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INFORMATION FOR

Guoping Cai, MD, MS

Professor of Pathology; Associate Director of Cytopathology, Pathology

Contact Information

Guoping Cai, MD, MS

Office Location

Mailing Address

  • Pathology

    310 Cedar Street, PO Box 208023

    New Haven, CT 06520-8023

    United States

Research Summary

Molecular testing in fine needle aspiration biopsy, and biomarker studies in lung, pancreas, thyroid and bladder cancers

Extensive Research Description

Molecular testing in fine needle aspiration biopsy, and biomarker studies in lung, pancreas, thyroid and bladder cancers

Coauthors

Research Interests

Lung Neoplasms; Neoplasms; Pancreas; Respiratory Tract Diseases; Male Urogenital Diseases

Selected Publications

  • Atypical Carcinoid Tumor Versus Large-Cell Neuroendocrine CarcinomaYoon E, Cai G. Atypical Carcinoid Tumor Versus Large-Cell Neuroendocrine Carcinoma 2022, 75-81. DOI: 10.1007/978-3-031-14402-8_14.
  • Small-Cell Carcinoma Versus Atypical Carcinoid TumorYoon E, Zhang X, Cai G. Small-Cell Carcinoma Versus Atypical Carcinoid Tumor 2022, 83-88. DOI: 10.1007/978-3-031-14402-8_15.
  • Cytological Evaluation of Upper Urinary Tract Specimens: An Institutional Retrospective Study Using The Paris System for Reporting Urine Cytology Second Edition with Histopathologic Follow UpKhajir G, Sun T, Wang H, Adeniran A, Cai G, Levi A. Cytological Evaluation of Upper Urinary Tract Specimens: An Institutional Retrospective Study Using The Paris System for Reporting Urine Cytology Second Edition with Histopathologic Follow Up Journal Of The American Society Of Cytopathology 2022, 11: s35. DOI: 10.1016/j.jasc.2022.07.065.
  • Fine-Needle Aspiration Evaluation of Pancreatic Cysts: An Institutional Experience Using the Upcoming WHO International System for Reporting Pancreaticobiliary CytopathologySardana R, Wang M, Gilani S, Sun T, Cai G. Fine-Needle Aspiration Evaluation of Pancreatic Cysts: An Institutional Experience Using the Upcoming WHO International System for Reporting Pancreaticobiliary Cytopathology Journal Of The American Society Of Cytopathology 2022, 11: s62. DOI: 10.1016/j.jasc.2022.07.113.
  • The Value of Parathyroid Hormone Immunostaining in Fine-Needle Aspiration Diagnosis of Parathyroid TissueSardana R, Abi-Raad R, Adeniran A, Cai G. The Value of Parathyroid Hormone Immunostaining in Fine-Needle Aspiration Diagnosis of Parathyroid Tissue Journal Of The American Society Of Cytopathology 2022, 11: s54. DOI: 10.1016/j.jasc.2022.07.098.
  • Cervical Cancer Screening Using Primary High-Risk HPV (hrHPV) Versus Cotesting: Implications for hrHPV-Negative Patients with High Grade Squamous Epithelial LesionManrai P, Levi A, Sun T, Wang M, Cai G, Abi-Raad R. Cervical Cancer Screening Using Primary High-Risk HPV (hrHPV) Versus Cotesting: Implications for hrHPV-Negative Patients with High Grade Squamous Epithelial Lesion Journal Of The American Society Of Cytopathology 2022, 11: s32. DOI: 10.1016/j.jasc.2022.07.060.
  • Role of Combined Endoscopic Ultrasound-Guided Fine Needle Aspiration and Fine Needle Biopsy in the Diagnosis of Upper Gastrointestinal Submucosal LesionsAhmed M, Gilani S, Muniraj T, Aslanian H, Cai G. Role of Combined Endoscopic Ultrasound-Guided Fine Needle Aspiration and Fine Needle Biopsy in the Diagnosis of Upper Gastrointestinal Submucosal Lesions Journal Of The American Society Of Cytopathology 2020, 9: s29. DOI: 10.1016/j.jasc.2020.07.061.
  • Diagnosis and Prognostic Evaluation of Uveal Melanoma via Fine Needle Aspiration BiopsyCai G. Diagnosis and Prognostic Evaluation of Uveal Melanoma via Fine Needle Aspiration Biopsy Journal Of Optometry And Ophthalmology 2020, 22: 81-86. DOI: 10.3760/cma.j.issn.1674-845x.2020.02.001.
  • Concordance Between the TIRADS Ultrasound Scoring Criteria, Fine-Needle Aspiration Cytology, and Thyroid Final Resection DiagnosisKaseb H, Charifa A, Abi-Raad R, Cai G, Hammers L, Prasad M, Adeniran A. Concordance Between the TIRADS Ultrasound Scoring Criteria, Fine-Needle Aspiration Cytology, and Thyroid Final Resection Diagnosis American Journal Of Clinical Pathology 2019, 152: s92-s92. DOI: 10.1093/ajcp/aqz118.001.
  • Fine Needle Aspiration Biopsy of Adrenal Gland Lesions: The Roles of Imaging Guidance, Rapid Onsite Evaluation, and Ancillary TestingDolezal D, Aslanian H, Cai G. Fine Needle Aspiration Biopsy of Adrenal Gland Lesions: The Roles of Imaging Guidance, Rapid Onsite Evaluation, and Ancillary Testing Journal Of The American Society Of Cytopathology 2019, 8: s2. DOI: 10.1016/j.jasc.2019.08.010.
  • Potential Role of Paraoxonase 2 Expression in Enhancing Fine Needle Aspiration Diagnosis of Pancreatic Ductal AdenocarcinomasMartinez M, Yoon E, Adeniran A, Cai G, Robert M, Wajapeyee N. Potential Role of Paraoxonase 2 Expression in Enhancing Fine Needle Aspiration Diagnosis of Pancreatic Ductal Adenocarcinomas Journal Of The American Society Of Cytopathology 2019, 8: s24. DOI: 10.1016/j.jasc.2019.08.058.
  • OverviewCai G, Adeniran A. Overview 2019, 3-11. DOI: 10.1007/978-3-030-21799-0_1.
  • MediastinumAbi-Raad R, Cai G. Mediastinum 2019, 305-323. DOI: 10.1007/978-3-030-21799-0_11.
  • Lymph NodeCai G. Lymph Node 2019, 119-150. DOI: 10.1007/978-3-030-21799-0_6.
  • Economics, Regulations, and Trends in PracticeLevi A, Cai G. Economics, Regulations, and Trends in Practice 2019, 407-412. DOI: 10.1007/978-3-030-21799-0_15.
  • LiverCai G. Liver 2019, 153-185. DOI: 10.1007/978-3-030-21799-0_7.
  • Facility, Equipment, Specimen Preparation, and StainsCai G. Facility, Equipment, Specimen Preparation, and Stains 2019, 13-27. DOI: 10.1007/978-3-030-21799-0_2.
  • PancreasCai G. Pancreas 2019, 327-363. DOI: 10.1007/978-3-030-21799-0_12.
  • Gastrointestinal TractAbi-Raad R, Cai G. Gastrointestinal Tract 2019, 365-384. DOI: 10.1007/978-3-030-21799-0_13.
  • Cytological Evaluation During Intraoperative ConsultationCai G. Cytological Evaluation During Intraoperative Consultation 2019, 387-405. DOI: 10.1007/978-3-030-21799-0_14.
  • LungCai G. Lung 2019, 267-304. DOI: 10.1007/978-3-030-21799-0_10.
  • Abstract A09: Impaired HLA Class I antigen processing and presentation as a mechanism of acquired Rrsistance to immune checkpoint inhibitors in lung cancerHastings K, Gettinger S, Jungmin C, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick M, Schlessinger J, Goldberg S, Chiang A, Melero I, Agorreta J, Montuenga L, Lifton R, Ferrone S, Kavathas P, Rimm D, Kaech S, Schalper K, Herbst R, Politi K. Abstract A09: Impaired HLA Class I antigen processing and presentation as a mechanism of acquired Rrsistance to immune checkpoint inhibitors in lung cancer Cancer Immunology Research 2018, 6: a09-a09. DOI: 10.1158/2326-6074.tumimm17-a09.
  • Reliability of p16 in Cytology Specimens from Head and Neck Squamous Cell CarcinomaAbi-Raad R, Prasad M, Cai G, Adeniran A. Reliability of p16 in Cytology Specimens from Head and Neck Squamous Cell Carcinoma Journal Of The American Society Of Cytopathology 2018, 7: s12. DOI: 10.1016/j.jasc.2018.06.037.
  • Fine Needle Aspiration Diagnosis of Malignant Neoplasms Secondarily Involving the Thyroid: An Institutional ExperienceDolezal D, Zuo T, Adeniran A, Raad R, Cai G. Fine Needle Aspiration Diagnosis of Malignant Neoplasms Secondarily Involving the Thyroid: An Institutional Experience Journal Of The American Society Of Cytopathology 2018, 7: s23. DOI: 10.1016/j.jasc.2018.06.058.
  • p40 is Superior to p63 and CK5/6 for Differentiating Lung Squamous Cell Carcinoma from Adenocarcinoma in Cytological SpecimensDelgado S, Cai G. p40 is Superior to p63 and CK5/6 for Differentiating Lung Squamous Cell Carcinoma from Adenocarcinoma in Cytological Specimens Journal Of The American Society Of Cytopathology 2017, 6: s46. DOI: 10.1016/j.jasc.2017.06.115.
  • A Semi-Quantitative Approach to Biopsy Diagnosis of Large Cell Neuroendocrine Carcinoma of the LungBaine M, Sinard J, Cai G, Homer R. A Semi-Quantitative Approach to Biopsy Diagnosis of Large Cell Neuroendocrine Carcinoma of the Lung Journal Of Thoracic Oncology 2017, 12: s1543. DOI: 10.1016/j.jtho.2017.06.051.
  • MA16.02 Mutational Landscape of TKI Naïve and Resistant EGFR Mutant Lung AdenocarcinomasHastings K, Hastings K, Choi J, Choi J, Wurtz A, Walther Z, Cai G, Oliva I, Oliva I, Zhao Z, Zhao Z, Gaffney S, Gaffney S, Iamarino A, Iamarino A, Zhao S, Zhao S, Bi M, Bi M, Goldberg S, Chiang A, Liu Z, Liu Z, Townsend J, Schlessinger J, Lifton R, Herbst R, Gettinger S, Politi K. MA16.02 Mutational Landscape of TKI Naïve and Resistant EGFR Mutant Lung Adenocarcinomas Journal Of Thoracic Oncology 2017, 12: s435. DOI: 10.1016/j.jtho.2016.11.507.
  • P3.02c-088 Acquired Resistance to Programmed Death-1 Axis Inhibitors in Non-Small Cell Lung Cancer (NSCLC) Topic: IT BiomarkersChoi J, Sowell R, Truini A, Schalper K, Wurtz A, Cai G, Perry C, Datar I, Hastings K, Melnick M, Kaftan E, Kavathas P, Kaech S, Rimm D, Goldberg S, Chiang A, Lifton R, Chen L, Herbst R, Politi K, Gettinger S. P3.02c-088 Acquired Resistance to Programmed Death-1 Axis Inhibitors in Non-Small Cell Lung Cancer (NSCLC) Topic: IT Biomarkers Journal Of Thoracic Oncology 2017, 12: s1331-s1332. DOI: 10.1016/j.jtho.2016.11.1884.
  • Tumor Genotyping Analysis Using Cytological Specimens of Primary and Metastatic Lung AdenocarcinomasRaad R, Walther Z, Gettinger S, Politi K, Puchalski J, Homer R, Cai G. Tumor Genotyping Analysis Using Cytological Specimens of Primary and Metastatic Lung Adenocarcinomas Journal Of The American Society Of Cytopathology 2016, 5: s53. DOI: 10.1016/j.jasc.2016.07.122.
  • GATA 3 is a Reliable Marker in the Detection of Metastatic Breast Cancers in Cytology Specimens from both ER-Positive and ER-Negative Breast CancersAbi-Raad R, Boto A, Lavik J, Fernandez S, Cai G, Adeniran A, Baldassarri R, Kowalski D, Harigopal M. GATA 3 is a Reliable Marker in the Detection of Metastatic Breast Cancers in Cytology Specimens from both ER-Positive and ER-Negative Breast Cancers Journal Of The American Society Of Cytopathology 2016, 5: s11. DOI: 10.1016/j.jasc.2016.07.023.
  • Rapid On-Site Evaluation for Endoscopic Ultrasound–Guided Fine-Needle Aspiration Diagnosis of Pancreatic LesionsCai G, Sun X, Aslanian H, Chhieng D. Rapid On-Site Evaluation for Endoscopic Ultrasound–Guided Fine-Needle Aspiration Diagnosis of Pancreatic Lesions AJSP Review And Reports 2015, 20: 164-168. DOI: 10.1097/pcr.0000000000000099.
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Ampullary MassesRoss J, Chhieng D, Aslanian H, Cai G. Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Ampullary Masses Journal Of The American Society Of Cytopathology 2014, 3: s71. DOI: 10.1016/j.jasc.2014.09.166.
  • Abstract C90: Dependence of afatinib and cetuximab resistant lung adenocarcinomas on mTOR signaling.Pirazzoli V, Nebhan C, Song X, Walter Z, Cai G, Wurtz A, Zhao Z, Elisa de Stanchina E, Horn L, Carbone D, Stevens P, Miller V, Gettinger S, Pao W, Politi K. Abstract C90: Dependence of afatinib and cetuximab resistant lung adenocarcinomas on mTOR signaling. Molecular Cancer Therapeutics 2013, 12: c90-c90. DOI: 10.1158/1535-7163.targ-13-c90.
  • The Value of Rapid On-site Evaluation for Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Cystic and Solid Pancreatic LesionsUstun B, Bernstein J, Chen X, Aslanian H, Chhieng D, Cai G. The Value of Rapid On-site Evaluation for Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Cystic and Solid Pancreatic Lesions Journal Of The American Society Of Cytopathology 2013, 2: s23. DOI: 10.1016/j.jasc.2013.08.059.
  • Calcitonin Immunostain Performed on Thin-Prep Slide Enhances Fine Needle Aspiration Diagnosis of Medullary Thyroid CarcinomaFu L, Theoharis C, Adeniran A, Ustun B, Chhieng D, Sosa J, Roman S, Holt E, Cai G. Calcitonin Immunostain Performed on Thin-Prep Slide Enhances Fine Needle Aspiration Diagnosis of Medullary Thyroid Carcinoma Journal Of The American Society Of Cytopathology 2013, 2: s21. DOI: 10.1016/j.jasc.2013.08.054.
  • Prognostic Significance of PAX8, Survivin, and Ki-67 Expression in Pancreatic Endocrine Neoplasms: A Tissue Microarray AnalysisBernstein J, Van Dyke A, Bao Y, Bao F, Kenney B, Prasad M, Chen G, Robert M, Cai G. Prognostic Significance of PAX8, Survivin, and Ki-67 Expression in Pancreatic Endocrine Neoplasms: A Tissue Microarray Analysis American Journal Of Clinical Pathology 2012, 138: a019-a019. DOI: 10.1093/ajcp/138.suppl2.323.
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Pancreatic Endocrine Neoplasms: An Institution's ExperienceBernstein J, Alomari A, Ustun B, Bao F, Chhieng D, Cai G. Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Pancreatic Endocrine Neoplasms: An Institution's Experience Journal Of The American Society Of Cytopathology 2012, 1: s100. DOI: 10.1016/j.jasc.2012.08.218.
  • Endoscopic Ultrasound Guided Fine Needle Aspiration (EUS-FNA) Diagnosis of Secondary Tumors Involving the Pancreas: Review of 102 CasesAlomari A, Eltoum I, Ustun B, Chhieng D, Cai G. Endoscopic Ultrasound Guided Fine Needle Aspiration (EUS-FNA) Diagnosis of Secondary Tumors Involving the Pancreas: Review of 102 Cases Journal Of The American Society Of Cytopathology 2012, 1: s100. DOI: 10.1016/j.jasc.2012.08.217.
  • Unsatisfactory and Suboptimal Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA) Biopsies: Follow-up and Clinical ImplicationsKarunamurthy A, Cai G, Dacic S, Khalbuss W, Pantanowitz L, Monaco S. Unsatisfactory and Suboptimal Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA) Biopsies: Follow-up and Clinical Implications Journal Of The American Society Of Cytopathology 2012, 1: s81. DOI: 10.1016/j.jasc.2012.08.179.
  • Vanishing Thyroid Nodules: A Rare Diagnostic Dilemma Induced by Ultrasound-Guided Fine-Needle AspirationEze O, Cai G, Baloch Z, Khan A, Hammers L, Udelsman R, Chhieng D, Theoharis C, Prasad M. Vanishing Thyroid Nodules: A Rare Diagnostic Dilemma Induced by Ultrasound-Guided Fine-Needle Aspiration American Journal Of Clinical Pathology 2012, 138: a206-a206. DOI: 10.1093/ajcp/138.suppl1.190.
  • The Complementary Role of CD68 Immunostaining in Diagnosing Sarcoidosis by Endobronchial UltrasounTobias L, Cai G, Puchalski J. The Complementary Role of CD68 Immunostaining in Diagnosing Sarcoidosis by Endobronchial Ultrasoun CHEST Journal 2011, 140: 864a. DOI: 10.1378/chest.1116965.
  • Su1383 25G Needles Provide Superior Diagnostic Yield of Malignancy With Rapid Onsite Evaluation (ROSE) in EUS-Guided FNA of Pancreatic MassesSiddiqui U, Mehra M, Cai G, Chhieng D, Aslanian H. Su1383 25G Needles Provide Superior Diagnostic Yield of Malignancy With Rapid Onsite Evaluation (ROSE) in EUS-Guided FNA of Pancreatic Masses Gastrointestinal Endoscopy 2011, 73: ab249. DOI: 10.1016/j.gie.2011.03.436.
  • Sp287: EUS Guided Confocal Laser Endomicroscopy of the PancreasAslanian H, Chhieng D, Cai G, Siddiqui U. Sp287: EUS Guided Confocal Laser Endomicroscopy of the Pancreas Gastrointestinal Endoscopy 2010, 71: ab101-ab102. DOI: 10.1016/j.gie.2010.03.1097.

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