Donna Wesolowski
Project Manager
Research & Publications
Biography
News
Selected Publications
- Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glassesLiu Y, Padmanabhan J, Cheung B, Liu J, Chen Z, Scanley BE, Wesolowski D, Pressley M, Broadbridge CC, Altman S, Schwarz UD, Kyriakides TR, Schroers J. Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses. Scientific Reports 2016, 6: 26950. PMID: 27230692, PMCID: PMC4882501, DOI: 10.1038/srep26950.
- Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparumGarg A, Wesolowski D, Alonso D, Deitsch KW, Mamoun C, Altman S. Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 11935-11940. PMID: 26351679, PMCID: PMC4586866, DOI: 10.1073/pnas.1515864112.
- Human RNase P ribonucleoprotein is required for formation of initiation complexes of RNA polymerase IIISerruya R, Orlovetskie N, Reiner R, Dehtiar-Zilber Y, Wesolowski D, Altman S, Jarrous N. Human RNase P ribonucleoprotein is required for formation of initiation complexes of RNA polymerase III. Nucleic Acids Research 2015, 43: 5442-5450. PMID: 25953854, PMCID: PMC4477669, DOI: 10.1093/nar/gkv447.
- Functional analysis of Plasmodium falciparum genome using morpholino‐based toolsGarg A, Kumar V, Wesolowski D, Altman S, Mamoun C. Functional analysis of Plasmodium falciparum genome using morpholino‐based tools. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.723.12.
- Identification and Functional Analysis of the Primary Pantothenate Transporter, PfPAT, of the Human Malaria Parasite Plasmodium falciparum *Augagneur Y, Jaubert L, Schiavoni M, Pachikara N, Garg A, Usmani-Brown S, Wesolowski D, Zeller S, Ghosal A, Cornillot E, Said HM, Kumar P, Altman S, Mamoun C. Identification and Functional Analysis of the Primary Pantothenate Transporter, PfPAT, of the Human Malaria Parasite Plasmodium falciparum *. Journal Of Biological Chemistry 2013, 288: 20558-20567. PMID: 23729665, PMCID: PMC3711320, DOI: 10.1074/jbc.m113.482992.
- A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound modelSawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S, Kyriakides TR. A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model. International Journal Of Pharmaceutics 2013, 453: 651-655. PMID: 23727592, PMCID: PMC3756894, DOI: 10.1016/j.ijpharm.2013.05.041.
- Combined effect of a peptide–morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibioticWesolowski D, Alonso D, Altman S. Combined effect of a peptide–morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 8686-8689. PMID: 23650357, PMCID: PMC3666680, DOI: 10.1073/pnas.1306911110.
- Gene selective mRNA cleavage inhibits the development of Plasmodium falciparumAugagneur Y, Wesolowski D, Tae HS, Altman S, Mamoun C. Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 6235-6240. PMID: 22474358, PMCID: PMC3341008, DOI: 10.1073/pnas.1203516109.
- Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modesWesolowski D, Tae HS, Gandotra N, Llopis P, Shen N, Altman S. Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 16582-16587. PMID: 21949365, PMCID: PMC3189074, DOI: 10.1073/pnas.1112561108.
- RNA binding properties of conserved protein subunits of human RNase PReiner R, Alfiya-Mor N, Berrebi-Demma M, Wesolowski D, Altman S, Jarrous N. RNA binding properties of conserved protein subunits of human RNase P. Nucleic Acids Research 2011, 39: 5704-5714. PMID: 21450806, PMCID: PMC3141246, DOI: 10.1093/nar/gkr126.
- Morpholino oligonucleotides do not participate perfectly in standard Watson-Crick complexes with RNAXiao G, Wesolowski D, Izadjoo M, Altman S. Morpholino oligonucleotides do not participate perfectly in standard Watson-Crick complexes with RNA. RNA 2010, 16: 2218-2225. PMID: 20817753, PMCID: PMC2957060, DOI: 10.1261/rna.2256610.
- Inactivation of expression of several genes in a variety of bacterial species by EGS technologyShen N, Ko JH, Xiao G, Wesolowski D, Shan G, Geller B, Izadjoo M, Altman S. Inactivation of expression of several genes in a variety of bacterial species by EGS technology. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 8163-8168. PMID: 19416872, PMCID: PMC2688897, DOI: 10.1073/pnas.0903491106.
- Analysis of Putative RNase P RNA from OrthopoxvirusesYang L, Wesolowski D, Li Y, Altman S. Analysis of Putative RNase P RNA from Orthopoxviruses. Journal Of Molecular Biology 2005, 354: 529-535. PMID: 16253270, DOI: 10.1016/j.jmb.2005.09.020.
- RNase P cleaves transient structures in some riboswitchesAltman S, Wesolowski D, Guerrier-Takada C, Li Y. RNase P cleaves transient structures in some riboswitches. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 11284-11289. PMID: 16061811, PMCID: PMC1183601, DOI: 10.1073/pnas.0505271102.
- Coordinate inhibition of expression of several genes for protein subunits of human nuclear RNase PKovrigina E, Wesolowski D, Altman S. Coordinate inhibition of expression of several genes for protein subunits of human nuclear RNase P. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 1598-1602. PMID: 12552092, PMCID: PMC149878, DOI: 10.1073/pnas.0337661100.
- Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P.Jarrous N, Reiner R, Wesolowski D, Mann H, Guerrier-Takada C, Altman S. Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P. RNA 2001, 7: 1153-64. PMID: 11497433, PMCID: PMC1370162, DOI: 10.1017/s1355838201010469.
- Inhibition of Escherichia coli viability by external guide sequences complementary to two essential genesMcKinney J, Guerrier-Takada C, Wesolowski D, Altman S. Inhibition of Escherichia coli viability by external guide sequences complementary to two essential genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6605-6610. PMID: 11381134, PMCID: PMC34400, DOI: 10.1073/pnas.121180398.
- Localization in the Nucleolus and Coiled Bodies of Protein Subunits of the Ribonucleoprotein Ribonuclease PJarrous N, Wolenski J, Wesolowski D, Lee C, Altman S. Localization in the Nucleolus and Coiled Bodies of Protein Subunits of the Ribonucleoprotein Ribonuclease P. Journal Of Cell Biology 1999, 146: 559-572. PMID: 10444065, PMCID: PMC2150555, DOI: 10.1083/jcb.146.3.559.
- Rpp14 and Rpp29, two protein subunits of human ribonuclease P.Jarrous N, Eder P, Wesolowski D, Altman S. Rpp14 and Rpp29, two protein subunits of human ribonuclease P. RNA 1999, 5: 153-7. PMID: 10024167, PMCID: PMC1369747, DOI: 10.1017/s135583829800185x.
- Mapping in Three Dimensions of Regions in a Catalytic RNA Protected from Attack by an Fe(II)-EDTA ReagentWesthof E, Wesolowski D, Altman S. Mapping in Three Dimensions of Regions in a Catalytic RNA Protected from Attack by an Fe(II)-EDTA Reagent. Journal Of Molecular Biology 1996, 258: 600-613. PMID: 8636995, DOI: 10.1006/jmbi.1996.0272.
- Nucleotide Sequences of the RNA Subunit of RNase P from Several MammalsAltman S, Wesolowski D, Puranam R. Nucleotide Sequences of the RNA Subunit of RNase P from Several Mammals. Genomics 1993, 18: 418-422. PMID: 7507079, DOI: 10.1006/geno.1993.1488.
- Protection from chemical modification of nucleotides in complexes of M1 RNA, the catalytic subunit of RNase P from E coli, and tRNA precursorsKnap A, Wesolowski D, Altman S. Protection from chemical modification of nucleotides in complexes of M1 RNA, the catalytic subunit of RNase P from E coli, and tRNA precursors. Biochimie 1990, 72: 779-790. PMID: 1707681, DOI: 10.1016/0300-9084(90)90187-l.
- Characterization in vitro of the defect in a temperature-sensitive mutant of the protein subunit of RNase P from Escherichia coli.Baer M, Wesolowski D, Altman S. Characterization in vitro of the defect in a temperature-sensitive mutant of the protein subunit of RNase P from Escherichia coli. Journal Of Bacteriology 1989, 171: 6862-6866. PMID: 2480345, PMCID: PMC210589, DOI: 10.1128/jb.171.12.6862-6866.1989.
- Characteristics of ribonuclease P from various organisms.Lawrence N, Wesolowski D, Gold H, Bartkiewicz M, Guerrier-Takada C, McClain W, Altman S. Characteristics of ribonuclease P from various organisms. Cold Spring Harbor Symposia On Quantitative Biology 1987, 52: 233-8. PMID: 2456877, DOI: 10.1101/sqb.1987.052.01.028.