Christine Ko, MD
Research & Publications
Biography
News
Research Summary
I am studying skin cancer, particularly squamous cell carcinoma and keratoacanthoma. I am also interested in clinical-pathologic correlation and biomarkers of skin disease.
Specialized Terms: Adnexal tumors; Benign and malignant epidermal tumors
Extensive Research Description
I tend to focus on how to distinguish between diseases and disorders that may present in a similar fashion clinically and/or microscopically. I have published papers as well as books in clinical dermatology and dermatopathology (Dermatology: Visual Recognition and Case Reviews, Dermatology Essentials, Dermatopathology: Diagnosis by First Impression).
I am also interested in mechanisms of carcinogenesis, particularly as they relate to squamous cell carcinoma of the skin and a spontaneously regressing tumor called keratoacanthoma.
Coauthors
Research Interests
Carcinoma, Squamous Cell; Dermatology; Epidermis; Keratoacanthoma; Pathology; Skin Neoplasms; Neoplasms, Adnexal and Skin Appendage; Vascular Neoplasms
Research Images
Selected Publications
- PRAME‐negativity in sclerosing nevi with pseudomelanomatous features supports classification as an indolent lesionTang H, McNiff J, Glusac E, Ko C. PRAME‐negativity in sclerosing nevi with pseudomelanomatous features supports classification as an indolent lesion. Journal Of Cutaneous Pathology 2023 PMID: 37565491, DOI: 10.1111/cup.14505.
- Vascular-Targeted Therapy for Systemic Lupus Erythematosus–Associated VasculitisXu S, Patrignelli R, Ramachandran S, Koumpouras F, Desir D, Ko C, Gehlhausen J. Vascular-Targeted Therapy for Systemic Lupus Erythematosus–Associated Vasculitis. JAMA Dermatology 2023, 159: 460-462. PMID: 36884229, DOI: 10.1001/jamadermatol.2023.0077.
- Squamous carcinogenesis: Potential truncal mutationsTang H, Seykora J, Ko C. Squamous carcinogenesis: Potential truncal mutations. Human Pathology 2023 PMID: 37001739, DOI: 10.1016/j.humpath.2023.03.016.
- Cognitive Bias in Pathology, as Exemplified in DermatopathologyKo C, Glusac E. Cognitive Bias in Pathology, as Exemplified in Dermatopathology. Human Pathology 2023 PMID: 36906184, DOI: 10.1016/j.humpath.2023.03.003.
- IL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin BiopsiesChen J, Murphy M, Singh K, Wang A, Chow R, Kim R, Cohen J, Ko C, Damsky W. IL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin Biopsies. JID Innovations 2023, 3: 100189. PMID: 37205304, PMCID: PMC10186614, DOI: 10.1016/j.xjidi.2023.100189.
- 003 Atypical bullous pemphigoid due to radiation therapyBelzer A, Ko C, Leventhal J. 003 Atypical bullous pemphigoid due to radiation therapy. Journal Of Investigative Dermatology 2022, 142: s1. DOI: 10.1016/j.jid.2022.05.057.
- LB731 GJA4 somatic mutations drive venous malformation in the skin and liver and reveal a novel pathway for therapeutic interventionUgwu N, Atzmony L, Ellis K, Panse G, Jain D, Ko C, Nassiri N, Choate K. LB731 GJA4 somatic mutations drive venous malformation in the skin and liver and reveal a novel pathway for therapeutic intervention. Journal Of Investigative Dermatology 2021, 141: b8. DOI: 10.1016/j.jid.2021.07.021.
- Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike proteinKo CJ, Harigopal M, Gehlhausen JR, Bosenberg M, McNiff JM, Damsky W. Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein. Journal Of Cutaneous Pathology 2020, 48: 47-52. PMID: 32895985, DOI: 10.1111/cup.13866.
- Perniosis during the COVID‐19 pandemic: Negative anti‐SARS‐CoV‐2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS‐CoV‐2Ko CJ, Harigopal M, Damsky W, Gehlhausen JR, Bosenberg M, Patrignelli R, McNiff JM. Perniosis during the COVID‐19 pandemic: Negative anti‐SARS‐CoV‐2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS‐CoV‐2. Journal Of Cutaneous Pathology 2020, 47: 997-1002. PMID: 32745281, PMCID: PMC7436569, DOI: 10.1111/cup.13830.
- A detailed analysis of the distribution, morphology, and histopathology of complex purpura in hospitalized patients: A case series of 68 patientsGehlhausen JR, Wetter DA, Nelson C, Ramachandran S, McNiff JM, Ko CJ. A detailed analysis of the distribution, morphology, and histopathology of complex purpura in hospitalized patients: A case series of 68 patients. Journal Of The American Academy Of Dermatology 2020, 84: 1188-1196. PMID: 32376433, DOI: 10.1016/j.jaad.2020.04.149.
- Histopathologic findings characteristic of CARD14‐associated papulosquamous eruptionRing NG, Craiglow BG, Panse G, Antaya RJ, Ashack K, Ashack R, Faith EF, Paller AS, McNiff JM, Choate KA, Ko CJ. Histopathologic findings characteristic of CARD14‐associated papulosquamous eruption. Journal Of Cutaneous Pathology 2019, 47: 425-430. PMID: 31849081, DOI: 10.1111/cup.13633.
- 390 Second-hit, post-zygotic PMVKand MVD mutations cause linear porokeratosisAtzmony L, Khan H, Lim Y, Paller A, Levinsohn J, Holland K, Mirza F, Yin E, Ko C, Leventhal J, Choate K. 390 Second-hit, post-zygotic PMVKand MVD mutations cause linear porokeratosis. Journal Of Investigative Dermatology 2019, 139: s67. DOI: 10.1016/j.jid.2019.03.466.
- Visual perception, cognition, and error in dermatologic diagnosis: Key cognitive principlesKo CJ, Braverman I, Sidlow R, Lowenstein EJ. Visual perception, cognition, and error in dermatologic diagnosis: Key cognitive principles. Journal Of The American Academy Of Dermatology 2019, 81: 1227-1234. PMID: 30797839, DOI: 10.1016/j.jaad.2018.10.082.
- Visual perception, cognition, and error in dermatologic diagnosis: Diagnosis and errorLowenstein EJ, Sidlow R, Ko C. Visual perception, cognition, and error in dermatologic diagnosis: Diagnosis and error. Journal Of The American Academy Of Dermatology 2019, 81: 1237-1245. PMID: 30797841, DOI: 10.1016/j.jaad.2018.12.072.
- Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host DiseaseKibbi N, Suozzi K, Ko C, Leffell D. Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease. Dermatologic Surgery 2018, 1. DOI: 10.1097/00042728-900000000-98571.
- 513 GNA14 somatic mutation causes congenital and sporadic vascular tumors by MAPK activationLim Y, Bacchiocchi A, Qiu J, Bruckner A, Bercovitch L, Narayan D, McNiff J, Ko C, Robinson-Bostom L, Antaya R, Halaban R, Choate K. 513 GNA14 somatic mutation causes congenital and sporadic vascular tumors by MAPK activation. Journal Of Investigative Dermatology 2017, 137: s88. DOI: 10.1016/j.jid.2017.02.533.
- 30 PediculosisKo C, Elston D. 30 Pediculosis. 2017, 387-392. DOI: 10.1016/b978-0-323-29634-2.00030-4.
- Keratoacanthoma Shares Driver Mutations with Cutaneous Squamous Cell CarcinomaLim YH, Fisher JM, Bosenberg MW, Choate KA, Ko CJ. Keratoacanthoma Shares Driver Mutations with Cutaneous Squamous Cell Carcinoma. Journal Of Investigative Dermatology 2016, 136: 1737-1741. PMID: 27283355, DOI: 10.1016/j.jid.2016.04.002.
- Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talkZito G, Saotome I, Liu Z, Ferro EG, Sun TY, Nguyen DX, Bilguvar K, Ko CJ, Greco V. Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk. Nature Communications 2014, 5: 3543. PMID: 24667544, PMCID: PMC3974217, DOI: 10.1038/ncomms4543.
- Chapter 20a Key diagnostic features of additional soft tissue neoplasmsKo C, Ferringer T. Chapter 20a Key diagnostic features of additional soft tissue neoplasms. 2014, e1-e5. DOI: 10.1016/b978-0-7020-5527-0.00078-9.
- DedicationsElston D, Ferringer T, Ko C, High W, Peckham S, DiCaudo D. Dedications. 2014, x. DOI: 10.1016/b978-0-7020-5527-0.00039-x.
- Chapter 1 The basics Diagnostic terms, skin anatomy, and stainsFerringer T, Ko C. Chapter 1 The basics Diagnostic terms, skin anatomy, and stains. 2014, 1-36. DOI: 10.1016/b978-0-7020-5527-0.00001-7.
- Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomasKim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas. Journal Of The American Academy Of Dermatology 2013, 70: 70-74. PMID: 24210370, DOI: 10.1016/j.jaad.2013.09.026.
- Chapter 59 Dermatologic Conditions in Kidney DiseaseKo C, Cowper S. Chapter 59 Dermatologic Conditions in Kidney Disease. 2012, 2156-2168. DOI: 10.1016/b978-1-4160-6193-9.10059-4.
- Chapter 13 Lichenoid dermatosesSkvarka C, Ko C. Chapter 13 Lichenoid dermatoses. 2009, 197-213. DOI: 10.1016/b978-0-7020-3093-2.10013-5.
- Chapter 1 The basics: diagnostic terms, skin anatomy, and stainsFerringer T, Ko C. Chapter 1 The basics: diagnostic terms, skin anatomy, and stains. 2009, 1-31. DOI: 10.1016/b978-0-7020-3023-9.10001-0.
- Chapter 30 PediculosisKo C, Elston D. Chapter 30 Pediculosis. 2006, 387-392. DOI: 10.1016/b978-0-443-06790-7.50034-x.
- ReplyElston D, Ko C. Reply. Journal Of The American Academy Of Dermatology 2004, 51: 1037-1038. DOI: 10.1016/j.jaad.2004.04.042.
- Intraethnic Comparison of Eating Attitudes in Native Koreans and Korean Americans Using a Korean Translation of the Eating Attitudes TestKO C, COHEN H. Intraethnic Comparison of Eating Attitudes in Native Koreans and Korean Americans Using a Korean Translation of the Eating Attitudes Test. The Journal Of Nervous And Mental Disease 1998, 186: 631-636. PMID: 9788640, DOI: 10.1097/00005053-199810000-00007.