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INFORMATION FOR

Andrey Zinchuk, MD, MHS

Assistant Professor; Director, Advanced Apnea Management Program; Director, Yale Sleep Fellowship Didactic and Research Curriculum, Internal Medicine, PCCSM; Director, Upper Airway Neurostimulation Program; Section of Pulmonary, Critical Care and Sleep Medicine

Research Summary

Research: My goal is to improve the lives of people with sleep disordered breathing. My colleagues and I hope to do so by making care of sleep apnea patients more precise, using unique patient physiology, prognosis and treatment responsiveness. Doing so we anticipate will allow for development of novel, effective and tolerable treatments.

Extensive Research Description

We have identified unique polysomnographic phenotypes of sleep apnea patients using cluster analysis, that are associated with differing clinical characteristics, co-morbid diseases and different rates of incident cardiovascular events or death. Currently, my team is conducting an NIH sponsored research study to identifying physiological traits (such as ease with which individuals arouse from sleep) that predict continuous positive airway pressure (CPAP) effectiveness and contribute to development of cardiovascular disease. I am also involved in an NIH sponsored, randomized, comparative effectiveness trial of the impact of usual care, oxygen or CPAP have on ventricular function and cardiopulmonary functional capacity in heart failure with central sleep apnea (a unique phenotype).

Mentors: Klar Yaggi MD, Andrew Wellman MD, PhD (Harvard), Scott Sands, PhD (Harvard), Nancy Redeker RN, PhD (UCONN)

Coauthors

Research Interests

Cardiovascular Diseases; Sleep Apnea Syndromes; Cluster Analysis; Polysomnography; Sleep Apnea, Central; Continuous Positive Airway Pressure

Selected Publications

  • 0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA)Sharma A, Byrne S, Deng A, Chu J, Sands S, Wellman A, Redeke N, Yaggi H, Zinchuk A. 0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA) Sleep 2022, 45: a73-a73. DOI: 10.1093/sleep/zsac079.156.
  • 0790 Racial Differences in Self-Efficacy for Positive Airway Pressure Therapy Among Individuals Newly Diagnosed with Obstructive Sleep ApneaByrne S, Sharma A, Deng A, Chu J, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. 0790 Racial Differences in Self-Efficacy for Positive Airway Pressure Therapy Among Individuals Newly Diagnosed with Obstructive Sleep Apnea Sleep 2022, 45: a343-a343. DOI: 10.1093/sleep/zsac079.786.
  • Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 DiabetesDing Q, Qin L, Wojeck B, Inzucchi S, Ibrahim A, Bravata D, Strohl K, Yaggi H, Zinchuk A. Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes 2021, a4679-a4679. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4679.
  • 441 Influence Of Chronotype On CPAP AdherenceAdekolu O, Xu Z, Chu J, Kushida C, Yaggi H, Knauert M, Zinchuk A. 441 Influence Of Chronotype On CPAP Adherence Sleep 2021, 44: a174-a175. DOI: 10.1093/sleep/zsab072.440.
  • Cardiovascular Benefit of CPAP Is Modified by the Sleep Apnea Related Pulse Rate Response in Coronary Artery Disease Patients with Nonsleepy OSA: Findings from the RICCADSA Randomized Controlled TrialAzarbarzin A, Zinchuk A, Wellman D, Taranto Montemurro L, Vena D, Gell L, Messineo L, White D, Gottlieb D, Redline S, Peker Y, Sands S. Cardiovascular Benefit of CPAP Is Modified by the Sleep Apnea Related Pulse Rate Response in Coronary Artery Disease Patients with Nonsleepy OSA: Findings from the RICCADSA Randomized Controlled Trial 2021, a1103-a1103. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1103.
  • Treatment-Emergent Central Sleep ApneaZinchuk A, Yaggi H. Treatment-Emergent Central Sleep Apnea 2021, 85-102. DOI: 10.1007/978-3-030-57942-5_8.
  • 0568 Physiologic OSA Traits and CPAP Adherence Among Patients with Coronary Artery Disease and OSAZinchuk A, Yaggi H, Liang J, Chu J, Op De Beeck S, Stepnowski C, Wellman A, Peker Y, Sands S. 0568 Physiologic OSA Traits and CPAP Adherence Among Patients with Coronary Artery Disease and OSA Sleep 2020, 43: a218-a218. DOI: 10.1093/sleep/zsaa056.565.
  • Physiologic Traits Predict Therapeutic Pressure Requirements and Residual Respiratory Events Among Patients with Coronary Artery Disease and Obstructive Sleep ApneaZinchuk A, Yaggi H, Liang J, Chu J, Op de Beeck S, Stepnowsky C, Wellman D, Peker Y, Sands S. Physiologic Traits Predict Therapeutic Pressure Requirements and Residual Respiratory Events Among Patients with Coronary Artery Disease and Obstructive Sleep Apnea 2020, a6439-a6439. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6439.
  • Introduction to Sleep Breathing DisordersZinchuk, A., Thomas, R. “Introduction to Sleep Breathing Disorders,“ in Principles and Practice of Sleep Medicine (Seventh Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2020
  • Central Sleep Apnea: Diagnosis and TreatmentZinchuk, A., Thomas, R. “Central Sleep Apnea: Diagnosis and Treatment,“ in Principles and Practice of Sleep Medicine (Seventh Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2020
  • The Arousal Threshold as a Drug-Target to Improve CPAP Adherence: Secondary Analysis of a Randomized TrialZinchuk A. The Arousal Threshold as a Drug-Target to Improve CPAP Adherence: Secondary Analysis of a Randomized Trial. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/the-arousal-threshold-as-a-drug-target-to-improve-cpap-adherence/103953/65/20/1. Aug 7, 2020
  • Low Arousal Threshold Correlates with Reduced Continuous Positive Airway Pressure Use in Non-Obese Individuals with Obstructive Sleep Apnea and StrokeZinchuk A, Yaggi H, Concato J, Jeon S, Bravata D, Wellman D, Sands S. Low Arousal Threshold Correlates with Reduced Continuous Positive Airway Pressure Use in Non-Obese Individuals with Obstructive Sleep Apnea and Stroke 2019, a2598-a2598. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2598.
  • Effect of Arousal Scoring on Reliability of Automated, Non-Invasive Phenotyping of Physiologic Sleep Apnea Traits from PolysomnographyZinchuk A, Yaggi H, Concato J, Wellman D, Smales E, Hess L, Denos J, Peker Y, Sands S. Effect of Arousal Scoring on Reliability of Automated, Non-Invasive Phenotyping of Physiologic Sleep Apnea Traits from Polysomnography 2019, a7078-a7078. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7078.
  • Shared Genetic Architecture Between Sleep and Blood Pressure Traits in HumansCade B, Lee J, Gharib S, Gottlieb D, He K, Hillman D, Liang J, Mukherjee S, Palmer L, Sofer T, Wang H, Zinchuk A, Saxena R, Purcell S, Zhu X, Redline S. Shared Genetic Architecture Between Sleep and Blood Pressure Traits in Humans 2019, a7259-a7259. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7259.
  • Treatment Emergent Central Sleep ApneaZinchuk, A. Yaggi, K. “Treatment Emergent Central Sleep Apnea” in Complex Sleep Breathing Disorders (1st Edition), edited by Christine Won; Springer Nature, 2019
  • 0574 A Composite Model of Commonly Derived Polysomnographic Variables Predicts Risk of Cardiovascular Outcomes Better than the Apnea Hypopnea Index AloneTrivedi V, Zinchuk A, Qin L, Bravata D, Strohl K, Selim B, Yaggi H. 0574 A Composite Model of Commonly Derived Polysomnographic Variables Predicts Risk of Cardiovascular Outcomes Better than the Apnea Hypopnea Index Alone Sleep 2018, 41: a213-a214. DOI: 10.1093/sleep/zsy061.573.
  • 0466 High Frequency Of PLMS Is Associated With Increased Risk Of Incident Adverse Cardiovascular Events And Death Among OSA PatientsZinchuk A, Jeon S, Yaggi H. 0466 High Frequency Of PLMS Is Associated With Increased Risk Of Incident Adverse Cardiovascular Events And Death Among OSA Patients Sleep 2018, 41: a176-a176. DOI: 10.1093/sleep/zsy061.465.
  • 0533 AROUSAL THRESHOLD, OBESITY, AGE AND RACE PREDICT CONTINUOUS POSITIVE AIRWAY PRESSURE USE AMONG U.S. VETERANS WITH OBSTRUCTIVE SLEEP APNEAZinchuk A, Jeon S, Edwards B, Yaggi K. 0533 AROUSAL THRESHOLD, OBESITY, AGE AND RACE PREDICT CONTINUOUS POSITIVE AIRWAY PRESSURE USE AMONG U.S. VETERANS WITH OBSTRUCTIVE SLEEP APNEA Sleep 2017, 40: a198-a199. DOI: 10.1093/sleepj/zsx050.532.
  • Chapter 110 Central Sleep Apnea Diagnosis and ManagementZinchuk A, Thomas R. Chapter 110 Central Sleep Apnea Diagnosis and Management 2017, 1059-1075.e6. DOI: 10.1016/b978-0-323-24288-2.00110-0.
  • Central Sleep Apnea: Diagnosis and TreatmentZinchuk, A., Thomas, R. “Central Sleep Apnea: Diagnosis and Treatment,“ in Principles and Practice of Sleep Medicine (Sixth Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2016.
  • Arts, Sleep and MedicineZinchuk, A., Kryger, M. “Arts, Sleep and Medicine,” American Thoracic Society Podcast Series, 2016, http://www.thoracic.org/about/ats-podcasts/interview-with-professor-dr-meir-h-kryger.php
  • Simultaneous Mantle Cell Lymphoma and Undifferentiated Carcinoma Manifested by Pleural Studding and EffusionZinchuk A, Saukkonen J, Boosalis V, Brahma P. Simultaneous Mantle Cell Lymphoma and Undifferentiated Carcinoma Manifested by Pleural Studding and Effusion CHEST Journal 2013, 144: 597a-597b. DOI: 10.1378/chest.1702019.
  • The relative density of pharmaceutical powders, blends, dry granulations and immediate release tabletsHancock, B.C., Colvin, J.T., Mullarney, M.P., Zinchuk, A.V., “The relative density of pharmaceutical powders, blends, dry granulations and immediate release tablets,” Pharmaceutical Technology, April 2003, 64-80