Henry C. Hsia, MD, FACS
Research & Publications
Biography
News
Research Summary
Tissue repair continues to present significant challenges to biomedical scientists and clinicians wishing to understand and manipulate its associated biological processes to facilitate wound healing while also preventing fibrotic complications. My research interests represent a long-term effort to better understand how wound healing can be optimized to benefit patients who suffer from chronic wounds or problematic scarring. These efforts include translational research studies into the roles of the extracellular matrix and microbiome in wound healing and fibrosis as well as clinical studies on the impact of diabetes, nicotine, and other risk factors for poor healing.
Extensive Research Description
As a board-certified plastic surgeon in active clinical practice, I have dedicated my professional life to finding innovative wound treatments for patients through basic and clinical research. My clinical training at Yale had given me a strong foundation to understand wound healing. I also acquired firsthand knowledge of the limitations of current therapies for treating difficult wounds and the great challenges in developing novel treatments that can be widely adopted by practitioners. I came to the conclusion during my clinical training that if I wished to make significant contributions to therapeutic advances for these challenging clinical entities, it would require a much deeper understanding on my part of the basic biological processes underlying wound healing. Through an NIH-funded postdoctoral position at Princeton University, I studied the role of the extracellular matrix in regulating wound cell behavior, work which led to a successful application for NIH funding in the form of a K08 career development award. Accordingly, I have developed an intellectual and professional background that is uniquely well rounded among my clinical and scientific colleagues and find myself poised to bridge the widening translational gap between the basic and clinical sciences. As the Director of the Yale Regenerative Wound Healing Center, I have developed the clinical wound program at Yale-New Haven Hospital into the foremost regional referral center for challenging chronic wounds using innovative approaches to achieve dramatic clinical outcomes. This clinical program is paired with a scientific program that encourages cross-disciplinary collaborations and has already yielded key insights on the role of macrophages in regulating fibroblast heterogeneity (Shook et al., Science, 2018) that I hope to one day will lead to the development of novel approaches in regenerative medicine. My lab's goal is also to attract trainees that will benefit from direct exposure to such approaches, and as a consequence, allow them deeper insights to answer questions relevant to the “bedside” as well as the “bench.”
Coauthors
Research Interests
Aging; Biomedical Engineering; Cells, Cultured; Pressure Ulcer; Fibrosis; Leg Ulcer; Surgery, Plastic; Surgical Wound Dehiscence; Wound Healing; Wounds and Injuries; Foot Ulcer; Telemedicine; Tissue Engineering; Regenerative Medicine; Tissue Scaffolds; Negative-Pressure Wound Therapy; Wound Closure Techniques; Acellular Dermis; Surgical Wound
Public Health Interests
Aging; Clinical Guidelines; Clinical Trials; Nutrition; e-Health
Research Image
Immunostained cells on flat and rolled scaffolds respectively.
Selected Publications
- An in situ collagen‐HA hydrogel system promotes survival and preserves the proangiogenic secretion of hiPSC‐derived vascular smooth muscle cellsDash BC, Duan K, Xing H, Kyriakides TR, Hsia HC. An in situ collagen‐HA hydrogel system promotes survival and preserves the proangiogenic secretion of hiPSC‐derived vascular smooth muscle cells. Biotechnology And Bioengineering 2020, 117: 3912-3923. PMID: 32770746, DOI: 10.1002/bit.27530.
- Self-Assembled Nanomaterials for Chronic Skin Wound HealingKang HJ, Chen N, Dash BC, Hsia HC, Berthiaume F. Self-Assembled Nanomaterials for Chronic Skin Wound Healing. Advances In Wound Care 2020, 10: 221-233. PMID: 32487014, PMCID: PMC8024239, DOI: 10.1089/wound.2019.1077.
- A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound HealingDash BC, Setia O, Gorecka J, Peyvandi H, Duan K, Lopes L, Nie J, Berthiaume F, Dardik A, Hsia HC. A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing. Cells 2020, 9: 966. PMID: 32295218, PMCID: PMC7226960, DOI: 10.3390/cells9040966.
- Safety of compression therapy for venous ulcer disease in the setting of congestive heart failureAttaran RR, Cavanaugh A, Tsay C, Ahmad T, Chaar C, Persing S, Hsia H. Safety of compression therapy for venous ulcer disease in the setting of congestive heart failure. Phlebology The Journal Of Venous Disease 2020, 35: 556-560. PMID: 32028849, DOI: 10.1177/0268355520905178.
- Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healingGorecka J, Gao X, Fereydooni A, Dash BC, Luo J, Lee SR, Taniguchi R, Hsia HC, Qyang Y, Dardik A. Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing. Regenerative Medicine 2020, 15: 1277-1293. PMID: 32228292, PMCID: PMC7304438, DOI: 10.2217/rme-2019-0086.
- Evidence-Based Gardening: Using Palliative Approaches to Cure Complex Wounds.Ching AH, Le N, Norwich-Cavanaugh A, Hsia HC. Evidence-Based Gardening: Using Palliative Approaches to Cure Complex Wounds. Annals Of Plastic Surgery 2019, 83: s45-s49. PMID: 31513065, DOI: 10.1097/sap.0000000000002100.
- Can Nicotine Replacement Therapy Decrease Complications in Plastic Surgery?Xu Z, Norwich-Cavanaugh A, Hsia HC. Can Nicotine Replacement Therapy Decrease Complications in Plastic Surgery? Annals Of Plastic Surgery 2019, 83: s55-s58. PMID: 31513067, DOI: 10.1097/sap.0000000000002095.
- Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing.Hetzler PT, Dash BC, Guo S, Hsia HC. Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing. Annals Of Plastic Surgery 2019, 83: e92-e95. PMID: 31246672, PMCID: PMC6851445, DOI: 10.1097/sap.0000000000001955.
- Significance of Friction and Shear in the Prevention of Contemporary Hospital-acquired Pressure UlcersCabrejo R, Ndon S, Saberski E, Chuang C, Hsia HC. Significance of Friction and Shear in the Prevention of Contemporary Hospital-acquired Pressure Ulcers. Plastic & Reconstructive Surgery Global Open 2019, 7: e2099. PMID: 31321159, PMCID: PMC6554149, DOI: 10.1097/gox.0000000000002099.
- Clinical Value of Single-photon Emission Computed Tomography Combined With Computed Tomography for Sentinel Lymph Node Identification in Melanoma.McGregor A, Kim S, Norwich-Cavanaugh A, Sun AH, Abbate DS, Hsia HC, Narayan D. Clinical Value of Single-photon Emission Computed Tomography Combined With Computed Tomography for Sentinel Lymph Node Identification in Melanoma. Annals Of Plastic Surgery 2019, 82: s192-s194. PMID: 30855387, DOI: 10.1097/sap.0000000000001895.
- An Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study.Tsay C, Kim S, Norwich-Cavanaugh A, Hsia HC, Narayan D. An Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study. Annals Of Plastic Surgery 2019, 82: s199-s201. PMID: 30855388, DOI: 10.1097/sap.0000000000001840.
- Incisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study.Shah A, Sumpio BJ, Tsay C, Swallow M, Dash B, Thorn SL, Sinusas AJ, Koo A, Hsia HC, Au A. Incisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study. Annals Of Plastic Surgery 2019, 82: s222-s227. PMID: 30855392, DOI: 10.1097/sap.0000000000001842.
- The potential and limitations of induced pluripotent stem cells to achieve wound healingGorecka J, Kostiuk V, Fereydooni A, Gonzalez L, Luo J, Dash B, Isaji T, Ono S, Liu S, Lee SR, Xu J, Liu J, Taniguchi R, Yastula B, Hsia HC, Qyang Y, Dardik A. The potential and limitations of induced pluripotent stem cells to achieve wound healing. Stem Cell Research & Therapy 2019, 10: 87. PMID: 30867069, PMCID: PMC6416973, DOI: 10.1186/s13287-019-1185-1.
- Mouse Model of Pressure Ulcers After Spinal Cord Injury.Kumar S, Tan Y, Yarmush ML, Dash BC, Hsia HC, Berthiaume F. Mouse Model of Pressure Ulcers After Spinal Cord Injury. Journal Of Visualized Experiments 2019 PMID: 30907872, DOI: 10.3791/58188.
- Impact of Acellular Dermal Matrix on Postsurgical Wound Fluid Biomarkers in Prosthetic Breast ReconstructionHsia HC, Weaver MR, Schwarzbauer JE. Impact of Acellular Dermal Matrix on Postsurgical Wound Fluid Biomarkers in Prosthetic Breast Reconstruction. Annals Of Plastic Surgery 2018, 81: s89-s96. PMID: 29851721, DOI: 10.1097/sap.0000000000001495.
- Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repairShook BA, Wasko RR, Rivera-Gonzalez GC, Salazar-Gatzimas E, López-Giráldez F, Dash BC, Muñoz-Rojas AR, Aultman KD, Zwick RK, Lei V, Arbiser JL, Miller-Jensen K, Clark DA, Hsia HC, Horsley V. Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair. Science 2018, 362 PMID: 30467144, PMCID: PMC6684198, DOI: 10.1126/science.aar2971.
- Telehealth in Plastic SurgeryDouglas S, Geiger E, McGregor A, Norwich A, Abbate D, Hsia H, Narayan D. Telehealth in Plastic Surgery. Plastic & Reconstructive Surgery Global Open 2018, 6: e1840. PMID: 30534478, PMCID: PMC6250470, DOI: 10.1097/gox.0000000000001840.
- The Impact of Microbial Communities on Wound HealingXu Z, Hsia HC. The Impact of Microbial Communities on Wound Healing. Annals Of Plastic Surgery 2018, 81: 113-123. PMID: 29746280, DOI: 10.1097/sap.0000000000001450.
- Stem Cells and Engineered Scaffolds for Regenerative Wound HealingDash BC, Xu Z, Lin L, Koo A, Ndon S, Berthiaume F, Dardik A, Hsia H. Stem Cells and Engineered Scaffolds for Regenerative Wound Healing. Bioengineering 2018, 5: 23. PMID: 29522497, PMCID: PMC5874889, DOI: 10.3390/bioengineering5010023.
- Impact of Complete Spinal Cord Injury on Healing of Skin Ulcers in Mouse ModelsKumar S, Yarmush ML, Dash BC, Hsia HC, Berthiaume F. Impact of Complete Spinal Cord Injury on Healing of Skin Ulcers in Mouse Models. Journal Of Neurotrauma 2018, 35: 815-824. PMID: 29160147, DOI: 10.1089/neu.2017.5405.
- Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancerChakraborty D, Benham V, Bullard B, Kearney T, Hsia HC, Gibbon D, Demireva EY, Lunt SY, Bernard JJ. Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer. Oncogene 2017, 36: 6668-6679. PMID: 28783178, PMCID: PMC5709202, DOI: 10.1038/onc.2017.278.
- Measurement of Pressure in Compressive Magnet Therapy for Auricular KeloidsDavid JA, Ghodbane SA, Chee M, Hsia HC. Measurement of Pressure in Compressive Magnet Therapy for Auricular Keloids. Plastic & Reconstructive Surgery Global Open 2017, 5: e1333. PMID: 28607859, PMCID: PMC5459642, DOI: 10.1097/gox.0000000000001333.
- Soluble Receptor for Advanced Glycation End Products Improves Stromal Cell–Derived Factor-1 Activity in Model Diabetic EnvironmentsOlekson MP, Faulknor RA, Hsia HC, Schmidt AM, Berthiaume F. Soluble Receptor for Advanced Glycation End Products Improves Stromal Cell–Derived Factor-1 Activity in Model Diabetic Environments. Advances In Wound Care 2016, 5: 527-538. PMID: 28078186, PMCID: PMC5165672, DOI: 10.1089/wound.2015.0674.
- On Beyond LidocaineHsia HC. On Beyond Lidocaine. Annals Of Plastic Surgery 2016, 77: s66-s69. PMID: 26808738, DOI: 10.1097/sap.0000000000000709.
- SDF‐1 liposomes promote sustained cell proliferation in mouse diabetic woundsOlekson MA, Faulknor R, Bandekar A, Sempkowski M, Hsia HC, Berthiaume F. SDF‐1 liposomes promote sustained cell proliferation in mouse diabetic wounds. Wound Repair And Regeneration 2015, 23: 711-723. PMID: 26110250, DOI: 10.1111/wrr.12334.
- Local Anesthetic Use in Tumescent LiposuctionPaik AM, Daniali LN, Lee ES, Hsia HC. Local Anesthetic Use in Tumescent Liposuction. Annals Of Plastic Surgery 2015, 74: 145-151. PMID: 25590254, DOI: 10.1097/sap.0000000000000420.
- The fate of internalized α5 integrin is regulated by matrix-capable fibronectinHsia HC, Nair MR, Corbett SA. The fate of internalized α5 integrin is regulated by matrix-capable fibronectin. Journal Of Surgical Research 2014, 191: 268-279. PMID: 25062814, PMCID: PMC4160403, DOI: 10.1016/j.jss.2014.05.084.
- Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem CellsDesai VD, Hsia HC, Schwarzbauer JE. Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells. PLOS ONE 2014, 9: e86865. PMID: 24466271, PMCID: PMC3900664, DOI: 10.1371/journal.pone.0086865.
- Local Anesthetics in LiposuctionPaik AM, Daniali LN, Lee ES, Hsia HC. Local Anesthetics in Liposuction. Plastic & Reconstructive Surgery 2014, 133: 66e-67e. PMID: 24374696, DOI: 10.1097/01.prs.0000436524.56422.04.
- The Fiber Diameter of Synthetic Bioresorbable Extracellular Matrix Influences Human Fibroblast Morphology and Fibronectin Matrix AssemblyHsia HC, Nair MR, Mintz RC, Corbett SA. The Fiber Diameter of Synthetic Bioresorbable Extracellular Matrix Influences Human Fibroblast Morphology and Fibronectin Matrix Assembly. Plastic & Reconstructive Surgery 2011, 127: 2312-2320. PMID: 21617465, PMCID: PMC3103705, DOI: 10.1097/prs.0b013e3182139fa4.
- Intraoperative Use of Bupivacaine for Tumescent Liposuction: The Robert Wood Johnson ExperienceFailey CL, Vemula R, Borah GL, Hsia HC. Intraoperative Use of Bupivacaine for Tumescent Liposuction: The Robert Wood Johnson Experience. Plastic & Reconstructive Surgery 2009, 124: 1304-1311. PMID: 19935317, DOI: 10.1097/prs.0b013e3181b455d0.
- Modulation of Cell–Fibronectin Matrix Interactions during Tissue RepairMidwood KS, Mao Y, Hsia HC, Valenick LV, Schwarzbauer JE. Modulation of Cell–Fibronectin Matrix Interactions during Tissue Repair. Journal Of Investigative Dermatology Symposium Proceedings 2006, 11: 73-78. PMID: 17069013, DOI: 10.1038/sj.jidsymp.5650005.
- Adenoviral-Mediated Expression and Local Deposition of Recombinant Tenascin-C Perturbs Cell-Dependent Matrix ContractionHsia HC, Schwarzbauer JE. Adenoviral-Mediated Expression and Local Deposition of Recombinant Tenascin-C Perturbs Cell-Dependent Matrix Contraction. Journal Of Surgical Research 2006, 136: 92-97. PMID: 16926030, DOI: 10.1016/j.jss.2006.05.030.
- Fibronectin fragmentation promotes α4β1 integrin-mediated contraction of a fibrin–fibronectin provisional matrixValenick LV, Hsia HC, Schwarzbauer JE. Fibronectin fragmentation promotes α4β1 integrin-mediated contraction of a fibrin–fibronectin provisional matrix. Experimental Cell Research 2005, 309: 48-55. PMID: 15992798, DOI: 10.1016/j.yexcr.2005.05.024.
- Meet the Tenascins: Multifunctional and Mysterious*Hsia HC, Schwarzbauer JE. Meet the Tenascins: Multifunctional and Mysterious*. Journal Of Biological Chemistry 2005, 280: 26641-26644. PMID: 15932878, DOI: 10.1074/jbc.r500005200.
- Coregulation of Fibronectin Signaling and Matrix Contraction by Tenascin-C and Syndecan-4Midwood KS, Valenick LV, Hsia HC, Schwarzbauer JE. Coregulation of Fibronectin Signaling and Matrix Contraction by Tenascin-C and Syndecan-4. Molecular Biology Of The Cell 2004, 15: 5670-5677. PMID: 15483051, PMCID: PMC532045, DOI: 10.1091/mbc.e04-08-0759.
- Differences in Breast Shape Preferences between Plastic Surgeons and Patients Seeking Breast AugmentationHsia HC, Thomson JG. Differences in Breast Shape Preferences between Plastic Surgeons and Patients Seeking Breast Augmentation. Plastic & Reconstructive Surgery 2003, 112: 312-320. PMID: 12832909, DOI: 10.1097/01.prs.0000066365.12348.a7.