Annalies Denoble, MD, MSc
Assistant Professor of Obstetrics, Gynecology and Reproductive Sciences
Research & Publications
Biography
News
Research Summary
Dr. Denoble's clinical research focuses on learning more about complications that can arise from heart disease in pregnancy and how better to address and prevent these complications.
Extensive Research Description
As an Assistant Professor in Obstetrics & Gynecology and a board-eligible maternal-fetal medicine specialist, Dr. Denoble's goal is to improve our understanding of cardiovascular diseases in pregnancy and the postpartum period through innovative, patient-relevant research. Cardiac disease is the leading cause of maternal mortality in the United States, but evidence-based strategies for diagnosing, treating, and preventing cardiovascular disease in pregnancy remain limited. Her clinical research involves improving the accuracy of risk prediction models for both adverse cardiac events in pregnancy and severe maternal morbidity and mortality. Ultimately, her goal is to develop strategies that can be employed in the pre-conception and early pregnancy period to better mitigate the risks of pre-existing cardiac disease in pregnancy. Her prior research focused on differences in clinical biomarkers of heart failure between pregnant women with and without obesity, given that obesity is a risk factor for cardiac disease and may complicate the diagnosis of cardiovascular complications in pregnancy. Her background in clinical research through a Master of Science in Clinical Research provides a solid foundation upon which to build her investigation.
She also conducts epidemiologic and clinical research in preeclampsia and hypertension in pregnancy, vaccine safety in pregnancy, and infections in pregnancy.
Coauthors
Research Interests
Pregnancy Complications, Cardiovascular
Selected Publications
- Antihypertensives in PregnancyDenoble A, Goldstein S, Pettker C. Antihypertensives in Pregnancy Obstetrics And Gynecology Clinics Of North America 2023, 50: 39-78. PMID: 36822710, DOI: 10.1016/j.ogc.2022.10.008.
- Delayed gestational diabetes diagnosis: maternal characteristics, reasons for delay, and delivery outcomesDing J, Lundsberg L, Culhane J, Partridge C, Denoble A, Son M. Delayed gestational diabetes diagnosis: maternal characteristics, reasons for delay, and delivery outcomes American Journal Of Obstetrics And Gynecology 2023, 228: s149-s150. DOI: 10.1016/j.ajog.2022.11.294.
- Maternal and pregnancy outcomes following heart transplantation in the United StatesCraig A, Campbell A, Snow S, Denoble A, Agarwal R, Ward C, Federspiel J. Maternal and pregnancy outcomes following heart transplantation in the United States American Journal Of Obstetrics And Gynecology 2023, 228: s427-s428. DOI: 10.1016/j.ajog.2022.11.742.
- Prospective Observational Study of N-terminal Pro–Brain Natriuretic Peptide Levels in Obese and Nonobese Women during PregnancyDenoble A, Moyett J, Goldstein S, Ward CC, Truong T, Erkanli A, James A, Grotegut C. Prospective Observational Study of N-terminal Pro–Brain Natriuretic Peptide Levels in Obese and Nonobese Women during Pregnancy American Journal Of Perinatology 2022, 40: 467-474. PMID: 35973801, PMCID: PMC10168705, DOI: 10.1055/a-1925-1532.
- Impact of Pre-Existing Ischemic Heart Disease on Severe Maternal Morbidity and Mortality During Delivery HospitalizationsDenoble A, Goldstein S, Wein L, Grotegut C, Federspiel J. Impact of Pre-Existing Ischemic Heart Disease on Severe Maternal Morbidity and Mortality During Delivery Hospitalizations JACC Advances 2022, 1: 100157. PMID: 36684662, PMCID: PMC9851052, DOI: 10.1016/j.jacadv.2022.100157.
- Impact of Pre-Existing Ischemic Heart Disease on Severe Maternal Morbidity and Mortality During Delivery HospitalizationsDenoble A, Goldstein S, Wein L, Grotegut C, Federspiel J. Impact of Pre-Existing Ischemic Heart Disease on Severe Maternal Morbidity and Mortality During Delivery Hospitalizations JACC Advances 2022, 1: 100157. DOI: 10.1016/j.jacadv.2022.100157.
- Comparison of severe maternal morbidity in pregnancy by modified World Health Organization Classification of maternal cardiovascular riskDenoble AE, Goldstein SA, Wein LE, Grotegut CA, Federspiel JJ. Comparison of severe maternal morbidity in pregnancy by modified World Health Organization Classification of maternal cardiovascular risk American Heart Journal 2022, 250: 11-22. PMID: 35526569, PMCID: PMC9836743, DOI: 10.1016/j.ahj.2022.04.009.
- Management of Preterm Premature Rupture of Membranes in the Late Preterm Period.Freeman SW, Denoble A, Kuller JA, Ellestad S, Dotters-Katz S. Management of Preterm Premature Rupture of Membranes in the Late Preterm Period. Obstetrical & Gynecological Survey 2022, 77: 283-292. PMID: 35522430, DOI: 10.1097/OGX.0000000000001024.
- Bad bugs: antibiotic-resistant bacteriuria in pregnancy and risk of pyelonephritis.Denoble A, Reid HW, Krischak M, Rosett H, Sachdeva S, Weaver K, Heine PR, Dotters-Katz S. Bad bugs: antibiotic-resistant bacteriuria in pregnancy and risk of pyelonephritis. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100540. PMID: 34856419, DOI: 10.1016/j.ajogmf.2021.100540.
- Maternal Anemia and the Severity of Urinary PathologyLuke S, Sachdeva S, Ohamadike O, Denoble A, Heine R, Dotters-Katz S. Maternal Anemia and the Severity of Urinary Pathology American Journal Of Obstetrics And Gynecology 2022, 226: 315. DOI: 10.1016/j.ajog.2021.11.1322.
- Impact of Maternal BMI on Urinary Pathology Severity in PregnancyLuke S, Krischak M, Mitchell C, Denoble A, Ellett T, Heine R, Dotters-Katz S. Impact of Maternal BMI on Urinary Pathology Severity in Pregnancy American Journal Of Obstetrics And Gynecology 2022, 226: s297. DOI: 10.1016/j.ajog.2021.11.501.
- Impact of chronic ischemic heart disease on severe maternal morbidity during delivery hospitalizationsDenoble A, Goldstein S, Grotegut C, Federspiel J. Impact of chronic ischemic heart disease on severe maternal morbidity during delivery hospitalizations American Journal Of Obstetrics And Gynecology 2022, 226: s77. DOI: 10.1016/j.ajog.2021.11.146.
- Impact of mechanical versus bioprosthetic heart valve on severe maternal morbidity during delivery hospitalizationsDenoble A, Federspiel J, Goldstein S, Grotegut C. Impact of mechanical versus bioprosthetic heart valve on severe maternal morbidity during delivery hospitalizations American Journal Of Obstetrics And Gynecology 2022, 226: s469-s470. DOI: 10.1016/j.ajog.2021.11.778.
- Pregnancy Outcomes among Women with Class III Obesity with Pre-diabetic Early Hemoglobin A1CDillon J, Mitchell CJ, Ellett T, Siegel A, Denoble AE, Dotters-Katz SK. Pregnancy Outcomes among Women with Class III Obesity with Pre-diabetic Early Hemoglobin A1C American Journal Of Perinatology 2021, 39: 238-242. PMID: 34891200, DOI: 10.1055/s-0041-1739358.
- Management of Cerclage in Patients With Preterm Prelabor Rupture of MembranesWu J, Denoble AE, Kuller JA, Dotters-Katz SK. Management of Cerclage in Patients With Preterm Prelabor Rupture of Membranes Obstetrical & Gynecological Survey 2021, 76: 681-691. PMID: 34854925, DOI: 10.1097/ogx.0000000000000957.
- Pregnancy outcomes among women with class III obesity with normal early glucolaEllett T, Mitchell CJ, Dillon J, Siegel A, Denoble AE, Dotters-Katz S. Pregnancy outcomes among women with class III obesity with normal early glucola The Journal Of Maternal-Fetal & Neonatal Medicine 2021, 35: 5834-5839. PMID: 33818267, DOI: 10.1080/14767058.2021.1895741.
- 532 Comparison of N-terminal pro-brain natriuretic peptide levels in healthy obese and non-obese pregnant womenDeNoble A, Moyett J, Goldstein S, Ward C, James A, Grotegut C. 532 Comparison of N-terminal pro-brain natriuretic peptide levels in healthy obese and non-obese pregnant women American Journal Of Obstetrics And Gynecology 2021, 224: s337. DOI: 10.1016/j.ajog.2020.12.553.
- 734 Severe maternal morbidity by modified WHO classification in women with cardiac disease in pregnancyDeNoble A, Federspiel J, Wein L, Goldstein S, Grotegut C. 734 Severe maternal morbidity by modified WHO classification in women with cardiac disease in pregnancy American Journal Of Obstetrics And Gynecology 2021, 224: s460-s461. DOI: 10.1016/j.ajog.2020.12.757.
- The impact of anemia on infectious and obstetric outcomes of women with pyelonephritisCunningham H, Federspiel J, Wein L, DeNoble A, Heine R, Dotters-Katz S. The impact of anemia on infectious and obstetric outcomes of women with pyelonephritis American Journal Of Obstetrics And Gynecology 2020, 223: 976. DOI: 10.1016/j.ajog.2020.08.152.
- Beyond Expert Opinion: A Comparison of Antibiotic Regimens for Infectious Urinary Tract Pathology in PregnancyKrischak MK, Rosett HA, Sachdeva S, Weaver KE, Heine RP, Denoble AE, Dotters-Katz SK. Beyond Expert Opinion: A Comparison of Antibiotic Regimens for Infectious Urinary Tract Pathology in Pregnancy American Journal Of Perinatology Reports 2020, 10: e352-e356. PMID: 33094027, PMCID: PMC7571572, DOI: 10.1055/s-0040-1718384.
- Lower Urinary Pathogens: Do More Pathogenic Bacteria Increase the Risk of Pyelonephritis?Rosett HA, Krischak MK, Sachdeva S, Weaver KE, Heine RP, Denoble AE, Dotters-Katz SK. Lower Urinary Pathogens: Do More Pathogenic Bacteria Increase the Risk of Pyelonephritis? American Journal Of Perinatology 2020, 39: 473-478. PMID: 32971563, DOI: 10.1055/s-0040-1717093.
- Chorioamnionitis versus intraamniotic infection among preterm deliveries—is postpartum infectious morbidity different?Denoble AE, Wu J, Mitchell CJ, Hughes BL, Dotters-Katz SK. Chorioamnionitis versus intraamniotic infection among preterm deliveries—is postpartum infectious morbidity different? American Journal Of Obstetrics & Gynecology MFM 2020, 2: 100176. PMID: 33345890, DOI: 10.1016/j.ajogmf.2020.100176.
- Risk Factors for Postpartum Maternal Infection Following Spontaneous Vaginal Delivery Complicated by ChorioamnionitisDaifotis H, Smith M, Denoble A, Dotters-Katz S. Risk Factors for Postpartum Maternal Infection Following Spontaneous Vaginal Delivery Complicated by Chorioamnionitis American Journal Of Perinatology Reports 2020, 10: e159-e164. PMID: 32426175, PMCID: PMC7228805, DOI: 10.1055/s-0040-1709983.
- Prenatal Treatment of Congenital Cytomegalovirus With Valganciclovir: A Case Report.DeNoble AE, Saccoccio FM, Permar SR, Hughes BL. Prenatal Treatment of Congenital Cytomegalovirus With Valganciclovir: A Case Report. Clinical Infectious Diseases 2020, 71: 2506-2508. PMID: 32198512, DOI: 10.1093/cid/ciaa305.
- Using the new definition of intraamniotic infection – is there morbidity among the women left out?Smith MM, Daifotis HA, DeNoble AE, Dotters-Katz SK. Using the new definition of intraamniotic infection – is there morbidity among the women left out? The Journal Of Maternal-Fetal & Neonatal Medicine 2020, 34: 4148-4152. PMID: 31928262, DOI: 10.1080/14767058.2020.1711723.
- 1069: Bad bugs: antibiotic-resistant lower urinary tract infections and risk of pyelonephritis in pregnancyDeNoble A, Krischak M, Rosett H, Sachdeva S, Weaver K, Heine P, Dotters-Katz S. 1069: Bad bugs: antibiotic-resistant lower urinary tract infections and risk of pyelonephritis in pregnancy American Journal Of Obstetrics And Gynecology 2020, 222: s660. DOI: 10.1016/j.ajog.2019.11.1082.
- 1205: Pregnancy outcomes among class 3 obese women with normal and pre-diabetic early hemoglobin A1CMitchell C, Ellett T, Dillon J, Siegel A, DeNoble A, Dotters-Katz S. 1205: Pregnancy outcomes among class 3 obese women with normal and pre-diabetic early hemoglobin A1C American Journal Of Obstetrics And Gynecology 2020, 222: s740-s741. DOI: 10.1016/j.ajog.2019.11.1217.
- 268: Beyond expert opinion: A comparison of antibiotic regimens for infectious urinary tract pathology in pregnancyKrischak M, Rosett H, Sachdeva S, Weaver K, Heine P, DeNoble A, Dotters-Katz S. 268: Beyond expert opinion: A comparison of antibiotic regimens for infectious urinary tract pathology in pregnancy American Journal Of Obstetrics And Gynecology 2020, 222: s183. DOI: 10.1016/j.ajog.2019.11.284.
- 470: Lower urinary pathogens: Do more virulent bacteria increase the risk of pyelonephritis?Rosett H, Krischak M, Sachdeva S, Weaver K, Heine P, DeNoble A, Dotters-Katz S. 470: Lower urinary pathogens: Do more virulent bacteria increase the risk of pyelonephritis? American Journal Of Obstetrics And Gynecology 2020, 222: s308. DOI: 10.1016/j.ajog.2019.11.486.
- 490: GBS Urinary Tract Infections: Is the risk of pyelonephritis as high as with E. Coli?Sachdeva S, Rosett H, Krischak M, Weaver K, Heine P, DeNoble A, Dotters-Katz S. 490: GBS Urinary Tract Infections: Is the risk of pyelonephritis as high as with E. Coli? American Journal Of Obstetrics And Gynecology 2020, 222: s320-s321. DOI: 10.1016/j.ajog.2019.11.506.
- Chorioamnionitis versus intraamniotic infection among preterm deliveries: is postpartum infectious morbidity different?DeNoble A, Mitchell C, Hughes B, Dotters-Katz S. Chorioamnionitis versus intraamniotic infection among preterm deliveries: is postpartum infectious morbidity different? American Journal Of Obstetrics And Gynecology 2019, 221: 666-667. DOI: 10.1016/j.ajog.2019.10.073.
- Chorioamnionitis and Infectious Complications after Vaginal DeliveryDeNoble AE, Heine RP, Dotters-Katz SK. Chorioamnionitis and Infectious Complications after Vaginal Delivery American Journal Of Perinatology 2019, 36: 1437-1441. PMID: 31238347, DOI: 10.1055/s-0039-1692718.
- Spiking in the Second Stage: What are the Neonatal Implications? [19D]Daifotis H, Smith M, Denoble A, Dotters-Katz S. Spiking in the Second Stage: What are the Neonatal Implications? [19D] Obstetrics And Gynecology 2019, 133: 47s-46s. DOI: 10.1097/01.aog.0000558975.44644.1a.
- Using the New Definition of Intraamniotic Infection: Is There Morbidity in the Women Left Out? [27D]Smith M, Daifotis H, Denoble A, Dotters-Katz S. Using the New Definition of Intraamniotic Infection: Is There Morbidity in the Women Left Out? [27D] Obstetrics And Gynecology 2019, 133: 50s-48s. DOI: 10.1097/01.aog.0000558983.61677.1d.
- Spiking in the Second Stage: The Significance of Isolated Maternal Fever During Labor [16A]Smith M, Daifotis H, Denoble A, Dotters-Katz S. Spiking in the Second Stage: The Significance of Isolated Maternal Fever During Labor [16A] Obstetrics And Gynecology 2019, 133: 14s-14s. DOI: 10.1097/01.aog.0000559363.72958.65.
- Management of Intraamniotic Infection After Spontaneous Vaginal Delivery: Is Nothing Really Enough? [24C]Daifotis H, Smith M, Denoble A, Dotters-Katz S. Management of Intraamniotic Infection After Spontaneous Vaginal Delivery: Is Nothing Really Enough? [24C] Obstetrics And Gynecology 2019, 133: 37s-37s. DOI: 10.1097/01.aog.0000559445.77903.c7.
- Factors Associated with Utilization of 17-Hydroxyprogesterone Caproate for the Prevention of Recurrent Preterm BirthDeNoble AE, Wynn CE, Weaver KE, Wheeler SM, Swamy GK. Factors Associated with Utilization of 17-Hydroxyprogesterone Caproate for the Prevention of Recurrent Preterm Birth American Journal Of Perinatology 2019, 37: 264-270. PMID: 30708392, DOI: 10.1055/s-0039-1678532.
- Beyond the Window: Patient Characteristics and Geographic Locations Associated with Late Prenatal Care in Women Eligible for 17-P Preterm Birth PreventionWheeler S, DeNoble A, Wynn C, Weaver K, Swamy G, Janko M, Lantos P. Beyond the Window: Patient Characteristics and Geographic Locations Associated with Late Prenatal Care in Women Eligible for 17-P Preterm Birth Prevention Journal Of Racial And Ethnic Health Disparities 2019, 6: 563-569. PMID: 30632084, DOI: 10.1007/s40615-018-00555-8.
- Chorioamnionitis and infectious complications after vaginal deliveryDenoble A, Heine R, Dotters-Katz S. Chorioamnionitis and infectious complications after vaginal delivery American Journal Of Obstetrics And Gynecology 2018, 219: 648. DOI: 10.1016/j.ajog.2018.10.046.
- Antibiotics for the Prevention and Treatment of Postsurgical Obstetric InfectionsDeNoble AE, Kuller JA, Heine RP, Dotters-Katz S. Antibiotics for the Prevention and Treatment of Postsurgical Obstetric Infections Obstetrical & Gynecological Survey 2018, 73: 475-485. PMID: 30169886, DOI: 10.1097/ogx.0000000000000590.
- 955: Beyond the window: Determining a geographical target for interventions to decrease late initiation of prenatal care in 17-P eligible pregnant womenWheeler S, DeNoble A, Swamy G, Weaver K, Wynn C, Lantos P. 955: Beyond the window: Determining a geographical target for interventions to decrease late initiation of prenatal care in 17-P eligible pregnant women American Journal Of Obstetrics And Gynecology 2018, 218: s565-s566. DOI: 10.1016/j.ajog.2017.11.442.
- Cost analysis of negative pressure wound therapy in morbidly obese women at the time of cesareanDeNoble A, Hughes B, Villers M. Cost analysis of negative pressure wound therapy in morbidly obese women at the time of cesarean American Journal Of Obstetrics And Gynecology 2017, 217: 723. DOI: 10.1016/j.ajog.2017.08.054.
- Controversies in the Management of Isolated Congenital Atrioventricular BlockDeNoble AE, Kuller JA, Rhee EJ. Controversies in the Management of Isolated Congenital Atrioventricular Block Obstetrical & Gynecological Survey 2015, 70: 518-523. PMID: 26314237, DOI: 10.1097/ogx.0000000000000208.
- Receipt of Prescription Contraception by Commercially Insured Women With Chronic Medical ConditionsDeNoble AE, Hall KS, Xu X, Zochowski MK, Piehl K, Dalton VK. Receipt of Prescription Contraception by Commercially Insured Women With Chronic Medical Conditions Obstetrics And Gynecology 2014, 123: 1213-1220. PMID: 24807345, PMCID: PMC4169713, DOI: 10.1097/aog.0000000000000279.
- Chronic disease and preventive reproductive health servicesDeNoble A, Hall K, Zochowski M, Dalton V. Chronic disease and preventive reproductive health services Contraception 2013, 88: 469-470. DOI: 10.1016/j.contraception.2013.05.148.
- Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activationDenoble AE, Huffman KM, Stabler TV, Kelly SJ, Hershfield MS, McDaniel GE, Coleman RE, Kraus VB. Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2088-2093. PMID: 21245324, PMCID: PMC3033282, DOI: 10.1073/pnas.1012743108.
- Patellar Skin Surface Temperature by Thermography Reflects Knee Osteoarthritis SeverityDenoble AE, Hall N, Pieper CF, Kraus VB. Patellar Skin Surface Temperature by Thermography Reflects Knee Osteoarthritis Severity Clinical Medicine Insights Arthritis And Musculoskeletal Disorders 2010, 3: cmamd.s5916. PMID: 21151853, PMCID: PMC2998980, DOI: 10.4137/cmamd.s5916.