Carl Hashimoto, PhD
Professor Emeritus of Cell Biology
Research & Publications
Biography
News
Research Summary
My past research focused on cellular and developmental pathways regulated by proteolysis, specifically in embryonic patterning and innate immunity.
Specialized Terms: Proteolysis; Serpins; Intercellular signaling; Morphogenesis; Disease modeling; Drosophila molecular genetics
Extensive Research Description
My laboratory’s original interest was in the molecular mechanism used to establish the dorsoventral axis of the Drosophila embryo. We sought to understand how a protease cascade that triggers dorsoventral patterning is only activated on the prospective ventral side of the embryo. Among our findings, we identified a serpin (serine protease inhibitor) that plays an essential role in ventrally restricting the protease cascade. We then studied proteases and serpins functioning in Drosophila innate immunity as part of a broader interest in biological processes regulated by proteolysis.
Research Interests
Cells; Cell Biology; Education, Medical; Endocrine System Diseases; Genetics; Molecular Biology; Tissues; Developmental Biology; Serpins; Neurodegenerative Diseases; Intercellular Signaling Peptides and Proteins; Proteolysis
Selected Publications
- A Serpin that Regulates Immune Melanization in the Respiratory System of DrosophilaTang H, Kambris Z, Lemaitre B, Hashimoto C. A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila. Developmental Cell 2008, 15: 617-626. PMID: 18854145, PMCID: PMC2671232, DOI: 10.1016/j.devcel.2008.08.017.
- Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila *Tang H, Kambris Z, Lemaitre B, Hashimoto C. Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila *. Journal Of Biological Chemistry 2006, 281: 28097-28104. PMID: 16861233, DOI: 10.1074/jbc.m601642200.
- The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpinRicher MJ, Keays CA, Waterhouse J, Minhas J, Hashimoto C, Jean F. The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 10560-10565. PMID: 15247425, PMCID: PMC489976, DOI: 10.1073/pnas.0401406101.
- Spatial Regulation of Developmental Signaling by a SerpinHashimoto C, Kim DR, Weiss LA, Miller JW, Morisato D. Spatial Regulation of Developmental Signaling by a Serpin. Developmental Cell 2003, 5: 945-950. PMID: 14667416, DOI: 10.1016/s1534-5807(03)00338-1.