Csaba Leranth, MD, PhD
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Appointments
Contact Info
Obstetrics, Gynecology & Reproductive Sciences
333 Cedar Street
New Haven, CT 06510-
United States
About
Titles
Professor of Obstetrics, Gynecology, and Reproductive Sciences and of Neuroscience
Appointments
Obstetrics, Gynecology & Reproductive Sciences
ProfessorPrimary
Other Departments & Organizations
- Neural Transplant and Neurobehavior Program
- Obstetrics, Gynecology & Reproductive Sciences
- Reproductive Neurosciences Group
- Reproductive Sciences
- Yale Ventures
Education & Training
- PhD
- Hungarian Academy of Sciences (1978)
- MD
- Semmelweis University (1964)
Research
Overview
Bisphenol A effect on the non-human primate brain.
Gene therapy of primate model of Parkinsons disease.
Morphological changes in the primate brain in PCP model of schizophrenia.
Medical Subject Headings (MeSH)
Anatomy; Endocrine System; Gynecology; Nervous System; Neurobiology
Research at a Glance
Yale Co-Authors
Frequent collaborators of Csaba Leranth's published research.
Publications Timeline
A big-picture view of Csaba Leranth's research output by year.
Jeremy Bober
10Publications
1,031Citations
Publications
2010
Bisphenol A interferes with synaptic remodeling
Hajszan T, Leranth C. Bisphenol A interferes with synaptic remodeling. Frontiers In Neuroendocrinology 2010, 31: 519-530. PMID: 20609373, PMCID: PMC2964437, DOI: 10.1016/j.yfrne.2010.06.004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2008
Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression
Hajszan T, Dow A, Warner-Schmidt JL, Szigeti-Buck K, Sallam NL, Parducz A, Leranth C, Duman RS. Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression. Biological Psychiatry 2008, 65: 392-400. PMID: 19006787, PMCID: PMC2663388, DOI: 10.1016/j.biopsych.2008.09.031.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHippocampal spine synapsesSpine synapse lossSpine synapsesInescapable footshockEscape deficitSynapse lossDepressive behaviorHippocampal synaptic changesLoss of synapsesNonstressed control ratsStress-related disordersElectron microscopic stereologyStructural synaptic modificationsDesipramine treatmentSynaptic alterationsMotor cortexControl ratsDentate gyrusHippocampal dysfunctionMale ratsSingle injectionSynaptic changesHelplessness paradigmBehavioral effectsSynaptic modificationBisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates
Leranth C, Hajszan T, Szigeti-Buck K, Bober J, MacLusky NJ. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14187-14191. PMID: 18768812, PMCID: PMC2544599, DOI: 10.1073/pnas.0806139105.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSpine synapse formationNonhuman primate modelSynapse formationPrimate modelAbility of BPAPrefrontal cortexOvariectomized nonhuman primatesLimbic brain areasHuman BPA exposureRodent animal modelsLow exposure levelsBPA administrationDaily doseMale ratsSpine synapsesBPA exposureAnimal modelsBrain areasSynthetic xenoestrogenCognitive functionNonhuman primatesAdverse effectsExposure levelsPolycarbonate plasticsExposure measurements
2007
Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats
Leranth C, Szigeti-Buck K, MacLusky NJ, Hajszan T. Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats. Endocrinology 2007, 149: 988-994. PMID: 18048497, PMCID: PMC2275360, DOI: 10.1210/en.2007-1053.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAdult male ratsMedial prefrontal cortexMale ratsSpine synapsesCA1 hippocampal areaAsymmetric spine synapsesSham-operated animalsElectron microscopic stereologyImpairs synaptogenesisSynaptogenic actionsOvariectomized ratsHippocampal areaTestosterone supplementationTestosterone propionateEstrogen receptorExposure measurement dataOil vehicleCompensatory increaseIntact animalsSynthetic xenoestrogenPrefrontal cortexRatsHippocampusCastrated malesPotential mechanismsPrenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex
Morrow BA, Hajszan T, Leranth C, Elsworth JD, Roth RH. Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex. Synapse 2007, 61: 862-865. PMID: 17630673, DOI: 10.1002/syn.20430.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPrenatal exposureFemale ratsSpine synapsesPrelimbic cortexDendritic spinesCognitive deficitsLayers II/IIIPrenatal saline controlsExcitatory synaptic inputsAsymmetric spine synapsesPrenatal cocaine exposureRat prelimbic cortexYoung adult malesPhysical disector methodPyramidal neuronsSaline controlsNeuronal activationCocaine exposureExcitatory synapsesFrontal cortexSynaptic inputsAnimal modelsExcess activationPrefrontal cortexCortexEffects of Androgens and Estradiol on Spine Synapse Formation in the Prefrontal Cortex of Normal and Testicular Feminization Mutant Male Rats
Hajszan T, MacLusky NJ, Johansen JA, Jordan CL, Leranth C. Effects of Androgens and Estradiol on Spine Synapse Formation in the Prefrontal Cortex of Normal and Testicular Feminization Mutant Male Rats. Endocrinology 2007, 148: 1963-1967. PMID: 17317772, PMCID: PMC2128740, DOI: 10.1210/en.2006-1626.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSpine synapse formationMale ratsWild-type animalsPrefrontal cortexTfm ratsSpine synapsesAndrogen receptorSynapse formationEffects of androgensSynaptogenic actionsTfm malesGonadal steroidsSynaptogenic effectsGonadal hormonesSynaptic remodelingTfm animalsFemale monkeysRatsCortexCortical spinesCognitive effectsAndrogensReceptorsSynapsesAdult malesExtrinsic afferent systems to the dentate gyrus
Leranth C, Hajszan T. Extrinsic afferent systems to the dentate gyrus. Progress In Brain Research 2007, 163: 63-799. PMID: 17765712, PMCID: PMC1989689, DOI: 10.1016/s0079-6123(07)63004-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDentate gyrusAfferent systemsMedial septum/diagonal bandExtrinsic afferent systemsVentral tegmental areaGranule cell dendritesPopulations of neuronsExtrinsic afferentsNoradrenergic afferentsCholinergic neuronsGlutamatergic innervationLocus ceruleusSerotonergic fibersCommissural afferentsGABAergic interneuronsPostsynaptic targetsEntorhinal afferentsTegmental areaCell dendritesDiagonal bandMedian rapheSupramammillary areaPontine nucleiHippocampal formationAfferentsSex steroids and the dentate gyrus
Hajszan T, Milner TA, Leranth C. Sex steroids and the dentate gyrus. Progress In Brain Research 2007, 163: 399-816. PMID: 17765731, PMCID: PMC1964752, DOI: 10.1016/s0079-6123(07)63023-4.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDentate gyrusSex steroidsGonadal hormonesSynaptic remodelingActivational effectsNormal dentate gyrusExpression of estrogenDentate gyrus neurogenesisCholinergic septohippocampal systemNormal cognitive functionSteroid-mediated actionsMore granule cellsCertain mouse strainsGyrus neurogenesisNeuroprotective potentialDentate neuronsAndrogen receptorGonadal originDentate cellsAdult brainHippocampal formationGranule cellsCellular injuryClinical importanceAlzheimer's disease
2006
Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors
MacLusky NJ, Hajszan T, Johansen JA, Jordan CL, Leranth C. Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors. Endocrinology 2006, 147: 2392-2398. PMID: 16439462, DOI: 10.1210/en.2005-0673.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDefective androgen receptorHippocampal synaptic responsesEstradiol benzoateAndrogen receptorMale ratsSpine synapsesTfm malesSynaptic responsesAndrogen effectsTfm mutationEffects of EBDose of EBHippocampal CA1 synapsesSpine synapse numberSesame oil vehicleDendritic spine synapsesCA1 stratum radiatumAdult male ratsHippocampal spine synapsesVehicle-injected controlsHormone-induced increaseAgonists/antagonistsWild-type animalsWild-type malesCA1 synapses
2005
The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis
MacLusky NJ, Hajszan T, Leranth C. The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis. Environmental Health Perspectives 2005, 113: 675-679. PMID: 15929888, PMCID: PMC1257590, DOI: 10.1289/ehp.7633.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEnvironmental BPA exposureHippocampal synapse formationDendritic spine synapsesEndogenous estrogen productionHuman exposureNormal sex differencesHippocampus-dependent memoryHippocampal synaptogenesisOvariectomized ratsPyramidal neuronsBPA doseCA1 areaEstrogen productionSpine synapsesBPA exposureSignificant inhibitory effectSynaptic remodelingHippocampal functionSynapse formationCognitive functionNormal agingRapid effectsInhibitory effectManufacture of plasticsDental prostheses
Academic Achievements and Community Involvement
activity Board Member
Professional OrganizationsAxion Research FoundationDetails01/30/1995 - PresentDescriptionScientific Advisory Boardhonor Wolfgang-Bargman Price
International AwardGerman Anatomical SocietyDetails03/20/1994United States
Links & Media
Media
PFC SPINE
Effect of Bisphenol A on the spine synapses of the prefrontal cortex of non-human primates. Bisphenol A dministration results in a loss of spine synapses (panel b) compared to controls (panel a).
News
- August 01, 2011
Peripheral vision
- September 03, 2008
More Evidence That BPA Found in Clear Plastics Impairs Brain Function
- April 15, 2001
Estrogen deprivation associated with loss of dopamine cells
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Contacts
Mailing Address
Obstetrics, Gynecology & Reproductive Sciences
333 Cedar Street
New Haven, CT 06510-
United States