Research & Publications
Dr. Denoble's clinical research focuses on learning more about complications that can arise from heart disease in pregnancy and how better to address and prevent these complications.
Extensive Research Description
As an Assistant Professor in Obstetrics & Gynecology and a board-eligible maternal-fetal medicine specialist, Dr. Denoble's goal is to improve our understanding of cardiovascular diseases in pregnancy and the postpartum period through innovative, patient-relevant research. Cardiac disease is the leading cause of maternal mortality in the United States, but evidence-based strategies for diagnosing, treating, and preventing cardiovascular disease in pregnancy remain limited. Her clinical research involves improving the accuracy of risk prediction models for both adverse cardiac events in pregnancy and severe maternal morbidity and mortality. Ultimately, her goal is to develop strategies that can be employed in the pre-conception and early pregnancy period to better mitigate the risks of pre-existing cardiac disease in pregnancy. Her prior research focused on differences in clinical biomarkers of heart failure between pregnant women with and without obesity, given that obesity is a risk factor for cardiac disease and may complicate the diagnosis of cardiovascular complications in pregnancy. Her background in clinical research through a Master of Science in Clinical Research provides a solid foundation upon which to build her investigation.
She also conducts epidemiologic and clinical research in preeclampsia and hypertension in pregnancy, vaccine safety in pregnancy, and infections in pregnancy.
Pregnancy Complications, Cardiovascular