Carl Hashimoto, PhD
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About
Titles
Professor Emeritus of Cell Biology
Education & Training
- Fellowship
- University of California, Berkeley (1990)
- PhD
- Yale University (1986)
Research
Overview
My laboratory’s original interest was in the molecular mechanism used to establish the dorsoventral axis of the Drosophila embryo. We sought to understand how a protease cascade that triggers dorsoventral patterning is only activated on the prospective ventral side of the embryo. Among our findings, we identified a serpin (serine protease inhibitor) that plays an essential role in ventrally restricting the protease cascade. We then studied proteases and serpins functioning in Drosophila innate immunity as part of a broader interest in biological processes regulated by proteolysis.
Medical Subject Headings (MeSH)
Cell Biology; Cells; Developmental Biology; Education, Medical; Endocrine System Diseases; Genetics; Intercellular Signaling Peptides and Proteins; Molecular Biology; Neurodegenerative Diseases; Proteolysis; Serpins; Tissues
Research at a Glance
Publications Timeline
A big-picture view of Carl Hashimoto's research output by year.
Research Interests
Research topics Carl Hashimoto is interested in exploring.
4Publications
408Citations
Publications
2008
A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila
Tang H, Kambris Z, Lemaitre B, Hashimoto C. A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila. Developmental Cell 2008, 15: 617-626. PMID: 18854145, PMCID: PMC2671232, DOI: 10.1016/j.devcel.2008.08.017.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAntifungal peptide drosomycinInternal tissuesToll pathwayChemical defensesProtease cascadeMelanin biosynthesisMelanization reactionKey enzymeSerpin familyDrosophilaMelanizationPresence of microorganismsEpithelial tissuesMicrobial infectionsPhenol oxidaseHost defenseSystemic expressionEpithelial defenseProtease inhibitorsDefensePhysical barrierPathogensDrosomycinBiosynthesisTissue
2006
Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila *
Tang H, Kambris Z, Lemaitre B, Hashimoto C. Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila *. Journal Of Biological Chemistry 2006, 281: 28097-28104. PMID: 16861233, DOI: 10.1074/jbc.m601642200.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMelanization cascadeMelanization reactionResistance of DrosophilaDownstream proteasesDrosophilaKey enzymeMicrobial pathogensGenetic characterizationMelanin synthesisSerine proteasesMelanizationProteasePathogenic bacteriaMicrobial infectionsMP1PhenoloxidaseFungal infectionsCascadeImportant roleImmune systemSpn27AArthropodsFungiEnzymeBacteria
2004
The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin
Richer MJ, Keays CA, Waterhouse J, Minhas J, Hashimoto C, Jean F. The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 10560-10565. PMID: 15247425, PMCID: PMC489976, DOI: 10.1073/pnas.0401406101.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsReactive site loopSecretory pathwayProprotein convertasesConsensus furin cleavage siteProteolytic cleavage eventsArg-LysSerpin-protease interactionsSDS-stable complexesDrosophila melanogasterEukaryotic cellsInfectious microbial pathogensFurin cleavage siteSerine protease inhibitorEndogenous serpinsSerine endoproteasesPrecise regulationSite loopSerpin moleculesStoichiometry of inhibitionMicrobial pathogensProteolytic eventsCleavage eventsCleavage sitePC inhibitorsHuman furin
2003
Spatial Regulation of Developmental Signaling by a Serpin
Hashimoto C, Kim DR, Weiss LA, Miller JW, Morisato D. Spatial Regulation of Developmental Signaling by a Serpin. Developmental Cell 2003, 5: 945-950. PMID: 14667416, DOI: 10.1016/s1534-5807(03)00338-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExtracellular serine protease cascadeDiverse biological processesSerine protease cascadeDevelopmental signalingDrosophila embryosDorsoventral polarityBlood-clotting cascadeSpatial regulationSerine protease inhibitorProtease cascadeBiological processesGeneral mechanismEssential roleProtease activitySpatial controlEmbryosCascadeProtease inhibitorsVentral sideMammalianSerpinsSignalingRegulationPathwayRole
Academic Achievements and Community Involvement
honor Established Investigator, American Heart Association
UnknownDetailsUnited Stateshonor Junior Faculty Research Award, American Cancer Society
UnknownDetailsUnited States