My laboratory is interested in the development of serum markers for the evaluation of osteoporosis and metabolic bone disease. We have focused primarily on osteocalcin, a vitamin K-dependent protein synthesized only in bone. We have conducted large population studies relating serum osteocalcin levels to race, gender, normal growth, development, and aging and to a variety of metabolic bone diseases including osteoporosis.
Specialized Terms: Function of non-collagenous bone matrix proteins with an emphasis on osteocalcin, a vitamin K-dependent protein synthesized only in bone; Animal Models; Biochemistry; Bone Disease; Bone Formation; Bone Markers; Cell Culture; Immunoassay
Bone Diseases; Bone Matrix; Immunoassay; Orthopedics; Vitamin K; Osteocalcin