Anurupa Devi Yadavalli, PhD
Research & Publications
Biography
Research Summary
I am a Bioinformatician by choice. I squeeze tons of data into the computer with the goal of extracting valuable information. In other words, I manage, interpret and analyze data at the genome, proteome, and transcriptome levels.
Extensive Research Description
I am interested in almost every question that deals with complex biological data involving B-cell development. During my Ph.D., I and my colleagues demonstrated that chromatin undergoes a dynamic switch to induce lineage-specific gene expression patterns. This study provided insights into how unique cis-regulatory networks are maintained across various B-cell stages and stood out as one of the first studies to report the dynamic nature of TADs (topologically associated domains). Later, I shifted my focus to implementing cutting-edge computational techniques and classification algorithms to identify transcriptional regulators that preserve B-cell identity.
Currently, my research is focused on understanding why V(D)J recombination and somatic hypermutation sometimes affect the off-target genes, and how such mistakes contribute to the development of B cell cancers known as lymphomas and leukemias.
Coauthors
Selected Publications
- HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutationWu L, Shukla V, Yadavalli AD, Dinesh RK, Xu D, Rao A, Schatz DG. HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation. Genes & Development 2022, 36: 433-450. PMID: 35450882, PMCID: PMC9067407, DOI: 10.1101/gad.349438.122.
- A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytesNikhat S, Yadavalli AD, Prusty A, Narayan PK, Palakodeti D, Murre C, Pongubala JMR. A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2104297118. PMID: 34750254, PMCID: PMC8609617, DOI: 10.1073/pnas.2104297118.
- The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombinationBeilinson HA, Glynn RA, Yadavalli AD, Xiao J, Corbett E, Saribasak H, Arya R, Miot C, Bhattacharyya A, Jones JM, Pongubala JMR, Bassing CH, Schatz DG. The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination. Journal Of Experimental Medicine 2021, 218: e20210250. PMID: 34402853, PMCID: PMC8374863, DOI: 10.1084/jem.20210250.
- Evaluation of high salinity tolerance in Pongamia pinnata (L.) Pierre by a systematic analysis of hormone‐metabolic networkMarriboina S, Sharma K, Sengupta D, Yadavalli AD, Sharma RP, Attipalli R. Evaluation of high salinity tolerance in Pongamia pinnata (L.) Pierre by a systematic analysis of hormone‐metabolic network. Physiologia Plantarum 2021, 173: 1514-1534. PMID: 34165187, DOI: 10.1111/ppl.13486.
- Developmentally regulated higher-order chromatin interactions orchestrate B cell fate commitmentBoya R, Yadavalli AD, Nikhat S, Kurukuti S, Palakodeti D, Pongubala JMR. Developmentally regulated higher-order chromatin interactions orchestrate B cell fate commitment. Nucleic Acids Research 2017, 45: gkx722. PMID: 28977418, PMCID: PMC5737614, DOI: 10.1093/nar/gkx722.