James A. Giles
MD, PhD, MPHS, MRCP
he/him/his
Assistant Professor
Research & Publications
Biography
Coauthors
Selected Publications
- Predictors of Recurrent Venous Thrombosis After Cerebral Venous ThrombosisShu L, Bakradze E, Omran SS, Giles J, Amar J, Henninger N, Elnazeir M, Liberman A, Moncrieffe K, Rotblat J, Sharma R, Cheng Y, Zubair AS, Simpkins A, Li G, Kung J, Perez D, Heldner MR, Scutelnic A, von Martial R, Siepen B, Rothstein A, Khazaal O, Do D, Al Kasab S, Rahman LA, Mistry EA, Kerrigan D, Lafever H, Nguyen TN, Klein P, Aparicio HJ, Frontera JA, Kuohn L, Agarwal S, Stretz C, Kala N, ElJamal S, Chang A, Cutting S, Indraswari F, de Havenon A, Muddasani V, Wu T, Wilson D, Nouh A, Asad D, Qureshi A, Moore J, Khatri P, Aziz Y, Casteigne B, Khan M, Cheng Y, Grory BM, Weiss M, Ryan D, Vedovati MC, Paciaroni M, Siegler J, Kamen S, Yu S, Guerrero CL, Atallah E, De Marchis GM, Brehm A, Dittrich T, Psychogios M, Alvarado-Dyer R, Kass-Hout T, Prabhakaran S, Honda T, Liebeskind D, Furie K, Yaghi S. Predictors of Recurrent Venous Thrombosis After Cerebral Venous Thrombosis. Neurology 2022, 99: e2368-e2377. PMID: 36123126, PMCID: PMC9687409, DOI: 10.1212/wnl.0000000000201122.
- Direct Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International StudyYaghi S, Shu L, Bakradze E, Omran S, Giles JA, Amar JY, Henninger N, Elnazeir M, Liberman AL, Moncrieffe K, Lu J, Sharma R, Cheng Y, Zubair AS, Simpkins AN, Li GT, Kung JC, Perez D, Heldner M, Scutelnic A, Seiffge D, Siepen B, Rothstein A, Khazaal O, Do D, Kasab SA, Rahman LA, Mistry EA, Kerrigan D, Lafever H, Nguyen TN, Klein P, Aparicio H, Frontera J, Kuohn L, Agarwal S, Stretz C, Kala N, Jamal S, Chang A, Cutting S, Xiao H, de Havenon A, Muddasani V, Wu T, Wilson D, Nouh A, Asad SD, Qureshi A, Moore J, Khatri P, Aziz Y, Casteigne B, Khan M, Cheng Y, Grory B, Weiss M, Ryan D, Vedovati MC, Paciaroni M, Siegler JE, Kamen S, Yu S, Guerrero C, Atallah E, De Marchis GM, Brehm A, Dittrich T, Psychogios M, Alvarado-Dyer R, Kass-Hout T, Prabhakaran S, Honda T, Liebeskind DS, Furie K. Direct Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study. Stroke 2022, 53: 728-738. PMID: 35143325, DOI: 10.1161/strokeaha.121.037541.
- Endovascular Treatment of Acute Stroke.Giles JA, Vellimana AK, Adeoye OM. Endovascular Treatment of Acute Stroke. Current Neurology And Neuroscience Reports 2022, 22: 83-91. PMID: 35098425, DOI: 10.1007/s11910-022-01168-9.
- Non-Vitamin K Antagonist Oral Anticoagulants for the Treatment of Cerebral Venous Sinus Thrombosis: a Retrospective, Matched Cohort Analysis.Giles JA, Balasetti VKS, Zazulia AR. Non-Vitamin K Antagonist Oral Anticoagulants for the Treatment of Cerebral Venous Sinus Thrombosis: a Retrospective, Matched Cohort Analysis. Neurocritical Care 2021, 35: 783-788. PMID: 34046861, DOI: 10.1007/s12028-021-01244-x.
- Blood Pressure Trajectory Groups and Outcome After Endovascular Thrombectomy: A Multicenter StudyPetersen NH, Kodali S, Meng C, Li F, Nguyen CK, Peshwe KU, Strander S, Silverman A, Kimmel A, Wang A, Anadani M, Almallouhi E, Spiotta AM, Kim JT, Giles JA, Keyrouz SG, Farooqui M, Zevallos C, Maier IL, Psychogios MN, Liman J, Riou-Comte N, Richard S, Gory B, Wolfe S, Brown PA, Fargen KM, Mistry EA, Fakhri H, Mistry AM, Wong KH, de Havenon A, Nascimento FA, Kan P, Matouk C, Ortega-Gutiérrez S, Sheth KN. Blood Pressure Trajectory Groups and Outcome After Endovascular Thrombectomy: A Multicenter Study. Stroke 2021, 53: 1216-1225. PMID: 34781705, PMCID: PMC8960326, DOI: 10.1161/strokeaha.121.034408.
- Differential effect of mechanical thrombectomy and intravenous thrombolysis in atrial fibrillation associated stroke.Akbik F, Alawieh A, Cawley CM, Howard BM, Tong FC, Nahab F, Saad H, Dimisko L, Mustroph C, Samuels OB, Pradilla G, Maier I, Goyal N, Starke RM, Rai A, Fargen KM, Psychogios MN, Jabbour P, De Leacy R, Giles J, Dumont TM, Kan P, Arthur AS, Crosa RJ, Gory B, Spiotta AM, Grossberg JA. Differential effect of mechanical thrombectomy and intravenous thrombolysis in atrial fibrillation associated stroke. Journal Of Neurointerventional Surgery 2021, 13: 883-888. PMID: 33318066, PMCID: PMC8377613, DOI: 10.1136/neurintsurg-2020-016720.
- Central Triage of Acute Stroke Patients Across a Distributive Stroke Network Is Safe and Reduces Transfer Denials.Holder D, Leeseberg K, Giles JA, Lee JM, Namazie S, Ford AL. Central Triage of Acute Stroke Patients Across a Distributive Stroke Network Is Safe and Reduces Transfer Denials. Stroke; A Journal Of Cerebral Circulation 2021, 52: 2671-2675. PMID: 34154389, PMCID: PMC8316396, DOI: 10.1161/STROKEAHA.120.033018.
- Effect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke StudyYaghi S, Mistry E, de Havenon A, Guerrero C, Nouh A, Liberman AL, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Grory B, Fakhri H, Espaillat K, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini‐Naghani I, Siddu M, Scher E, Trivedi T, Wu T, Khan M, Keyrouz S, Furie K, Henninger N. Effect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke Study. Journal Of The American Heart Association 2021, 10: e020945. PMID: 34323120, PMCID: PMC8475683, DOI: 10.1161/jaha.121.020945.
- Ischaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC studyYaghi S, Henninger N, Giles JA, Guerrero C, Mistry E, Liberman AL, Asad D, Liu A, Nagy M, Kaushal A, Azher I, Grory B, Fakhri H, Espaillat K, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Trivedi T, Furie KL, Keyrouz SG, Nouh A, de Havenon A, Khan M, Smith EE, Gurol ME. Ischaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study. Journal Of Neurology Neurosurgery & Psychiatry 2021, 92: 1062-1067. PMID: 33903185, PMCID: PMC8448925, DOI: 10.1136/jnnp-2021-326166.
- Thrombectomy Technique Predicts Outcome in Posterior Circulation Stroke-Insights from the STAR Collaboration.Alawieh AM, Eid M, Anadani M, Sattur M, Maier IL, Feng W, Goyal N, Starke RM, Rai A, Fargen KM, Psychogios MN, De Leacy R, Grossberg JA, Keyrouz SG, Dumont TM, Kan P, Lena J, Liman J, Arthur AS, Elijovich L, Mccarthy DJ, Saini V, Wolfe SQ, Mocco J, Fifi JT, Nascimento FA, Giles JA, Allen M, Crosa R, Fox WC, Gory B, Spiotta AM. Thrombectomy Technique Predicts Outcome in Posterior Circulation Stroke-Insights from the STAR Collaboration. Neurosurgery 2020, 87: 982-991. PMID: 32433730, DOI: 10.1093/neuros/nyaa179.
- Anticoagulation Timing in Cardioembolic Stroke and Recurrent Event Risk.Yaghi S, Trivedi T, Henninger N, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Brown Espaillat K, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Liberman AL, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Leon Guerrero CR, Khan M, Nouh A, Mistry E, Keyrouz S, Furie K. Anticoagulation Timing in Cardioembolic Stroke and Recurrent Event Risk. Annals Of Neurology 2020, 88: 807-816. PMID: 32656768, PMCID: PMC8259451, DOI: 10.1002/ana.25844.
- Using electrodiagnostics to define injury patterns amenable to nerve transfer surgery in tetraplegia: an illustrative case report.Hill EJR, El-Haj M, Giles JA, Fox IK. Using electrodiagnostics to define injury patterns amenable to nerve transfer surgery in tetraplegia: an illustrative case report. Spinal Cord Series And Cases 2020, 6: 78. PMID: 32826861, PMCID: PMC7442626, DOI: 10.1038/s41394-020-00325-x.
- Anticoagulation Type and Early Recurrence in Cardioembolic StrokeYaghi S, Mistry E, Liberman AL, Giles J, Asad SD, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Brown Espaillat K, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Trivedi T, Lord A, Furie K, Keyrouz S, Nouh A, Leon Guerrero CR, de Havenon A, Khan M, Henninger N. Anticoagulation Type and Early Recurrence in Cardioembolic Stroke. Stroke 2020, 51: 2724-2732. PMID: 32757753, PMCID: PMC7484360, DOI: 10.1161/strokeaha.120.028867.
- Early ischaemic and haemorrhagic complications after atrial fibrillation-related ischaemic stroke: analysis of the IAC study.Yaghi S, Henninger N, Scher E, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Espaillat KB, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Liberman AL, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Trivedi T, Leon Guerrero CR, Khan M, Nouh A, Mistry E, Keyrouz S, Furie K. Early ischaemic and haemorrhagic complications after atrial fibrillation-related ischaemic stroke: analysis of the IAC study. Journal Of Neurology, Neurosurgery, And Psychiatry 2020, 91: 750-755. PMID: 32404380, PMCID: PMC8179007, DOI: 10.1136/jnnp-2020-323041.
- Blood Pressure Goals and Clinical Outcomes after Successful Endovascular Therapy: A Multicenter Study.Anadani M, Arthur AS, Tsivgoulis G, Simpson KN, Alawieh A, Orabi Y, Goyal N, Alexandrov AV, Maier IL, Psychogios MN, Liman J, Brinton D, Swisher CB, Shah S, Inamullah O, Keyrouz S, Kansagra AP, Allen M, Giles JA, Wolfe SQ, Fargen KM, Gory B, De Marini P, Kan P, Nascimento FA, Almallouhi E, Petersen N, Kodali S, Rahman S, Richard S, Spiotta AM. Blood Pressure Goals and Clinical Outcomes after Successful Endovascular Therapy: A Multicenter Study. Annals Of Neurology 2020, 87: 830-839. PMID: 32187711, DOI: 10.1002/ana.25716.
- Factors associated with therapeutic anticoagulation status in patients with ischemic stroke and atrial fibrillationYaghi S, Liberman AL, Henninger N, Grory BM, Nouh A, Scher E, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Fakhri H, Espaillat KB, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Trivedi T, Ishida K, Frontera J, Lord A, Furie K, Keyrouz S, de Havenon A, Mistry E, Leon Guerrero CR, Khan M. Factors associated with therapeutic anticoagulation status in patients with ischemic stroke and atrial fibrillation. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 104888. PMID: 32414583, PMCID: PMC8207529, DOI: 10.1016/j.jstrokecerebrovasdis.2020.104888.
- Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter studyAnadani M, Arthur AS, Alawieh A, Orabi Y, Alexandrov A, Goyal N, Psychogios MN, Maier I, Kim JT, Keyrouz SG, de Havenon A, Petersen NH, Pandhi A, Swisher CB, Inamullah O, Liman J, Kodali S, Giles JA, Allen M, Wolfe SQ, Tsivgoulis G, Cagle BA, Oravec CS, Gory B, De Marini P, Kan P, Rahman S, Richard S, Nascimento FA, Spiotta A. Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study. Journal Of NeuroInterventional Surgery 2019, 12: 932-936. PMID: 31806668, PMCID: PMC7998040, DOI: 10.1136/neurintsurg-2019-015561.
- Blood Pressure and Outcome After Mechanical Thrombectomy With Successful Revascularization.Anadani M, Orabi MY, Alawieh A, Goyal N, Alexandrov AV, Petersen N, Kodali S, Maier IL, Psychogios MN, Swisher CB, Inamullah O, Kansagra AP, Giles JA, Wolfe SQ, Singh J, Gory B, De Marini P, Kan P, Nascimento FA, Freire LI, Pandhi A, Mitchell H, Kim JT, Fargen KM, Al Kasab S, Liman J, Rahman S, Allen M, Richard S, Spiotta AM. Blood Pressure and Outcome After Mechanical Thrombectomy With Successful Revascularization. Stroke; A Journal Of Cerebral Circulation 2019, 50: 2448-2454. PMID: 31318633, DOI: 10.1161/STROKEAHA.118.024687.
- "You understand that whole big situation they're in": interpretative phenomenological analysis of peer-assisted learning.Tamachi S, Giles JA, Dornan T, Hill EJR. "You understand that whole big situation they're in": interpretative phenomenological analysis of peer-assisted learning. BMC Medical Education 2018, 18: 197. PMID: 30107801, PMCID: PMC6092812, DOI: 10.1186/s12909-018-1291-2.
- Neutrophil infiltration to the brain is platelet-dependent, and is reversed by blockade of platelet GPIbα.Giles JA, Greenhalgh AD, Denes A, Nieswandt B, Coutts G, McColl BW, Allan SM. Neutrophil infiltration to the brain is platelet-dependent, and is reversed by blockade of platelet GPIbα. Immunology 2018, 154: 322-328. PMID: 29325217, PMCID: PMC5979746, DOI: 10.1111/imm.12892.
- Examining our hidden curricula: powerful, visible, gendered and discriminatory.Giles JA, Hill EJ. Examining our hidden curricula: powerful, visible, gendered and discriminatory. Medical Education 2015, 49: 244-6. PMID: 25693983, DOI: 10.1111/medu.12664.
- Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity.Giles JA, Greenhalgh AD, Davies CL, Denes A, Shaw T, Coutts G, Rothwell NJ, McColl BW, Allan SM. Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity. European Journal Of Immunology 2015, 45: 525-30. PMID: 25367678, PMCID: PMC4357393, DOI: 10.1002/eji.201444748.
- Looking more reflexively at surgical culture.Giles JA, Hill EJ. Looking more reflexively at surgical culture. Medical Education 2014, 48: 1245. PMID: 25413918, DOI: 10.1111/medu.12611.
- Career decisions and gender: the illusion of choice?Hill EJ, Giles JA. Career decisions and gender: the illusion of choice? Perspectives On Medical Education 2014, 3: 151-4. PMID: 24957796, PMCID: PMC4078050, DOI: 10.1007/s40037-014-0128-x.
- Teaching in a busy clinic.Hill EJ, Giles JA, Dornan T. Teaching in a busy clinic. Practical Neurology 2012, 12: 376-9. PMID: 23144301, DOI: 10.1136/practneurol-2012-000267.
- Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.Luheshi NM, Giles JA, Lopez-Castejon G, Brough D. Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages. European Journal Of Immunology 2012, 42: 716-25. PMID: 22105559, PMCID: PMC3491674, DOI: 10.1002/eji.201142079.
- Peer-assisted learning from three perspectives: student, tutor and co-ordinator.Hill E, Liuzzi F, Giles J. Peer-assisted learning from three perspectives: student, tutor and co-ordinator. The Clinical Teacher 2010, 7: 244-6. PMID: 21134199, DOI: 10.1111/j.1743-498X.2010.00399.x.
- Surgical training and the European Working Time Directive: The role of informal workplace learning.Giles JA. Surgical training and the European Working Time Directive: The role of informal workplace learning. International Journal Of Surgery (London, England) 2010, 8: 179-80. PMID: 20144752, DOI: 10.1016/j.ijsu.2010.01.011.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Diseases of the Cardiovascular System | Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH) |
| Diseases of the Nervous System; Hypertension | Regulating Blood Pressure During Recovery from Intracerebral Hemorrhage and Ischemic Stroke (REDUCE) |
| Diseases of the Cardiovascular System; Diseases of the Nervous System | Anticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE) |