Featured Publications
Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion
Chaguza C, Jamrozy D, Bijlsma M, Kuijpers T, van de Beek D, van der Ende A, Bentley S. Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion. Nature Communications 2022, 13: 4215. PMID: 35864107, PMCID: PMC9304382, DOI: 10.1038/s41467-022-31858-4.Peer-Reviewed Original ResearchConceptsPopulation genomicsMicrobial population genomicsGroup B streptococciWide association studyPopulation structureGenetic variationGenetic signaturesCapsule biosynthesis locusDisease onset timeAssociation studiesB streptococciInvasive neonatal GBS diseaseNeonatal GBS diseaseGenomicsPathogen surveillanceAcute invasive diseaseGeneticsOnset timeDisease pathogenesisGBS diseasePreterm birthTissue infectionsDisease burdenDisease onsetInvasive disease
2022
Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci
Chaguza C, Ebruke C, Senghore M, Lo S, Tientcheu P, Gladstone R, Tonkin-Hill G, Cornick J, Yang M, Worwui A, McGee L, Breiman R, Klugman K, Kadioglu A, Everett D, Mackenzie G, Croucher N, Roca A, Kwambana-Adams B, Antonio M, Bentley S. Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci. Genome Biology And Evolution 2022, 14: evac052. PMID: 35439297, PMCID: PMC9048925, DOI: 10.1093/gbe/evac052.Peer-Reviewed Original ResearchConceptsGenomic variationGenome-wide association studiesComparative genomicsGenetic variationLineage distributionAssociation studiesPhenotypic variabilityPathogen surveillanceSystemic tissuesIsolatesSerotype 1GenomicsLineagesGeneticsMinimal effectVariationInvasivenessSerotype 1 pneumococciIsolationInvasive disease
2015
Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae
Chaguza C, Cornick JE, Everett DB. Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae. Computational And Structural Biotechnology Journal 2015, 13: 241-247. PMID: 25904996, PMCID: PMC4404416, DOI: 10.1016/j.csbj.2015.03.007.Peer-Reviewed Original ResearchGenetic recombinationWhole-genome sequence dataKey evolutionary mechanismGenome sequence dataPopulation geneticsEvolutionary mechanismsGenetic variationSequence dataExogenous DNASelective pressureSpontaneous mutationsHuman diseasesEvolution studiesPneumococcal adaptationRecombinationAdaptive immune responsesComputational toolsGenomeEvolutionGeneticsOrganismsImmune responseRapid influxDNABacterium