2020
The pseudoGTPase group of pseudoenzymes
Stiegler AL, Boggon TJ. The pseudoGTPase group of pseudoenzymes. The FEBS Journal 2020, 287: 4232-4245. PMID: 32893973, PMCID: PMC7544640, DOI: 10.1111/febs.15554.Peer-Reviewed Original ResearchConceptsSignal transductionAmino acid divergenceEnzymatic activityLeucine-rich repeat kinase 2Amino acid differencesP190RhoGAP proteinsRepeat kinase 2Membrane traffickingCellular rolesEnzyme foldImportant mechanistic componentSmall GTPasesTranscriptional controlCellular functionsGTPasesKinase 2PseudoenzymesAcid differencesEC numbersCell migrationFunctional roleMitochondrial activityProteinCargo transportMechanistic components
2018
PseudoGTPase domains in p190RhoGAP proteins: a mini-review.
Stiegler AL, Boggon TJ. PseudoGTPase domains in p190RhoGAP proteins: a mini-review. Biochemical Society Transactions 2018, 46: 1713-1720. PMID: 30514771, PMCID: PMC6501215, DOI: 10.1042/bst20180481.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGTPase-Activating ProteinsHumansProtein BindingRhoA GTP-Binding ProteinSignal TransductionConceptsP190RhoGAP proteinsDetectable catalytic activityAbundant GTPaseSmall GTPasesRho familyStructural biologyCatalytic cleftEnzyme classesNew family membersFamily membersNoncanonical residuesGTPase enzymeKey regulatorCell migrationOverall proteinProteinBiochemical analysisGTPaseRecent discoveryRecent studiesDomainPseudoenzymesGTPasesCytokinesisDiscovery