fibroblasts Regluate the Prolferation of Bile Duct Epithelia via Expression of NTPDase2. J. Biol. Chem. 280: 22986-92(2005). Jhandier MN, Kruglov EA, Lavoie EG, Sevigny J, and Dranoff JA. Portal Fibroblasts Regluate the Prolferation of Bile Duct Epithelia via Expression of NTPDase2. J. Biol. Chem. 280: 22986-92(2005).
• Dranoff JA, Kruglov EA, Toure J, Braun N, Zimmermann H, Jain D, Knowles AF, and Sevigny J, The Ectonucleotidase NTPDase2 is Selectively Down-Regulated in Biliary Fibrosis, J. Invest. Med. 52:475-82 (2004). Dranoff JA, Kruglov EA, Toure J, Braun N, Zimmermann H, Jain D, Knowles AF, and Sevigny J, The Ectonucleotidase NTPDase2 is Selectively Down-Regulated in Biliary Fibrosis, J. Invest. Med. 52:475-82 (2004).
• Dranoff JA, Ogawa M, Kruglov EA, Gaca MD, Sevigny J, Robson SC, Wells RG. Expression of P2Y Nucleotide Receptors and Ecto-Nucleotidases in Quiescent and Activated Hepatic Stellate Cells. Am. J. Physiol. 287:G417-24 (2004). Dranoff JA, Ogawa M, Kruglov EA, Gaca MD, Sevigny J, Robson SC, Wells RG. Expression of P2Y Nucleotide Receptors and Ecto-Nucleotidases in Quiescent and Activated Hepatic Stellate Cells. Am. J. Physiol. 287:G417-24 (2004).