Csaba Leranth, MD, PhD
Professor of Obstetrics, Gynecology, and Reproductive Sciences and of Neuroscience
Research & Publications
Biography
News
Research Summary
Positive gonadal hormonal and negative bisphenol A effects on brain areas involved mnemonic functions (hippocampus and prefrontal cortex) of females and males
Specialized Terms: Positive gonadal hormonal negative bisphenol A effects
Extensive Research Description
Bisphenol A effect on the non-human primate brain.
Gene therapy of primate model of Parkinsons disease.
Morphological changes in the primate brain in PCP model of schizophrenia.
Coauthors
Research Interests
Anatomy; Endocrine System; Gynecology; Nervous System; Neurobiology
Research Image
PFC SPINE
Effect of Bisphenol A on the spine synapses of the prefrontal cortex of non-human primates. Bisphenol A dministration results in a loss of spine synapses (panel b) compared to controls (panel a).
Selected Publications
- Bisphenol A interferes with synaptic remodelingHajszan T, Leranth C. Bisphenol A interferes with synaptic remodeling. Frontiers In Neuroendocrinology 2010, 31: 519-530. PMID: 20609373, PMCID: PMC2964437, DOI: 10.1016/j.yfrne.2010.06.004.
- Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of DepressionHajszan T, Dow A, Warner-Schmidt JL, Szigeti-Buck K, Sallam NL, Parducz A, Leranth C, Duman RS. Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression. Biological Psychiatry 2008, 65: 392-400. PMID: 19006787, PMCID: PMC2663388, DOI: 10.1016/j.biopsych.2008.09.031.
- Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primatesLeranth C, Hajszan T, Szigeti-Buck K, Bober J, MacLusky NJ. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14187-14191. PMID: 18768812, PMCID: PMC2544599, DOI: 10.1073/pnas.0806139105.
- Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male RatsLeranth C, Szigeti-Buck K, MacLusky NJ, Hajszan T. Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats. Endocrinology 2007, 149: 988-994. PMID: 18048497, PMCID: PMC2275360, DOI: 10.1210/en.2007-1053.
- Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortexMorrow BA, Hajszan T, Leranth C, Elsworth JD, Roth RH. Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex. Synapse 2007, 61: 862-865. PMID: 17630673, DOI: 10.1002/syn.20430.
- Effects of Androgens and Estradiol on Spine Synapse Formation in the Prefrontal Cortex of Normal and Testicular Feminization Mutant Male RatsHajszan T, MacLusky NJ, Johansen JA, Jordan CL, Leranth C. Effects of Androgens and Estradiol on Spine Synapse Formation in the Prefrontal Cortex of Normal and Testicular Feminization Mutant Male Rats. Endocrinology 2007, 148: 1963-1967. PMID: 17317772, PMCID: PMC2128740, DOI: 10.1210/en.2006-1626.
- Sex steroids and the dentate gyrusHajszan T, Milner TA, Leranth C. Sex steroids and the dentate gyrus. 2007, 163: 399-816. PMID: 17765731, PMCID: PMC1964752, DOI: 10.1016/s0079-6123(07)63023-4.
- Extrinsic afferent systems to the dentate gyrusLeranth C, Hajszan T. Extrinsic afferent systems to the dentate gyrus. 2007, 163: 63-799. PMID: 17765712, PMCID: PMC1989689, DOI: 10.1016/s0079-6123(07)63004-0.
- Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen ReceptorsMacLusky NJ, Hajszan T, Johansen JA, Jordan CL, Leranth C. Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors. Endocrinology 2006, 147: 2392-2398. PMID: 16439462, DOI: 10.1210/en.2005-0673.
- The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal SynaptogenesisMacLusky NJ, Hajszan T, Leranth C. The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis. Environmental Health Perspectives 2005, 113: 675-679. PMID: 15929888, PMCID: PMC1257590, DOI: 10.1289/ehp.7633.