Hanieh Falahati, PhD
Postdoctoral Fellow
Research & Publications
Biography
Research Summary
I study the spine apparatus, which is a specialized compartment of the neuronal smooth endoplasmic reticulum (ER) located in a subset of dendritic spines. It consists of stacks of ER cisterns that are interconnected by an unknown dense matrix and are continuous with each other and with the ER of the dendritic shaft. While this organelle has been first observed over 60 years ago, the mechanism of its formation and function remains a mystery. The focus of my work is to take an interdisciplinary approach to address these longstanding questions and better understand the contributions of this enigmatic organelle in neuronal physiology and in disease.
Coauthors
Research Image
The Enigmatic Spine Apparatus of Neuronal Dendritic Spines
Spine Apparatus (orange) is a specialization of neuronal endoplasmic reticulum, which is located at dendritic spines.
Selected Publications
- Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spinesFalahati H, Wu Y, Feuerer V, Simon HG, De Camilli P. Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spines. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2203750119. PMID: 36215465, PMCID: PMC9586327, DOI: 10.1073/pnas.2203750119.
- Temperature-Induced uncoupling of cell cycle regulatorsFalahati H, Hur W, Di Talia S, Wieschaus E. Temperature-Induced uncoupling of cell cycle regulators. Developmental Biology 2020, 470: 147-153. PMID: 33278404, PMCID: PMC8106975, DOI: 10.1016/j.ydbio.2020.11.010.
- Thermodynamically driven assemblies and liquid–liquid phase separations in biologyFalahati H, Haji-Akbari A. Thermodynamically driven assemblies and liquid–liquid phase separations in biology. Soft Matter 2019, 15: 1135-1154. PMID: 30672955, DOI: 10.1039/c8sm02285b.
- Independent active and thermodynamic processes govern the nucleolus assembly in vivoFalahati H, Wieschaus E. Independent active and thermodynamic processes govern the nucleolus assembly in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 1335-1340. PMID: 28115706, PMCID: PMC5307486, DOI: 10.1073/pnas.1615395114.
- Nucleation by rRNA Dictates the Precision of Nucleolus AssemblyFalahati H, Pelham-Webb B, Blythe S, Wieschaus E. Nucleation by rRNA Dictates the Precision of Nucleolus Assembly. Current Biology 2016, 26: 277-285. PMID: 26776729, PMCID: PMC5866055, DOI: 10.1016/j.cub.2015.11.065.
- Asynchronous release sites align with NMDA receptors in mouse hippocampal synapsesLi S, Raychaudhuri S, Lee SA, Brockmann MM, Wang J, Kusick G, Prater C, Syed S, Falahati H, Ramos R, Bartol TM, Hosy E, Watanabe S. Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses. Nature Communications 2021, 12: 677. PMID: 33514725, PMCID: PMC7846561, DOI: 10.1038/s41467-021-21004-x.
- Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cellsBenedetti L, Marvin JS, Falahati H, Guillén-Samander A, Looger LL, De Camilli P. Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. ELife 2020, 9: e63230. PMID: 33174843, PMCID: PMC7735757, DOI: 10.7554/elife.63230.
- Mitosis-associated repression in developmentEsposito E, Lim B, Guessous G, Falahati H, Levine M. Mitosis-associated repression in development. Genes & Development 2016, 30: 1503-1508. PMID: 27401553, PMCID: PMC4949323, DOI: 10.1101/gad.281188.116.
- Effect of sorbitol and glycerol on the stability of trypsin and difference between their stabilization effects in the various solventsPazhang M, Mehrnejad F, Pazhang Y, Falahati H, Chaparzadeh N. Effect of sorbitol and glycerol on the stability of trypsin and difference between their stabilization effects in the various solvents. Biotechnology And Applied Biochemistry 2015, 63: 206-213. PMID: 25757511, DOI: 10.1002/bab.1366.
- Biochemical Characterization and Computational Identification of Mycobacterium tuberculosis Pyrazinamidase in Some Pyrazinamide-Resistant Isolates of IranDoustdar F, Pazhang M, Mehrnejad F, Safarzadeh M, Rabiei D, Chaparzadeh N, Falahati H, Mir-Derikvand M. Biochemical Characterization and Computational Identification of Mycobacterium tuberculosis Pyrazinamidase in Some Pyrazinamide-Resistant Isolates of Iran. The Protein Journal 2015, 34: 181-192. PMID: 25972249, DOI: 10.1007/s10930-015-9610-5.
- Transmitting the allosteric signal in methylglyoxal synthaseFalahati H, Pazhang M, Zareian S, Ghaemi N, Rofougaran R, Hofer A, Rezaie AR, Khajeh K. Transmitting the allosteric signal in methylglyoxal synthase. Protein Engineering Design And Selection 2013, 26: 445-452. PMID: 23592737, DOI: 10.1093/protein/gzt014.
- Mesophilic alcohol dehydrogenase behavior in imidazolium based ionic liquidsDabirmanesh B, Khajeh K, Akbari J, Falahati H, Daneshjoo S, Heydari A. Mesophilic alcohol dehydrogenase behavior in imidazolium based ionic liquids. Journal Of Molecular Liquids 2011, 161: 139-143. DOI: 10.1016/j.molliq.2011.05.007.
- Mesophilic alcohol dehydrogenase behavior in imidazolium based ionic liquidsDabirmanesh, Bahareh, Khosro Khajeh, Jafar Akbari, Hanieh Falahati, Somayeh Daneshjoo, and Akbar Heydari. Journal of Molecular Liquids 161, no. 3 (2011): 139-143.
- Cloning, Expression, and Characterization of a Novel Methylglyoxal Synthase from Thermus sp. Strain GH5Pazhang M, Khajeh K, Asghari SM, Falahati H, Naderi-Manesh H. Cloning, Expression, and Characterization of a Novel Methylglyoxal Synthase from Thermus sp. Strain GH5. Applied Biochemistry And Biotechnology 2010, 162: 1519-1528. PMID: 20419481, DOI: 10.1007/s12010-010-8933-0.
- Effects of ionic liquids on the kinetic behavior of thermophilic alcohol dehydrogenase and its mesophilic counterpartDabirmanesh B, Falahati H, Khajeh K, Akbari J, Heydari A. Effects of ionic liquids on the kinetic behavior of thermophilic alcohol dehydrogenase and its mesophilic counterpart. New Biotechnology 2009, 25: s143. DOI: 10.1016/j.nbt.2009.06.470.