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Jonathan Dranoff, MD

Contact Information

Jonathan Dranoff, MD

Office Location

Mailing Address

  • Yale School of Medicine

    Department of Medicine (Digestive Diseases), PO Box 208019

    New Haven, CT 06520-8019

    United States

Research Summary

My primary research activities at this time focus on pathogenesis and management of fatty liver disease, acetaminophen hepatotoxicity, liver fibrosis, and noninvasive assessment of chronic liver disease.

Coauthors

Research Interests

Acetaminophen; Fibrosis; Liver Cirrhosis; Chemical and Drug Induced Liver Injury; Non-alcoholic Fatty Liver Disease

Selected Publications

  • FRI-208 Leukemia inhibitory factor induces cholangiocyte proliferation and corrects the impaired bile duct proliferation in sortilin-deficient mice following cholestatic injuryZvibel I, Hubel E, Avraham R, Lavoie E, Fishman S, Dranoff J, Shibolet O. FRI-208 Leukemia inhibitory factor induces cholangiocyte proliferation and corrects the impaired bile duct proliferation in sortilin-deficient mice following cholestatic injury Journal Of Hepatology 2018, 68: s453-s454. DOI: 10.1016/s0168-8278(18)31150-4.
  • I drink for my liver, Doc: emerging evidence that coffee prevents cirrhosisFeld J, Lavoie É, Fausther M, Dranoff J. I drink for my liver, Doc: emerging evidence that coffee prevents cirrhosis F1000Research 2015, 4: 95. DOI: 10.12688/f1000research.6368.1.
  • Proten Shakes: An Unusual Cause of Gastric Phytobezoar in a Health Obsessed PersonKlair J, Girotra M, Dranoff J, Aduli F. Proten Shakes: An Unusual Cause of Gastric Phytobezoar in a Health Obsessed Person The American Journal Of Gastroenterology 2014, 109: s250-s251. DOI: 10.14309/00000434-201410002-00855.
  • P375 SORTILIN DEFICIENCY ABOLISHES DUCTULAR REACTION AND REDUCES HEPATOCYTE APOPTOSIS AND LIVER FIBROSIS IN BILE DUCT LIGATION-INDUCED CHOLESTASISZvibel I, Hubel E, Dranoff J, Park W, Lavoie E, Erez N, Fishman S, Bruck R. P375 SORTILIN DEFICIENCY ABOLISHES DUCTULAR REACTION AND REDUCES HEPATOCYTE APOPTOSIS AND LIVER FIBROSIS IN BILE DUCT LIGATION-INDUCED CHOLESTASIS Journal Of Hepatology 2014, 60: s193. DOI: 10.1016/s0168-8278(14)60537-7.
  • Su1684 Adenosine Regulates Cholangiocyte IL-6 Secretion via the A2B ReceptorLavoie E, Yu J, Syal G, Fausther M, Dranoff J. Su1684 Adenosine Regulates Cholangiocyte IL-6 Secretion via the A2B Receptor Gastroenterology 2013, 144: s-996-s-997. DOI: 10.1016/s0016-5085(13)63701-4.
  • Erratum: Role of purinergic P2X receptors in the control of liver homeostasisFausther M, Gonzales E, Dranoff J. Erratum: Role of purinergic P2X receptors in the control of liver homeostasis Wiley Interdisciplinary Reviews Membrane Transport And Signalling 2012, 1: 829-829. DOI: 10.1002/wmts.60.
  • Changes in LTCC protein expression and channel function in A7r5 cells by a truncated β subunitTelemaque S, Fausther M, Flynn S, Liu M, Singleton T, Dranoff J, Marsh J. Changes in LTCC protein expression and channel function in A7r5 cells by a truncated β subunit The FASEB Journal 2012, 26: lb638-lb638. DOI: 10.1096/fasebj.26.1_supplement.lb638.
  • Activated Hepatic Stellate Cells Transcriptionally Upregulate Ecto-5'-Nucleotidase/CD73 via Specific Promoter ElementsFausther M, Dranoff J. Activated Hepatic Stellate Cells Transcriptionally Upregulate Ecto-5'-Nucleotidase/CD73 via Specific Promoter Elements Gastroenterology 2011, 140: s-915-s-916. DOI: 10.1016/s0016-5085(11)63798-0.
  • Monocyte Chemoattractant Protein-1 Blocks Release of Matrix Metalloproteinase-9 From Portal Fibroblasts via Alterations in Vesicular TraffickingHickman D, Yu J, Sheung N, Dranoff J. Monocyte Chemoattractant Protein-1 Blocks Release of Matrix Metalloproteinase-9 From Portal Fibroblasts via Alterations in Vesicular Trafficking Gastroenterology 2011, 140: s-981. DOI: 10.1016/s0016-5085(11)64067-5.
  • Biliary CirrhosisDranoff J. Biliary Cirrhosis 2010, 5: 467-473. DOI: 10.1007/978-1-4419-7107-4_31.
  • Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis.Dranoff J, Kruglov E, Toure J, Braun N, Zimmermann H, Jain D, Knowles A, Sévigny J. Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis. Journal Of Investigative Medicine 2004, 52: 475. DOI: 10.1097/00042871-200411000-00042.
  • Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary CirrhosisDranoff J, Kruglov E, Toure J, Braun N, Zimmermann H, Jain D, Knowles A, Sévigny J. Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis Journal Of Investigative Medicine 2004, 52: 475. DOI: 10.2310/6650.2004.00710.
  • Molecular Biology and Immunology in HepatologyDranoff J. Molecular Biology and Immunology in Hepatology Journal Of Clinical Gastroenterology 2003, 37: 352. DOI: 10.1097/00004836-200310000-00020.
  • 377 The ecto-nucleotidase NTPDase2 selectively down-regulated in biliary fibrosisKruglov E, Toure J, Jhandier M, Jain D, Sévigny J, Robson S, Dranoff J. 377 The ecto-nucleotidase NTPDase2 selectively down-regulated in biliary fibrosis Hepatology 2003, 38: 341. DOI: 10.1016/s0270-9139(03)80420-2.
  • 1101 Portal fibroblasts attenuate proliferation of bile duct epithelia through blockade of purinergic stimulation of MAP kinasesJhandier M, Kruglov E, Dranoff J. 1101 Portal fibroblasts attenuate proliferation of bile duct epithelia through blockade of purinergic stimulation of MAP kinases Hepatology 2003, 38: 686. DOI: 10.1016/s0270-9139(03)81139-4.
  • Polarized expression and function of P2Y ATP receptors in rat bile duct epitheliaDranoff J, Masyuk A, Kruglov E, LaRusso N, Nathanson M. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia AJP Gastrointestinal And Liver Physiology 2001, 281: g1059-g1067. PMID: 11557527, DOI: 10.1152/ajpgi.2001.281.4.g1059.
  • The nucleotide triphosphate dihydrolases CD39 and CD39L1 are expressed in distinct compartments within the rat liverDranoff J, Kruglov E, Robson S. The nucleotide triphosphate dihydrolases CD39 and CD39L1 are expressed in distinct compartments within the rat liver Gastroenterology 2001, 120: a91. DOI: 10.1016/s0016-5085(08)80449-0.
  • The nucleotide triphosphate dihydrolases CD39 and CD39L1 are expressed in distinct compartments within the rat liverDRANOFF J, KRUGLOV E, ROBSON S. The nucleotide triphosphate dihydrolases CD39 and CD39L1 are expressed in distinct compartments within the rat liver Gastroenterology 2001, 120: a91-a91. DOI: 10.1016/s0016-5085(01)80449-2.
  • A Primitive ATP Receptor from the Little Skate Raja erinacea *Dranoff J, O'Neill A, Franco A, Cai S, Connolly G, Ballatori N, Boyer J, Nathanson M. A Primitive ATP Receptor from the Little Skate Raja erinacea * Journal Of Biological Chemistry 2000, 275: 30701-30706. PMID: 10900200, DOI: 10.1074/jbc.m003366200.
  • It's swell to have ATP in the liverDranoff J, Nathanson M. It's swell to have ATP in the liver Journal Of Hepatology 2000, 33: 323-325. PMID: 10952251, DOI: 10.1016/s0168-8278(00)80374-8.
  • Molecular identification of a primitive P2Y ATP receptor in liver from the little skate Raja erinaceaDranoff J, O’Neill A, Cai S, Franco A, Connelly G, Ballatori N, Boyer J, Nathanson M. Molecular identification of a primitive P2Y ATP receptor in liver from the little skate Raja erinacea Gastroenterology 2000, 118: a911. DOI: 10.1016/s0016-5085(00)85777-7.
  • Transnasal endoscopy for enteral feeding tube placement in critically ill patientsDranoff J, Angood P, Topazian M. Transnasal endoscopy for enteral feeding tube placement in critically ill patients The American Journal Of Gastroenterology 1999, 94: ajg1999650. PMID: 10520841, DOI: 10.1111/j.1572-0241.1999.01434.x.
  • Short‐term regulation of bile acid uptake by microfilament‐dependent translocation of rat ntcp to the plasma membraneDranoff J, McClure M, Burgstahler A, Denson L, Crawford A, Crawford J, Karpen S, Nathanson M. Short‐term regulation of bile acid uptake by microfilament‐dependent translocation of rat ntcp to the plasma membrane Hepatology 1999, 30: 223-229. PMID: 10385660, DOI: 10.1002/hep.510300136.
  • Regulation of bile acid transport: Beyond molecular cloningDranoff J, Nathanson M. Regulation of bile acid transport: Beyond molecular cloning Hepatology 1999, 29: 1912-1913. PMID: 10347140, DOI: 10.1002/hep.510290643.
  • Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cellsLEITE M, DRANOFF J, Ling G, NATHANSON M. Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells Biochemical Journal 1999, 337: 305-309. DOI: 10.1042/bj3370305.
  • Kruglov EA, Nathanson RA, Nguyen T, Dranoff JA. Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts. Am. J. Physiol. 290:G765-71 (2006). Kruglov EA, Nathanson RA, Nguyen T, Dranoff JA. Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts. Am. J. Physiol. 290:G765-71 (2006).
  • Minagawa N, Kruglov EA, Dranoff JA, Robert ME, Gores GF, and Nathanson MH. The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals. J. Biol. Chem. 280:33637-44 (2005). Minagawa N, Kruglov EA, Dranoff JA, Robert ME, Gores GF, and Nathanson MH. The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals. J. Biol. Chem. 280:33637-44 (2005).
  • Jhandier MN, Kruglov EA, Lavoie EG, Sevigny J, and Dranoff JA. Portal Fibroblasts Regluate the Prolferation of Bile Duct Epithelia via Expression of NTPDase2. J. Biol. Chem. 280: 22986-92(2005). Jhandier MN, Kruglov EA, Lavoie EG, Sevigny J, and Dranoff JA. Portal Fibroblasts Regluate the Prolferation of Bile Duct Epithelia via Expression of NTPDase2. J. Biol. Chem. 280: 22986-92(2005).
  • Dranoff JA, Kruglov EA, Toure J, Braun N, Zimmermann H, Jain D, Knowles AF, and Sevigny J, The Ectonucleotidase NTPDase2 is Selectively Down-Regulated in Biliary Fibrosis, J. Invest. Med. 52:475-82 (2004). Dranoff JA, Kruglov EA, Toure J, Braun N, Zimmermann H, Jain D, Knowles AF, and Sevigny J, The Ectonucleotidase NTPDase2 is Selectively Down-Regulated in Biliary Fibrosis, J. Invest. Med. 52:475-82 (2004).
  • Dranoff JA, Ogawa M, Kruglov EA, Gaca MD, Sevigny J, Robson SC, Wells RG. Expression of P2Y Nucleotide Receptors and Ecto-Nucleotidases in Quiescent and Activated Hepatic Stellate Cells. Am. J. Physiol. 287:G417-24 (2004). Dranoff JA, Ogawa M, Kruglov EA, Gaca MD, Sevigny J, Robson SC, Wells RG. Expression of P2Y Nucleotide Receptors and Ecto-Nucleotidases in Quiescent and Activated Hepatic Stellate Cells. Am. J. Physiol. 287:G417-24 (2004).
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