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Carl Hashimoto, PhD

Professor Emeritus of Cell Biology

Contact Information

Carl Hashimoto, PhD

Research Summary

My past research focused on cellular and developmental pathways regulated by proteolysis, specifically in embryonic patterning and innate immunity.

Specialized Terms: Proteolysis; Serpins; Intercellular signaling; Morphogenesis; Disease modeling; Drosophila molecular genetics

Extensive Research Description

My laboratory’s original interest was in the molecular mechanism used to establish the dorsoventral axis of the Drosophila embryo. We sought to understand how a protease cascade that triggers dorsoventral patterning is only activated on the prospective ventral side of the embryo. Among our findings, we identified a serpin (serine protease inhibitor) that plays an essential role in ventrally restricting the protease cascade. We then studied proteases and serpins functioning in Drosophila innate immunity as part of a broader interest in biological processes regulated by proteolysis.

Research Interests

Cells; Cell Biology; Education, Medical; Endocrine System Diseases; Genetics; Molecular Biology; Tissues; Developmental Biology; Serpins; Neurodegenerative Diseases; Intercellular Signaling Peptides and Proteins; Proteolysis

Selected Publications