Hyesun Cho, PhD
Postdoctoral Associate in NeuroscienceAbout
Titles
Postdoctoral Associate in Neuroscience
Education & Training
- PhD
- Seoul National University (2020)
Research
Overview
Medical Subject Headings (MeSH)
Brain; Neurons
ORCID
0000-0003-1254-768X
Research at a Glance
Publications Timeline
A big-picture view of Hyesun Cho's research output by year.
Research Interests
Research topics Hyesun Cho is interested in exploring.
6Publications
598Citations
Publications
2021
Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models
Woo J, Cho H, Seol Y, Kim SH, Park C, Yousefian-Jazi A, Hyeon SJ, Lee J, Ryu H. Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models. Antioxidants 2021, 10: 229. PMID: 33546471, PMCID: PMC7913624, DOI: 10.3390/antiox10020229.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOxidative stressMitochondrial functionMitochondrial dysfunctionAntioxidant therapeutic strategiesAmyotrophic lateral sclerosisNeuronal damageLateral sclerosisParkinson's diseaseTherapeutic strategiesNeuronal activitySubcellular eventsAlzheimer's diseaseBiochemical energyNeurodegenerative disordersLiving organismDiseaseHuntington's diseaseNeurodegenerationArt computational modelsMitochondriaDysfunctionBrainSclerosisStressOrganisms
2020
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production
Chun H, Im H, Kang YJ, Kim Y, Shin JH, Won W, Lim J, Ju Y, Park YM, Kim S, Lee SE, Lee J, Woo J, Hwang Y, Cho H, Jo S, Park JH, Kim D, Kim DY, Seo JS, Gwag BJ, Kim YS, Park KD, Kaang BK, Cho H, Ryu H, Lee CJ. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production. Nature Neuroscience 2020, 23: 1555-1566. PMID: 33199896, DOI: 10.1038/s41593-020-00735-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsReactive astrocytesAlzheimer's diseaseAPP/PS1 micePathogenesis of ADReactivity of astrocytesBrains of patientsAppropriate experimental modelsGlial activationPS1 miceAstrocytic reactivityBrain atrophyPathological featuresNeuronal deathMonoamine oxidase BPathological hallmarkAD modelPrecise molecular mechanismsAnimal modelsAstrocytesCognitive impairmentPathological contributionExperimental modelDiseaseOxidase BEventual deathAlterations of transcriptome signatures in head trauma-related neurodegenerative disorders
Cho H, Hyeon SJ, Shin JY, Alvarez VE, Stein TD, Lee J, Kowall NW, McKee AC, Ryu H, Seo JS. Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders. Scientific Reports 2020, 10: 8811. PMID: 32483284, PMCID: PMC7264177, DOI: 10.1038/s41598-020-65916-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseBlotting, WesternCell Adhesion MoleculesChronic Traumatic EncephalopathyCraniocerebral TraumaEndothelial CellsFemaleGene OntologyGene Regulatory NetworksHumansMaleMemoryMiddle AgedNerve Tissue ProteinsNeurogliaNeuronsReal-Time Polymerase Chain ReactionSequence Analysis, RNASynaptic TransmissionTemporal LobeTranscription, GeneticTranscriptomeConceptsProtein kinase AProtein kinase CQuantitative real-time PCRChronic traumatic encephalopathyCell adhesion moleculeSynaptotagmin-1Transcriptome signaturesGene co-expression network analysisCAM-related genesCo-expression network analysisAMPA receptor genesCalmodulin-dependent protein kinase IICalcium/calmodulin-dependent protein kinase IIUnique transcriptome signaturesTraumatic brain injuryProtein kinase IIAlzheimer's diseaseFunction-related genesKinase AMemory function-related genesKinase IISpecific pathological markersKinase CWestern blot analysisReal-time PCREpigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease
Lee MY, Lee J, Hyeon SJ, Cho H, Hwang YJ, Shin J, McKee AC, Kowall NW, Kim J, Stein TD, Hwang D, Ryu H. Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease. Aging Cell 2020, 19: e13153. PMID: 32419307, PMCID: PMC7294781, DOI: 10.1111/acel.13153.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGenome-wide ChIPMRNA sequence dataBiological network analysisHistone H3K9me3Heterochromatin remodelingEpigenetic modificationsAD postmortem brainsEpigenetic signaturesFunction-related genesH3K9me3Cell motilityHeterochromatin condensationEpigenetic alterationsEpigenomeEpigenome signaturesNeuronal differentiationAlzheimer's diseaseExpression levelsHeterochromatinIntegrated analysisPostmortem brainsMRNA expression levelsSporadic Alzheimer's diseaseNetwork analysisPotential role
2017
Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy
Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Experimental & Molecular Medicine 2017, 49: e333-e333. PMID: 28524178, PMCID: PMC5454448, DOI: 10.1038/emm.2017.56.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProtein phosphataseChronic traumatic encephalopathyProtein phosphatase expressionRNA sequencing analysisCalcium-signaling pathwayIntraneuronal tau aggregatesTranscriptome analysisNeuropathological featuresMAP kinaseAlzheimer's diseasePhosphatase expressionSequencing analysisDistinctive neuropathological featuresRepetitive head injuryPhosphatase activityPost-mortem brain tissueAltered expressionProgressive neurodegenerative disorderNovel therapeutic approachesCommon pathological mechanismCell linesTau aggregatesNeurodegenerative diseasesNeurodegenerative disordersTraumatic encephalopathy
2016
Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers
Yoo SK, Lee S, Kim SJ, Jee HG, Kim BA, Cho H, Song YS, Cho SW, Won JK, Shin JY, Park do J, Kim JI, Lee KE, Park YJ, Seo JS. Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers. PLOS Genetics 2016, 12: e1006239. PMID: 27494611, PMCID: PMC4975456, DOI: 10.1371/journal.pgen.1006239.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsClassical papillary thyroid carcinomaFollicular thyroid carcinomaFollicular adenomaHistological featuresThyroid cancerMolecular subtypesThyroid carcinomaInvasive follicular thyroid carcinomaSimilar histological featuresPapillary thyroid cancerPapillary thyroid carcinomaFollicular thyroid neoplasmBenign follicular adenomaPAX8-PPARGIndolent behaviorPreoperative diagnosisNovel molecular subtypesFollicular variantTherapeutic approachesNRAS mutationsThyroid neoplasmsMIFTCUpregulation of genesBRAF-likeCarcinoma
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