Christopher Burd, MS, PhD
Professor and Chair of Cell Biology; Interim Chair, Cell Biology
Research & Publications
Biography
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Coauthors
Selected Publications
- Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesisKim Y, Mavodza G, Senkal C, Burd C. Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesis. Journal Of Cell Biology 2023, 222: e202308055. PMID: 37787764, PMCID: PMC10547602, DOI: 10.1083/jcb.202308055.
- Lipid Sorting and Organelle Identity.Kim Y, Burd C. Lipid Sorting and Organelle Identity. Cold Spring Harbor Perspectives In Biology 2023, 15: a041397. PMID: 37487627, PMCID: PMC10547387, DOI: 10.1101/cshperspect.a041397.
- Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathwaySokoya T, Parolek J, Foged M, Danylchuk D, Bozan M, Sarkar B, Hilderink A, Philippi M, Botto L, Terhal P, Mäkitie O, Piehler J, Kim Y, Burd C, Klymchenko A, Maeda K, Holthuis J. Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway. ELife 2022, 11: e79278. PMID: 36102623, PMCID: PMC9531943, DOI: 10.7554/elife.79278.
- Syndecan-1 Mediates Sorting of Soluble Lipoprotein Lipase with Sphingomyelin-Rich Membrane in the Golgi ApparatusSundberg EL, Deng Y, Burd CG. Syndecan-1 Mediates Sorting of Soluble Lipoprotein Lipase with Sphingomyelin-Rich Membrane in the Golgi Apparatus. Developmental Cell 2019, 51: 387-398.e4. PMID: 31543446, PMCID: PMC6832887, DOI: 10.1016/j.devcel.2019.08.014.
- Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi NetworkDeng Y, Pakdel M, Blank B, Sundberg EL, Burd CG, von Blume J. Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network. Developmental Cell 2018, 47: 464-478.e8. PMID: 30393074, PMCID: PMC6261503, DOI: 10.1016/j.devcel.2018.10.012.
- Cell-Penetrating Peptide Mediates Intracellular Membrane Passage of Human Papillomavirus L2 Protein to Trigger Retrograde TraffickingZhang P, da Silva G, Deatherage C, Burd C, DiMaio D. Cell-Penetrating Peptide Mediates Intracellular Membrane Passage of Human Papillomavirus L2 Protein to Trigger Retrograde Trafficking. Cell 2018, 174: 1465-1476.e13. PMID: 30122350, PMCID: PMC6128760, DOI: 10.1016/j.cell.2018.07.031.
- Lipid trafficking by yeast Snx4 family SNX-BAR proteins promotes autophagy and vacuole membrane fusionMa M, Kumar S, Purushothaman L, Babst M, Ungermann C, Chi RJ, Burd CG. Lipid trafficking by yeast Snx4 family SNX-BAR proteins promotes autophagy and vacuole membrane fusion. Molecular Biology Of The Cell 2018, 29: 2190-2200. PMID: 29949447, PMCID: PMC6249802, DOI: 10.1091/mbc.e17-12-0743.
- Sphingomyelin is sorted at the trans Golgi network into a distinct class of secretory vesicleDeng Y, Rivera-Molina FE, Toomre DK, Burd CG. Sphingomyelin is sorted at the trans Golgi network into a distinct class of secretory vesicle. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 6677-6682. PMID: 27247384, PMCID: PMC4914164, DOI: 10.1073/pnas.1602875113.
- Roles of lipids in Golgi sortingBurd C, Wood C, Hung C. Roles of lipids in Golgi sorting. The FASEB Journal 2011, 25: 83.2-83.2. DOI: 10.1096/fasebj.25.1_supplement.83.2.
- Functions of Rab GTPases in organelle biogenesisBurd C, Collins R. Functions of Rab GTPases in organelle biogenesis. 2004, 10: 65-88. DOI: 10.1007/b97781.
- FYVE Domain Targets Pib1p Ubiquitin Ligase to Endosome and Vacuolar Membranes*Shin M, Ogburn K, Varban O, Gilbert P, Burd C. FYVE Domain Targets Pib1p Ubiquitin Ligase to Endosome and Vacuolar Membranes*. Journal Of Biological Chemistry 2001, 276: 41388-41393. PMID: 11526110, DOI: 10.1074/jbc.m105665200.
- GDP Dissociation Inhibitor Domain II Required for Rab GTPase Recycling*Gilbert P, Burd C. GDP Dissociation Inhibitor Domain II Required for Rab GTPase Recycling*. Journal Of Biological Chemistry 2000, 276: 8014-8020. PMID: 11116150, DOI: 10.1074/jbc.m008845200.
- Determinants of NPC1 Expression and Action: Key Promoter Regions, Posttranscriptional Control, and the Importance of a “Cysteine-Rich” LoopWatari H, Blanchette-Mackie E, Dwyer N, Watari M, Burd C, Patel S, Pentchev P, Strauss J. Determinants of NPC1 Expression and Action: Key Promoter Regions, Posttranscriptional Control, and the Importance of a “Cysteine-Rich” Loop. Experimental Cell Research 2000, 259: 247-256. PMID: 10942596, DOI: 10.1006/excr.2000.4976.
- Visualizing protein dynamics in yeast with green fluorescent proteinBurd C. Visualizing protein dynamics in yeast with green fluorescent protein. 2000, 327: 61-69. PMID: 11044974, DOI: 10.1016/s0076-6879(00)27267-4.
- Phosphatidylinositol 3-Phosphate Recognition by the FYVE DomainKutateladze T, Ogburn K, Watson W, de Beer T, Emr S, Burd C, Overduin M. Phosphatidylinositol 3-Phosphate Recognition by the FYVE Domain. Molecular Cell 1999, 3: 805-811. PMID: 10394369, DOI: 10.1016/s1097-2765(01)80013-7.
- Molecular Dissection of Guanine Nucleotide Dissociation Inhibitor Function in Vivo Rab-INDEPENDENT BINDING TO MEMBRANES AND ROLE OF RAB RECYCLING FACTORS*Luan P, Balch W, Emr S, Burd C. Molecular Dissection of Guanine Nucleotide Dissociation Inhibitor Function in Vivo Rab-INDEPENDENT BINDING TO MEMBRANES AND ROLE OF RAB RECYCLING FACTORS*. Journal Of Biological Chemistry 1999, 274: 14806-14817. PMID: 10329679, DOI: 10.1074/jbc.274.21.14806.
- Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosomePeterson M, Burd C, Emr S. Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Current Biology 1999, 9: 159-s1. PMID: 10021387, DOI: 10.1016/s0960-9822(99)80071-2.
- Novel pathways, membrane coats and PI kinase regulation in yeast lysosomal traffickingBurd C, Babst M, Emr S. Novel pathways, membrane coats and PI kinase regulation in yeast lysosomal trafficking. Seminars In Cell And Developmental Biology 1998, 9: 527-533. PMID: 9835640, DOI: 10.1006/scdb.1998.0255.
- Acidic Di-leucine Motif Essential for AP-3–dependent Sorting and Restriction of the Functional Specificity of the Vam3p Vacuolar t-SNAREDarsow T, Burd C, Emr S. Acidic Di-leucine Motif Essential for AP-3–dependent Sorting and Restriction of the Functional Specificity of the Vam3p Vacuolar t-SNARE. Journal Of Cell Biology 1998, 142: 913-922. PMID: 9722605, PMCID: PMC2132875, DOI: 10.1083/jcb.142.4.913.
- Phosphatidylinositol(3)-Phosphate Signaling Mediated by Specific Binding to RING FYVE DomainsBurd C, Emr S. Phosphatidylinositol(3)-Phosphate Signaling Mediated by Specific Binding to RING FYVE Domains. Molecular Cell 1998, 2: 157-162. PMID: 9702203, DOI: 10.1016/s1097-2765(00)80125-2.
- A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast.Burd C, Peterson M, Cowles C, Emr S. A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast. Molecular Biology Of The Cell 1997, 8: 1089-1104. PMID: 9201718, PMCID: PMC305716, DOI: 10.1091/mbc.8.6.1089.
- Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport componentCowles C, Snyder W, Burd C, Emr S. Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component. The EMBO Journal 1997, 16: 2769-2782. PMID: 9184222, PMCID: PMC1169886, DOI: 10.1093/emboj/16.10.2769.
- Information and peer review on the InternetBurd C, Babst M, Emr S. Information and peer review on the Internet. Trends In Biochemical Sciences 1997, 22: 86. DOI: 10.1016/s0968-0004(97)01000-1.
- Receptor signalling and the regulation of endocytic membrane transportSeaman M, Burd C, Emr S. Receptor signalling and the regulation of endocytic membrane transport. Current Opinion In Cell Biology 1996, 8: 549-556. PMID: 8791448, DOI: 10.1016/s0955-0674(96)80034-2.
- A Yeast Protein Related to a Mammalian Ras-Binding Protein, Vps9p, Is Required for Localization of Vacuolar ProteinsBurd C, Mustol P, Schu P, Emr S. A Yeast Protein Related to a Mammalian Ras-Binding Protein, Vps9p, Is Required for Localization of Vacuolar Proteins. Molecular And Cellular Biology 1996, 16: 2369-2377. PMID: 8628304, PMCID: PMC231225, DOI: 10.1128/mcb.16.5.2369.
- The determinants of RNA-binding specificity of the heterogeneous nuclear ribonucleoprotein C proteins.Görlach M, Burd C, Dreyfuss G. The determinants of RNA-binding specificity of the heterogeneous nuclear ribonucleoprotein C proteins. Journal Of Biological Chemistry 1994, 269: 23074-23078. PMID: 8083209, DOI: 10.1016/s0021-9258(17)31621-6.
- Conserved Structures and Diversity of Functions of RNA-Binding ProteinsBurd C, Dreyfuss G. Conserved Structures and Diversity of Functions of RNA-Binding Proteins. Science 1994, 265: 615-621. PMID: 8036511, DOI: 10.1126/science.8036511.
- The mRNA Poly(A)-Binding Protein: Localization, Abundance, and RNA-Binding SpecificityGörlach M, Burd C, Dreyfuss G. The mRNA Poly(A)-Binding Protein: Localization, Abundance, and RNA-Binding Specificity. Experimental Cell Research 1994, 211: 400-407. PMID: 7908267, DOI: 10.1006/excr.1994.1104.
- RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing.Burd C, Dreyfuss G. RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. The EMBO Journal 1994, 13: 1197-204. PMID: 7510636, PMCID: PMC394929, DOI: 10.1002/j.1460-2075.1994.tb06369.x.
- The hnRNP proteinsGörlach M, Burd C, Portman D, Dreyfuss G. The hnRNP proteins. Molecular Biology Reports 1993, 18: 73-78. PMID: 8232298, DOI: 10.1007/bf00986759.
- hnRNP Proteins and the Biogenesis of mRNADreyfuss G, Matunis M, Piñol-Roma S, Burd C. hnRNP Proteins and the Biogenesis of mRNA. Annual Review Of Biochemistry 1993, 62: 289-321. PMID: 8352591, DOI: 10.1146/annurev.bi.62.070193.001445.
- RNA binding characteristics of a 16 kDa glycine‐rich protein from maizeLudevid M, Freire M, Gómez J, Burd C, Albericio F, Giralt E, Dreyfuss G, Pagès M. RNA binding characteristics of a 16 kDa glycine‐rich protein from maize. The Plant Journal 1992, 2: 999-1003. PMID: 1302645, DOI: 10.1046/j.1365-313x.1992.t01-10-00999.x.
- RNA binding characteristics of a 16 kDa glycine-rich protein from maizeLudevid M, Freire M, Gomez J, Burd C, Albericio F, Giralt E, Dreyfuss G, Pages M. RNA binding characteristics of a 16 kDa glycine-rich protein from maize. The Plant Journal 1992, 2: 999-1003. DOI: 10.1111/j.1365-313x.1992.00999.x.
- The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities.Burd C, Matunis E, Dreyfuss G. The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities. Molecular And Cellular Biology 1991, 11: 3419-3424. PMID: 1675426, PMCID: PMC361068, DOI: 10.1128/mcb.11.7.3419.
- The Multiple RNA-Binding Domains of the mRNA Poly(A)-Binding Protein Have Different RNA-Binding ActivitiesBurd C, Matunis E, Dreyfuss G. The Multiple RNA-Binding Domains of the mRNA Poly(A)-Binding Protein Have Different RNA-Binding Activities. Molecular And Cellular Biology 1991, 11: 3419-3424. DOI: 10.1128/mcb.11.7.3419-3424.1991.
- Recent studies on hnRNP complexesPiñol-Roma S, Swanson M, Görlach M, Burd C, Matunis M, Matunis E, Michael M, Dreyfuss G. Recent studies on hnRNP complexes. Molecular Biology Reports 1990, 14: 85-85. PMID: 2362581, DOI: 10.1007/bf00360426.
- Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.Burd C, Swanson M, Görlach M, Dreyfuss G. Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 9788-9792. PMID: 2557628, PMCID: PMC298587, DOI: 10.1073/pnas.86.24.9788.