Edward L. Snyder, MD, FACP
Research & Publications
Biography
News
Research Summary
Dr. Snyder's research relates to the broad field of Transfusion Medicine and, more specifically, Transfusion Oncology and Transfusion Immunobiology. His current research includes an on-going evaluation of new pathogen reduction technology for reduction of pathogens in red cells, platelets and plasma. This technology includes the addition of various compounds to blood to inactivate known, as well as unknown, viral, bacterial, and protozoal contaminants in donated blood. The laboratory has a special expertise in conducting Phase III trials for transfusion of pathogen-reduced blood components into patients. We are also involved in ongoing evaluations of clinical responses of patients to pheresis interventions for a variety of immunologic disorders.
Specialized Terms: Health and Medicine; Membranes; Metabolism; Apheresis Technology; Pathogen Inactivation; Platelet Apoptosis; Platelet Storage Lesion Manufacturing Tissue Engineered Vascular Grafts for Pediatric Surgical Patients
Extensive Research Description
We are conducting 2 Phase III RCTs for pathogen reduced RBCs. One involves patients undergoing complex cardiovascular surgery (ReCePI) and the other anemic oncology patients receiving simple transfusions (RedeS).
Research Interests
Blood Banks; Blood Transfusion; Membranes; Metabolism; Medical Laboratory Science; Organisms; Chemicals and Drugs
Selected Publications
- Analysis of transfusion reactions associated with prestorage‐pooled platelet componentsTormey CA, Sweeney JD, Champion MH, Pisciotto PT, Snyder EL, Wu Y. Analysis of transfusion reactions associated with prestorage‐pooled platelet components. Transfusion 2009, 49: 1242-1247. PMID: 19389029, DOI: 10.1111/j.1537-2995.2009.02128.x.
- Development of a Humanized Mouse Model to Study the Role of Macrophages in Allograft InjuryKirkiles-Smith NC, Harding MJ, Shepherd BR, Fader SA, Yi T, Wang Y, McNiff JM, Snyder EL, Lorber MI, Tellides G, Pober JS. Development of a Humanized Mouse Model to Study the Role of Macrophages in Allograft Injury. Transplantation 2009, 87: 189-197. PMID: 19155972, PMCID: PMC2776641, DOI: 10.1097/tp.0b013e318192e05d.
- Mobilization, collection, and transplantation of peripheral blood hematopoietic progenitor cells in a patient with multiple myeloma and hemoglobin SC diseaseTormey CA, Snyder EL, Cooper DL. Mobilization, collection, and transplantation of peripheral blood hematopoietic progenitor cells in a patient with multiple myeloma and hemoglobin SC disease. Transfusion 2008, 48: 1930-1933. PMID: 18513256, DOI: 10.1111/j.1537-2995.2008.01777.x.
- Component therapy to cellular therapy and beyond— a Darwinian approach to transfusion medicineSnyder EL. Component therapy to cellular therapy and beyond— a Darwinian approach to transfusion medicine. Transfusion 2008, 48: 2000-2007. PMID: 18694467, DOI: 10.1111/j.1537-2995.2008.01859.x.
- Successful in vivo recovery and extended storage of additive solution (AS)‐5 red blood cells after deglycerolization and resuspension in AS‐3 for 15 days with an automated closed systemBandarenko N, Cancelas J, Snyder EL, Hay SN, Rugg N, Corda T, Joines AD, Gormas JF, Pratt GP, Kowalsky R, Rose M, Rose L, Foley J, Popovsky MA. Successful in vivo recovery and extended storage of additive solution (AS)‐5 red blood cells after deglycerolization and resuspension in AS‐3 for 15 days with an automated closed system. Transfusion 2007, 47: 680-686. PMID: 17381627, DOI: 10.1111/j.1537-2995.2007.01171.x.
- Logistics of Platelet ConcentratesEisenbarth S, Champion M, Snyder EL. Logistics of Platelet Concentrates. Vox Sang. 2007:
- Platelet dose consistency and its effect on the number of platelet transfusions for support of thrombocytopenia: an analysis of the SPRINT trial of platelets photochemically treated with amotosalen HCl and ultraviolet A lightMurphy S, Snyder E, Cable R, Slichter SJ, Strauss RG, McCullough J, Lin J, Corash L, Conlan MG, Group T. Platelet dose consistency and its effect on the number of platelet transfusions for support of thrombocytopenia: an analysis of the SPRINT trial of platelets photochemically treated with amotosalen HCl and ultraviolet A light. Transfusion 2005, 46: 24-33. PMID: 16398727, DOI: 10.1111/j.1537-2995.2005.00671.x.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Diseases of the Cardiovascular System | Study to Evaluate the Efficacy & Safety of the INTERCEPT Blood System for RBCs in Complex Cardiac Surgery Patients (ReCePI) |